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1 Comparison of physical fitness, indices of lifestyle disease, and biochemical property of muscle according to sarcopenia and obesity in elderly women Won-Sang Jung, Hyun-Seok Cho, & Man-Gyoon Lee* Kyung Hee University [Purpose] [Methods] m2 [Results] [Conclusion] Key words: ㆍ


3 m2 ㆍ cm kg kg m2 kg kg Table 1. Physical characteristics of subjects Variables +obesity F value P value Age(yrs) 77.55± ± ± ± Height( cm ) ± ± ± ± Body weight( kg ) 55.73±0.96a 47.66±0.93b 61.00±1.06c 53.80±1.12a *** BMI( kg / m2 ) 24.12±0.33a 20.73±0.32b 26.45±0.35c 23.59±0.39a *** Fat-free mass( kg ) 32.80±0.55a 31.62±0.44a 36.40±0.65b 35.65±0.66b *** Fat mass( kg ) 21.98±0.71a 14.77±0.58b 23.31±0.59a 16.70±0.55b *** Percent body fat(%) 39.43±0.80a 30.93±0.83b 38.06±0.49a 30.88±0.59b *** ASM( kg / m2 ) 5.06±0.11a 5.24±0.04a 6.12±0.07b 6.15±0.10b ***

4 ml µ ml l α

5 Table 2. Comparison of physique and body composition among four groups Variables +obesity F values P value Height( cm ) ± ± ± ± Body weight( kg ) 55.73±0.96 a 47.66±0.93 b 61.00±1.06 c 53.80±1.12 a *** BMI( kg m -2 ) 24.12±0.33 a 20.73±0.32 b 26.45±0.35 c 23.59±0.39 a *** Waist circumference( cm ) 90.75±1.37 a 80.66±1.21 b 92.67±1.30 a 86.16±0.97 c *** Hip circumference( cm ) 93.80±1.09 a 88.12±1.07 b 95.12±0.87 a 90.86±0.52 c *** Waist-hip ratio 0.97±0.01a c 0.92±0.01 b 0.97±0.01 a 0.95±0.01 c *** Fat-free mass( kg ) 32.80±0.55 a 31.62±0.44 a 36.40±0.65 b 35.65±0.66 b *** Fat mass( kg ) 21.98±0.71 a 14.77±0.58 b 23.31±0.59 a 16.70±0.55 b *** Percent body fat(%) 39.43±0.80 a 30.93±0.83 b 38.06±0.49 a 30.88±0.59 b *** Table 3. Comparison of daily living fitness among four groups Variables +obesity F values P value Left grip strength( kg ) 20.08±1.06 a 19.73±0.72 a 23.36±0.62 b 24.27±0.56 b *** Right grip strength( kg ) 21.04±0.86 a 21.25±0.82 a 23.96±0.69 b 25.22±0.67 b *** Upper arm flexion(times) 20.52±1.10 a 21.04±0.90 a 23.39±0.63 b 23.41±0.59 b * Chair sit to stand(times) 17.60±1.31 a 18.99±0.92 ab 20.43±1.16 ab 21.54±0.64 b * Sit-and-reach( cm ) 10.54±1.93 a 11.12±1.48 a 11.81±1.38 a 15.47±1.09 b * Back scratch( cm ) 16.70± ± ± ± One leg standing: left (sec) 10.91± ± ± ± One leg standing: right(sec) 9.00± ± ± ± Functional reach( cm ) 26.91± ± ± ± Tandem test(sec) 11.94±0.74 a 10.91±0.67 b 10.31±0.58 ab 9.46±0.54 b * Up and go(sec) 7.12±0.41 a 6.88±0.25 a 6.50±0.20 ab 6.14±0.17b * Foot stepping(times) 26.95± ± ± ± Carrying beans using chopsticks 12.43± ± ± ± Pegboard 33.69± ± ± ± VO2max(ml kg -1 min -1 ) 23.65±1.01 a 24.41±1.11 a 25.84±0.54 ab 27.14±0.88 b * Table 4. Comparison of isokinetic function(60 /sec) among four groups Variables +obesity F values P value Peak torque(nm) 62.11±4.54 a 62.51±3.03 a 73.11±2.40 b 77.70±4.17 b ** Peak torque per BW(%BW) ±8.68 a ±6.69 ab ±4.54 a ±7.36 b * Extension Total work(nm) ± ± ± ± Total work per BW(%BW) ± ± ± ± Average power(w) 37.75±2.76 a 38.49±1.63 a 42.29±1.57 ab 46.44±2.75 b * Average power per BW(%BW) 67.38±5.38 a 78.45±3.63 ab 70.23±2.53 a 83.89±4.69 b * Peak torque(nm) 35.14± ± ± ± Peak torque per BW(%BW) 62.85±5.38 a 72.20±4.56 ab 64.31±3.57 a 78.45±4.54 b * Flexion Total work(nm) 80.81± ± ± ± Total work per BW(%BW) ± ± ± ± Average power(w) 23.24±2.05 a 24.53±1.38 a 27.01±1.83 ab 30.47±1.90 b * Average power per BW(%BW) 41.43±3.84 a 49.77±3.15 ab 45.70±2.98 a 55.45±3.35 b *

6 Table 5. Comparison of variables related to hypertension among four groups Variables +obesity F values P value Heart rate(beats min -1 ) 79.72±2.46 a 74.80±2.31 ab 77.04±2.23 a 70.45±1.83 b * SBP(mmHg) ± ± ± ± DBP(mmHg) 85.92± ± ± ± MAP(mmHg) ± ± ± ± PP(mmHg) 49.01± ± ± ± RPP ± a ± ab ± a ± b * Table 6. Comparison of variables related to diabetes mellitus among four groups Variables +obesity F values P value FPG( mg dl -1 ) ± ± ± ± FPI(μU ml -1 ) 7.86±0.85 a 5.52±0.56 b 7.33±0.69 a 5.60±0.41 b * HOMA-IR 2.26±0.27 a 1.51±0.19 bc 2.09±0.27 ac 1.41±0.10 b * Table 7. Comparison of variables related to hyperlipidemia among four groups Variables +obesity F values P value TC( mg dl -1 ) ± ± ± ± TG( mg dl -1 ) ± ± ± ± LDL-C( mg dl -1 ) ± ± ± ± HDL-C( mg dl -1 ) 43.20±2.18 a 51.72±2.64 bc 48.07±1.68 ac 53.99±2.41 b ** Table 8. Comparison of variables related to atherosclerosis among four groups Variables +obesity F values P value TC/HDL-C ratio 4.62±0.28 a 3.68±0.23 b 3.97±0.22 ab 3.47±0.21 b ** TG/HDL-C ratio 3.46± ± ± ± LDL-C/HDL-C ratio 2.93±0.22 a 2.18±0.21 b 2.39±0.18 ab 1.98±0.17 b ** Table 9. Comparison of biochemical property of muscle among four groups Variables +obesity F values P value hs-crp( mg l -1 ) 1.44± ± ± ± IL-6(pg ml -1 ) 1.95±0.26 a 1.60±0.29 ab 1.67±0.21 a 1.13±0.10 b * IGF-1(ng ml -1 ) ± ± ± ±






12 Ansari, M., Javadi, H., Pourbehi, M., Mogharrabi, M., Rayzan, M., Semnani, S., Jallalat, S., Amini, A., Abbaszadeh, M., Barekat, M., & Nabipour, I.(2012). The association of rate pressure product (RPP) and myocardial perfusion imaging (MPI) findings: a preliminary study. Perfusion, 27(3), Aragao, F., Abrantes, C., Gabriel, R., Mota, P., & Moreira, H.(2010). Cardiorespiratory fitness and sarcopenic obesity in postmenopausal women. Reviews, 11(1), Atkins, J. L., Whincup, P. H., Morris, R. W., Lennon, L. T., Papacosta, O., & Wannamethee, S. G.(2014). Sarcopenic obesity and risk of cardiovascular disease and mortality: a population based cohort study of older men. Journal of the American Geriatrics Society, 62(2), Auyeung, T. W., Lee, J. S. W., Leung, J., Kwok, T., & Woo, J.(2013). Adiposity to muscle ratio predicts incident physical limitation in a cohort of 3,153 older adults an alternative measurement of sarcopenia and sarcopenic obesity. Age, 35(4), Baek, S. J., Nam, G. E., Han, K. D., Choi, S. W., Jung, S. W., Bok, A. R., Kim, Y. H., Lee, K. S., Han, B. D., & Kim, D. H.(2014). and sarcopenic obesity and their association with dyslipidemia in korean elderly men: the korea national health and nutrition examination

13 survey. Journal of Endocrinological Investigation, 37(3), Bahat, G. & Ilhan, B.(2016). and the cardiometabolic syndrome: A narrative review. European Geriatric Medicine, 7(3), Bartnik, M., Rydén, L., Ferrari, R., Malmberg, K., Pyörälä, K., Simoons, M., & Öhrvik, J.(2004). The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. European Heart Journal, 25(21), Bhan, V., Yan, R. T., Leiter, L. A., Fitchett, D. H., Langer, A., Lonn, E., Tan, M., Silagy, S., Goodman, S., G. & Yan, A. T.(2010). Relation between obesity and the attainment of optimal blood pressure and lipid targets in high vascular risk outpatients. The American Journal of Cardiology, 106(9), Bouchonville, M. F. & Villareal, D. T.(2013). Sarcopenic How Do We Treat It?. Current Opinion in Endocrinology, Diabetes, and, 20(5), Bray, G. A.(2004). Medical consequences of obesity. The Journal of Clinical Endocrinology & Metabolism, 89(6), Breen, L. & Phillips, S. M.(2011). Skeletal muscle protein metabolism in the elderly: interventions to counteract the anabolic resistance of ageing. Nutrition and Metabolism, 8(1), Cesari, M., Penninx, B. W., Pahor, M., Lauretani, F., Corsi, A. M., Williams, G. R., Guralnik, J. M., & Ferrucci, L.(2004). Inflammatory markers and physical performance in older persons. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 59(3), M242-M248. Chang, C. I., Huang, K. C., Chan, D. C., Wu, C. H., Lin, C. C., Hsiung, C. A., Hsu, C. C., & Chen, C. Y.(2015). The impacts of sarcopenia and obesity on physical performance in the elderly. Research and Clinical Practice, 9(3), Chen. L. K., Liu, L. K., Woo, J., Assantachai, P., Auyeung, T, W., Bahyah, K. S., Chou, M. Y., Chen, L. Y., Hsu, P. S., Krairit, O., Lee, S. W., Lee, W. J., Lee, Y., Liang, C. K., Limpawattana, P., Lin, C. S., Peng, L. N., Satake, S., Suzuki, T., Won, C. W., Wu, C. H., Wu, S. N., Zhang, T., Zeng, P., Akishita, M., & Arai, H.(2014). in Asia: consensus report of the Asian working group for sarcopenia. Journal of the American Medical Directors Association, 15(2), Cleasby, M. E., Jamieson, P. M., & Atherton, P. J.(2016). Insulin resistance and sarcopenia: mechanistic links between common co-morbidities. Journal of Endocrinology, 229(2), R67-R81. Courand, P. Y. & Lantelme, P.(2014). Significance, prognostic value and management of heart rate in hypertension. Archives of Cardiovascular Diseases, 107(1), Cramer, J. T., Jenkins, N. D., Mustad, V. A., & Weir, J. P.(2015). Isokinetic dynamometry in healthy versus sarcopenic and malnourished elderly beyond simple measurements of muscle strength. Journal of Applied Gerontology, 2015, Cryer, P. E.(2004). Diverse causes of hypoglycemia-associated autonomic failure in diabetes. New England Journal of Medicine, 350(22), Deschenes, M. R.(2004). Effects of aging on muscle fibre type and size. Sports Medicine, 34(12), Dutra, M. T., Gadelha, A. B., Nóbrega, O. T., & Lima, R. M.(2017). Body adiposity index, but not visceral adiposity index, correlates with inflammatory markers in sarcopenic obese elderly women. Experimental Aging Research, 43(3), Emilio, E. J., Hita-Contreras, F., Jiménez-Lara, P. M., Latorre-Román, P., & Martínez-Amat, A.(2014). The association of flexibility, balance, and lumbar strength with balance ability: risk of falls in older adults. Journal of Sports Science and Medicine, 13(2), Grundy, S. M., Cleeman, J. I., Daniels, S. R., Donato, K. A., Eckel, R. H., Franklin, B. A., Gordon, D. J., Krauss, R. M., Savage, P. J., Smith, S. C., Spertus, J. A., & Costa, F.(2005). Diagnosis and management of the metabolic syndrome. Circulation, 112(17), Han, D. S., Chang, K. V., Li, C. M., Lin, Y. H., Kao, T. W., Tsai, K. S., Wang, T. G., & Yang, W. S.(2016). Skeletal muscle mass adjusted by height correlated better with muscular functions than that adjusted by body weight in defining sarcopenia. Scientific Reports, 6, 1-8. Han, K., Park, Y. M., Kwon, H. S., Ko, S. H., Lee, S. H., Yim, H. W., Lee, W. C., Park, Y. G., Kim, M. K., & Park, Y. M.(2014). as a determinant of blood pressure

14 in older Koreans: findings from the Korea National Health and Nutrition Examination Surveys (KNHANES) PLoS One, 9(1), e Hardy, R., Cooper, R., Sayer, A. A., Ben-Shlomo, Y., Cooper, C., Deary, I. J., Demakakos, P., Gallacher, J., Martin, R. M., McNeill, G., Starr, J. M., Steptoe, A., Syddall, H., & Kuh, D.(2013). Body mass index, muscle strength and physical performance in older adults from eight cohort studies: the HALCyon programme. PLoS One, 8(2), e Heyward, V. H. & Gibson, A.(2014). Advanced Fitness Assessment and Exercise Prescription, 7th edition. Human Kinetics: Champaign, IL. Hui, S. C., Jackson, A. S., & Wier, L. T.(2000). Development of normative values for resting and exercise rate pressure product. Medicine and Science in Sports and Exercise, 32(8), Kalinkovich, A. & Livshits, G.(2017). Sarcopenic obesity or obese sarcopenia: a cross talk between age-associated adipose tissue and skeletal muscle inflammation as a main mechanism of the pathogenesis. Ageing Research Reviews, 35, Kang, H. G. & Dingwell, J. B.(2008). Effects of walking speed, strength and range of motion on gait stability in healthy older adults. Journal of Biomechanics, 41(14), Kim, J. H., Choi, S. H., Lim, S., Yoon, J. W., Kang, S. M., Kim, K. W., Lim, J. Y., Cho, N. H., & Jang, H. C.(2013). and obesity: gender-different relationship with functional limitation in older persons. Journal of Korean Medical Science, 28(7), Kim, M., Lee, Y. J., Song, H. J., Shim, J. K., Chang, D. H., Yu, W. K., Lee, S. H., & Lee, J. H.(2017). Supplementation with nutrients modulating insulin like growth factor 1 negatively correlated with changes in the levels of pro inflammatory cytokines in communitydwelling elderly people at risk of undernutrition. Journal of Human Nutrition and Dietetics, 30(1), Kim, T. N., Park, M. S., Kim, Y. J., Lee, E. J., Kim, M. K., Kim, J. M., Ko, K. S., Rhee, B. D., & Won, J. C.(2014). Association of low muscle mass and combined low muscle mass and visceral obesity with low cardiorespiratory fitness. PLoS One, 9(6), e Kohara, K.(2014). Sarcopenic obesity in aging population: current status and future directions for research. Endocrine, 45(1), Kohli, A., Siddhu, A., Pandey, R. M., & Reddy, K. S.(2017). Relevance of the triglyceride-to-high-density lipoprotein cholesterol ratio as an important lipid fraction in apparently healthy, young, and middle-aged Indian men. Indian Journal of Endocrinology and Metabolism, 21(1), 113. Kramer, I. F., Snijders, T., Smeets, J. S., Leenders, M., van Kranenburg, J., den Hoed, M., Verdijk, L. B., Poeze, M., & van Loon, L. J.(2017). Extensive type II muscle fiber atrophy in elderly female hip fracture patients. The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences, 72(6), 1-7. Lazarus, R., Sparrow, D., & Weiss, S. T.(1997). Handgrip strength and insulin levels: cross-sectional and prospective associations in the Normative Aging Study. Metabolism, 46(11), Levine, M. E. & Crimmins, E. M.(2012). The impact of insulin resistance and inflammation on the association between sarcopenic obesity and physical functioning., 20(10), Lim, S., Kwon, S. Y., Yoon, J. W., Kim, S. Y., Choi, S. H., Park, Y. J., Yoon, H. I., Chang, Y. S., Lee, J. H., Lee, C. T., Kim, K. W., Park, K. S., & Jang, H. C.(2011). Association between body composition and pulmonary function in elderly people: the Korean Longitudinal Study on Health and Aging., 19(3), Lu, C. W., Yang, K. C., Chang, H. H., Lee, L. T., Chen, C. Y., & Huang, K. C.(2013). Sarcopenic obesity is closely associated with metabolic syndrome. Research and Clinical Practice, 7(4), e301-e307. Manfre, M. J., Yu, G. H., Varmá, A. A., Mallis, G. I., Kearney, K., & Karageorgis, M. A.(1994). The effect of limited handrail support on total treadmill time and the prediction of VO2max. Clinical Cardiology, 17(8), Manini, T. M., Hong, S. L., & Clark, B. C.(2013). Aging and muscle: a neuron s perspective. Current Opinion in Clinical Nutrition and Metabolic Care, 16(1), Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., & Turner, R. C.(1985). Homeostasis model assessment: insulin resistance and β-cell function

15 from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), Milanović, Z., Pantelić, S., Trajković, N., Sporiš, G., Kostić, R., & James, N.(2013). Age-related decrease in physical activity and functional fitness among elderly men and women. Clinical Interventions in Aging, 8, Pisciottano, M. V. C., Pinto, S. S., Szejnfeld, V. L., & de Moura Castro, C. H.(2014). The relationship between lean mass, muscle strength and physical ability in independent healthy elderly women from the community. The Journal of Nutrition, Health & Aging, 18(5), Poggiogalle, E., Lubrano, C., Gnessi, L., Mariani, S., Lenzi, A., & Donini, L. M.(2016). Fatty liver index associates with relative sarcopenia and GH/IGF-1 status in obese subjects. PLoS One, 11(1), e Pouliot, M. C., Després, J. P., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Nadeau, A., & Lupien, P. J.(1994). Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. The American Journal of Cardiology, 73(7), Rikli, R. E. & Jones, C. J.(2001). Senior Fitness Test Manual. Human Kinetics: Champaign, IL. Sanada, K., Iemitsu, M., Murakami, H., Gando, Y., Kawano, H., Kawakami, R., Tabata, I., & Miyachi, M.(2012). Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women. European Journal of Clinical Nutrition, 66(10), Sara, J. D., Prasad, M., Zhang, M., Lennon, R. J., Herrmann, J., Lerman, L. O., & Lerman, A.(2017). High-sensitivity C-reactive protein Is an independent marker of abnormal coronary vasoreactivity in patients with non-obstructive coronary artery disease. American Heart Journal, 190, e1-e8. Schmitz, K. H., Hannan, P. J., Stovitz, S. D., Bryan, C. J., Warren, M., & Jensen, M. D.(2007). Strength training and adiposity in premenopausal women: strong, healthy, and empowered study. The American Journal of Clinical Nutrition, 86(3), Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L.(2007). Sarcopenic obesity and inflammation in the Invecchiare in Chianti Study. Journal of Applied Physiology, 102(3), Segal, N. A., Zimmerman, M. B., Brubaker, M., & Torner, J. C.(2011). and knee osteoarthritis are not associated with impaired quadriceps specific strength in adults. The Journal of Injury, Function, and Rehabilitation, 3(4), Serra, R. J.(2006). Clinical consequences of sarcopenia. Nutricion Hospitalaria, 21(1), Siparsky, P. N., Kirkendall, D. T., & Garrett, W. E.(2014). Muscle changes in aging: understanding sarcopenia. Sports Health, 6(1), Stenholm, S., Alley, D., Bandinelli, S., Griswold, M. E., Koskinen, S., Rantanen, T., & Ferrucci, L.(2009). The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study. International Journal of, 33(6), Taylor, V. H., Forhan, M., Vigod, S. N., McIntyre, R. S., & Morrison, K. M.(2013). The impact of obesity on quality of life. Best Practice and Research Clinical Endocrinology and Metabolism, 27(2), Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F.(2010). The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. International Journal of Cardiology, 141(2), Waters, D. L. & Baumgartner, R. N.(2011). and obesity. Clinics in Geriatric Medicine, 27(3), Whelton, S. P., Narla, V., Blaha, M. J., Nasir, K., Blumenthal, R. S., Jenny, N. S., Al-Mallah, M. H., & Michos, E. D.(2014). Association between resting heart rate and inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin-6, and fibrinogen)(from the Multi-Ethnic Study of Atherosclerosis). The American Journal of Cardiology, 113(4), Williams, R. S., Heilbronn, L. K., Chen, D. L., Coster, A. C., Greenfield, J. R., & Samocha-Bonet, D.(2015). Dietary acid load, metabolic acidosis and insulin resistance Lessons from cross-sectional and overfeeding studies in humans. Clinical Nutrition, 2015, 1-7. Winer, D. A., Luck, H., Tsai, S., & Winer, S.(2016). The intestinal immune system in obesity and insulin resistance. Cell Metabolism, 23(3),

16 Yamada, M., Nishiguchi, S., Fukutani, N., Tanigawa, T., Yukutake, T., Kayama, H., Aoyama, T., & Arai, H.(2013). Prevalence of sarcopenia in community-dwelling Japanese older adults. Journal of the American Medical Directors Association, 14(12), Zhu, S., Wang, Z., Heshka, S., Heo, M., Faith, M. S., & Heymsfield, S. B.(2002). Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: clinical action thresholds. The American Journal of Clinical Nutrition, 76(4), m2