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17 Patient number Sex Age Animal contact 1 F 36 No 2 F 31 Cat scratch Result of biopsy/aspiration cytology of lymph nodes Chronic granulomatous inflammation with caseation necrosis, compatible with tuberculous lymphadenopathy Tuberculous lymphadenitis: caseation necrosis, positive PCR to Mycobacterium tuberculosis. 3 F 40 Dog 4 M 9 Cat scratch, dog Tuberculous lymphadenopathy: chronic granulomatous inflammation with caseation necrosis. Tuberculous lymphadenopathy: chronic granulomatous inflammation 5 F 26 No Not done. Clinically tuberculous lymphadenitis 6 M 41 No Reactive lymphoid hyperplasia with noncaseating granuloma 7 M 28 No Kikuchi's disease 8 M 28 Dog Kikuchi's disease 9 F 32 No Kikuchi's disease 10 F 26 No Kikuchi's disease 11 F 13 No Kikuchi's disease 12 M 34 No Kikuchi's disease 13 M 6 No Chronic reactive lymphadenitis, Kawasaki disease 14 F 25 Dog Chronic reactive lymphadenitis 15 F 49 No Chronic reactive lymphadenitis 16 F 31 No Chronic reactive lymphadenitis 17 M 28 No Reactive lymphoid hyperplasia 18 F 26 No Reactive hyperplasia 19 F 21 Cat Reactive lymphoid hyperplasia 20 F 14 No Reactive hyperplasia 21 M 38 No Reactive hyperplasia

18 22 F 35 No Reactive lymphoid hyperplasia 23 F 22 No Reactive hyperplasia 24 F 51 No Chronic reactive hyperplasia 25 F 59 Cat, dog Chronic reactive lymphadenitis 26 F 31 No Chronic reactive lymphadenitis 27 F 22 No Benign reactive lymphadenopathy 28 F 18 Dog Chronic reactive lymphadenitis 29 F 28 Dog Not done, Clinically viral infection 30 F 24 No Reactive lymphoid hyperplasia, viral meningitis 31 F 76 No Suspicious for malignancy

19 B. henselae B. quintana Titer to: Positive, No. (%) No. of patients that contact with a cat Positive, * No. (%) 1:64 21 (67.7) 3 20 (64.5) 1: (38.7) 1 11 (35.5) 1:256 4 (12.9) 0 4 (12.9) 1:512 3 (9.7) 0 3 (9.7) All patients in this category were seropositive to B. henselae. These patients were also positivefor immunoglobulin G (IgG) against Bartonella henselae with titers of 256 or lower.

20 Patients with lymphadenopathy Patients with rheumatoid factor Healthy adults B. henselae (>1:64) 21 (67.7) 2 (10%) 1 (5%) B. quintana (>1:64) 20 (64.5) 2 (10%) 2 (10%)

21 Patient number Animal contact Antibody titer to B. henselae Antibody titer to B. quintana 1 No 1:128 1:128 2 Cat scratch 1:64-3 Dog 1:128 1:128 4 Cat scratch, dog 1:64 1:64 6 No 1:512 1:512 7 No 1:64 1:64 8 Dog 1:64 1:64 9 No 1:128 1: No 1:512 1: Dog 1:64 1:64 17 No 1:64 1:64 18 No 1:64 1:64 19 Cat 1:128 1: No 1:128 1: No 1:128 1: No 1:64 1:64 24 No 1:512 1: Dog 1:128 1: Dog 1:256 1:64 30 No 1:128 1: No 1:64 1:64

22 Patient number Sex Age Animal contact Antibody titer to B. henselae 1 F 36 No 1:128 3 F 40 Dog 1:128 4 M 9 Cat scratch, dog 1:64 6 M 41 No 1:512

23 Patient number Sex Age Animal contact Antibody titer to B. henselae Antibody titer to B. quintana Biopsy/Aspiration cytology 2 M 28 No 1:64 1:64 Kikuchi's disease 13 F 13 No - - Kikuchi's disease 17 F 26 No 1:512 1:512 Kikuchi's disease 18 M 28 Dog 1:64 1:64 Kikuchi's disease 20 F 32 No 1:128 1:128 Kikuchi's disease 31 M 34 No - - Kikuchi's disease

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