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Transcription:

Contents 06 08 11 14 17 17 18 19

23 28 28 33 37 41 45 45 51 56 59 64 66 72 80

26 29 31 34 35 35 38 39 40 42 43 43 46 46 47 49 50 51 52 53 54 56

57 59 60 61 62 69 73 74 77 78 79 14 15 25 36 48

06

07

08

é 09

12

13

14

15

16

17

18

19

20

21

24

25

Adverse drug reactions as cause of admission to hospital: prospective analysis of 18,820 patients 12) Investigation into the reasons for preventable drug related admissions to a medical admissions unit: observational study 24) Incidence of Adverse Drug Events and Medication Errors in Japan: the JADE Study 25) 26 Adverse Drug Events in Pediatric Outpatients 26) Adverse Drug Events in Adult Patients Leading to Emergency Department Visits 27) Drug-related admissions and hospital-acquired adverse drug events in Germany: a longitudinal analysis from 2003 to 2007 of ICD-10-coded routine data 28)

Hospital admissions for dru g-induceddisorders in England: a study using the Hospital Episodes Statistics(HES) database 29) Adverse Drug Events in the Outpatient Setting: An 11-Year National Analysis 11) National Surveillance of Emergency Department Visits for Outpatient Adverse Drug Events in Children and Adolescents 30) Prevalence of Adverse Drug Events in Ambulatory Care: A Systematic Review 31) Adverse drug reactions in hospital patients. A systematic review of the prospective and retrospective studies. 15) Incidence of adverse drug reactions in hospitalized patients: A meta-analysis of prospective studies. 10) 27 é ö

28

29

30

31

32

33

34

1,531 25,734 504 19.6 17.9-21.3 32.9 30.6-35.3 4,148 1,469 30,419 407 13.4 12.1-14.7 27.7 25.4-30.0 3,218 459 3,230 99 30.7 24.6-36.7 21.6 17.8-25.3 634 16(14) 1.6 0.85-2.4 35 49(46) 4.9 3.5-6.2 330(272) 32.7 29.8-35.6 615(521) 60.9 57.9-63.9

36

37

38

3 (3-4) 13 (11-15) 0 (0%) 1 (0.4%) 8 (14%) 26 (11%) 49 (86%) 199 (88%) 17 (30%) 69 (31%) 11 (19%) 111 (49%) 7 (12%) 0 (0%) 6 (11%) 34 (15%) 4 (7%) 0 (0%) 3 (5%) 0 (0%) 3 (5%) 1 (0.4%) 39 2 (4%) 3 (1%)

15 (26.0%) 123 (54.0%) 6 (11.0%) 6 (3.0%) 4 (7.0%) 1 (0.4%) 4 (7.0%) 2 (1.0%) 3 (5.0%) - 40 3 (5.0%) 16 (7.0%) 3 (5.0%) 18 (8.0%) 3 (5.0%) 13 (6.0%) 2 (4.0%) 6 (3.0%)

41

42

55 2.4(1.8-3.0) 22 1.6(1.0-2.2) 33 3.1(2.1-4.2) 18-44 4 0.7(0.0-1.4) 45-64 10 1.9(0.8-2.9) 65 41 7.8(5.6-9.9) 43 6(22.2) 21(77.8) 27 10(35.7) 18(64.3) 28 0.43 16(29.1) 39(70.9) 55

44

45

46

104 20.6 78 15.4 133 26.3 15 3.0 30 5.9 83 16.4 62 12.3 47 505 100.0

48

2003 2004 2005 2006 2007 0.06% 9,546 0.10% 14,728 0.10% 14,867 0.12% 18,287 0.11% 17,664 0.10% 0.22% 36,614 0.23% 34,894 0.23% 34,194 0.20% 30,689 0.20% 31,842 0.22% 0.08% 13,676 0.10% 14,958 0.09% 13,582 0.11% 16,840 0.07% 10,424 0.09% 0.04% 6,188 0.03% 5,172 0.03% 4,823 0.03% 4,857 0.03% 4,697 0.03% 0.14% 22,883 0.16% 24,394 0.18% 27,082 0.20% 30,699 0.22% 34,623 0.19% 1.09% 181,152 1.19% 179,801 1.17% 175,682 1.24% 187,583 1.40% 218,105 1.23% 49 2.95% 490,194 3.10% 469,040 3.16% 474,140 3.36% 509,535 3.10% 482,905 3.14% 4.58% 760,252 4.91% 742,987 4.97% 744,369 5.26% 798,490 5.14% 800,260 4.98% 16,598,546 15,127,645 14,989,953 15,181,779 15,559,359

2003 2004 2005 2006 2007 0.61% 101,850 0.80% 121,181 0.84% 126,113 0.90% 136,963 1.00% 155,226 0.85% 2.78% 460,850 2.54% 383,580 2.48% 371,473 2.47% 374,988 2.29% 356,265 2.52% 0.24% 39,127 0.23% 34,158 0.21% 31,197 0.21% 31,816 0.14% 21,425 0.21% 0.13% 20,939 0.12% 17,627 0.10% 15,521 0.10% 14,712 0.07% 11,039 0.11% 50 0.79% 130,548 0.81% 122,058 0.83% 124,617 0.92% 139,172 1.05% 163,740 0.89% 9.55% 1,585,917 10.79% 1,632,913 11.87% 1,778,861 12.56% 1,907,125 13.28% 2,066,457 11.74% 19.18% 3,184,349 20.36% 3,080,717 21.00% 3,148,326 22.01% 3,342,171 23.92% 3,721,954 21.40% 33.28% 5,523,579 35.64% 5,392,233 37.33% 5,596,108 39.17% 5,946,946 41.75% 6,496,107 37.61% 16,598,546 15,127,645 14,989,953 15,181,779 15,559,359

51

52

11,080,026 (100.0) 11,544,549 (100.0) 11,984,728 (100.0) 12,196,271 (100.0) 12,265,485 (100.0) 59,071,059 (100.0) 8,837 (0.08) 32,582 (0.29) 9,493 (0.08) 37,994 (0.33) 10,403 (0.09) 42,263 (0.35) 9,984 (0.08) 47,164 (0.39) 9,773 (0.08) 49,729 (0.41) 48,490 (0.08) 209,732 (0.36) 10,239,806 (100.0) 8,176 (0.08) 27,172 (0.27) 10,463,971 (100.0) 8,839 (0.08) 30,845 (0.29) 11,005,351 (100.0) 9,677 (0.09) 34,439 (0.31) 11,137,174 (100.0) 9,159 (0.08) 37,809 (0.34) 11,001,106 (100.0) 8,560 (0.08) 38,693 (0.35) 53,847,408 (100.0) 44,411 (0.08) 168,958 (0.31) 53 7,454 8,083 8,860 8,430 7,857 40,684 24,786 27,638 30,952 33,924 34,843 152,143

94 84 88 85 86 58 57 30 63 47 54 92 79 63 71 73 71 50 58 67 56 0 0 0 0 0 0 1 1 2 1 0 0 0 0 0 19 34 30 19 20 42 33 36 44 45 60 68 74 70 77 4 4 7 5 0 71 74 69 61 82 0 100 50 40 67 64 52 50 53 63 50 55 64 76 78 16 19 20 22 24 60 83 100 75 50

50 77 63 75 82 33 20 36 20 20 0 0 0 0 25 60 55 61 78 67 0 100 0 0 29 77 80 83 83 87 63 69 66 73 71 13 13 12 14 15 55

56

57

58

59

60

6,681 158,520(100.0) 2.0(1.5-2.6) 9.5 835 19,628(12.4) 4.8 5.4 3,362 78,242(49.4) 4.8 12.7 747 16,464(10.4) 1.1 7.2 517 12,726(8.0) 0.8 7.0 1,220 31,459(19.9) 1.2 6.6 3,299 78,224(49.4) 2.1 9.8 3,381 80,255(50.6) 2.0 9.3 61 3,098 78,621(49.6) 1.3 9.2 1,285 17,932(11.3) 1.5 11.5 842 16,724(10.6) 2.6 12.9

3,034 71,224 (44.9) 2,082 55,464 (35.0) 1,025 20,024 (12.6) 432 9,329 (5.9) 108 2,480 (1.6) 62 177 2,227 231 115 284 4,313 (22.0) 52,103 (66.6) 4,765 (28.9) 2,754 (21.6) 7,288 (23.2) 386 703 302 216 475 9,622 (49.2) 17,878 (22.9) 7,621 (46.3) 6,608 (51.9) 13,736 (43.7) 87 212 154 161 411 1,594 (8.1) 3,428 (4.4) 2,852 (17.3) 2,857 (22.5) 9,291 (29.5) 168 190 43 19 12 3,731 (19.0) 4,180 (5.3) 768 (4.7) 345 (2.7) 306 (1.0) 17 30 17 6 38 368 (1.9) 654 (0.8) 458 (2.8) 163 (1.3) 837 (2.7)

63

64

1 2 3 4 5 65

é ö 66

67

68

282/1,788 (15.8) 57/283 (20.1) 64/2,248 (2.8) 8/64 (13) 162/661 (24.5) 20/181(11) 58/167 (34.7) 1532/27,617 (5.5) 421/1,532 (27.5) 24/242(9.9) 58/1,682 (3.4) 161/579 (27.8) 280/8,061 (3.4) 96/187 (51.3) 317/158,520 (0.2) 69 68/2,575(2.6) 14/69 (20.3) 40/729 (5.5) 55/965 (5.7) 3/55 (5) 49/565(8.7) 33/50 (66) 76/3,238 (2.3) 21/76 (28) 76/400 (19) 12/78 (15) 176/1,562(11.2) 106/280 (38) 34/379 (9) 25/34 (73.5) 96/1,163(8.3) 439/3,904 (11.2) 214/445 (48.1) 55/1458 (3.8)

162/718 (22.6) 18/86 (18.9) 3/18 (16.7) 67/219 (30.6) 37/67 (55.2) 86/208 (41.3) 259/2,643(9.8) 159/259 (61.4) 107/797 (13.4) 70 177/6,063 (2.9) 43/849 (5.1) 31/293 (10.6) 293/10,184 (2.9) 211/5,757 (3.7) ü 40/1097 (3.6) ó 776/33,975 (2.3) 322/776 (41.5) 42/3,187 (1.3) 32/42 (76.2) 217/13,004(1.7) 22/502 (4.4) 370/1663 (22.2) 150/370 (40.5) 629/18,854 (3.3) 598/90,810 (0.66) 21,298/922,196 (2.3) 53/558(9.5) 44/53 (83) 122/1,017 (12) 83/122 (68) é ö

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72

18 154,154 3.7 37 133,471 3.1 73

59,665 8.1 (7.9-8.3) 172,796 3.0 (2.9-3.0) 77,628 17.2 (17-17.5) 36,203 7.3 (7.0-7.5) 74 4,156 10.9 (10-11.9) 21,706 7.1 (6.8-7.5) 8,771 4.4 (4.0-4.8) 657 3.4 (2.0-4.8) 3,639 4.9 (4.2-5.6)

75

76

5.3 0.8-4.4 1.5 0.08 10.3 1.1-3.6 1.9-14.8 2.8-16.8 - - 7.2 1.4-10.2 - - 22.5 2.4 0.29 12.2 2.3 0.15 1.2-0.01 10.5 2.1 0.85 77 24.1 6-10.9 - - 13.6 0.8 0.42 10.8-0.22 8.2 - - 10.2 0.8 0.39

5.3-16.8-1 0.03 6.9-4.2-78 12.2-5 - 6.8-5.6-1.9 0.11 2.9 0.18 1.8~5.6-2.9 0.15 5.1-4.5-3.9 0.7 1.7 -

79 3,607 (2,618-4,596) 1,547 (1,033-2,060) 4,986 (3,976-5,995) 702 (635-770) 1,547 (1033-2060) 2,216 (1,721-2,711) 63 (41-85) 43 (15-71) 106 (76-137)

80

81