슬라이드 1

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Anti-aging Peptide Anti-wrinkle peptide Whitening peptide Anti-hair loss & hair growing peptide BF-Dynorphin

Healix Gallovax Elastin scalp peptide Heal-VB7 Keratin essential peptide Melabet Elastin hair peptide

Respep Innogrowin Rejucell-US Silk essential peptide Sonitin Keratin essential peptide Retinovax Sinpep

Anti-oxidant peptide Antiox-VH Qtant Ursolin Phytopeptide-1 Anti-microbial and skin protecting peptide

2 Anti-aging Peptide Anti-wrinkle peptide Whitening peptide Anti-hair loss & hair growing peptide BF-Dynorphin Elastin essential peptide Cyclitol Anagen BF-Enkephalin Elastin anti-wrinkle peptide ElaX-MV Elanoren Epiderm-X Healix Gallovax Elastin scalp peptide Heal-VB7 Keratin essential peptide Melabet Elastin hair peptide Neuropeptide-1 Lipovax Purosol HG-Thymopentin Neoendorphin Prospin Redovax HG-Phyto-Thymopentin Polyol Skinup-US Respep Innogrowin Rejucell-US Silk essential peptide Sonitin Keratin essential peptide Retinovax Sinpep Symvastin Keratin scalp peptide VH-Cellup Wrinkle-X Whitening peptide Phyto-thymosin beta 4 Anti-inflammatory & Anti-oxidant peptide Antiox-VH Qtant Ursolin Phytopeptide-1 Anti-microbial and skin protecting peptide Anti-Microbial Peptide-Aurein Anti-acne peptide Acnobet Acnoheal Acnoin Hairen Anti-atopic dermatitis peptide Phyto-NEP Therapep Vitamin peptide

Peptides are short polymer formed from the linking, in a defined order, of α-amino acid.

3 Peptides are short polymer formed from the linking, in a defined order, of α-amino acid. The link between one amino acid residue and the next is known as an amide bond or a peptide bond. Peptide bond Molecular structure of BIO-FD&C biomimetic peptide BIO-FD&C Cosmetic Biomimetic Peptides? - highly active biological materials can bind cellular receptors - physically stable in cosmetic chemical conditions - very small to effectively penetrate skin barrier and transdermal layers - highly safe based on amino acid composition

General Information Trade Name INCI Name Molecular Characteristics Product Type Cosmetic Function Biological Function Recommended Dosage HAIREN TM Azelaoyl Tripeptide-1 Bioactive conjugation of

defense by antimicrobial activity Improvement of microbial related skin disease ~ 20 200 ppm What is HAIREN TM? - Highly Aactive & Inhibitory Reagent for Every Needs!

4 General Information Trade Name INCI Name Molecular Characteristics Product Type Cosmetic Function Biological Function Recommended Dosage HAIREN TM Azelaoyl Tripeptide-1 Bioactive conjugation of azelaic acid with biomimetic tripeptide, GHK Pure Peptide Powder or Nanosome Treated Antimicrobial activity, Anti-Acne, Anti-Atopic Dermatitis, Anti-inflammation, Improve skin health Cell and Skin defense by antimicrobial activity Improvement of microbial related skin disease ~ ppm What is HAIREN TM? - Highly Aactive & Inhibitory Reagent for Every Needs! Acne Whitening Rosacea Chemically conjugated with GHK Azelaic acid (well known agent for acne, whiteining, rosacea, etc.) directly improve inflammatory signaling induced pathological skin conditions. Azelaic acid show reasonable anti-microbial activity against all kinds of skin related microorganisms. Skin cell rejuvenating by Tripeptide, GHK Anti-microbial activity on P. acnes and/or S. aureus From Acne, Atopic dermatitis, etc. Enhance anti-microbial activity of azelaic acid by reducing any possible side effects of azelaic acid on skin cell by tripeptide (or copper tripeptide) at pathological skin conditions

5 So, what is Azelaic acid? Azelaic acid is industrially produced by the ozonolysis of oleic acid. The side product is nonanoic acid. It is produced naturally by Malassezia furfur (also known as Pityrosporum ovale), a yeast that lives on normal skin. The bacterial degradation of nonanoic acid gives azelaic acid. Uses in hair and skin treatments Acne treatment Azelaic acid is used to treat mild to moderate acne; i.e. both comedonal acne and inflammatory acne. It works in part by stopping the growth of skin bacteria that cause acne, and by keeping skin pores clear. Rosacea treatment Azelaic acid is also used as a topical gel treatment for rosacea, due to its ability to reduce inflammation. In some cases, females have reported hair growth on face and neck. Pigmentation treatment Azelaic acid has been used for treatment of skin pigmentation including melasma and post inflammatory hyperpigmentation, particularly in those with darker skin types. It has been recommended as an alternative to hydroquinone (HQ), the current gold standard for skin lightening, as countries such as Japan and the EU have questioned the safety of HQ. It is a Tyrosinase inhibitor. This reduces synthesis of melanin. Hair loss Azelaic acid may be useful as a hair growth stimulant. A research report by Stamatiadis in 1988 suggested that azelaic acid (and combinations of it, with zinc ion and vitamin B6) was a strong type I 5-alpha reductase (5-AR) inhibitor. The enzyme, 5-AR (both Types I and II) convert testosterone to dihydrotestosterone (DHT). DHT has been shown to contribute to prostate enlargement (benign prostatic hyperplasia, BPH) and to damage hair follicles. However, no clinical studies have confirmed its efficacy in helping with hair loss.

Strong Anti-microbial Activity & Higher Skin Cell Compatibility Control Azelaic Acid 1mg/ml Control HAIREN 1mg/ml Against P. acnes 120.0% 100.0% 100.0% 100.0% 80.0% 60.0% 40.0% 20.0% 17.

It is effective in destroying all the free radicals in your skin, at reducing any inflammation and pigmentation that arises from acne or rosacea attacks, and for treating facial scars.

6 Strong Anti-microbial Activity & Higher Skin Cell Compatibility Control Azelaic Acid 1mg/ml Control HAIREN 1mg/ml Against P. acnes 120.0% 100.0% 100.0% 100.0% 80.0% 60.0% 40.0% 20.0% 17.6% 19.6% 0.0% Azelaic acid Hairen Azelaic acid is famous as an antibacterial that helps reduce and kill most of the bacteria that cause various skin problems. It is effective in destroying all the free radicals in your skin, at reducing any inflammation and pigmentation that arises from acne or rosacea attacks, and for treating facial scars. It is because of all these beneficial properties of this acid that it is today an important ingredient in cleansing and beauty products. HAIREN is Biologically Improved and Safely Enhanced Bio-Mimetic Azelaic Acid!!!

7 Strong Anti-microbial Activity & Higher Skin Cell Compatibility HAIREN shows highly enhanced safety on skin fibroblast cells by MTT assay Azelaic acid Hairen 20 0

Important Inflammatory Cytokines (IL-8 & TNF-alpha) in acne IL-8 and TNF-alpha is inflammatory key molecule in acne by P. acne Reference) INFECTION AND IMMUNITY, Aug. 1995, p.

8 Important Inflammatory Cytokines (IL-8 & TNF-alpha) in acne IL-8 and TNF-alpha is inflammatory key molecule in acne by P. acne Reference) INFECTION AND IMMUNITY, Aug. 1995, p Interleukin 8 (IL-8) TNF-alpha mrna expression fold (fold changes) HAIREN HAIREN 0 Control P. Acne sup. treatment Control P. Acne sup. treatment Relative expression of acne-related inflammaotry cytokines from keratincotye. Treatment various concentration (50ppm & 200ppm) of HAIREN significantly reduced proinflammatory cytokines, IL-8 and TNF-a from keratinocyte by real-time PCR.

9 Experimental Data P. Acne sup. P. Acne sup. + + P. Acne sup. HAIREN 200ppm HAIREN 50ppm Treatment 50 & 200ppm HAIREN significantly reduced expression of COX-2 from P. Acne supernatant-simulated expression. 350 MMP-1 expression HAIREN MMP-2 expression HAIREN mrna expression fold (fold changes) MMP-1,2 can be induced by P. Acne. Via PAR2 activation. HAIREN block MMP-1,2 expressions!. 0 Control P. Acne sup. treatment Control P. Acne sup. treatment

( )Kju269.hwp

( )Kju269.hwp 만성세균성전립선염모델흰쥐에서 의항염효과 Anti-inflammatory Effect of Lycopene on Chronic Bacterial Prostatitis Rat Model Cho Hwan Yang, Dong Wan Sohn, Yong-Hyun Cho From the Department of Urology, The Catholic University