Original Articles Korean Circulation J 2002;32 12 : Tc-99m MIBI 심근관류스펙트를이용한좌심실질량의측정 : 심초음파를이용한측정법과의비교 배선근 1 안병철 1 이상우 1 정신영 1 양동헌 2 박헌식 2 조용근

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1 Original Articles Korean Circulation J 2002;3212: Tc-99m MIBI 심근관류스펙트를이용한좌심실질량의측정 : 심초음파를이용한측정법과의비교 배선근 1 안병철 1 이상우 1 정신영 1 양동헌 2 박헌식 2 조용근 2 이재태 1 채성철 2 전재은 2 박의현 2 이규보 1 Left Ventricular Mass Measurement Using Tc-99m MIBI Myocardial Perfusion SPECTComparison with Echocardiographic Method Sun Keun Bae, MD 1, Byeong-Cheol Ahn, MD 1, Sang Woo Lee, MD 1, Shin Young Jeong, MD 1, Dong Heon Yang, MD 2, Hun Sik Park, MD 2, Yong Geun Jo, MD 2, Jaetae Lee, MD 1, Shung Chull Chae, MD 2, Jae Eun Jun, MD 2, Wee Hyun Park, MD 2 and Kyu Bo Lee, MD 1 1 Department of Nuclear Medicine, 2 Internal Medicine, Kyungpook National University Hospital, Kyungpook National Unversity Medical School, Daegu, Korea ABSTRACT Background and ObjectivesA left ventricular mass LVM can be used as a prognostic factor in patients with cardiovascular disease, and echocardiographic LVM measurements are most commonly used. We have measured LVM using quantitativel gated myocardial perfusion SPECT QGS, and compared these results with LVM measured by echocardiography. Subjects and MethodsOne hundred and sixteen subjects M/F66/50, mean age58 yrs underwent both rest QGS with Tc-99m MIBI and echocardiography. On visual interpretation, thirty-six subjects 31% showed perfusion defects. The myocardial volume was obtained using the AutoQU- ANT program, and the LVM LVMSPECT was calculated by multiplying the volume by the specific gravity of the myocardium. We also measured the echocardiographic LVM LVMEcho by the Devereux formula, within one month of the LVMSPECT. ResultsThe LVMSPECT and LVMEcho were well correlated r 0.717, p0.001, but a significant difference was noted between the two values. The mean difference between the LVMSPECT and LVMEcho was 24 g. The LVMEcho was smaller than the LVMSPECT in those subjects with a small LVMEcho, and greater than the LVMSPECT in the subjects with a large LVMEcho. The difference between the LVMEcho and LVMSPECT LVMEcho-LVMSPECT was positively correlated with the LVMEcho r0.893, p ConclusionThe LVMs measured by gated myocardial perfusion SPECT and echocardiography were well correlated. But they were significantly different, especially in subjects with large LVMs. Korean Circulation J 2002;3212: KEY WORDSHypertrophy, left ventricularradionulcide imagingechocardiography. 1072

$서론 대상및방법 대상 방법 - - Fig. 1. Echocardigraphic measurement of LV mass using M-mode technique. LV mass g0.80\1.04ist PWTLVID 3 -LVID 3 0.6.$

2 서론 대상및방법 대상 방법 - - Fig. 1. Echocardigraphic measurement of LV mass using M-mode technique. LV mass g0.80\1.04ist PWTLVID 3 -LVID ISTinterventricular septal thickness, PWTposterior wall thickness, LVIDleft ventricular internal diameter. Table 1. Comparison between LV masses measured by M-mode echocardiography and by gated myocardial perfusion SPECT MeanSD g Range g LVMEcho 15749* LVMSPECT 13323* p0.001 by wilcoxon signed ranks test, LVMEcho LV mass measured by M-mode echocardiography, LV- MSPECTLV mass measured by gated myocardial perfusion SPECT 1073

3 통계처리 결과 고찰 Fig. 3. Comparsion between LV masses measured by gated myocardial perfusion SPECT and by M-mode echocardiography. p0.001, LVleft ventricular. Fig. 2. Correlation between LV masses measured by gated myocardial perfusion SPECT and by M-mode echocardiog-raphy. LVleft ventricular Fig. 4. Correlation between LV mass measured by M- mode echocardiography and diff erence of LV masses, measured by M-mode echocaridography and gated myocardial perfusion SPECT. LVleft ventricular. Korean Circulation J 2002;3212:

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5 요약 배경및목적 : 방법 : 결과 : 결론 : 중심단어 REFERENCES 1) Boudoulas H. Determination of left ventricular mass in clinical practice. J Heart Valve Dis ) Verdecchia P, Schillaci G, Borgioni C, Ciucci A, Gattobigio R, Zampi I, Reboldi G, Porcellati C. Prognostic significance of serial changes in left ventricular mass in essential hypertension. Circulation ) Manunta P, Stella P, Rivera R, Ciurlino D, Cusi D, Ferrandi M, Hamlyn JM, Bianchi G. Left ventricular mass, stroke volume, and ouabain-like factor in essential hypertension. Hypertension ) Naqvi TZ, Goel RK, Forrester JS, Davidson RM, Siegel RJ. Usefulness of left ventricular mass in predicting recovery of left ventricular systolic function in patients with symptomatic idiopathic dilated cardiomyopathy. Am J Cardiol ) Germano G, Kavanagh PB, Berman DS. An automatic approach to the analysis, quantitation and review of perfusion and function from myocardial perfusion SPECT images. Int J Card Imaging ) Devereux RB, Alonso DR, Lutas EM, Gottlieb GJ, Campso E, Sachs I, Reichek N. Echocardiographic assessment of left ventricular hypertrophy comparison to necropsy findings. Am J Cardiol ) Beller GA. Myocardial perfusion imaging with thallium J Nucl Med ) Germano G, Kiat H, Kavannagh PB, Moriel M, Massanti M, Su HT, van Train KF, Berman DS. Automatic quantification of ejection fraction from gated myocardial perfusion SPECT. J Nucl Med ) Choragudi NL, Prakash AM, Sun Y, Prasad P, Chioramida SA, Lucariello RJ. Comparison of echocardiography with technetium-99m gated single photon emmission computed tomography as diagnostic tools for left ventricular ejection fraction. Echocardiog-raphy ) Bavelaar-Croon CD, Atsma DE, van der Wall EE, Dibbets- Schneider P, Zwinderman AH, Pauwels EK. The additive value of gated SPET myocardial perfusion imagings in patients with known and suspected coronary artery disease. Nucl Med Commun ) Acampa W, Cuocolo A, Sullo P, Varrone A, Nicolai E, Pace L, Petretta M, Salvatore M. Direct comparison of technetium 99m-sestamibi and technetium 99m-tetrofosmin cardiac single photon emission computed tomography in 1076 Korean Circulation J 2002;3212:

6 patients with coronary artery disease. J Nucl Cardiol ) Thorley PJ, Ball J, Sheard KL, Silvananthan UM. Evaluation of 99Tcm-tetrofosmin as a myocardial perfusion agent in routine clinical use. Nucl Med Commun ) Bavelaar-Croon CD, Pauwels EK, van der Wall EE. Gated single-photon emission computed tomographic myocardial imaging a new tool in clinical cardiology. Am Heart J ) Konno M, Morita K, Adachi I, Ito Y, Kohya T, Kitabatake A, Tsukamoto E, Tamaki N. Quantitative analysis of regional wall motion and thickening by quantitative gated SPECT comparison with visual analysis. Clin Nucl Med ) Iskandrian AE, Germano G, VanDecker W, Ogilby JD, Wolf N, Mintz R, Berman DS. Validation of left ventricular volume measurements by gated SPECT 99mTc-labeled sestamibi imaging. J Nucl Cardiol ) Germano G, Berman DS. On the accuracy and reproducibility of quantitative gated myocardial perfusion SPECT. J Nucl Med ) Germano G, Kavanagh PB, Waechter P, Areeda J, van Kriekinge S, Sharir T, Lewin HC, Berman DS. A new algorithm for the quantitation of myocardial perfusion SP- ECT I. technical principles and reproducibility. J Nucl Med ) Hyun IY, Kwan J, Park KS, Lee WH. Reproducibility of Tl-201 and Tc-99m sestamibi gated myocardial perfusion SPECT measurement of myocardial function. J Nucl Cardiol ) Vallejo E, Dione DP, Bruni WL, Constable RT, Borek PP, Soares JP, Carr JG, Condos SG, Wackers FJ, Sinusas AJ. Reproducibility and accuracy of gated SPECT for determination of left ventricular volumes and ejection fraction experimental validation using MRI. J Nucl Med ) Levy D, Anderson KM, Savage DD, Balkus SA, Kannel EB, Castelli WP. Risk of ventricular arrhythmias in left ventricular hypertrophy the framingham heart study. Am J Cardiol ) Messerli FH, Ventura HO, Elizardi DJ, Dunn FG, Frohlich ED. Hypertension and sudden death increased ventricular ectopic activity in LV hypertrophy. Am J Med ) Levy D, Anderson KM, Savage DD, Kannel WB, Cristiansen JC, Castelli WP. Echocardiographically detected left ventricular hypertrophy prevalence and risk factors. Ann Intern Med ) Haider AW, Larson MG, Benjamin EJ, Levy D. Increased left ventricular mass and hypertrophy are associated with increased risk for sudden death. J Am Coll Cardiol ) Chuang ML, Danias PG, Riley MF, Hibberd MG, Manning WJ, Douglas PS. Effect of increased body mass index on accuracy of two-dimensional echocardiography for measurement of left ventricular volume, ejection fraction, and mass. Am J Cardiol ) Williams KA, Lang RM, Reba RC, Tallion LA. Comparison of technetium-99m sestamibi-gated tomographic perfusion imag-ing with echocardiographiy and electrocardiography for determi-nation of left ventricular mass. Am J Cardiol ) Stewart GA, Foster J, Cowan M, Rooney E, McDonagh T, Dargie HJ, Rodger RS, Jardine AG. Echocardiography overestimates left ventricular mass in hemodialysis patients relative to magnetic resonance imaging. Kidney Int ) Yoshioka J, Hasegawa S, Yamaguchi H, Tokita N, Paul AK, Xiuli M, Maruyama A, Hori M, Nishimura T. Left ventricular volumes and ejection fraction calculated from quantitative electrocardiographic-gated Tc-99m tetrofosmin myocardial SPECT. J Nucl Med

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012임수진 Received : 2012. 11. 27 Reviewed : 2012. 12. 10 Accepted : 2012. 12. 12 A Clinical Study on Effect of Electro-acupuncture Treatment for Low Back Pain and Radicular Pain in Patients Diagnosed with Lumbar