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28 Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients 12) Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study 24) Incidence of Adverse Drug Events and Medication Errors in Japan: the JADE Study 25) 26 Adverse Drug Events in Pediatric Outpatients 26) Adverse Drug Events in Adult Patients Leading to Emergency Department Visits 27) Drug-related admissions and hospital-acquired adverse drug events in Germany: a longitudinal analysis from 2003 to 2007 of ICD-10-coded routine data 28)

29 Hospital admissions for dru g-induceddisorders in England: a study using the Hospital Episodes Statistics(HES) database 29) Adverse Drug Events in the Outpatient Setting: An 11-Year National Analysis 11) National Surveillance of Emergency Department Visits for Outpatient Adverse Drug Events in Children and Adolescents 30) Prevalence of Adverse Drug Events in Ambulatory Care: A Systematic Review 31) Adverse drug reactions in hospital patients. A systematic review of the prospective and retrospective studies. 15) Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies. 10) 27 é ö

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37 1,531 25, ,148 1,469 30, , , (14) (46) (272) (521)

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41 3 (3-4) 13 (11-15) 0 (0%) 1 (0.4%) 8 (14%) 26 (11%) 49 (86%) 199 (88%) 17 (30%) 69 (31%) 11 (19%) 111 (49%) 7 (12%) 0 (0%) 6 (11%) 34 (15%) 4 (7%) 0 (0%) 3 (5%) 0 (0%) 3 (5%) 1 (0.4%) 39 2 (4%) 3 (1%)

42 15 (26.0%) 123 (54.0%) 6 (11.0%) 6 (3.0%) 4 (7.0%) 1 (0.4%) 4 (7.0%) 2 (1.0%) 3 (5.0%) (5.0%) 16 (7.0%) 3 (5.0%) 18 (8.0%) 3 (5.0%) 13 (6.0%) 2 (4.0%) 6 (3.0%)

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45 55 2.4( ) ( ) ( ) ( ) ( ) ( ) 43 6(22.2) 21(77.8) 27 10(35.7) 18(64.3) (29.1) 39(70.9) 55

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51 % 9, % 14, % 14, % 18, % 17, % 0.22% 36, % 34, % 34, % 30, % 31, % 0.08% 13, % 14, % 13, % 16, % 10, % 0.04% 6, % 5, % 4, % 4, % 4, % 0.14% 22, % 24, % 27, % 30, % 34, % 1.09% 181, % 179, % 175, % 187, % 218, % % 490, % 469, % 474, % 509, % 482, % 4.58% 760, % 742, % 744, % 798, % 800, % 16,598,546 15,127,645 14,989,953 15,181,779 15,559,359

52 % 101, % 121, % 126, % 136, % 155, % 2.78% 460, % 383, % 371, % 374, % 356, % 0.24% 39, % 34, % 31, % 31, % 21, % 0.13% 20, % 17, % 15, % 14, % 11, % % 130, % 122, % 124, % 139, % 163, % 9.55% 1,585, % 1,632, % 1,778, % 1,907, % 2,066, % 19.18% 3,184, % 3,080, % 3,148, % 3,342, % 3,721, % 33.28% 5,523, % 5,392, % 5,596, % 5,946, % 6,496, % 16,598,546 15,127,645 14,989,953 15,181,779 15,559,359

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55 11,080,026 (100.0) 11,544,549 (100.0) 11,984,728 (100.0) 12,196,271 (100.0) 12,265,485 (100.0) 59,071,059 (100.0) 8,837 (0.08) 32,582 (0.29) 9,493 (0.08) 37,994 (0.33) 10,403 (0.09) 42,263 (0.35) 9,984 (0.08) 47,164 (0.39) 9,773 (0.08) 49,729 (0.41) 48,490 (0.08) 209,732 (0.36) 10,239,806 (100.0) 8,176 (0.08) 27,172 (0.27) 10,463,971 (100.0) 8,839 (0.08) 30,845 (0.29) 11,005,351 (100.0) 9,677 (0.09) 34,439 (0.31) 11,137,174 (100.0) 9,159 (0.08) 37,809 (0.34) 11,001,106 (100.0) 8,560 (0.08) 38,693 (0.35) 53,847,408 (100.0) 44,411 (0.08) 168,958 (0.31) 53 7,454 8,083 8,860 8,430 7,857 40,684 24,786 27,638 30,952 33,924 34, ,143

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63 6, ,520(100.0) 2.0( ) ,628(12.4) ,362 78,242(49.4) ,464(10.4) ,726(8.0) ,220 31,459(19.9) ,299 78,224(49.4) ,381 80,255(50.6) ,098 78,621(49.6) ,285 17,932(11.3) ,724(10.6)

64 3,034 71,224 (44.9) 2,082 55,464 (35.0) 1,025 20,024 (12.6) 432 9,329 (5.9) 108 2,480 (1.6) , ,313 (22.0) 52,103 (66.6) 4,765 (28.9) 2,754 (21.6) 7,288 (23.2) ,622 (49.2) 17,878 (22.9) 7,621 (46.3) 6,608 (51.9) 13,736 (43.7) ,594 (8.1) 3,428 (4.4) 2,852 (17.3) 2,857 (22.5) 9,291 (29.5) ,731 (19.0) 4,180 (5.3) 768 (4.7) 345 (2.7) 306 (1.0) (1.9) 654 (0.8) 458 (2.8) 163 (1.3) 837 (2.7)

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71 282/1,788 (15.8) 57/283 (20.1) 64/2,248 (2.8) 8/64 (13) 162/661 (24.5) 20/181(11) 58/167 (34.7) 1532/27,617 (5.5) 421/1,532 (27.5) 24/242(9.9) 58/1,682 (3.4) 161/579 (27.8) 280/8,061 (3.4) 96/187 (51.3) 317/158,520 (0.2) 69 68/2,575(2.6) 14/69 (20.3) 40/729 (5.5) 55/965 (5.7) 3/55 (5) 49/565(8.7) 33/50 (66) 76/3,238 (2.3) 21/76 (28) 76/400 (19) 12/78 (15) 176/1,562(11.2) 106/280 (38) 34/379 (9) 25/34 (73.5) 96/1,163(8.3) 439/3,904 (11.2) 214/445 (48.1) 55/1458 (3.8)

72 162/718 (22.6) 18/86 (18.9) 3/18 (16.7) 67/219 (30.6) 37/67 (55.2) 86/208 (41.3) 259/2,643(9.8) 159/259 (61.4) 107/797 (13.4) /6,063 (2.9) 43/849 (5.1) 31/293 (10.6) 293/10,184 (2.9) 211/5,757 (3.7) ü 40/1097 (3.6) ó 776/33,975 (2.3) 322/776 (41.5) 42/3,187 (1.3) 32/42 (76.2) 217/13,004(1.7) 22/502 (4.4) 370/1663 (22.2) 150/370 (40.5) 629/18,854 (3.3) 598/90,810 (0.66) 21,298/922,196 (2.3) 53/558(9.5) 44/53 (83) 122/1,017 (12) 83/122 (68) é ö

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75 18 154, ,

76 59, ( ) 172, ( ) 77, ( ) 36, ( ) 74 4, ( ) 21, ( ) 8, ( ) ( ) 3, ( )

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81 79 3,607 (2,618-4,596) 1,547 (1,033-2,060) 4,986 (3,976-5,995) 702 ( ) 1,547 ( ) 2,216 (1,721-2,711) 63 (41-85) 43 (15-71) 106 (76-137)

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