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24 Major Bio-Resources Regenerative Medicine Brain Science Mouse Rat Plant Experimental Immunology, Animals Allergy Medaka Fish and Zebrafish Information Center and Plants Genome-based Location, Drug Discovery Characteristics and Genetic Information Gene Therapy on Bio-resources Cancer Cells Research C. elegans and Genes Food Production Amphibian Microorganisms Sea Squirt in Extreme Environments ES Cell Environmental Conservation Basic Research Development of New Medical Treatments and Drugs Promotion of Original Research in Japan International Cooperation and Initiatives

Clean bench 정리법 6 사용후 clean bench 내의 sprayer로소독할것 Notice * 사용후뒷정리에유념 ex) 혈흔, syringe, ep-tube etc. * Needle 등날카로운것은 needle box에 * 사용한물품중실험에직접사용된것은감염성폐기물 box * 기타 syringe 포장지, 일반 box 등은쓰레기통으로 7 Glass door 내리기 8 형광등 switch turn-off 9 Control box switch turn-off 10 반드시사용대장을작성할것

(8) 관리자관련 : 실험동물기술원 자격증 획득 (1급-1인, 2급- 3인) - 58 -

Discovery of Drug Targets in Cancer Vescovi et al. (2006) Nature Reviews Cancer 6, 425 436 vant Veer et al (2002). Nature 415, 530-536

암표적분자개발 꼬마선충모델 제브라피쉬모델 Clinical trial Preclinical trial 표적치료를위한암동물모델개발및표적인자개발 천연물 / 화합물후보물질 Before treatment After treatment Identify effective drugs 표적장기 / 유전자재조합마우스모델 / 실험동물실 항암제스크리닝시스템개발

(Watanabe and Uchida, 1995, Johansson, 2003, Zhang et al., 2004)

Arum, O., and Johnson, T.E. (2007). Reduced expression of the Caenorhabditis elegans p53 ortholog cep-1 results in increased longevity. The journals of gerontology 62, 951-959. Derry, W.B., Putzke, A.P., and Rothman, J.H. (2001). Caenorhabditis elegans p53: role in apoptosis, meiosis, and stress resistance. Science (New York, N.Y 294, 591-595. Hong, M., Kwon, J.Y., Shim, J., and Lee, J. (2004). Differential hypoxia response of hsp-16 genes in the nematode. Journal of molecular biology 344, 369-381. Johansson, M. (2003). Identification of a novel human uridine phosphorylase. Biochemical and biophysical research communications 307, 41-46. Kwok, T.C., Ricker, N., Fraser, R., Chan, A.W., Burns, A., Stanley, E.F., McCourt, P., Cutler, S.R., and Roy, P.J. (2006). A small-molecule screen in C. elegans yields a new calcium channel antagonist. Nature 441, 91-95. Lackner, M.R., Kindt, R.M., Carroll, P.M., Brown, K., Cancilla, M.R., Chen, C., de Silva, H., Franke, Y., Guan, B., Heuer, T., Hung, T., Keegan, K., Lee, J.M., Manne, V., O'Brien, C., Parry, D., Perez-Villar, J.J., Reddy, R.K., Xiao, H., Zhan, H., Cockett, M., Plowman, G., Fitzgerald, K., Costa, M., and Ross-Macdonald, P. (2005). Chemical genetics identifies Rab geranylgeranyl transferase as an apoptotic target of farnesyl transferase inhibitors. Cancer cell 7, 325-336. Maring, J.G., Groen, H.J., Wachters, F.M., Uges, D.R., and de Vries, E.G. (2005). Genetic factors influencing pyrimidine-antagonist chemotherapy. The pharmacogenomics journal 5, 226-243. Mauritz, R., van Groeningen, C.J., Smid, K., Jansen, G., Pinedo, H.M., and Peters, G.J. (2007). Thymidylate synthase and dihydropyrimidine dehydrogenase mrna expression after administration of 5-fluorouracil to patients with colorectal cancer. International journal of cancer 120, 2609-2612. Niho, S., Kubota, K., Goto, K., Yoh, K., Ohmatsu, H., Kakinuma, R., Saijo, N., and Nishiwaki, Y. (2006). First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: a phase II study. J Clin Oncol 24, 64-69. Petrascheck, M., Ye, X., and Buck, L.B. (2007). An antidepressant that extends lifespan in adult Caenorhabditis elegans. Nature 450, 553-556. Pinkston, J.M., Garigan, D., Hansen, M., and Kenyon, C. (2006). Mutations that increase the life span of C. elegans inhibit tumor growth. Science (New York, N.Y 313, 971-975. Temmink, O.H., de Bruin, M., Turksma, A.W., Cricca, S., Laan, A.C., and Peters, G.J. (2007). Activity and substrate specificity of pyrimidine phosphorylases and their role in fluoropyrimidine sensitivity in colon cancer cell lines. The international journal of biochemistry & cell biology 39, 565-575. Teng, M.S., Dekkers, M.P., Ng, B.L., Rademakers, S., Jansen, G., Fraser, A.G., and McCafferty, J. (2006). Expression of mammalian GPCRs in C. elegans generates novel behavioural responses to human ligands. BMC biology 4, 22. Tracy, S., Mukohara, T., Hansen, M., Meyerson, M., Johnson, B.E., and Janne, P.A. (2004). Gefitinib induces apoptosis in the EGFRL858R non-small-cell lung cancer cell line H3255.

Cancer research 64, 7241-7244. van Kuilenburg, A.B., Haasjes, J., Richel, D.J., Zoetekouw, L., Van Lenthe, H., De Abreu, R.A., Maring, J.G., Vreken, P., and van Gennip, A.H. (2000). Clinical implications of dihydropyrimidine dehydrogenase (DPD) deficiency in patients with severe 5-fluorouracil-associated toxicity: identification of new mutations in the DPD gene. Clin Cancer Res 6, 4705-4712. Watanabe, S., and Uchida, T. (1995). Cloning and expression of human uridine phosphorylase. Biochemical and biophysical research communications 216, 265-272. Zhang, Y., Repa, J.J., Inoue, Y., Hayhurst, G.P., Gonzalez, F.J., and Mangelsdorf, D.J. (2004). Identification of a liver-specific uridine phosphorylase that is regulated by multiple lipid-sensing nuclear receptors. Molecular endocrinology (Baltimore, Md 18, 851-862.