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1 9 th Annual Meeting of The Korean Hair Research Society 제 9 차대한모발학회학술대회 일시 : 2012년 6월 3일 ( 일 ) 09:00~17:30 장소 : 백범김구기념관 대한모발학회

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3 I would like to welcome everyone who joined us here at the 9th Meeting of The Korean Hair Research Society. Time has come by, and it is the 9th time we are holding this Meeting of The Korean Hair Research Society. Neither many nor few, but I think that we have developed hair related treatment techniques more and more, and made positive contributions to development of hair health related products through the symposium. This was all possible thanks to active participations by all of you, and thanks to the passion of the medical staff striving at the site. As you may well know, hair related industry is rapidly growing, and on the other side, such growth is supported by the increasing trend of hair loss patients derived from complicated modern lives. Many people, however, are still mistaken that hair loss only occurs due to hereditary reasons, and there are numerous cases where people rely on non medical methods. So Meeting of The Korean Hair Research Society has conducted The Green Hair Campaign last September to publicly promote the necessity of early diagnosis for hair loss and the appropriate treatment methods. We hope that The Green Hair Campaign continues in future, and medical treatment of hair loss positions itself as a common knowledge. From that perspective, the Meeting of The Korean Hair Research Society where opinions on latest treatment methods are shared and new clinical activities are introduced can be said to provide a reliable matrix for various campaign activities held and hosted by the society. Today, at the 9th Meeting, we have prepared lectures from renowned professors and medical staffs from all around the world in the field of hair. We express our infinite gratitude to Dr. Mayumi Ito of NYU, Dr. Maria Hordinsky of University of Minnesota, and Dr. Takashi Matsuzaki of Shimane University. Also, we would like to thank for the outstanding lecture preparations by domestic lecturers. Anyhow, we wish that this be a fruitful hour for all participants today acquiring much knowledge through the lectures. Also, we hope that this be an opportunity for old acquaintances to share precious opinions and promote amity. For the successful hosting of the 8th World Congress for Hair Research in 2014 where the competence of Korea Hair Research Society shall be revealed, we ask for the love and support of the members. Thank you. June 2012 Jin Soo Kang President of the Korean Hair Research Society

4 9 th Annual Meeting of The Korean Hair Research Society 제 9 차대한모발학회학술대회 일정표

5 9 th Annual Meeting of The Korean Hair Research Society 제 9 차대한모발학회학술대회 프로그램 Session 1 Free Communication (English speaking session) Chairs: Chull Wan Ihm, Kyung Hwan Cho 09:00-10:10 Original & Case report 10:00-10:20 Coffee break 10:20-10:30 Opening Address Jin-Soo Kang (President, KHRS) Congratulatory Address Kyung Hwan Cho (Vice President, KDA) Session 2 Hair Stem Cell and Morphogenesis (English speaking session) Chairs: Do Won Kim, Kyu Han Kim 10:30-11:05 Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration Mayumi Ito (NYU, USA) 11:05-11:40 Expression of clock genes is differentially controlled between follicular epithelia and dermal papillae during hair cycles Takashi Matsuzaki (Shimane University, Japan) 11:40-12:05 Defining the function of genes in differentiation of hair follicle stem cells : toward cure for baldness Joonsung Hwang (KRIBB) 12:05-12:20 Group Photo 12:20-13:20 Lunch & Exhibitions Session 3 Educational Lecture (English speaking session) Chair: Won-Soo Lee 13:20-13:55 Alopecia areata: biomarkers and clinical trials, quest for a safe and effective therapy Maria Hordinsky (University of Minnesota, USA)

6 Session 4 Updates of Pattern Hair Loss (Korean speaking session) Chairs: Byung In Ro, Jin-Soo Kang 14:00-14:20 Algorithmic guideline for management of pattern hair loss in Asian Won-Soo Lee (Yonsei Wonju University) 14:20-14:40 Update of female pattern hair loss Oh Sang Kwon (Seoul National University) 14:40-15:00 Coffee break Session 5 Hair Transplantation (Korean speaking session) Chairs: Hong Jig Kim, Si Yong Kim 15:00-15:25 Basic concept of hair transplantation Hangrae Cho (Ohkims Dermatologic Clinic) 15:25-15:50 Checkpoints for each hair transplantation step Byung Cheol Park (Dankook University) 15:50-16:15 Hairline design for male pattern hair loss Sung Joo Hwang (Dr. Hwang s Hair Clinic) 16:15-16:40 Weighting in androgenetic alopecia type VI-VII In Gang Jang (SkinLine Clinic) 16:45-17:15 Panel discussion [ Satellite ] Rumination on Diagnosis and Treatment Options (Korean speaking session) Chairs: Jang Kyu Park, Woo-Young Sim 15:00-15:15 Treatments of alopecia areata Byung In Ro (Kwandong University) 15:15-15:30 Diagnosis and treatment options : Pattern hair loss Woo-Young Sim (Kyunghee University) 15:30-15:45 Trichotillomania Chull Wan Ihm (Chonbuk University) 15:45-16:00 Folliscopic diagnosis of pattern hair loss Jin-Soo Kang (Kangskin Clinic)

7 9 th Annual Meeting of The Korean Hair Research Society 제 9 차대한모발학회학술대회 목 차 Session 1 Free Communication (English speaking session) Alopecia areata in the elderly: A 10 years retrospective study Kyung Hea Park et al. (Kyungpook National University) 14 ㆍ Hairline preference among various layers of Korean population Inho Park et al. (Inha University) 15 ㆍ Characteristic aging features in Korean women s hair Su-na Kim et al. (Amorepacific R&D Center) 16 ㆍ Ultrastructural localization and maturation of integral hair lipid in human hair follicle Long-Quan Pi et al. (Yonsei Wonju University) 17 ㆍ Identification of a novel U2HR mutation in a Korean woman with Marie Unna Hereditary Hypotrichosis Ki-Hun Song et al. (Chonbuk National University) 18 ㆍ The effects of sortilin on human hair growth Xing-Hai Jin et al. (Yonsei Wonju University) 19 Session 2 Hair Stem Cell and Morphogenesis (English speaking session) Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration Mayumi Ito (NYU, USA) 22 Expression of clock genes is differentially controlled between follicular epithelia and dermal papillae during hair cycles Takashi Matsuzaki (Shimane University, Japan) 25 Defining the function of genes in differentiation of hair follicle stem cells : toward cure for baldness Joonsung Hwang (KRIBB) 28 Session 3 Educational Lecture (English speaking session) Alopecia areata: Biomarkers and clinical trials, quest for a safe and effective therapy Maria Hordinsky (University of Minnesota, USA) 32

8 Session 4 Updates of Pattern Hair Loss (Korean speaking session) Algorithmic guideline for management of pattern hair loss in Asian Won-Soo Lee (Yonsei Wonju University) 36 Update of female pattern hair loss Oh Sang Kwon (Seoul National University) 38 Session 5 Hair Transplantation (Korean speaking session) Basic concept of hair transplantation Hangrae Cho (Ohkims Dermatologic Clinic) 42 Checkpoints for each hair transplantation step Byung Cheol Park (Dankook University) 45 Hairline design for male pattern hair loss Sung Joo Hwang (Dr. Hwang s Hair Clinic) 47 Weighting in androgenetic alopecia type VI-VII In Gang Jang (SkinLine Clinic) 49 [ Satellite ] Rumination on Diagnosis and Treatment Options (Korean speaking session) Treatments of alopecia areata Byung In Ro (Kwandong University) 52 Diagnosis and treatment options : Pattern hair loss Woo-Young Sim (Kyunghee University) 54 Trichotillomania Chull Wan Ihm (Chonbuk University) 56 Folliscopic diagnosis of pattern hair loss Jin-Soo Kang (Kangskin Clinic) 58

9 Free Communication [ Original & Case report ] 1. Alopecia areata in the elderly: A 10 years retrospective study Kyung Hea Park, Yoon Hyuk Choi, Han Jin Jung, Hyun Jung Lim, Weon Ju Lee, Seok-Jong Lee, Do Won Kim Department of Dermatology, Kyungpook National University School of Medicine Hairline preference among various layers of Korean population Inho Park 1, Chan Yl Bang 2, Min Ji Kang 2, Jong Hyuk Moon 2, Bo Hee Yang 2, Ji Won Byun 2, Hee Jin Song 2, Jeong Hyun Shin 2, Gwang Seong Choi 2 1 ilove Hair Center, 2 Department of Dermatology, Inha University School of Medicine Characteristic aging features in Korean women s hair Su-na Kim¹, Ahreum Kim¹, Soo-yeon Lee², Won-Seok Park¹ 1 Advanced Hair Research Lab, Amorepacific R&D Center, Yong-in, South Korea 2 Dermapro/Skin Research Center, Seoul, South Korea Ultrastructural localization and maturation of integral hair lipid in human hair follicle Long-Quan Pi¹, Sungjoo Tommy Hwang², Won-Soo Lee¹ 1 Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, 2 Dr. Hwang s Hair-Hair Clinic Identification of a novel U2HR mutation in a Korean woman with Marie Unna Hereditary Hypotrichosis Ki-Hun Song, Jin Park, Seok-Kweon Yun, Han-Uk Kim Department of Dermatology, Chonbuk National University Medical School The effects of sortilin on human hair growth Xing-Hai Jin¹, Long-Quan Pi¹, Sungjoo Tommy Hwang², Won-Soo Lee¹ 1 Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, 2 Dr. Hwang s Hair-Hair Clinic 19

10 [ Posters ] 1. 각질형세포와피지선세포공배양을통한지루성두피억제소재연구김아름, 김수나, 이현기, 전병배, 박원석아모레퍼시픽기술연구원에스테틱연구팀모발노화연구실 Clinical and prognostic factors in early-onset alopecia totalis and alopecia universalis Hyun Hee Cho, Seong Jin Jo, Seung Hwan Paik, Hye Chan Jeon, Kyu Han Kim, Hee Chul Eun, Oh Sang Kwon Department of Dermatology, Seoul National University College of Medicine Efficacy and safety of Pueraria lobata extract in prevention of hair graying Seong Jin Jo 1, Seung Hwan Paik 1, Sun Jae Na 1, Ji Ying Jin 1,2, Won Seok Park 3, Soo Na Kim 3, Oh Sang Kwon 1 1 Department of Dermatology, Seoul National University Hospital, Seoul, Korea, 2 Department of Dermatology, Yanbian University Hospital, Jilin, China, 3 Advanced Hair Research Laboratory, AmorePacific R&D Center, Korea Association between EGF and EGFR gene polymorphisms and susceptibility to alopecia areata in Korean 서동우, 허식 1, 이은주, 정주호 2, 유박린, 심우영경희대학교의과대학피부과학교실, 1 인제대학교의과대학피부과학교실, 2 경희대학교의과대학약리학교실 Wnt5a attenuates the Wnt/β-catenin signaling in human dermal papilla cells 곽미희, 김문규, 김정철, 성영관경북대학교의학전문대학원면역학교실 OVO homologue-like 1, a target gene of Wnt/β-catenin pathway, controls the hair follicle neogenesis Seung Hyun Shin, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung Department of Immunology, School of Medicine, Kyungpook National University 발모벽 69 례의임상조직학적고찰김정희, 이은주, 유박린, 심우영강동경희대학교병원피부과학교실 Clinical manifestations of early onset female androgenetic alopecia patients Sung-yul Lee, Noo Ri Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea 69

11 9. Characteristics of juvenile androgenetic alopecia patients Noo Ri Lee, Sung-yul Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Medical comorbidities in early onset Androgenetic alopecia patients Noo Ri Lee, Sung-yul Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine Bilateral treatment with anthralin and diphenylcyclopropenone for recalcitrant alopecia areata Won Suk Lim, Do Hun Kim, Sang Yun Jin, Yun Seok Choi, Ai Young Lee, Seung Ho Lee Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea Induction of hair growth by phytosphingosine-1-phosphate in C3H/HeJ mice model 임윤영, 김형미, 손인평, 최명준 1, 홍창권, 김범준중앙대학교의과대학피부과학교실, 1 ( 주 ) 피토스 Inhibitory effect of tianeptine on catagen induction in alopecia areata-like lesions of mice 김형미, 임윤영, 손인평, 박소라 1, 서성기 1, 이마세 1, 김명남, 김범준중앙대학교의과대학피부과학교실, 1 ( 주 ) 건일제약 Prevalence and classification of Androgenetic alopecia in cardiovascular in-patients Sung Yul Lee, Hannah Hong, Noo Ri Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea 영아에서발생한원형탈모증노병인, 이상윤, 김신한, 고재완관동대학교의과대학피부과학교실 The effect of red ginseng on the growth of cultured human hair follicles Gyeong-hun Park, Chong-Hyun Won, Ki-young Park 1, Sang-Min Lee, Sung-Eun Chang, Mi-Woo Lee, Jee-Ho Choi, Kee-Chan Moon, Hong-il Cho 1 Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, 1 Asan Institute for Life Sciences, Seoul, Korea 77

12 17. Ultraviolet radiation alters lipid metabolism in human hair follicle Long-Quan Pi1 1, Xing-Hai Jin 1, Sungjoo Tommy Hwang 2, Won-Soo Lee 1 1 Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, 2 Dr. Hwang s Hair-Hair Clinic Two cases of hair shaft abnormalities associated with hair breakage Won Joon Choi, Young Sun Eun, Chul Hwan Bang, Jung Eun Kim, Hoon Kang Department of Dermatology, St. Paul s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea 79

13 Free Communication (English speaking session)

14 th Meeting of The Korean Hair Research Society Alopecia areata in the elderly: A 10 years retrospective study Kyung Hea Park, Yoon Hyuk Choi, Han Jin Jung, Hyun Jung Lim, Weon Ju Lee, Seok-Jong Lee, Do Won Kim Department of Dermatology, Kyungpook National University School of Medicine Alopecia areata (AA) is a well-known immune-mediated form of hair loss that usually occurs in the young adults. AA in the elderly is relatively rare, therefore, little data have been reported. We performed a 10 years retrospective study of AA in the elderly who visited our dermatologic clinic from January 2002 to December 2011 for better understanding of AA in the elderly. Among 1761 patients who were newly diagnosed as AA, 61 patients (3.5%) were older than 6o years of age at first visit. The oldest patient was 90 years old and the mean age was 71. A clinical review of medical records and subsequent telephone interviews were performed by dermatologists. The age of onset, duration of disease, family history, past history, emotional stress before onset, AA type and severity, ophiasis, nail changes, gray hair, coexisting systemic and/or dermatologic diseases, current status of physical/mental conditions, therapeutic responses and clinical courses were observed. We also compared the characteristics of AA in the elderly with those in general population using review of published literature.

15 구연 Hairline preference among various layers of Korean population Inho Park 1, Chan Yl Bang 2, Min Ji Kang 2, Jong Hyuk Moon 2, Bo Hee Yang 2, Ji Won Byun 2, Hee Jin Song 2, Jeong Hyun Shin 2, Gwang Seong Choi 2 1 ilove Hair Center, 2 Department of Dermatology, Inha University School of Medicine When planning hair transplantation, degree of alopecia as well as esthetic preference should be considered for hairline design. There are various methods and criteria for hairline design. However, the techniques introduced in previous reports are subjective and ethnic and racial differences result in different hairline preference, making it difficult to apply to various races. The aim of this study was to determine hairline preference among four different hairline shapes in Korean population. We investigated the preference of height of hairline because hair transplantation to a round type hairline is commonly done in female patients in Korea and determination of height of hairline is very important. Also, we investigated whether hairline preference is affected by sex, age, education, social status, location, mariatal status and history of hair transplantation. A total of 609 raters were asked to evaluate and rate the hairline profile through online questionnaire using 8 photographs showing different hairlines. M-type hairline was selected as the most preferred hairline whereas round type hairline was selected the least. In contrast, round type hairline was selected as the most preferred hairline in group with history of hair transplantation. As well as history of hair transplantation, several factors such as sex, age, education, social status, location and mariatal status also affected the hairline preference.

16 th Meeting of The Korean Hair Research Society Characteristic aging features in Korean women s hair Su-na Kim¹, Ahreum Kim¹, Soo-yeon Lee², Won-Seok Park¹ 1 Advanced Hair Research Lab, Amorepacific R&D Center, Yong-in, South Korea 2 Dermapro/Skin Research Center, Seoul, South Korea There have been few studies of the characteristic features of hair with aging in Korean women. We investigated the changes of various features of Korean women s hair with 150 Korean women in 5 age groups. Hair density and hair diameter were analyzed by phototrichogram, and the tensile strength of hair shaft was measured with rheometer. Hair graying severity was observed by investigators and the hair color was measured using chromameter. Hair luster was evaluated with the maximum brightness (L) value of the luster ring under the fixed light source. The mineral, amino acids and steroidal hormones compositions of hair shaft were analyzed by conventional method. The hair loss parameter (hair density, diameter and tensile strength) and hair luster decline with age significantly from 50s. The hair brightness (L) value increases with aging significantly in 60s due to hair graying ratio growth. In the hair mineral analysis, calcium and magnesium decrease with aging while potassium and phosphorus increase with age-dependent manner. In case of amino acids in hair shaft, there are no significant changes in each group. The contents of steroid hormone precursors (cholesterol, pregnenolone, desmosterol and lanosterol) increase significantly with age in all groups, but there are no correlation between the steroidal hormones level and age. These results show that intrinsic aging cause changes in various hair and scalp features of Korean women.

17 구연 Ultrastructural localization and maturation of integral hair lipid in human hair follicle Long-Quan Pi¹, Sungjoo Tommy Hwang², Won-Soo Lee¹ 1 Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, 2 Dr. Hwang s Hair-Hair Clinic Integral hair lipid (IHL) plays an important role in all compartments of hair and skin substructures and also in involvement of hair development and function. In this study, we described the ultrastructural localization and maturation of IHL in human hair follicle. Electron microscopy was performed to observe the ultrastructure of the hair lipid. Hair follicles were cut and observed longitudinally along the hair axis. For revealing IHL with electron microscopy, Lee s fixative, composed of OsO4 and RuO4 was designed and used. Ultrastructure of anagen hair follicle at the level where Henle layers are keratinizing, showed the intercellular lipid layer (IL) and lamellar structure (LS). Ultrastructure of anagen hair follicle at the level where the inner root sheath (IRS) is completely keratinized showed multiple LS and lamellar granules (LG). Multitudes of LS and IL are observed between the keratinized cells in IRS. The IHL in the hair follicle may be regarded as hair barrier to be similar to the epidermal lipid layer functioning as skin barrier.

18 th Meeting of The Korean Hair Research Society Identification of a novel U2HR mutation in a Korean woman with Marie Unna Hereditary Hypotrichosis Ki-Hun Song, Jin Park, Seok-Kweon Yun, Han-Uk Kim Department of Dermatology, Chonbuk National University Medical School Marie-Unna hereditary hypotrichosis(muhh) is a rare autosomal dominant hair loss disorder with progressive alopecia. Recently, researchers have identified mutations in U2HR, an upstream regulator of the Hr gene, as genetically responsible for MUHH. So far, 16 mutations in U2HR gene have been identified as far as we know. We report a novel heterozygous missense mutation within U2HR of the Hr gene was identified in a Korean woman with MUHH. A 24-year-old woman presented with progressive hair loss. Since puberty, she showed decreased hair density and coarse hair texture on vertex and occipital scalp. Her eyebrows, eyelashes, and pubic hairs were scanty. But there are no other ectodermal abnormalities or psychological impairments. On her pedigree, at least 6 people of her family members, including her father, had similar symptoms. Light microscopy and scanning electron microscope revealed increased hair shaft diameter, longitudinal grooves and irregular hair shaft twists which are characteristics of MUHH. Sequencing of the upstream ORF U2HR in the 5 UTR of the hairless gene resulted in the identification of a novel heterozygous missense mutation (c.80c>t) that has not been yet reported worldwide.

19 구연 The effects of sortilin on human hair growth Xing-Hai Jin¹, Long-Quan Pi¹, Sungjoo Tommy Hwang², Won-Soo Lee¹ 1 Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, 2 Dr. Hwang s Hair-Hair Clinic The pro-nerve growth factor (prongf) and its apoptosis-promoting low-affinity receptor (p75ntr) regulate apoptosis process in human hair follicle. Sortilin is well known as a required component for transmitting prongf-dependent death signals via p75ntr. However, the expression and role of sortilin in human hair follicles (HFs) has not yet been clearly shown. The purpose of current study was to investigate the expression and role of sortilin in human HFs. We examined the expression of sortilin in human HFs and its expression change according to the hair cycle. Furthermore, we examined the effects of sortilin on human hair growth. We observed that HFs expressed sortilin at mrna and protein level. Sortilin immunoreactivity can be detected in the epithelium of human anagen hair follicles. During the transformation from anagen to catagen, sortilin expression appeared to be up-regulated. ProNGF significantly inhibited the human hair growth and promoted apoptosis process in organ cultured human follicles. Moreover, sortilin antagonist inhibited the apoptosis process which induced by prongf. Altogether, these results indicate that sortilin might be an important regulatory factor for human hair cycle.

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21 Hair Stem Cell and Morphogenesis (English speaking session)

22 th Meeting of The Korean Hair Research Society Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration Mayumi Ito, Ph.D. Department of Dermaology and the Department of Cell Biology, New York University School of Medicine, USA Melanocyte stem cells (McSCs) intimately interact with epithelial stem cells (EpSCs) in the hair follicle bulge. Together, these stem cells undergo activation and differentiation to regenerate pigmented hair. However, the mechanisms behind this coordinated stem cell behavior have not been elucidated. Here, we reveal the presence of a functional interaction between McSCs and EpSCs and identify Wnt signaling as a key pathway governing this communication. EpSCs and McSCs coordinately activate Wnt signaling, at the onset of hair follicle regeneration. Using genetic mouse models that specifically target either EpSCs or McSCs, we show that Wnt activation in McSCs drives their differentiation into pigment-producing melanocytes, while EpSC Wnt signaling not only dictates hair formation, but also regulates McSC proliferation during hair regeneration. Our data define a novel role for Wnt signaling in the regulation of McSCs and also illustrate a mechanism for regeneration of complex organs through heterotypic interactions between stem cells.

23 Mayumi Ito: Coordinated activation of Wnt in epithelial and melanocyte stem cells initiates pigmented hair regeneration [ CURRICULUM VITAE ] Mayumi Ito, Ph.D. Assistant Professor (Tenure Track) The Ronald O. Perelman Department of Dermaology and the Department of Cell Biology, New York University School of Medicine, USA Education : Nagoya University, Nagoya, Japan 1996 B.S., Department of Molecular Biology, School of Science 1998 M.S., Division of Biological Science, Graduate School of Science 2003 Ph.D, supervised by professor K. Owaribe, Unit of Biosystems, Graduate School of Human Informatics Research Training : Research Fellow, Kanebo Ltd., Odawara, Japan Postdoctoral research fellow, Dr. George Cotsarelis Lab, Department of Dermatology, University of Pennsylvania School of Medicine Academic Appointments : 2008-present Assistant Professor, Department of Dermatology, Department of Cell Biology, New York University School of Medicine 2008-present Faculty, Cellular and Molecular Biology Program, Sackler Institute of Biomedical Sciences, New York University s Graduate School of the Arts and Sciences 2008-present Member, The Helen and Martin Kimmel Center for Stem Cell Biology, Skirball Institute for Biomolecular Medicine, New York University School of Medicine 2008-present Member, Stem Cell Biology Translational Research Program, New York University Cancer Institute (NIH designated Cancer Center) Awards and Honors : 2004 Dermatology Foundation, Research Fellowship (USA) 2005 Society of investigative dermatology poster presentation award (USA) 2006 Dermatology of the College of Physicians of Philadelphia, Johnson-Beerman Award (USA) 2006 Heinz Maurer Prize (Germany) 2007 North american hair research society travel award (USA) 2008 International Investigative Dermatology travel award (USA)

24 th Meeting of The Korean Hair Research Society 2009 Dermatology Foundation, Career development award (USA) 2010 Ellison Medical foundation, New scholar award (USA) Memberships : North American hair research society (2010-present) Patents : Hair follicle neogenesis (University of Pennsylvania)

25 Takashi Matsuzaki: Expression of clock genes is differentially controlled between follicular epithelia and dermal papillae during hair cycles Expression of clock genes is differentially controlled between follicular epithelia and dermal papillae during hair cycles Takashi Matsuzaki, Ph.D. Department of Biological Science, Faculty of Life and Environmental Science, Shimane University, Japan We can distinguish various types of hair on our body such as eyebrows, eyelashes, mustaches, beards, pubes, pelage and scalp hair. Each hair has the defined length, thickness and hair cycle depending on the site it grows, suggesting that a precise control mechanism exists and defines those characteristics. The hair cycle progresses synchronously in pelage follicles in young mice along a rostral-caudal axis, then it becomes less synchronized in aged ones. In human follicles, timing of hair cycles usually differs one by one, but we know our scalp hair tends to shed in spring and autumn. Therefore, the control mechanism must complete in an individual follicle, which can be modified by some systemic condition like hormonal levels. We actually noticed that isolated vibrissa follicles hold their hair cycle with similar timing as those in intact ones even when they were grafted in the kidney. Recently, it has been revealed that a variety of biological rhythms are regulated by periodic expression and mutual interactions of a set of clock genes. Thus, we focused on clock genes for understanding the mechanisms controlling the hair cycle. We used isolated vibrissa follicles rather than pelage follicle-containing skin to exclude the influence of non-follicular tissues on gene expression profiling. Vibrissa follicles were divided into 5 stages in anagen and 3 stages in catagen and were analyzed the expression of clock genes by real-time RT-PCR (Q-PCR) for total RNAs that had been extracted from isolated vibrissa follicles or dermal papillae. Expression patterns of clock genes in whole follicles were classified into 3 categories. 1) Bmal1, Clock and Per2 had a peak of expression at proanagen and were down-regulated in catagen; 2) Cry1 and ROR alpha mrnas increased around midanagen then decreased in catagen; 3) Rev-Erb alpha and Dbp reached the maximum expression at very early anagen and vastly reduced their expression until early catagen. In the dermal papillae, most clock genes were down-regulated as anagen progressed. Interestingly, Rev-Erb alpha showed an opposite pattern of expression to that in the whole follicles, which had

26 th Meeting of The Korean Hair Research Society a peak of expression in early catagen. In addition, hair elongation of anagen hair follicles was suppressed by adding CK1 inhibitor IC261 in organ culture of vibrissa follicles. CK1 is thought to be a kinase that regulates clock genes-feedback loops. Q-PCR revealed that Per2, ROR alpha, Rev-Erb alpha, Hlf and Tef transcripts were diminished in the IC261-treated follicles. Then, we focused on a nuclear receptor ROR alpha in order to understand control mechanisms that generate rhythms longer than an approximately 24 hours-cycle. We found ROR alpha proteins localized in the nuclei of the dermal papilla cells of vibrissa follicles during anagen. Then their expression faded away from the nuclei. Increased ROR alpha could cease the activity of Rev-Erb alpha, because both nuclear receptors bind to the same element named RORE and competitively inhibit each other. In conclusion, vibrissa dermal papillae and whole follicles showed different expression patterns for some clock genes. These differences might reflect multiple roles of clock genes in the hair follicle system. The hair cycle progression is likely controlled by clock genes and could be influenced by CK1 activity and extent of nuclear transportation of ROR proteins, but its control mechanisms seem to be more complicated.

27 Takashi Matsuzaki: Expression of clock genes is differentially controlled between follicular epithelia and dermal papillae during hair cycles [ CURRICULUM VITAE ] Takashi Matsuzaki, Ph.D. Education : April March 1984 April March 1990 March 1990 Shinshu University, Faculty of Science, Department of Biology The University of Tokyo, Graduate School of Science, Department of Zoology Ph.D., Zoology, The University of Tokyo Employment : April March 1991 Tokyo Metropolitan Institute of Medical Science, Postdoctoral fellow April March 1993 RIKEN Tsukuba Life Science Center, Postdoctoral fellow April March 1998 Research Development Corporation of Japan (Japan Science and Technology Agency), Yoshizato MorphoMatrix Project, Researcher / Research manager April January 2006 Shimane University, Faculty of Life and Environmental Science, Department of Biological Science, Assistant professor February March 2012 Shimane University, Associate professor April Shimane University, Professor April Shimane University, Associate dean (Education and students)

28 th Meeting of The Korean Hair Research Society Defining the function of genes in differentiation of hair follicle stem cells : toward cure for baldness Joonsung Hwang, Ph.D. Korea Research Institute of Bioscience and Biotechnology (KRIBB) / World Class Institute (WCI) The hair repeats its re-growth and loss continuously through three distinct phases known as hair cycle: anagen of proliferative phase, catagen of regressing phase, and telogen of resting phase. Therefore, continuous induction of hair follicle stem cells (HFSCs) is necessary to maintain the certain amount of hair in body. It has been reported that (1) the quiescent HFSCs reside in the bulge region of hair follicle (hf), (2) a few stem cells in the bulge region react to signals from dermal papillae and become new progenitor cells in the hair matrix, and (3) these distinctly proliferative cells in the hair matrix differentiate into the outer root sheet (ORS), inner root sheet (IRS), cuticle, cortex, and medulla to form the new anagen hair shaft during each hair cycle. In previous study, we examined that Dlx3 is a transcription factor expressed in the hf matrix cells, extending its expression to the IRS, and the hair-forming compartments, including the cortex, medulla and cuticle. Interestingly, nuclear Dlx3 expression persists in bulge cells at the telogen resting stage and the conditional deletion of Dlx3 in the epidermis resulted in complete alopecia, suggesting that Dlx3 function in HFSCs might be necessary for hair regeneration. To further define the role of Dlx3-expressing subset of bulge cells in the reinitiation of the hair cycle, we are currently characterizing a new mouse line, K15cre;Dlx3 Kin/f mice. The analysis of Dlx3 function in HFSCs will provide insight into the key mechanism required for HFSCs differentiation and hair regeneration.

29 Joonsung Hwang: Defining the function of genes in differentiation of hair follicle stem cells: toward cure for baldness [ CURRICULUM VITAE ] Joonsung Hwang, Ph.D. Korea Research Institute of Bioscience and Biotechnology (KRIBB) Research Experience : Researcher, Research Institute for Life Sciences, Hanyang University, Korea Research Assistant, National Institute of Nioscience and Human Technology, Agency of Industrial Science and Technology, MITI, Japan JSPS Fellow, Japan Society for the Promotion of Science, National Institute of Advanced Industrial Science and Technology (AIST), METI, Japan Visiting Fellow, Developmental Skin Biology Unit, NIAMS, NIH, DHHS, USA Research Fellow, Developmental Skin Biology Section, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), National Institutes of Health (NIH), Department of Health & Human Services (DHHS), USA present Investigator, World Class Institute (WCI), Korean Research Institute of Bioscience and Biotechnology (KRIBB), Korea Education : 1994 B.S., Hanyang University, Korea 1996 M.S., Hanyang University, Korea 2001 Ph.D, University fo Tsukuba, Japan Progessional Membership : The Society for Investigative Dermatology (SID) American Society for Developmental Biology (ASDB) The American Society for Biochemistry and Molecular Biology (ASBMB) The Korean Society for Investigative Dermatology (KSID) The Korean Society for Skin Barrier Research (KSSBR) The Korean Society Hair Research Society (KHRS) Korean-American Scientists and Engineers Association (KSEA) NIH-Korean Scientists Association (NIH-KSA) Honors and Awards : Albert M. Kligman Travel Fellowship (2009) The Society for Investigative Dermatology (SID), USA NIH Fellows Award for Research Excellence (2009) NIH, USA Outstanding Poster Award in NIAMS Intramural Retreat (2009) NIH/NIAMS, USA Honorable Mention Poster Award in NIAMS Intramural Retreat (2007, 2006) NIH/NIAMS, USA Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellowship ( ) JSPS, Japan Yoenyama Doctor Course Scholarship (2000) Rotary Yoneyama Memorial Foundation, Japan

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31 Educational Lecture (English speaking session)

32 th Meeting of The Korean Hair Research Society Alopecia areata: Biomarkers and clinical trials, quest for a safe and effective therapy Maria Hordinsky, M.D. University of Minnesota Department of Dermatology, Minneapolis, Minnesota, USA There is currently no cure for alopecia areata, an autoimmune disease. Although many therapies are available there is no universally proven therapy that induces and sustains remission. In the United States there is no therapy approved by the Food and Drug Administration for alopecia areata so treatments are considered off label. Current treatment choices are frequently based on disease extent, duration, and age of the patient and include a variety of topical, intralesional and systemic agents. New drug treatment opportunities based on the results of genome-wide association studies which implicate T-cell and NK-cell activation pathways are now leading to new approaches in future clinical trials of alopecia areata. Special attention is being given to the UL 16-binding protein (ULBP3) gene cluster on chromosome 6q25 as these genes make the NKGD-activating ligand or signal which can trigger the NKG2D receptor, initiating an autoimmune response. A greater expression of ULBP3 has also been found in hair follicles in scalp biopsy specimens from patients with active disease. Future treatment approaches for alopecia areata are now being categorized into three broad categories and include studying drugs that block natural killer cell innate immunity, halt activated T cells or modify the inflammatory cytokine network. Multiple drugs are currently being used or are being evaluated for other autoimmune diseases. Several of these have the theoretical potential to be very effective in treating alopecia areata. Examples of potential therapies to test in clinical trials include Anti CD25, Anti-CTLA-4, Jak 1/2 inhibitor, Anti-NKG2D, Syk inhibitor, Anti-IL-15, Anti-IL-6, Anti-Interferon-gamma, Anti IL-1 and Anti-IL-17. The risk/benefit ratio of this approach will need to be carefully evaluated as both adults and children enter clinical trials.

33 Maria Hordinsky: Alopecia areata: Biomarkers and clinical trials, quest for a safe and effective therapy [ CURRICULUM VITAE ] Maria K. Hordinsky, M.D. Education : Forest School, London E17 University of Newcastle-upon-Tyne Education/Training : 1972 B.S., Fordham University, Bronx, New York, University of North Dakota, Grand Forks, N.D., Biology 1976 M.D., Fordham University, Bronx, New York, University of North Dakota, Grand Forks, N.D., M.D. Positions and Honors : Intern, Henry Ford Hospital, Detroit, Michigan University of Minnesota Medical School: Resident in Dermatology University of Minnesota Medical School: NIH Post-Doctoral Fellow University of Minnesota Medical School: Dermatology Foundation Fellowship University of Minnesota Medical School: NIH National Research Service Award University of Minnesota Medical School: Instructor, Dept. of Dermatology University of Minnesota Medical School: Assistant Professor, tenure track, Dermatology University of Minnesota Medical School: Associate Professor with tenure, Dermatology University of Minnesota Medical School: Professor, Dermatology, Interim Chair 2002 Present University of Minnesota Medical School: Professor and Chair, Department of Dermatology Other Experience and Professional Memberships : 2005-Present Member, Scientific Advisory Board, Cicatricial Alopecia Research Foundation 2006-Present Representative, Association of Professors of Dermatology to the Council of Academic Societies of the AAMC Member, Dermatology Residency Review (RRC) Committee Member, Board of Directors, American Dermatologic Association 2010-Present Chair, Scientific Advisory Board, National Alopecia Areata Foundation

34 th Meeting of The Korean Hair Research Society 2009-Present Member, Education Committee, American Dermatologic Society 2010-Present Chair, National Alopecia Areata Foundation Scientific Advisory Board President Elect, Association of Professors of Dermatology 2011-Present Secretary-Treasurer, North American Hair Research Society 2011-Present Member, University of Minnesota Women s Faculty Cabinet, Representative from the Academic Health Center

35 Updates of Pattern Hair Loss (Korean speaking session)

36 th Meeting of The Korean Hair Research Society Algorithmic guideline for management of pattern hair loss in Asian Won-Soo Lee, M.D. Department of Dermatology ㆍ Institute of Hair & Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Pattern hair loss (PHL) or androgenetic alopecia (AGA) is a common disorder in both Asian men and women. There are several guidelines for the treatment of PHL which are suitable for Caucasian patients; however, each of these has some limitations. Furthermore, in comparison with Caucasian patients, Asian patients with PHL have different types of hair loss and family histories which may alter the treatment response. There is currently no published PHL guideline for Asian patients. Therefore, we developed an algorithmic guideline, based on the Basic and Specific (BASP) classification, for the treatment of AGA especially in Asian patients. This treatment guideline may be useful for dermatologists in their approach to treating Asian patients with PHL in clinical practice. Ideally, clinicians should try to utilise this guideline consistently in their practice to monitor treatment response with the goal of enhancing successful outcomes. This will help boost patients' confidence and self-esteem, thus improving patients compliance with the prescribed treatments.

37 Won-Soo Lee: Algorithmic guideline for management of pattern hair loss in Asian [ CURRICULUM VITAE ] Won-Soo Lee, M.D., Ph.D. Education & Career Yonsei University CollegeofMedicine,Seoul,Korea(MD) Dermatologic Residency, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea (Dermatologist, Korean Board of Dermatology) Flight Surgeon, Air Force, Republic of Korea Yonsei University Graduate School of Medicine, Seoul, Korea (PhD) Research fellow, Instructor, Assistant, Associate, and Full Professor of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea Visiting Clinical Assistant Professor, Department of Dermatology, University of Minnesota, Minneapolis, USA Korean Society of Cosmetic Dermatology, Secretary General Executive board, Publication Chairman, 2011 World Congress of Dermatology Current Position : 2003-present Director, Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea 2012-present Chairman, Department of Dermatology, Yonsei University Wonju College of Medicine, Wonju, Korea 1993-present European Hair Research Society, Active Member 2008-present Korean Hair Research Society, Secretary General 2010-present Asian Regional Editor, International Journal of Trichology 2010-present Congress President, 2014 World Congress for Hair Research Summary of Academic Activities : More than 180 peer-reviewed scientific publications including over 80 SCI publications More than 50 international invited lectures and 150 domestic invited lectures Fourteen academic awards internationally and domestically including - Woo-Am Academic Award. Korean Society for Investigative Dermatology ( ) - Excellent academic faculty award. Yonsei University ( ) - Best Clinical Poster Award. International Meeting of Hair Research Societies.( Melbourne, Australia) - Young Investigator Award. Tricontinental Meeting of Hair research Societies.( Brussels, Belgium)

38 th Meeting of The Korean Hair Research Society Update of female pattern hair loss Oh Sang Kwon, M.D. Seoul National University College of Medicine Female pattern hair loss (FPHL) is a common condition in women characterized by a progressive thinning of scalp hair and widening of the central parting. In Korean women, the prevalence of FPHL (Ludwig I or above) at all ages was reported as 5.6% around near half of that in Caucasian females. It increases steadily with advancing age: 7.4% in the sixth decade, 11.7% in the seventh decade and 24.7% over 70 years. FPHL may be considered as a natural biological process, but it can provoke great anxiety and psychological upset. It is previously known as female androgenetic alopecia (AGA), suggesting that it is the female equivalent of male AGA. However, the role of androgens in female hair loss is less clear than in males and it is likely that other non-androgenic mechanisms are also involved, as anti-androgen treatments are generally unsatisfactory for FPHL and there have been several case reports of FPHL in androgen-deficient and androgen-insensitive women. Furthermore, the prevalence and severity of FPHL increase with advancing age, which suggests that their pathogenesis would include age-related factors and environmental influence. Medical treatment can help to prevent progression of hair loss and promote modest regrowth of hair but is probably not able to reverse follicular miniaturization. In this review, we will re-evaluate our concepts of FPHL and focus on recent advances in the treatment options.

39 Oh Sang Kwon: Update of female pattern hair loss [ CURRICULUM VITAE ] Oh Sang Kwon, M.D., Ph.D. Department of Dermatology, Seoul National University Hospital Education : Graduate School, Seoul National University, Seoul, Korea (Ph.D.) Graduate School, Seoul National University, Seoul, Korea (M.S.) College of Medicine, Seoul National University, Seoul, Korea (M.D.) Postgraduate Training & Academic Appointment : present Associate Professor, Department of Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea Visiting Scholar, Department of Dermatology, University of Pennsylvania, Philadelphia PA, USA Assistant Professor, Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea Clinical Instructor, Department of Dermatology, Seoul National University Hospital, Seoul, Korea Visiting Fellowship, Elective Course for Dermatological Surgery, Department of Dermatology, Oregon Health Science University, Portland OR, USA Research Fellowship, Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea Resident, Department of Dermatology, Seoul National University Hospital, Seoul, Korea Research Interests : Hair diseases, Regenerative medicine, Pigmentary disorder Memberships and Committees : present Organizing Committee for 8 th World Congress for Hair Research in 2014, Congress Secretary present Korean Hair Research Society (KHRS), Board director for Publication and Information present Korean Society of Investigative Dermatology (KSID), Board director for Publication present Korean Society for Pigment Cell Research (KSPCR), Treasurer, board member of directors present Annals of Dermatology, Assistant Editor Since 1999 Korean Dermatological Association, member Since 2002 Society for Investigative Dermatology (USA), member Since 2010 American Academy of Dermatology (USA), member

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41 Hair Transplantation (Korean speaking session)

42 th Meeting of The Korean Hair Research Society Basic concept of hairtransplantation 오킴스피부과 조항래 모발이식수술은 20여년전부터급격히발전되어왔고, 오늘날새로운급격한변화를보이고있다. 모발이식수술은두피모발, 눈썹, 속눈썹, 음모의부분또는전체적인소실을개선시키는수술이지만, 여기에서는두피모발에대해서만언급해보고자한다. 모발이식의 Basic concept, 즉기본적인개념이라는것은여러가지측면에서고려해볼수있지만, 가장근본이되는개념은 첫인상의일반성 을증가시키기위함이라할수있다. 사람은사회적또는개인적활동을통해처음만나는사람을접하면서, 첫인상 (facial attraction) 을머릿속에기억하게된다. 사람이첫인상을인지하는시간은불과 5분이넘지않는다고하며, 그첫인상은계속해서머릿속에기억된다. 사람이상대방의첫인상을느낄때에는얼굴의내측에주로자리잡고있는눈, 코, 입만을인식하지않고, 내측의구조물과함께, 외측의윤곽을구성하는모발, 귀, 턱라인을함께인식하는것으로알려져있다. 즉, 어떤사람의첫인상은 턱이사각이다, 얼굴이길다, 이마가넓다, 이마가좁다, 대머리다, 숱이적다 등등의외측윤곽에의한첫인상과, 눈이초롱초롱하더라, 코가오똑하더라, 입술이얇더라 등등의내측윤곽에의한첫인상이함께공존하는것이다. 현대에는매우발달된미용성형의학이존재하고, 더섬세하고더완벽한아름다움을만들어내기위해부단한연구와개발을하고있다. 이렇게미용성형의학이무한대적인팽창을하고있는것은사람은누구나아름다움을추구하고, 상대방으로부터더욱매력적인첫인상으로기억되고싶은욕망과본능이있기때문이다. 첫인상이더욱매력적으로발산되기위해서는각각의눈, 코, 입, 턱, 두피모발등의 각각의일반성 과이들이서로조합된 얼굴의일반성 (facial averageness) 이높아야한다. 이말은누가봐도일반적으로예쁜오똑한코, 도톰한입술, 서글서글한눈을가지고있어야하고, 누가봐도갸름한턱선을가지고있고, 이러한것들이균형있게조합된경우에매력적인첫인상을가졌다고말할수있다는것이다. 이러한첫인상중에서두피모발은얼굴의외측윤곽에의한첫인상을만들어내는데, 가장중요한구조물이라할수있다. 두피모발의높은일반성은얼굴의양쪽과위쪽테두리를결정하는얼굴의틀 (facial frame) 을갖추고있는형태라할수있다. 얼굴의틀을제대로갖추지못한두피모발은외측윤곽에의한첫인상이얼굴의일반성을높히지못하고, 따라서, 아무리일반성이높은내측구조물들을가졌다하더라도, 전체적인조합에의해

43 조항래 : Basic concept of hairtransplantation 이뤄지는첫인상은매력적이못할것이다. 따라서, 많은사람들이첫인상을매력적이게하는, 외측구조물의윤곽에관심이많아지게되었다. 이러한관점에서, 외측구조물중에하부구조물인턱선을갸름하게하기위해, 사각턱교정수술과사각턱교정보톡스시술에많은관심이있어왔고, 최근에는양악수술에폭발적관심이증가되었다. 외측구조물중에얼굴의틀을구성하는상부구조물인두피모발에도최근에관심이늘어나, 탈모치료에관심이많아졌고, 따라서탈모치료의한분야인모발이식에도급격한관심이늘어나고있는실정이다. 얼굴의틀을구성하는두피모발이가장높은일반성을나타내기위해서는, 숱이많아야하겠고, 자연스러운헤어라인을가져야하며, 가지런히정돈된머릿결을나타내야한다. 따라서, 모발이식수술도높은모발밀도을재현하며, 자연스러운헤어라인과가지런한머릿결을재건하는것이수술성공의관건이라할수있다. 중요한관건을한가지더추가한다면, 유전성탈모는진행형탈모이므로, 모발이식수술을통해얻어진새로운얼굴의틀이세월이지나도계속해서높은일반성을유지하도록재건하는것이라할수있다. 첫째로높은모발밀도를재현하기위해서는많은모발을공여부에서얻는것이필수적이라할수있다. 그리고, 뒤통수의일반성은흉터가없는것이일반성이므로, 이러한일반성을유지하기위해서, 흉터를최소한으로남기면서이식모를얻는것이필요하다. 따라서최대한의이식모를얻으면서, 최소한의흉터를남기는방법들이개발되고있으며, trichophytic suture, FUE 등이이러한관점에서개발된방법이다. 그리고, 밀도를높게이식하는것도중요한데 dense packing 방법이이식모의밀도를최대한높게심는방법이다. 공여부에서얻은이식모들이이식후에높은생착율을나타내는것도모발밀도를높게하는데중요하므로, 이식후에이식모들의성장에도움을주는모낭주위주사, 저출력레이저치료등등다양한치료법들도개발되고있다. 자연스러운헤어라인재건법, 가지런한머릿결재건법에대한다양한시술법들도계속해서논의되고있고, 다양한방법들이제시되고있는데, slit 방법, implanter 방법들이여기에속한다고할수있다. 지금까지설명한것들은전적으로환자의입장에서환자의얼굴의일반성을높이기위한방법들로, 시술을하는의사나수술팀입장에서보면매우노동적이고단순반복의과정이있는데, 특히 FUE 방법이나 slit 방법으로이식을하는과정이라할수있다. 최근에는이과정을기계화하는방법들이개발되고있는데, 이것은어떻게보면, 의사의입장에서더욱효율적인수술을완수하기위한방법이라할수있다. 하지만, 모발이식수술전과정이라는것이, 2차원또는 3차원적인공간에그림을그리는것이아니라, 시간이라는개념을포함한 4차원적공간에예술의경지에서수술을하는과정이라할수있으므로, 수술전과정이기계화되기는힘들것으로생각되며, 기계의효율성과의사의예술성이조화를이루는수술법이미래에는개발될것으로생각된다. 이번발표에서는위에서설명한대로, 얼굴의일반성 (facial averageness) 를극대화하는개념에서의모발이식수술에관해이야기해보고자한다.

44 th Meeting of The Korean Hair Research Society [ CURRICULUM VITAE ] 조항래 학력및경력 : 대한피부과학회 (Korean Dermatologic Association) 회원대한피부과의사회 (Association of Korean Dermatologist) 이사대한미용피부외과학회 (Korean Cosmetic Dermatologic Surgery Society) 이사대한모발학회 (Korean Hair Research Society) 이사대한모발이식학회 (Korean Society of Hair Restoration Surgery) 홍보이사아시아모발이식학회 (Asian Association of Hair Restoration Surgeons) 회원세계모발이식학회 (International Society of Hair Restoration Surgery) 회원미국 Mt. Sinai 대학병원미용피부외과학교실 international fellowship (Manhattan) 국제전임의캐나다 Dr. Walter P. Unger 모발이식병원 visiting fellowship (Toronto) 국제전임의

45 박병철 : Checkpoints for each hair transplantation step Checkpoints for each hair transplantation step 단국대학교의과대학피부과학교실 박병철 모발이식술자체는크게공여부의선택과두피모발채취, 수여부의헤어라인디자인과모발의이식으로구성되나, 모발이식술을의료현장에서시행하기수술실의셋팅, 환자와의상담, 모발이식수술, 수술후관리의단계로구분하여접근할수있다. 1. 수술실의셋팅단계 1) 장소 : 안락하고, 채광이잘되는외래수술실에서셋팅한다. 2) 조명 : 무영등이나, 수술실전체에형광램프나, LED 램프를다량으로설치할수있다. 3) 수술침대 : 전동침대를사용하고, 시술자가발로쉽게높낮이를조절할수있는것을선택하며, 일반수술침대보다는폭이넓은것을선택한다. 4) 식모기와모낭분리사의선택 : 식모기는리드엠, 인큐렘, 한스, KNU 식모기등이있으며, 각각의장단점이있다. 모낭분리사는상주직원을채용하거나, 외주할수있는데, 모낭분리의정도관리가잘되도록의사가자주점검한다. 2. 환자와의상담수술의결과에대해서환자의기대와의사의목표에대해서충분한대화가이루어져서, 합리적인수술의결과에대해서로합의하는것이가장중요하다. 3. 모발아식수술 1) 공여부의선택 : 환자의상태, 시술자의기호에따라측면 ( 측두부및후두부일부 ) 선택혹은중앙 ( 후두부중심 ) 부위를선택한다. 2) 이식모의양의결정 : 공여부의 cm 당모발양을사전에측정하고, 본인의수술능력, 환자의탈모상태, 두피의조건등을신중히고려하여결정한다. 3) 공여부두피절제 : 공여부마취는신경과혈관의주행경로를고려하여후두부아래쪽부터먼저시행하며, 통증이최소화되도록노력한다. 절개는기존모발의방향을따라시행하며, 주변모발이보존되도록한다. 두피의박리는지방층사이를박리한다. 봉합은환자에따라 two layer suture, single layer suture, trichophytic suture 를선택적으로시행한다. 4) 이식모의보관 : 수술이 6시간이내에이루어진다면, 4도씨생리식염수나, 하트만용액에보관

46 th Meeting of The Korean Hair Research Society 하여도무관한다. 5) 수여부의모발이식 : 수여부마취는신경의주행경로를고려하여, 전도부앞쪽헤어라인을따라먼저시행한다. 헤어라인이나이식할부위에대해사전에색연필등으로그림을두피에그려서이식모의분포정도를미리계획한다. 모발이식은기존모발의방향을고려하야모낭이삽입하도록하되, 환자의원하는헤어스타일에따라서약간의변형을둘수있다. 항상두피표면과모낭의삽입각도가예각이되도록유지한다. 이식모의밀도는상황에따라다르게되며대략적으로 cm 2 당 20~25 모낭이되도록한다면, 수술의결과가미용적으로용납되는수준이다. 이식의힘의벡터방향을고려하여, 모발이식의진행방향은뒤에서앞쪽으로, 왼쪽에서오른쪽으로진행한다. 이식모는앞쪽헤어라인은단일모로이식하며, 기타부위는단일모와복합모를적절히배치하여자연스러움을만든다. 4. 수술후관리 1) 수술직후 : 희석된 H 2 O 2 용액으로수여부의피딱지등을제거하여청결하게한다. 후두부에붕대를하루정도감아주면지혈과봉합부위를보호할수있다. 수술당일진통제외에자기전에안정제를복용하도록하면여러가지장점이있다. 갑작스런자세변화는피하도록하며, 가능하면대중교통을이용하여퇴원하도록유도한다. 2) 수술초기관리및후기관리에대해서는충분한설명과, 주의사항에대해인쇄물을작성하여환자가참고및숙지하도록하여, 적절한관리가이루어지도록한다. [ CURRICULUM VITAE ] 박병철 학력및경력 : 경북대학교의과대학및동대학원경북대학교병원피부과 / 모발센터전공의아주대학교병원피부과학교실임상강사 ( 현 ) 단국대학교의과대학피부과학교실조교수대한모발학회교육부이사대한모발이식학회학술부이사

47 황성주 : 남성형탈모증환자의헤어라인디자인 남성형탈모증환자의헤어라인디자인 황성주털털한피부과의원 황성주 사람의얼굴이천차만별인것처럼헤어라인역시개인차가크므로환자개인별특성을종합적으로검토한후결정해야한다연자는헤어라인디자인시검토해야할특성에대해살펴보고실례를소개하고자한다. 1. 나이사춘기이전에는헤어라인의양쪽모서리가둥글지만, 나이가들면서차츰위로올라가거나약간씩 M자가되는경향을보인다. 또한중년이후에는이마가약간높거나 M자모양의헤어라인이자연스럽게보이는경우가많다. 간혹 20대환자들이남성형탈모증이진행되기전의낮은헤어라인을만들어줄것을요청하지만한번이식한모발은영구적으로탈모가되지않으므로, 젊은나이에어울리게헤어라인을만들경우중년이되어서는나이에비해상대적으로낮은헤어라인이되는까닭에부자연스럽게보일수도있다. 따라서젊은환자들에게는이런과정을잘설명해서환자의요구대로따르지말고중년에서도어울릴수있는헤어라인으로설득하는것이필요하다. 40대이상의중년층은약간높은헤어라인을쉽게받아들이는편이다. 2. 얼굴형태및이마모양한국인의머리모양은서양인과는다르다. 서양인들은주로타원형의두상을, 한국인은둥근형태의두상을갖고있다. 서양남성들은대개헤어라인가장자리가움푹들어가거나중간이약간뾰족한헤어라인을선호하는반면, 한국남성들은서양인보다더넓고완만한곡선의평평한헤어라인을선호하는편이다 3. 탈모면적남성형탈모증은지속적으로탈모가진행된다는점과공여부모발의숫자가제한적이라는점을감안할때정상적인높이보다는약간높게헤어라인을만들어주면정수리방향으로도좀더많은이식모를확보할수가있다. 따라서탈모가심한경우라면적절한범위내에서가급적헤어라인을높게권하는것이필요하다. 4. 공여부밀도및이식할모발의숫자공여부에서채취할수있는모발수가적은경우라면넓은범위의탈모부위를가리기가쉽지

48 th Meeting of The Korean Hair Research Society 않으므로가급적헤어라인을높게만들어이식면적을줄여주는것이현명한방법이다. 5. 기존헤어라인의모양나이가들면조금높은헤어라인이오히려자연스럽다. 따라서기존의헤어라인보다 1~2cm 위로헤어라인을재건하는것이일반적이다. 그러나적당한높이의헤어라인을제안하더라도기존헤어라인이매우낮았던환자들은과거에비해높다며좀더내리기를원하는반면, 기존헤어라인이높았던환자들은조금더위로올려줄것을요구하는경향이있다. 일부환자에서는남성형탈모증이진행됨에따라측두부앞쪽탈모 (temporal peak hair loss) 가동반되는경우도있는데, 측두부앞쪽탈모부위를교정하게되면측두부탈모가진행이될경우이식된모발이섬 (island) 처럼남게되는현상이생길수있으므로주의해야한다. 6. 환자의요구헤어라인디자인을결정하는과정에환자의요구를참고는하되의사의의학적지식과경험을바탕으로최종결정을해야한다. 지나칠정도로어색한헤어라인을고집하는경우에는신체추형질환 (Body Dysmorphic Disorder) 를의심해볼필요도있다. [ CURRICULUM VITAE ] 황성주 학력및경력 : 황성주털털한피부과의원원장경북대학교의과대학졸업, 의학박사아시아모발이식학회 (AAHRS) 회장세계모발이식학회상임이사 (Board of Governor, ISHRS) 대한모발이식학회 (KSHRS) 총무이사대한모발학회이사미국모발이식의사회상임이사 (Board of Director, ABHRS) 역임 2006년세계모발이식학회 (ISHRS) Platinum Follicle Award 수상미국모발이식교과서

49 In Gang Jang: Weighting in androgenetic alopecia type VI-VII Weighting in androgenetic alopecia type VI-VII In Gang Jang, M.D. Lineskin Clinic The number of hair follicles a person gains through a hair implant surgery under the method of incision on the temporal and occipital scalp varies on individual, but on average, the number is around 3000 hairs. For AGA type VI-VII, due to a comparatively large area of hair loss, usually 4000 to 6000 hairs are necessary for the hair implant surgery. Therefore, covering the entire bald area on a hair whirl is hardly operative; instead, the implant focuses on grafting the hair from center of forehead hairline up to the top of the head. For AGA type VI-VII, if possible, the design that increases the probability of an aesthetic improvement is necessary because most cases require fewer number of hair follicles for a large area of hair loss. Compared to the cases with regular dense implant, weighting which increases the density of hair on particular area to give more volume, is more preferred. Weighting is operated after considering the total number of implantable hair, distribution of single hair and follicular units, the density of hair, the direction of hairline, and hairstyle. [ CURRICULUM VITAE ] 장인강 학력및경력 : Graduate from College of Medicine, The Catholic Universigy of Korea, Seoul, Korea Board of Dermatology Instructor of College of Medicine, The Catholic Universigy of Korea, Seoul, Korea Director of Lineskin clinic

50

51 Rumination on Diagnosis and Treatment Options (Korean speaking session)

52 th Meeting of The Korean Hair Research Society Treatments of alopecia areata Byung In Ro, M.D. Department of Dermatology, Myongji Hospital, Kwandong University College of Medicine Alopecia areata (AA) is difficult to treat because of its chronic, relapsing, inflammatory condition and few treatments have been assessed in randomized controlled trials. Some cases will progress to alopecia totalis (AT) and alopecia universalis (AU). Topical minoxidil promotes hair growth and application must be continued in order to sustain the gain in hair growth. However, mild irritation symptoms and localized hypertrichosis developed in children and women. Contact immunotherapy (DPCP), cryotherapy, and oral or topical psoralen plus ultraviolet A (PUVA) has been treated for extensive AA, it is not widely available. Oral prednisolone can be appropriate for rapidly progressing AA, but there are potential adverse effects including acne, hypertension, cataracts, diabetes mellitus and bodyweight gain. Oral cyclosporine is an immunosuppressant agent that inhibits helper T-cell activation and suppresses IFN-γ production. It has been used alone or in conjunction with corticosteroids for AT and AU, but its use is limited by its side effects and high relapse rate. Intralesional corticosteroids represent a common therapy for mild patchy hair loss. Treatment should be stopped if there is no response by 6 months and it may induce skin atrophy. Recently, intralesional injection of systemic growth factors composing hair growth factors should be comfortable and painless for the patient, especially in children. [ CURRICULUM VITAE ] 노병인 학력 : 가톨릭의과대학졸업 - < 의학사 > 가톨릭대학의학부대학원박사과정수료 - < 의학박사 >

53 Byung In Ro: Treatments of alopecia areata 경력 : 가톨릭의대부속성모병원피부과전공의과정 피부과전문의자격취득 육군군의관 ( 소령예편 ) 서울시립강남병원피부과과장 중앙대학교의과대학피부과학교실교수 관동의대피부과주임교수및명지병원피부과장 관동대학교정년퇴임 현재 관동의대피부과초빙교수 학회활동 : 대한피부과학회 (KDA) 이사 학술(81-85), 간행 (85-87) 및총무 (87-89) 상 임이사역임 대한피부과학회제43차추계학술대회대회장 대한피부과학회이사장 대한피부과학회회장 현재 대한피부과학회경기서부지부회회장 제22차세계피부과학회 (WCD 2011년서울 ), 조직위원회명예회장 상동모발연구분과위원회 (KHRS) 위원장-창립회원 대한모발학회 (KHRS) 회장, 현재고문 현재 일본모발과학연구회 (SHSR) 평의원-창립세화인 제11차 SHSR 학술대회및한일모발연구합동, 학술대회대회장 - 제주 대한피부연구학회이사장 대한피부연구학회회장 대한의진균학회 (KSMM) 총무이사-창립회원 대한의진균학회제5대회장, 현재고문 아세아태평양의진균학회 (APSMM) 총무-창립회원 제4차 APSMM 학술대회장, 현재부회장 일본의진균학회 (JSMM) 명예회원 상훈 : 가톨릭의과대학졸업식에서공로상 ( 은메달 ) 수상 의학신문사일간보사신문의사평론가기장수상 Belgium Brussels에서개최된제9차 EHRS( 구라파모발연구학회 ) 학술대회에서 포스타상수상 녹조근정훈장수상

54 th Meeting of The Korean Hair Research Society Diagnosis and treatment options : Pattern hair loss Woo-Young Sim, M.D., Ph.D. Department of Dermatology, Kyunghee University hospital at Gang-dong, Seoul, Korea Male and female pattern hair loss is the most common hair loss disorder, affecting both men and women. Due to the frequency and the often significant impairment of life perceived by the affected patients, competent advice, diagnosis and treatment is particularly important. The diagnosis of pattern hair loss in men is usually not difficult. The diagnosis is normally made clinically, but aggravating associated factors and other diseases affecting scalp and hair growth need to be excluded. The hair loss in male pattern hair loss is nonscarring and shows a preservation of the follicular ostia. It is characterized by its special pattern; by a variation in hair shaft diameter; and by the occurrence of miniaturized, vellus-like hairs that sometimes can be seen only with a magnifier or a dermatoscope. Basic qualitative tests, such as the hair pull test, contrast paper, and dermoscopy, can easily be used as a tool during a hair consultation. To monitor AGA in men, standardized overview photos are helpful as a qualitative assessment of the progression of the hair loss and as therapy control. For routine diagnostics, a scalp biopsy is usually not necessary. For accurate therapy monitoring, it is reasonable to use quantitative tests such as trichogram and trichoscan. The diagnosis of pattern hair loss in women is much more difficult to make than in men, both because of less obvious patterns of hair loss than in men and because of the frequency with which other types of hair loss occur. In women, any complaint of diffuse or widespread hair loss should trigger consideration of female pattern hair loss as a potential explanation. And this lecture will outline the mechanisms of action, side effects, and expected results from each medication that has been approved by the FDA.

55 Woo-Young Sim: Diagnosis and treatment options : Pattern hair loss [ CURRICULUM VITAE ] Woo Young Sim, M.D., Ph.D. Education : 1982 Graduate of College of Medicine, Kyung Hee University 1985 Master of Medicine, Kyung Hee University 1990 Doctor of Medicine, Kyung Hee University Positions Held Since Graduation : Internship, Kyung Hee University Hospital Residency in Dermatology, Kyung Hee University Hospital Captin, Medical Corps in R.O. Korea Army Clinical fellow, Dept. of Dermatology, Kyung Hee University Hospital Clinical Instructor, Dept. of Dermatology, Kyung Hee University Hospital Assistant Professor, Dept. of Dermatology, Kyung Hee University Hospital Research Fellow, Dept. of Dermatology, University of Sheffield, UK Associate Professor, Dept. of Dermatology, Kyung Hee University Hospital Professor, Dept. of Dermatology, Kyung Hee University Hospital Professor and the Head, Dept. of Dermatology, Kyung Hee University Hospital at Gang-dong Certification and Licensure : 1982 Korean Medical License(#23818) 1986 Diplomates of Korean Board of Dermatology(#453) Medical Society Membership : Korean Hair Research Society: Inspector, and Director Korean Dermatological Association: Educational Director Korean Society for Investigative Dermatology: Director

56 th Meeting of The Korean Hair Research Society Trichotillomania 전북대학교의과대학피부과학교실 임철완 진단을위하여도움되는사항 : -발모벽의임상도다양하므로어떠한탈모환자나진찰할때발모벽가능성도마음속에두고감별진단할필요가있다. -두발및두피를초진할때는항상피부전체를관찰한다. 발모벽환자는손톱이너무짧거나피부의태선화, 색소침착등을동반하는경우가최소절반은넘기때문이다. -모든탈모환자에서환자가가져온매일탈락모 (Daily hair shed) 를관찰할때숫자만볼것이아니고확대경으로모근과근위부를관찰한다. 두툼하고색소가짙은생장기모근이하나만보여도발모벽의가능성이크다. -두피의탈모반을관찰할때대조카드 ( 모발색에대조가되는하얀색카드 ) 를이용하여병변부위에남아있는모발의원위부를관찰한다. -감탄부모발은원형탈모증특징이긴하지만발모벽에서도보인다. -병리조직상모연화 (trichomalacia) 는발모벽의특징이기는하지만원형탈모증에서도나타난다. 치료를위하여도움되는사항 : -어린이발모벽과성인의발모벽은그정신병리기전이다르다. -성인의발모벽은예후가극히불량하나다행히피부과진료실에서는아주드물다. -피부과진료실에서종종만나는어린이발모벽은예후가좋고, 일종의 버릇 으로간주하고버릇고치기를해주는것이가장좋다. -무슨버릇이든지그버릇이있는아이는그자신그버릇을의식하지않는다. 이때가장우수한치료법이인지행동요법 (CBT:cognitive behavioral therapy) 이다. 향정신약물이나정신분석치료보다효과가훨씬우수하고피부과의사가실시하기에용이하다. -발모벽은자신의손이머리에올라가서모발을만지는일이중단되면치료되는것이다. 그러므로자신의버릇을깨닫고인정하도록다시말하면손이머리에얼마나자주올라가는가를스스로모니터링할수있도록그횟수를스스로기록하여이횟수가줄어들게하는것이소위 CBT의 self-monitoring이다. 그리고그어린아이의생활이머리에손을댈수있는시간즉혼자앉아서공부하는시간보다친구들과같이운동하는시간이더많도록배려하는것이 stimulus control이다.

57 임철완 : Trichotillomania -발모벽은중학생년령이전에는예후가좋으나성인이되면일종의난치병이된다. 그러나환자부모들은발모벽자녀가결혼년령이되면서부터그때에야비로소심각하게관심을갖는경향이있다. -연자는이상에기술한발모벽환자의진단과치료를실례를들어소개하고자한다. [ CURRICULUM VITAE ] 임철완 학력 : 전남대학교의과대학졸업전남대학교의학석사전남대학교의학박사 경력 : 대한피부과학회회장역임대한모발학회감사대한피부과학회부회장역임대한피부과학회이사역임대한피부과학회전북지회회장역임대한피부병리분과위원회위원장대한모발학회부회장역임

58 th Meeting of The Korean Hair Research Society Folliscopic diagnosis of pattern hair loss 강한피부과 강진수 Androgenic pattern hair loss 에서초기에는탈모의유무판단이어려울때가있다. 즉육안적검사 (1배율) 상탈모가이미진행되어확실한경우는문제가없으나, 탈모가없는것처럼보이나탈모가있다고호소하거나탈모가있는것처럼보이나탈모가없는경우심리적탈모염려증등은진단에어려움을준다. 특히이마선이올라가는초기때는원래탈모전이마선을알수없어환자의설명에따를수밖에없다. 이러한경우들에서의해결책으로 Folliscope이유효하게사용될수있다. Folliscope으로확대 (40배율) 하여정수리부위와후두부부위를비교하여탈모여부판단하고이마라인도형태학적탈모유형판단과함께 Folliscape상탈모진행여부를판단할수있다. 탈모아닌것같은데탈모인경우

59 강진수 : Folliscopic diagnosis of pattern hair loss 탈모있는것같으나정상인경우 탈모있다고호소하나정상인경우 이마부위 Folliscope 상탈모판단

60 th Meeting of The Korean Hair Research Society 이마탈모있는것같으나정상인경우 [ CURRICULUM VITAE ] Jin-Soo Kang, M.D. Graduated from Yonsei University College of Medicine Completed Department of Dermatology of Severance Hospital Resident of Dermatology. Severance Hospital. Yonsei University Graduated from Yonsei University Graduate School Adjunct professor at Yonsei University Adjunct professor at Soon Chun Hyang University Adjunct professor at Ajou University (Former) Director, auditor, and vice chairman of Korean Dermatological Association (Former) Chairman of Seoul branch of Korean Dermatological Association (Former) Executive director of the Association of Korean Dermatologists (Former) Executive director of Korean Society of Cosmetic Dermatology (Former) Director of the Korean Society of Phlebology (Former) Chairman of the Korean Society for Aesthetic and Dermatologic Surgery (Present) Chairman of the Korean Hair Research Society (Present) Chairman of the Korean Society of Chemical Peeling Member of American Academy of Dermatology (AAD) Member of International Society for Dermatologic Surgery

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62 th Meeting of The Korean Hair Research Society 각질형세포와피지선세포공배양을통한지루성두피억제소재연구 김아름, 김수나, 이현기, 전병배, 박원석 아모레퍼시픽기술연구원에스테틱연구팀모발노화연구실 Seborrheic dermatitis (SD) is the skin disease occurred because of Malassezia yeast which grows on the skin and scalp, and this yeast lives on sebum lipid, and their metabolite, free lipid acids are thought to be the main irritant on skin. To find out effective cosmeceutical ingredients to treat SD symptoms, we established novel cell-based in vitro model mimicking SD symptoms. This in vitro model adopted the co-culture system with primary sebocyte & HaCaT keratinocyte. We used Malassezia globosa yeast extract, arachidonic acid, linoleic acid and dihydrotestosterone as SD inducers. In the co-culture system with optimized concentrations for SD-inducing cocktail, the production of IL-8 and sebum lipids increased up to 2-fold, and then we screened with commercial essential oils by monitoring IL-8 as a key inflammatory biomarker. Then we found that Cinnamomum zeylanicum oil, Mentha arvensis oil effectively down-regulated IL-1α, IL-6, IL-8 cytokines which over-produced by SD-inducing cocktail. Additionally, two essential oils also showed inhibitory effect on sebum lipid synthesis from primary sebocyte and growth inhibitory effect to Malassezia globosa yeast (MICs were lower than %). Our recent results suggest that Cinnamomum zeylanicum oil and Mentha arvensis oil could be effective natural herbal remedies to relieve or protect scalp seborrheic dermatitis.

63 포스터 Clinical and prognostic factors in early-onset alopecia totalis and alopecia universalis Hyun Hee Cho, Seong Jin Jo, Seung Hwan Paik, Hye Chan Jeon, Kyu Han Kim, Hee Chul Eun, Oh Sang Kwon Department of Dermatology, Seoul National University College of Medicine Alopecia totalis (AT) and alopecia universalis (AU), severe forms of alopecia areata (AA), show distinguishable clinical characteristics from those of patch AA. In this study, we investigated the clinical characteristics of AT/AU according to the onset age. Based on the onset age around adolescence (< or 13 years), 108 patients were classified in an early-onset group and the other 179 patients in a late-onset group. We found that more patients in the early-onset group had a family history of AA, nail dystrophy, and history of atopic dermatitis than those in the late-onset group. These clinical differences were more prominent in patients with AU than in those with AT. In addition, significantly more patients with concomitant medical disorders, especially allergic diseases were found in the early-onset group (45.8%) than in the late-onset group (31.2%). All treatment modalities failed to show any association with the present hair condition of patients. In the early-onset group, patients with AU or a family history of AA showed worse prognosis, whereas this trend was not observed in the late-onset group. Systemic evaluations might be needed in early-onset patients due to the higher incidence of comorbid diseases. We hope our results will be helpful in predicting the prognosis of AT/AU patients.

64 th Meeting of The Korean Hair Research Society Efficacy and safety of Pueraria lobata extract in prevention of hair graying Seong Jin Jo 1, Seung Hwan Paik 1, Sun Jae Na 1, Ji Ying Jin 1,2, Won Seok Park 3, Soo Na Kim 3, Oh Sang Kwon 1 1 Department of Dermatology, Seoul National University Hospital, Seoul, Korea, 2 Department of Dermatology, Yanbian University Hospital, Jilin, China, 3 Advanced Hair Research Laboratory, AmorePacific R&D Center, Korea Hair-graying leads to a cosmetic concern and some old people make their hair dyed for aesthetic purposes. However, hair colorants have many adverse effects including skin irritation, allergic reaction, hair-breakage and so on. We performed this randomized, double-blind clinical trial to examine the change of hair graying by APHG-1001, a compound including extracts from Pueraria lobata which activates microphthalmia-associated transcriptional factor, a transcriptional factor associated with melanin synthesis, as well as reduces oxidative stress. A total of 43 female subjects, 40 to 63 years old, were randomized to spray either of APHG-1001 (21 subjects) or placebo (22 subjects) twice a day for 24 weeks. Count of the newly developed gray hair, subject self-assessment and photographic assessment by investigators were used for the evaluation of efficacy. Subject self-assessment and photographic assessment did not show a certain notable difference in efficacy between groups. However, mean count of newly developed gray hair for 24 weeks was 6.3/cm 2 in APHG-1001 group and 11.4/cm 2 in placebo group and the difference was statistically significant (p=0.049). There were no severe adverse events in both groups and the difference between groups was insignificant. In conclusion, this clinical trial showed APHG-1001 containing Pueraria lobata extract could prevent hair graying in phototrichogram analysis without any remarkable adverse event.

65 포스터 Association between EGF and EGFR gene polymorphisms and susceptibility to alopecia areata in Korean 서동우, 허식 ¹, 이은주, 정주호 ², 유박린, 심우영 경희대학교의과대학피부과학교실, 1 인제대학교의과대학피부과학교실, 2 경희대학교의과대학약리학교실 Epidermal growth factor(egf) is a growth factor that plays an important role in the regulation of cell growth, proliferation, and differentiation by binding to epidermal growth factor receptor(egfr). The roles of EGF and EGFR on the pathogenesis of alopecia areata(aa) are uncertain. However, several reports suggest the association between EGF signaling and AA. To investigate the significance of EGF and EGFR gene polymorphisms in the susceptibility to AA and understand the pathogenesis of AA. Two hundred thirty-one AA patients and 270 healthy controls were enrolled in this study. Genotype frequency of 5 single nucleotide polymorphims(snps) in EGF gene and 5 SNPs in EGFR gene were studied. The statistical analyses were performed according to onset age, the family history, clinical subtypes of AA, and presence of nail involvement or body hair involvement. One SNP (rs ) of EGF gene and one SNP (rs ) of EGFR gene showed significant difference between AA patients and controls group. One SNP (rs ) of EGF gene showed significant difference between the AA patients with nail involvement and without. One SNP (rs ) of EGFR showed a significant difference between the patch type AA and alopecia totalis, and another SNP (rs ) showed significant differences according to body hair loss and nail involvement. EGF and EGFR gene polymorphisms might contribute to the increased susceptibility to AA in Korean population. EGF gene polymorphisms could be associated with nail involvement and EGFR gene polymorphisms could be associated with body hair loss and nail involvement.

66 th Meeting of The Korean Hair Research Society Wnt5a attenuates the Wnt/β-catenin signaling in human dermal papilla cells 곽미희, 김문규, 김정철, 성영관 경북대학교의학전문대학원면역학교실 The hair follicular dermal papilla (DP) plays a key role in hair growth and cycling by regulating the activity of various cells in the follicle. Recent studies showed that Wnt5a modulates hair growth. Here, we investigated whether Wnt5a acts as an autocrine factor and modulates canonical Wnt/β -catenin signaling in human DP cells. We observed that the Wnt3a-mediated elevation of β-catenin signaling was inhibited by Wnt5a as examined by reporter assay. In addition, Wnt5a sirna-transfected DP cells and isolated DPs from Wnt5a sirna-transfected cultured hair follicles showed higher elevation of β-catenin signaling by Wnt3a. Moreover, Wnt5a repressed the expression of Wnt/β-catenin target genes such as Axin2, EP2 and LEF1. Wnt3a-mediated nuclear accumulation of β-catenin was also blocked in the presence of Wnt5a in DP cells. Our data, the first of its kind to the best of our knowledge, demonstrate that Wnt5a acts as an autocrine factor and attenuates canonical Wnt signaling pathway in human DP cells.

67 포스터 OVO homologue-like 1, a target gene of Wnt/β-catenin pathway, controls the hair follicle neogenesis Seung Hyun Shin, Moon Kyu Kim, Jung Chul Kim, Young Kwan Sung Department of Immunology, School of Medicine, Kyungpook National University Recent studies demonstrated that Wnt signaling through the β-catenin pathway maintains hair-inducing activity of the dermal cells, suggesting that β-catenin activity of dermal cells is required for hair follicle neogenesis. In this study, we adopted small interfering(si) RNA-mediated gene knockdown approach together with patch assay to examine whether β-catenin signaling in dermal cells are critical for hair follicle neogenesis. As expected, control sirna-transfected dermal cells induced new hair follicles in vivo. However, we observed significant impairment of hair follicle neogenesis in β-catenin sirna-transfected dermal cells. These results demonstrate that β-catenin activity of dermal cells is crucial for hair follicle neogenesis and strongly suggest that transcriptional target genes of β-catenin pathway are essential for maintaining tricogenicity of dermal cells. To further explore the transcriptional target genes of Wnt/β-catenin pathway, we performed microarray hybridization analysis and identified a zinc-finger transcription factor, OVO homologue-like 1 (OVOL1). We observed significant impairment of hair follicle neogenesis in OVOL1 sirna-transfected dermal cells. Altogether, our data demonstrate that OVOL1, a downstream target of Wnt/β-catenin pathway, play an important role in regulating the hair follicle neogenesis.

68 th Meeting of The Korean Hair Research Society 발모벽 69 례의임상조직학적고찰 김정희, 이은주, 유박린, 심우영 강동경희대학교병원피부과학교실 발모벽은습관적으로혹은충동적으로자신의모발을반복적으로비틀거나, 비비거나, 잡아당겨일어나는외상성탈모증의한임상형이다. 지금까지발모벽에대한연구는주로정신과혹은소아과영역에서이루어졌으나원형탈모증, 견인탈모등을포함한기타의탈모증과감별을요하는경우가많고조기발견과치료가예후에중요하기때문에피부과의사의역할이매우중요한질환이다. 저자들은강동경희대학교병원피부과에서최근 10년간발모벽으로진단된 69명의환자를대상으로임상조직학적고찰을시행하였다. 진단당시연령은 11개월부터 38세까지로평균나이는 10.6세였고, 그분포는초등학생층 (7-12세) 이 40명 (58%) 으로가장많았다. 남녀수는각각 25명과 44명으로 1:1.76의비율을보였다. 주로침범하는부위는전두부, 측두부였으며전체두피면적의 25% 이상을침범한중증환자는 16명으로전체환자의 23% 를차지하였다. 타병원에서원형탈모증을포함한기타의탈모증으로진단받고치료하던중발모벽으로진단된환자는 19명으로전체의 27.5% 를차지하였다. 정신적스트레스가동반된경우는 21명 (30.4%) 이었으며, 신경정신과적질환이동반된경우는 2명 (2.9%) 이었다. 치료는대부분환자에서약물치료없이질병에대해설명하고경과를추적관찰하였으며초등학생층에서는이러한중재만으로도치료가되는경우가많았다. 재발하였거나중증환자의경우, 다른긴장상황이나정신병리학적장애의동반이의심되는경우정신과의사와의상담을권유하였다.

69 포스터 Clinical manifestations of early onset female androgenetic alopecia patients Sung-yul Lee, Noo Ri Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Androgenetic alopecia (AGA) in female patients is also called as female pattern hair loss. Female pattern hair loss shows thinning of hair thickness and decrease of hair density in the frontal and temporal area, whereas hair density in the occipital area is maintained. Characteristically, hair thinning presents predominantly over the top of the head, which shows similar to christmas tree. To evaluate clinical and laboratory manifestations of Korean female AGA patients, we reviewed medical records of female patients who were diagnosed as AGA before 35 years old, at the Department of Dermatology, Yonsei University Wonju Christian Hospital in the last 8 years. Total 230 patients with early onset AGA (diagnosed before 35 years) were reviewed, and we assessed their past medical histories and laboratory results such as hemoglobin, hematocrit, TIBC, ferritin, BUN, Cr, glucose, SGOT/PT, TG, cholesterol, testosterone and DHEA-S. In addition, we analyzed their hair loss pattern with BASP classification. As results, only 0.4% of the patient had a history of DM, and 2.6% had a history of thyroid disease. No patients with other medical histories were detected. Also, average levels of the laboratory findings listed above did not show any abnormal findings. All of the patients showed F type hair loss in BASP classification.

70 th Meeting of The Korean Hair Research Society Characteristics of juvenile androgenetic alopecia patients Noo Ri Lee, Sung-yul Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Androgenetic alopecia (AGA) is known to be associated with elevated androgenic hormone levels or increased response to the hormones. It is assumed that clinical and laboratory manifestations of juvenile groups may be different from adult groups, because of different response rates to the sex hormones. Herein, we performed a retrospective study to assess clinical and laboratory findings of juvenile group with AGA. We reviewed medical records of patients who were diagnosed as AGA before 19 years old. Total 54 patients with juvenile AGA (diagnosed before 19 years) were reviewed, and we assessed their past medical histories and laboratory results such as hemoglobin, hematocrit, TIBC, ferritin, BUN, Cr, glucose, SGOT/PT, TG, cholesterol, testosterone and DHEA-S. As results, medical histories of juvenile AGA group showed different aspect compared to the adult AGA population, that is, prevalence of suspected lupus erythematosus was high (4%). Patients with other medical histories (hypertenstion, diabetes mellitus and cardiovascular diseases) were not detected. Sex ratio (Male:Female) was 1.7:1. In the aspects of the degrees of alopecia, only two patients (3.7%) showed moderate to severe degrees (more than degree 2 of M and V types of BASP classification). Also, average levels of the laboratory findings listed above did not show any abnormal findings.

71 포스터 Medical comorbidities in early onset androgenetic alopecia patients Noo Ri Lee, Sung-yul Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine Androgenetic alopecia (AGA) is a specific type of hair loss mediated by systemic androgen and genetic factors, and is the most common type of hair loss in both sexes. Epidemiological studies have shown that insulin resistance and coronary artery disease are more frequently observed in men with AGA, and early onset AGA patients (younger than 35 years) were shown to have higher risk for systemic diseases such as insulin resistance and hypercholesterolemia than late onset AGA patients. There have been several reports on the epidemiologic studies of medical co-morbidities in early onset AGA in Caucasians, but few studies on Asians have been reported. We performed a retrospective study with early onset AGA by reviewing 810 medical records of patients diagnosed as AGA before 35 years who visited Yonsei Wonju Christian hospital in the last 10 years. We checked their laboratory findings that represent risk factors of cardiovascular and cerebrovascular diseases, such as fasting glucose level, lipid profiles, and insulin level. Also, we reviewed their medical histories. As results, early onset Korean AGA patients group showed no significant differences compared to non-aga control group with similar ages in the laboratory findings that indicate cardiovascular and cerebrovascular disease risk. This is notable that ethnic difference is likely to present in relevance of medical comorbidities with early onset AGA patients.

72 th Meeting of The Korean Hair Research Society Bilateral treatment with anthralin and diphenylcyclopropenone for recalcitrant alopecia areata Won Suk Lim, Do Hun Kim, Sang Yun Jin, Yun Seok Choi, Ai Young Lee, Seung Ho Lee Department of Dermatology, Dongguk University Ilsan Hospital, College of Medicine, Dongguk University, Goyang, Korea Various therapeutic agents have been described for the treatment of alopecia areata. The effectiveness of each treatment modality varies according to patients. Therefore, it is essential to find out the most effective treatment method for each alopecia areata patient, especially in case of recalcitrant one. Bilateral treatment strategy, that is, dividing scalp by the mid sagittal suture and treating each side with different remedy can diminish the time necessary to identify an effective therapeutic method for extensive alopecia areata. Synergistic effect might be expected when performing the bilateral treatment with diphenylcyclopropenone(dpcp) immunotherapy and anthralin, although that has not been identified yet. A 47-year-old man was referred for a 7-month history of extensive alopecia areata. He was treated with triamcinolone intralesional injection and oral cyclosporine for 6 months. Complete recovery could not be achieved, so we started DPCP immunotherapy. Hair loss progressed, and there was no treatment response for 6 months. Then, bilateral treatment with DPCP and anthralin 1% ointment was applied. After 3 months, both sides of the scalp showed some terminal hair growth. There was more significant improvement on the right side treated with DPCP 2 months later, so that anthralin was discontinued and DPCP immunotherapy was applied on the whole scalp.

73 포스터 Induction of hair growth by phytosphingosine-1-phosphate in C3H/HeJ mice model 임윤영, 김형미, 손인평, 최명준 1, 홍창권, 김범준 중앙대학교의과대학피부과학교실, 1 ( 주 ) 피토스 Sphingosine-1-phosphate (S1P) which is stored in and released from platelet seems to play various roles physiologically. S1P through S1P receptor induces angiogenesis which is one of the major therapeutic strategies of hair growth. Phytosphingosine-1-phosphate (PhS1P), a S1P receptor agonist, has been shown to have angiogenic activity. We investigated the efficacy of PhS1P to hair growth in C3H/HeJ mice. The efficacy was assessed by dermoscope and histologic analysis. And increased expression of Wnt3a, Wnt5a, and mice hair growth-related molecules was observed in PhS1P and cyclic PhS1P group. These findings suggest that PhS1P could be one of treatment options for hair growth.

74 th Meeting of The Korean Hair Research Society Inhibitory effect of tianeptine on catagen induction in alopecia areata-like lesions of mice 김형미, 임윤영, 손인평, 박소라 ¹, 서성기 ¹, 이마세 ¹, 김명남, 김범준 중앙대학교의과대학피부과학교실, 1 ( 주 ) 건일제약 Stress is one of the important triggering factors in alopecia areata. We were to identify inhibitory effect of tianeptine on catagen induction in C57BL/6 mice with ultrasound wave stress-induced alopecia areata-like lesions. The mice were divided into three groups: Oral administration of tianeptine before and after ultrasound wave stress (group 1), oral administration of tianeptine only after ultrasound wave stress (group 2), and control group (group 3). The assessment was made by phototrichigram and dermoscopy. Group 1 mice presented increased hair growth rate and thickness of hair shaft than group 2 and group 3 mice. Tianeptine might play a role in suppressing catagen induction in stress-induced alopecia areata mice model.

75 포스터 Prevalence and classification of androgenetic alopecia in cardiovascular in-patients Sung Yul Lee, Hannah Hong, Noo Ri Lee, Won-Soo Lee Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea Androgenetic alopecia (AGA) is now considered as a risk factor of the medical co-morbidities such as cardiovascular, cerebrovascular and metabolic disease, nowadays. Especially, there are many reports about the association between AGA and cardiovascular disease in Caucasian population. However, there is lack of evidence in Asian population of this association between those two disease. The aim of this study is evaluating the prevalence of AGA in cardiovascular in-patients and classifying type of AGA in these patients. We interviewed cardiovascular disease in-patients who were already diagnosed myocardial infarction and stable/unstable angina by coronary angiography. Then we reviewed the type of AGA with BASP classification approved by KHRS and also, analyzed other laboratory findings including AGA family history of the patients. The mean age of the patients was over the 60s so, almost patients showed somewhat degree of AGA. Therefore, we compared all data obtained from patients with age/sex matched normal control group. There was a tendency that high prevalence of V (vertex involved type) type in cardiovascular disease patients group compared with control group. So, we suggest that the V type is the more risky than other types (M or F) for cardiovascular disease.

76 th Meeting of The Korean Hair Research Society 영아에서발생한원형탈모증 노병인, 이상윤, 김신한, 고재완 관동대학교의과대학피부과학교실 원형탈모증은비반흔성탈모증의흔한원인으로동전크기의원형의탈모반이있으면서그부위의모발이소실되는질환으로최근에는자가면역질환의한종류로생각되고있다. 주로젊은성인이나소아에서많이발생하지만, 신생아나어린영아에서발생한경우는매우드문것으로알려져있다. 첫번째환아는 2개월된남아로 16일전부터두피에다발성의원형탈모반이발생하여내원하였다. 내원당시후두부와양측두부에다발성의병변이관찰되었으며, 출산시두피에외상은없었으나, 1개월전타병원에서패혈증으로입원치료받고퇴원한병력있었다. 두번째환아는 4개월된남아로 2개월전우측측두부에서원형의탈모반발생한후점차양측두부와후두부에다발성의병변이발생하여내원하였으며피부병변이외의다른질환및외상의병력, 가족력등은없었다. 신생아및영아에서발생한원형탈모증의경우특히, 후두부에발생할경우에는뒤통수뼈융기부위에지속적인마찰및압력과관련하여환상의형태로발생하는경우가흔하지만, 산류와관련된주산기외상으로인한압박성탈모증과선천성모반, 선천삼각탈모증, 수막류및발달장애등과관련되어탈모증이발생할수도있기때문에주의깊은관찰이필요하다. 이에저자들은어린영아에서발생한원형탈모증 2예를드물고흥미로운증례로생각하여보고한다.

77 포스터 The effect of red ginseng on the growth of cultured human hair follicles Gyeong-hun Park, Chong-Hyun Won, Ki-young Park¹, Sang-Min Lee, Sung-Eun Chang, Mi-Woo Lee, Jee-Ho Choi, Kee-Chan Moon, Hong-il Cho¹ Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, 1 Asan Institute for Life Sciences, Seoul, Korea Several recent murine studies showed that ginseng and its bioactive components, saponins, may be beneficial to hair growth promotion. However, the effects on human hair follicles have not yet been elucidated sufficiently. To investigate the effect of red ginseng and its saponins on the hair growth. Methods: We determined the proliferation of HaCaT cells, human outer root sheath cells and human dermal papilla cells (hdpcs) after treatment of red ginseng extract and ginsenoside Rb1 and Rg1 using MTT assay. The effect on cultured human hair follicles was assessed by the hair shaft elongation and proliferation of hair matrix keratinocytes with immunofluorescence staining of Ki67. In addition, we investigated the signal changes of hdpcs and the effect on hair growth in C57BL/6 mice. The red ginseng extract, ginsenoside Rb1 and Rg1 increased the proliferation of hdpcs in MTT assays. In the cultured human hair follicles, both ginsenoside Rb1 and Rg1 upregulated the proliferation of hair matrix keratinocytes, and ginsenoside Rg1 promoted hair shaft elongation. In addition, ginsenoside Rb1 increased the phosphorylation of ERK1/2. The red ginseng extract, ginsenoside Rb1 and Rg1 enhanced the proliferation of hdpcs and both ginsenosides upregulated the proliferation of hair matrix keratinocytes. These results suggest that red ginseng may be beneficial for human hair growth promotion.

78 th Meeting of The Korean Hair Research Society Ultraviolet radiation alters lipid metabolism in human hair follicle Long-Quan Pi¹, Xing-Hai Jin¹, Sungjoo Tommy Hwang², Won-Soo Lee¹ 1 Department of Dermatology and Institute of Hair and Cosmetic Medicine, Yonsei University Wonju College of Medicine, 2 Dr. Hwang s Hair-Hair Clinic Although integral hair lipid (IHL) plays essential roles in hair morphogenesis and formation of lipid envelop of hair cells, their roles on ultraviolet (UV)-induced photoaging in human hair follicle are poorly understood. In this study, we investigated the photo-degradation of IHL in human hair follicle. Organ-cultured human anagen hair follicles were irradiated with UV, and IHL metabolism was studied. We observed that UV irradiation decreased the free fatty acid contents, but increased the ceramide and sphingomyelin contents. The expressions of genes related to lipid synthesis, including acetyl-coa carboxylase (ACC), fatty acid synthase (FAS), stearoyl-coa desaturase (SCD), and sterol regulatory element binding proteins (SREBPs) were also markedly decreased. These results suggest that UV radiation alters IHL in human hair follicle and IHL may play important roles in photoaging of human hair follicle.

79 포스터 Two cases of hair shaft abnormalities associated with hair breakage Won Joon Choi, Young Sun Eun, Chul Hwan Bang, Jung Eun Kim, Hoon Kang Department of Dermatology, St. Paul s hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea Pili torti which means twisted hair is a rare hair abnormality. The hair is characterized by twisting of the hair shaft by its own axis. It shows brittle, easily broken hair and segmental thickening. We report a 33year-old woman whose hair has been diffusely thin and kinky since birth. Her sister has similar symptoms. She denied any trauma history. Dermoscopy and electron microscope study revealed twisting of hair and different thicknesses of one hair shaft. Histopathologically, there were no hair follicular destruction and inflammatory reactions. Trichorrhexis nodosa is the most common hair shaft anomaly characterized by the development of node-like swelling, weakning of the shaft and finally develops paint brush effect on the side of the fracture. It is commonly followed by a chemical or physical traumatic injury. We also report a 4 year old boy whose hair has been diffusely short and curly with diffuse alopecia since birth. His hair had growth retardation. We found shaft breakages and fractures similar to paintbrush by electron microscope. Both cases are congenital cases that are rare than acquired ones. We experienced 2 cases of hair shaft abnormalities with hair breakage diagnosed by dermoscopy and electron microscope.

80 대한모발학회회칙 제 1 장 총칙 제 1 조 ( 명칭 ) 본회는대한모발학회 (The Korean Hair Research Society) 라하며대한피부과학회의산하학회이다. 제 2 조 ( 구성 ) 본회는모발및모발과관련된질환을다루고연구하는사람으로구성한다. 제 3 조 ( 목적 ) 본회는모발에대한연구, 교육및학술활동을수행하고회원간의친목을도모함을목적으로한다. 제 4 조 ( 사업 ) 본회는전항의목적을달성하기위하여다음과같은사업을수행한다. 1. 총회및학술대회개최 2. 초록집, 학술지및소식지의발간 3. 모발및모발질환에대한연구, 교육등제문제에대한사업 4. 국내외관련학술단체와의교류및제휴 5. 기타본학회목적달성에필요한사업 제 2 장 회원 제 5 조 ( 자격 ) 본회의회원은모발관련진료및연구에종사하거나관심을가지고본학회의취지에찬동하는자로서소정의입회수속을밟고이사회의의결을거쳐총회에서인준을받은자로한다. 제 6 조 ( 구분 ) 본회의회원은다음과같이구분한다. 1. 정회원 : 대한피부과학회정회원자격자로본회목적에찬동하는자로한다. 2. 명예회원 : 모발관련진료및연구업적이탁월하고본회발전에공헌이지대한자로한다. 3. 연구회원 : 생명과학관련분야에종사하는박사학위소지자이거나이에준하는경력자로본회목적에찬동하는자로한다. 4. 준회원 : 전공의및모발연구에종사하는연구원으로한다. 제 7 조 ( 의무 ) 회원은본회의회칙, 제규정및결의사항을준수하여야하고, 정회원및연구회원은회비및기타의부담금을납부할의무가있다.

81 제 8 조 ( 권리 ) 모든회원은본회에서발간하는소식지및학회지를배부받을권리가있으며정회원은선거권, 피선거권및기타소정의의결권을가진다. 제 9 조 ( 제명 ) 본회의의무를준수하지않거나명예를훼손한회원은이사회를거쳐총회의인준을받아제명할수있다. 제 3 장 임원 제 10 조 ( 임원 ) 본회는회장, 부회장 3명이내, 총무, 학술, 교육, 재무, 홍보, 간행정보의상임이사와부이사, 감사 2명및 3명이내의고문을두며이사의정원은 30 명내외로한다. 제 11 조 ( 선임 ) 1. 회장, 감사는총회에서선출한다. 2. 부회장, 상임이사및상임부이사는회장이위촉한다. 3. 이사는상임이사회에서추천하여회장이위촉한다. 4. 고문은회장이위촉한다. 제 12 조 ( 임기 ) 임원의임기는 2년으로하며연임할수있다. 전임자의유고로인해보선된임원의임기는전임자의잔여임기로한다. 제 13 조 ( 직무 ) 1. 회장은본회를대표하여업무를총관리하고총회, 이사회의의장이된다. 2. 부회장은회장의유고시그직무를대행하며, 본회운영의주요한사항을심의하고제반업무를집행한다. 3. 총무이사는본회운영의주요한사항을심의하고제반업무를집행한다. 총무부이사는총무이사를보좌하여제반총무업무를수행한다. 4. 학술이사는학술모임에관한업무를집행한다. 학술부이사는학술이사를보좌하여제반학술업무를수행한다. 5. 교육이사는회원교육에관한업무를집행한다. 교육부이사는교육이사를보좌하여제반교육업무를수행한다. 6. 재무이사는재무에관한업무를집행한다. 재무부이사는재무이사를보좌하여제반재무업무를수행한다. 7. 홍보이사는홍보및대중매체에다루어지는업무를집행한다. 홍보부이사는홍보이사를보좌하여제반홍보업무를수행한다. 8. 간행정보이사는간행및정보에관한업무를집행한다. 간행정보부이사는간행정보이사를보좌하여제반간행정보업무를수행한다. 9. 감사는본학회의재산상황과사업과관련된사항을감사하고이를총회에보고한다. 10. 이사와부이사는이사회를구성하여본학회운영의주요사항을심의의결한다.

82 11. 고문은본학회의운영전반에대한자문을한다. 제 4 장 회의 제 14 조 ( 구분 ) 본회에는총회와이사회, 상임이사회를둔다. 제 15 조 ( 총회 ) 1. 정기총회는연 1 회회장이소집한다. 단정회원 5분의 1이상의요구나이사회의요청이있으면임시총회를소집하여야한다. 2. 총회는출석정회원으로성립되고재석인원과반수로의결한다. 3. 총회는다음과같은사항을의결한다. (1) 회장, 감사선출 (2) 예산과결산의인준 (3) 회칙개정의인준 (4) 기타이사회에서제출한사항 제 16 조 ( 이사회 ) 1. 이사회는임원, 이사및부이사로구성하며회장이의장이되어회의를진행한다. 2. 이사회는과반수출석으로성립하고재석인원과반수로의결한다. 3. 이사회는총회에제출하여인준또는의결할사항, 제규정의제정과개정, 회원의자격과제명및기타필요한사항에대하여심의의결또는인준한다. 제 17 조 ( 상임이사회 ) 1. 상임이사회는상임이사로구성하며회장이의장이되어회의를진행한다. 2. 상임이사회는이사회및총회에제출하여인준또는의결할사항을포함하여회무전반에관한사항을심의의결또는인준하여집행한다. 제 18 조 ( 각종위원회 ) 1. 이사회의의결을거쳐각종위원회를둘수있다. 제 5 장 재정 제 19 조 ( 재원 ) 본회의재원은회비, 입회비, 찬조금및기타수입금으로한다. 제 20 조 ( 회계년도 ) 본회의회계연도는매년정기총회일에서다음정기총회전일까지로한다. 제 21 조 ( 임기 ) 본회의수지결산은감사의감사를거쳐차기정기총회에보고한다.

83 제 6 장 부칙 제 22 조본회칙에규정되지않은세칙은일반관례에준한다. 제 23 조본회칙의개정은이사회의심의를거쳐총회의인준을받아야한다. 제 24 조본회칙은공포일로부터시행한다 제정 개정 개정 개정

84 대한모발학회임원명단 (2010 년 6 월 년 5 월 ) 고 문 노병인, 박장규, 임철완 회 장 강진수 부회장 김도원 총 무 이원수 학 술 강훈 교 육 김문범 홍 보 민복기 재 무 최광성 간행정보 권오상 총무부이사 김범준 학술부이사 유박린 교육부이사 박병철 재무부이사 조성빈 홍보부이사 원종현 간행정보부이사이상훈 감 사 심우영, 김정철 이 사 강광영, 계영철, 김규한, 김기호, 김성진, 김시용, 김양제김풍명, 김형옥, 김홍직, 박성욱, 서구일, 신기식, 윤태영은희철, 이동윤, 이양원, 임이석, 장승호, 조성환, 조항래허창훈, 홍창권, 황성주

85 대한모발학회연혁 대한모발학회소개 대한모발학회는 1998년 10월 29일대한피부과학회내에모발연구분과위원회를설립하기위한발기인모임을가진것을시작으로하여태동이되었습니다. 이후모발연구분과위원회의주도로매년대한피부과학회춘추계학술대회때마다모발심포지엄을개최하여왔습니다. 이후기존의모발연구분과위원회를확대개편하여대한모발학회를창립하기로하고 2004년 7월 11일제주도샤인빌호텔에서창립총회를가졌습니다. 초대회장으로노병인교수를비롯한임원진이선출되었고, 이후본격적인활동을시작하였습니다. 2006년 5월 28 일제 2대회장으로박장규교수가선출되어 2기임원진을구성하여학회를이끌었고, 2008년 5월 25일제 3대회장으로임철완교수가선출되어제 3기집행부를구성하여회무를담당하였습니다. 현재는 2010년 6월 13일개최된제 7차학술대회에서강진수회장이선출되어제 4기집행부를구성하여회무를담당하고있습니다. 현재대한모발학회는북미모발연구학회, 유럽모발연구학회, 일본모발연구학회, 호주모발연구학회와함께세계모발연구학회를구성하는 5대메이저학회로서당당히어깨를겨누는세계속의모발학회로성장하였습니다. 더우기 2014년제 8차세계모발연구학회의한국유치에성공하여그위상을세계에드높이고있습니다. 학술활동소개 1. 대한모발학회학술대회 대한모발학회학술대회는 1년에한번개최되며, 해외학자초청강연, 특강및교육강연, 각종구연및포스터연제발표등으로이루어지는대한모발학회의꽃이라고할수있습니다. 제 1차및제 2차심포지엄을거쳐 2006년제 3차대회때부터정식학술대회의면모를갖추게되었습니다. 1) 제1차대한모발학회심포지엄 년 11월 7일밀레니엄힐튼호텔 - 탈모에서 Mesotherapy 외 9 강좌 2) 제2차대한모발학회심포지엄 년 6월 19일밀레니엄힐튼호텔 - 탈모증의진단외 12강좌

86 3) 제3차대한모발학회학술대회 년 5월 28일밀레니엄힐튼호텔 - 원형탈모증의임상적특징외 8강좌및일반연제 4) 제4차대한모발학회학술대회 년 5월 27일밀레니엄힐튼호텔 - 원형탈모증의원인과발생기전외 10강좌및일반연제 5) 제5차대한모발학회학술대회 년 5월 25일밀레니엄힐튼호텔 - 모낭과안드로겐외 15강좌및일반연제 6) 제 6차대한모발학회학술대회 년 5월 24일밀레니엄힐튼호텔 - 모낭의발생외 12 강좌및일반연제 7) 제 7차대한모발학회학술대회 년 6월 13일밀레니엄힐튼호텔 - New insights into hair biology 외 14 강좌및일반연제 8) 제 8차대한모발학회학술대회 년 9월 18일코엑스회의실 Hall E (3층) - Current and new aspects of female pattern hair loss 외 23 강좌및일반연제 2. Hair Forum 2001년시작하여해마다참석하는인원이늘어나고있는 Hair Forum은모발학회회원들간의격식없는모임입니다. 이는자유로운토론과회원상호간의친목도모를위하여마련되고있으며, 주로진단및치료가어려운증례에대한토론, 그동안연구했던내용발표, 해외모발학회참관기소개등다른회원들과의의견공유를위해서밤늦은시간까지진행됩니다. 최근에개최된 Hair Forum 현황은다음과같습니다. 1) 2004년 8월 28일대전유성스파피아호텔모낭유래세포에서의 androgen receptor, estrogen receptor의발현양상외 13건발표 2) 2005년 8월 20일대전유성스파피아호텔원형탈모증환자 400명의임상적고찰외 8건발표

87 3) 2006년 8월 19일대전유성레전드호텔 Acute diffuse alopecia areata 외 11건발표 4) 2007년 8월 18일대전유성리베라호텔모낭유래세포의특성분석외 13건발표 5) 2008년 8월 23일대전유성리베라호텔전두탈모증환자에서모반제거후모발재생의치료경험외 18 건발표 6) 2009년 8월 22일대전유성리베라호텔원형탈모증환자에서스트레스평가에대한예비연구외 9건발표 7) 2010년 8월 21일대전유성리베라호텔 Effect of radiofrequency radiation on human hair follicle cells 외 16 건발표 8) 2011년 8월 27일대전유성호텔아드리아 Uitraviolet radiation alters lipid metabolism in human hair follicle 외 11 건발표 3. 대한피부과학회학술대회시모발심포지엄개최 대한모발학회는대한피부과학회산하의모발연구분과위원회이기도하므로, 1999년부터매년대한피부과학회의춘추계학술대회에서모발심포지엄을진행하고있습니다. 2009년부터는대한피부과학회춘추계학술대회시한번에한해분과심포지엄을개최할수있는대한피부과학회의새로운자체규정에따라추계학술대회에서모발심포지엄을개최해오고있습니다.

88 대한모발학회학술대회전시및광고회사 전시회사등급 회사명 연락처 한국MSD 갈더마코리아 골드 현대약품 글락소스미스클라인 동화약품 토탈헬스포인트 메디웨이 실버 미라 종근당 리드엠 반석메디칼 브론즈 정우의학서적 광고회사 No. 회사명 연락처 1 한국MSD 글락소스미스클라인 현대약품 보령제약 갈더마코리아 토탈헬스포인트 라로슈포제 동구제약

89 2012 년제 9 차대한모발학회학술대회 인쇄발행 2012년 6월 1일 2012년 6월 3일 발행처 대한모발학회 학술대회사무국나림컨벤스서울시영등포구선유로 27 대륭오피스텔 613호 Tel: , Fax: narim2007@paran.com