Special Issue Colorectal Polyps : Endoscopic Diagnosis and Polypectomy Seung Taek Oh, M.D. Department of General Surgery The Catholic University of Ko

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1 Colorectal Polyps : Endoscopic Diagnosis and Polypectomy Seung Taek Oh, M.D. Department of General Surgery The Catholic University of Korea, College of Medicine Kangnam St. Mary's Hospital E mail : stoh@catholic.ac.kr Abstract Acolonic polyp is a circumscribed mass of tissue that projects above the surface of the intestinal mucosa, which may be classified as either pedunculated or sessile, depending on whether or not it contains a discrete stalk, and according to the size and type. It has been believed that colorectal cancer evolves from a precursor lesion, the adenomatous polyp. The introduction of colonoscopy in the early 1970s, followed by the demonstration of the feasibility of colonoscopic polypectomy, provided the technology for the application of this concept to clinical practice. Colorectal cancer can be prevented through examination of the entire colon and identification of a polyp to be resected. According to the National Polyp Study in the USA, the incidence of colorectal cancer is reduced by 76~90% following colonoscopic polypectomy. Colonoscopy and polypectomy, when performed by adequately trained physicians, is a safe and effective procedure that can decrease deaths resulting from colorectal cancer. Keywords : Colonic polyp; Colon cancer; Colonoscopic polypectomy 594

2 sporadic polyps Non neoplastic NeoHyperplastic* (metaplastic) NeoInflammatory NeoJuvenile NeoLymphoid Neoplastic NeoAdenoma* NeoDALM* Hereditary polyps and polyposis Non neoplastic polyposis `Hyperplastic polyposis NeoJuvenile polyposis NeoPeutz Jeghers syndrome Neoplastic polyps NeoHNPCC* Neoplastic polyposis NeoFAP* NeoFlat adenoma syndrome DALM, dysplasia associated lesion or mass ; HNPCC, hereditary nonpolyposis colorectal cancer ; FAP, famillial adenomatous polyposis (includes Gardner's syndrome). * These polyps may display protruding and nonprotruding (flat) profiles. Despite the benign histological profile, patients are at risk for gastrointestinal and/or extraintestinal cancers. Carcinoma changes in neoplastic polyps and lesions : carcinoma in situ, intramucosal carcinoma, questionable invaslve carcinoma, submucosal carcinoma, de novo carcinoma. 595

3 Ip pedunculated Protruded Isp subpedunculated type Is sessile IIa flat elevated Superficial elevated IIa+dep flat elevated with depression type IIb flat Flat type IIa+IIc IIc slightly depressed Depressed type IIc+IIa LST 596

4 597

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6 599

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8 601

9 11. Nagasako K. Colonoscopic interpretation. 1st ed. Tokyo : lgakushoin, Rubio CA, Jaramillo E, Lindblom A, Fogt F. Classification of colorectal polyps : guidelines for the endoscopist. Endoscopy 2002 ; 34 : Macrae FA, Young GP. Neoplastic and nonneoplastic polyps of the colon and rectum. In : Yamada T, ed. Textbook of gastroenterology. Volume 2. 3rd ed. Philadelphia : Lippincott. Williams Wilkins, 1999 : Jackman RJ, Mayo CW. The adenoma carcinoma sequence 602

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11 of polypethylene glycol lavage versus sodium phosphate for colonoscopy preparation. Gastrointest Endosc 1998 ; 48 : Waye JD. Endoscopic mucosal resection of colon polyps. Gastrointest Endosc Clin N Am 2001 ; 11 : Van Gossum A, Cozzoli A, Adler M, Taton G, Cremer M. Colonoscopic snare polypectomy : analysis of 1485 resections comparing two types of current. Gastrointest Endosc 1992 ; 38 : Waye JD. Techniques of polypectomy : hot biopsy forceps and snare polypectomy. Am J Gastroenterol 1987 ; 82 : , 2000 : Waye JD, Lewis BS, Frankel A, Geller SA. Small colon polyps. Am J. Gastroenterol 1988 ; 83 : Waye JD. Saline injection colonoscopic polypectomy [editorial]. Am J Gastroenterol 1994 ; 89 ; Axelrad AM, Fleischer D, Geller AJ, Nguyen CC, Lewis JH, Al- Kawas FH, et al. High resolution chromoendoscopy for the diagnosis of diminutive colon polyps : Implications for colon cancer screening. Gastroenterology 1996 ; 110 : Shirai M, Nakamura T, Matsuura A, Ito Y, Kobayashi S. Safer colonoscopic polypectomy with local submucosal injection of hypertonic saline epinephrine solution. Am J Gastroenterol 1994 ; 89 : Uno Y, Munakata A. The non lifting sign of invasive colon cancer. Gastrointest Endosc 1994 ; 40 : Stein BL, Coller JA. Management of malignant colorectal polyps. Surg Clin North Am 1993 : 73 - I : Waye JD. New method of polypectomy. Gastrointest Endosc Clin N Am 1997 ; 7 : Nelson D. Colonoscopy and polypectomy. Hematol Oncol Clin N Am 2002 ; 16 : Morson BC. Factors influencing the prognosis of early cancer 43. Fenoglio CM, Kaye GI, Lane N. Distribution of human colonic lymphatics in normal, hyperplastic and adenomatous tissue. Its relationship to metastasis from small carcinomas in pedunculated adenomas. Gastroenterology 1973 ; 64 : Karita M, Tada M, Okita K. The successive strip biopsy partial resection technique for large early gastric and colon cancers. Gastrointest Endosc 1992 ; 38 : Muto T, Ishikawa K, Kino I, Nakamura K, Sugano HH. Comparative histologic study of adenomas of the large intestine in Japan and England with special reference to malignant potential. Dis Colon Rectum 1977 ; 20 : Nivatvongs S, Goldberg SM. Management of patients who have polyps containing invasive carcinoma removed via colonoscope. Dis Colon Rectum 1978 ; 21 : Tada M, Inoue H, Yabata E, Okabe S, Endo M. Colonic mucosal resection using a transparent capfitted endoscope. Gastrointest Endosc 1996 ; 44 : Rex DK, Smith JJ, Ulbright TM, Lehman GA. Distal colonic hyperplastic polyps do not predict proximal adenomas in asymptomatic average risk subjects. Gastroenterology 1992 ; 102 : Morson BC, Konishi F. Contribution of the pathologist to the radiology and management of colorectal polyps. Gastrointest Radiol 1982 ; 7 : Matek W, Guggenmoos Holzman I, Demling L. Follow up of patients with colorectal adenomas. Endoscopy 1985 ; 17 : Waye JD, Braunfeld SF. Surveillance interval after colonoscopic polypectomy. Endoscopy 1982 ; 14 : Bond JH. Polyp Guide lines: diagnosis treatment and surveillance for patients with non familial colorectal polyps. Ann Intern Med 1993 ; 119 : ASGE. Guidelines for colorectal cancer screening and surveillance. Gastrointest Endosc 2000 ; 51 : of the rectum. Proc R Soc Med 1966 ; 59 :

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