Contents I. 항생제내성 / 감수성기준및용어설명 II. III. 호흡기질병 5 종항생제내성검사결과 소화기질병 3 종항생제내성검사결과

2017 년양돈질병세균 항생제내성검사결과 I Seul Oh ACE of Optipharm ois@optipharm.co.kr 043-249-7532

Contents I. 항생제내성 / 감수성기준및용어설명 II. III. 호흡기질병 5 종항생제내성검사결과 소화기질병 3 종항생제내성검사결과 2018-01-30 2

1. 항생제감수성 / 내성기준 2018-01-30 3

항생제감수성 / 내성기준 항생제종류및기준 ( 디스크확산법기준으로검역원자료참조 ) 약제명감수성효과중간내성약제명감수성효과중간내성 Amikacin(AK30) 17 13 6 Gentamicin(CN10) 17 13 6 Amoxicillin(AML30) 17 13 6 Linsmycin(LS109) 17 13 6 Ampicillin(AMP10) 16 13 6 Neomycin(N30) 17 13 6 Cefazolin(KZ30) 17 14 6 Penicillin G(P10) 15 13 6 Tilmicosin(TIL15) 17 14 6 Tiamulin H.Fumarate(Ti25) 17 13 6 Colistin(CT10) 11 9 6 Streptomycin(S10) 15 11 6 Enrofloxacin(ENR5) 22 16 6 Tetracycline(T30) 23 18 6 Florfenicol(FFC25) 18 13 6 Trimethoprim/ Sulfamethoxazole(STX25) 18 15 6 Ceftiofur sodium(c2.5) 17 12 6 Tylosin tartrate(ty25) 18 13 6 항생제종류및기준 Sensitive( 감수성 ) 감수성이있다는의미로치료효과를기대할수있음. Resistant( 내성 ) 내성이있다는의미로치료효과없음. Intermediate( 효과중간 ) 감수성과내성의중간정도. 2018-01-30 4

2. 호흡기질병 5 종 소화기질병 3 종 2018-01-30 5

Haemophilus parasuis 약제명농장수 Test Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 Test % Test % Test % 12 19.7% 40 65.6% 9 14.8% Amoxicillin(AML30) 1 1.6% 0 0.0% 60 98.4% Ampicillin(AMP10) 5 8.2% 0 0.0% 56 91.8% Cefazolin(KZ30) 4 6.6% 1 1.6% 56 91.8% Tilmicosin(TIL15) 10 16.4% 7 11.5% 44 72.1% Colistin(CT10) 0 0.0% 0 0.0% 61 100.0% Enrofloxacin(ENR5) 18 29.5% 7 11.5% 36 59.0% Florphenicol(FFC25) 2 3.3% 0 0.0% 59 96.7% Ceftiofur sodium(c2.5) 4 6.6% 1 1.6% 56 91.8% 38 61 Gentamycin(CN10) 6 9.8% 15 24.6% 40 65.6% Linsmycin(LS109) 4 6.6% 0 0.0% 57 93.4% Neomycin(N30) 9 14.8% 29 47.5% 23 37.7% Penicillin G(P10) 4 6.6% 0 0.0% 57 93.4% Tiamulin H.Fumarate(Ti25) 2 3.3% 2 3.3% 57 93.4% Streptomycin(S10) 38 62.3% 11 18.0% 12 19.7% Tetracycline(T30) 3 4.9% 1 1.6% 57 93.4% Trimethoprim/ Sulfamethoxazole(STX25) 37 60.7% 8 13.1% 16 26.2% Tylosin tartrate(ty25) 8 13.1% 16 26.2% 37 60.7% 2018-01-30 6

Haemophilus parasuis 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 7

Haemophilus parasuis 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 8

Actinobacillus pleuropneumoniae 약제명농장수 Test Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 Test % Test % Test % 13 22.0% 38 64.4% 8 13.6% Amoxicillin(AML30) 10 16.9% 1 1.7% 48 81.4% Ampiciilin(AMP10) 13 22.0% 0 0.0% 46 78.0% Cefazolin(KZ30) 0 0.0% 0 0.0% 59 100.0% Tilmicosin(TIL15) 9 15.3% 23 39.0% 27 45.8% Colistin(CT10) 0 0.0% 0 0.0% 59 100.0% Enrofloxacin(ENR5) 5 8.5% 8 13.6% 46 78.0% Florphenicol(FFC30) 25 42.4% 6 10.2% 28 47.5% Ceftiofur sodium(c30) 0 0.0% 0 0.0% 59 100.0% 36 59 Gentamicin(CN10) 13 22.0% 30 50.8% 16 27.1% Linsmycin(LS109) 12 20.3% 17 28.8% 30 50.8% Neomycin(N30) 18 30.5% 36 61.0% 5 8.5% Penicillin G(P10) 16 27.1% 0 0.0% 43 72.9% Tiamulin H.Fumarate(Ti25) 0 0.0% 1 1.7% 58 98.3% Streptomycin(S10) 25 42.4% 32 54.2% 2 3.4% Tetracycline(T30) 56 94.9% 3 5.1% 0 0.0% Trimethoprim/ Sulfamethoxazole(STX25) 7 11.9% 1 1.7% 51 86.4% Tylosin tartrate(ty25) 11 18.6% 45 76.3% 3 5.1% 2018-01-30 9

Actinobacillus pleuropneumoniae 100.00% 90.00% 80.00% 70.00% 60.00% 50.00% 40.00% 30.00% 20.00% 10.00% 0.00% 2018-01-30 10

Actinobacillus pleuropneumoniae 100.00% 90.00% 80.00% 70.00% 60.00% 50.00% 40.00% 30.00% 20.00% 10.00% 0.00% 2018-01-30 11

Actinobacillus suis 약제명농장수 Test Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 Test % Test % Test % 0 0.0% 1 100.0% 0 0.0% Amoxicillin(AML30) 0 0.0% 0 0.0% 1 100.0% Ampiciilin(AMP10) 0 0.0% 0 0.0% 1 100.0% Cefazolin(KZ30) 0 0.0% 0 0.0% 1 100.0% Tilmicosin(TIL15) 0 0.0% 0 0.0% 1 100.0% Colistin(CT10) 0 0.0% 0 0.0% 1 100.0% Enrofloxacin(ENR5) 0 0.0% 0 0.0% 1 100.0% Florphenicol(FFC25) 0 0.0% 0 0.0% 1 100.0% Ceftiofur sodium(c2.5) 0 0.0% 0 0.0% 1 100.0% 1 1 Gentamicin(CN10) 0 0.0% 1 100.0% 0 0.0% Linsmycin(LS109) 0 0.0% 0 0.0% 1 100.0% Neomycin(N30) 0 0.0% 1 100.0% 0 0.0% Penicillin G(P10) 0 0.0% 0 0.0% 1 100.0% Tiamulin H.Fumarate(Ti25) 0 0.0% 0 0.0% 1 100.0% Streptomycin(S10) 0 0.0% 1 100.0% 0 0.0% Tetracycline(T30) 0 0.0% 0 0.0% 1 100.0% Trimethoprim/ Sulfamethoxazole(STX25) 0 0.0% 0 0.0% 1 100.0% Tylosin tartrate(ty25) 1 100.0% 0 0.0% 0 0.0% 2018-01-30 12

Actinobacillus suis 100.00% 90.00% 80.00% 70.00% 60.00% 50.00% 40.00% 30.00% 20.00% 10.00% 0.00% 2018-01-30 13

Actinobacillus suis 100.00% 90.00% 80.00% 70.00% 60.00% 50.00% 40.00% 30.00% 20.00% 10.00% 0.00% 2018-01-30 14

Pasteurella multocida 약제명농장수검사횟수 Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 검출횟수 % 검출횟수 % 검출횟수 % 7 10.3% 52 76.5% 9 13.2% Amoxicillin(AML30) 1 1.5% 3 4.4% 64 94.1% Ampicillin(AMP10) 4 5.9% 1 1.5% 63 92.6% Cefazolin(KZ30) 0 0.0% 0 0.0% 68 100.0% Tilmicosin(TIL15) 6 8.8% 17 25.0% 45 66.2% Colistin(CT10) 3 4.4% 0 0.0% 65 95.6% Enrofloxacin(ENR5) 4 5.9% 5 7.4% 59 86.8% Florphenicol(FFC25) 20 29.4% 8 11.8% 40 58.8% Ceftiofur sodium(c2.5) 0 0.0% 0 0.0% 68 100.0% Gentamycin(CN10) 54 68 9 13.2% 32 47.1% 27 39.7% Linsmycin(LS109) 10 14.7% 9 13.2% 49 72.1% Neomycin(N30) 17 25.0% 32 47.1% 19 27.9% Penicillin G(P10) 6 8.8% 0 0.0% 62 91.2% Tiamulin H.Fumarate(Ti25) 2 2.9% 12 17.6% 54 79.4% Streptomycin(S10) 40 58.8% 20 29.4% 8 11.8% Tetracycline(T30) 6 8.8% 6 8.8% 56 82.4% Trimethoprim/ Sulfamethoxazole(STX25) 6 8.8% 3 4.4% 59 86.8% Tylosin tartrate(ty25) 13 19.1% 40 58.8% 15 22.1% 2018-01-30 15

Pasteurella multocida 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 16

Pasteurella multocida 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 17

Streptococcus suis 약제명농장수검사횟수 Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 검출횟수 % 검출횟수 % 검출횟수 % 71 86.6% 9 11.0% 2 2.4% Amoxicillin(AML30) 0 0.0% 1 1.2% 81 98.8% Ampicillin(AMP10) 0 0.0% 0 0.0% 82 100.0% Cefazolin(KZ30) 0 0.0% 1 1.2% 81 98.8% Tilmicosin(TIL15) 81 98.8% 1 1.2% 0 0.0% Colistin(CT10) 82 100.0% 0 0.0% 0 0.0% Enrofloxacin(ENR5) 15 18.3% 31 37.8% 36 43.9% Florphenicol(FFC25) 4 4.9% 13 15.9% 65 79.3% Ceftiofur sodium(c2.5) 1 1.2% 1 1.2% 80 97.6% Gentamycin(CN10) 65 82 47 57.3% 29 35.4% 6 7.3% Linsmycin(LS109) 21 25.6% 23 28.0% 38 46.3% Neomycin(N30) 74 90.2% 6 7.3% 2 2.4% Penicillin G(P10) 4 4.9% 0 0.0% 78 95.1% Tiamulin H.Fumarate(Ti25) 4 4.9% 10 12.2% 68 82.9% Streptomycin(S10) 66 80.5% 16 19.5% 0 0.0% Tetracycline(T30) 81 98.8% 1 1.2% 0 0.0% Trimethoprim/ Sulfamethoxazole(STX25) 24 29.3% 17 20.7% 41 50.0% Tylosin tartrate(ty25) 79 96.3% 1 1.2% 2 2.4% 2018-01-30 18

Streptococcus suis 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 19

Streptococcus suis 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 20

Clostridium perfringens 약제명농장수 Test Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 Test % Test % Test % 201 90.1% 19 8.5% 3 1.3% Amoxicillin(AML30) 4 1.8% 1 0.4% 218 97.8% Ampicillin(AMP10) 11 4.9% 3 1.3% 209 93.7% Cefazolin(KZ30) 1 0.4% 6 2.7% 216 96.9% Tilmicosin(TIL15) 172 77.1% 31 13.9% 20 9.0% Colistin(CT10) 147 65.9% 3 1.3% 73 32.7% Enrofloxacin(ENR5) 198 88.8% 17 7.6% 8 3.6% Florphenicol(FFC25) 4 1.8% 6 2.7% 213 95.5% Ceftiofur sodium(c2.5) 0 0.0% 5 2.2% 218 97.8% 112 223 Gentamycin(CN10) 217 97.3% 6 2.7% 0 0.0% Linsmycin(LS109) 112 50.2% 74 33.2% 37 16.6% Neomycin(N30) 212 95.1% 10 4.5% 1 0.4% Penicillin G(P10) 17 7.6% 4 1.8% 202 90.6% Tiamulin H.Fumarate(Ti25) 17 7.6% 13 5.8% 193 86.5% Streptomycin(S10) 219 98.2% 1 0.4% 3 1.3% Tetracycline(T30) 129 57.8% 88 39.5% 6 2.7% Trimethoprim/ Sulfamethoxazole(STX25) 202 90.6% 15 6.7% 6 2.7% Tylosin tartrate(ty25) 38 17.0% 39 17.5% 146 65.5% 2018-01-30 21

Clostridium perfringens 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 22

Clostridium perfringens 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 23

Escherichia coli 약제명농장수 Test Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 Test % Test % Test % 45 8.1% 208 37.6% 300 54.2% Amoxicillin(AML30) 391 70.7% 39 7.1% 123 22.2% Ampicillin(AMP10) 449 81.2% 32 5.8% 72 13.0% Cefazolin(KZ30) 83 15.0% 63 11.4% 407 73.6% Tilmicosin(TIL15) 466 84.3% 80 14.5% 7 1.3% Colistin(CT10) 8 1.4% 23 4.2% 522 94.4% Enrofloxacin(ENR5) 182 32.9% 97 17.5% 274 49.5% Florphenicol(FFC25) 397 71.8% 54 9.8% 102 18.4% Ceftiofur sodium(c2.5) 29 5.2% 34 6.1% 490 88.6% 316 553 Gentamycin(CN10) 255 46.1% 170 30.7% 128 23.1% Linsmycin(LS109) 371 67.1% 122 22.1% 60 10.8% Neomycin(N30) 227 41.0% 222 40.1% 104 18.8% Penicillin G(P10) 549 99.3% 1 0.2% 3 0.5% Tiamulin H.Fumarate(Ti25) 351 63.5% 190 34.4% 12 2.2% Streptomycin(S10) 479 86.6% 66 11.9% 8 1.4% Tetracycline(T30) 442 79.9% 89 16.1% 22 4.0% Trimethoprim/ Sulfamethoxazole(STX25) 315 57.0% 54 9.8% 184 33.3% Tylosin tartrate(ty25) 542 98.0% 6 1.1% 5 0.9% 2018-01-30 24

Escherichia coli 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 25

Escherichia coli 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 계열 1 계열 2 계열 3 2018-01-30 26

Salmonella spp.(serogroup B) 약제명농장수검사횟수 Amikacin(AK30) 항생제내성, 효과중간, 감수성비율 검출횟수 % 검출횟수 % 검출횟수 % 3 6.0% 11 22.0% 36 72.0% Amoxicillin(AML30) 48 96.0% 1 2.0% 1 2.0% Ampicillin(AMP10) 49 98.0% 1 2.0% 0 0.0% Cefazolin(KZ30) 3 6.0% 4 8.0% 43 86.0% Tilmicosin(TIL15) 46 92.0% 4 8.0% 0 0.0% Colistin(CT10) 0 0.0% 0 0.0% 50 100.0% Enrofloxacin(ENR5) 13 26.0% 6 12.0% 31 62.0% Florfenicol(FFC25) 19 38.0% 1 2.0% 30 60.0% Ceftiofur sodium(c2.5) 0 0.0% 4 8.0% 46 92.0% Gentamicin(CN10) 31 50 41 82.0% 3 6.0% 6 12.0% Linsmycin(LS109) 19 38.0% 15 30.0% 16 32.0% Neomycin(N30) 8 16.0% 25 50.0% 17 34.0% Penicillin G(P10) 48 96.0% 0 0.0% 2 4.0% Tiamulin H.Fumarate(Ti25) 33 66.0% 15 30.0% 2 4.0% Streptomycin(S10) 37 74.0% 13 26.0% 0 0.0% Tetracycline(T30) 48 96.0% 1 2.0% 1 2.0% Trimethoprim/Sulfamethoxazole(STX 25) 16 32.0% 8 16.0% 26 52.0% Tylosin tartrate(ty25) 50 100.0% 0 0.0% 0 0.0% 2018-01-30 27

Salmonella spp.(serogroup B) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 28

Salmonella spp.(serogroup B) 100% 90% 80% 70% 60% 50% 40% 30% 20% 10% 0% 2018-01-30 29