109~119특집_최연현

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1 Focused Issue of This Month MDCT Noninvasive Detection of Coronary Atherosclerotic Plaques and Assessment of Stenosis Degree at Multidetector CT Coronary Angiography Yeon Hyeon Choe, MD Department of Radiology, Sungkyunkwan University School of Medicine yhchoe@smc.samsung.co.kr J Korean Med Assoc 2007; 50(2): Abstract 64 slice MDCT has shown a sensitivity of 86 ~ 99% and a specificity of 79 ~ 96% in detecting lesions >50% stenosis. Spatial resolution of current MDCT technology enables reliable detection of nonobstructing noncalcific plaques as well as significantly stenotic lesions. CT densitometry on the plaques may give an insight on vulnerability of the lesions defined as less than 30~50 HU. MDCT coronary angiography has a tendency of overestimation of stenosis degree especially in distal segments of left anterior descending and circumflex arteries and their branches and in heavily calcified lesions as compared with quantitative catheter coronary angiography. Semiautomatic vessel segmentation techniques for coronary CT angiography may help assess the stenosis degree quantitatively. Recently developed dualsource 128slice CT has shown diagnostic quality images in patients with high heart rates. Along with forthcoming 256slice CT, new CT technologies are expected to enable highly reliable detection of coronary artery plaques and accurate estimation of stenosis degree. Keywords : Computed tomography; Coronary CT angiography; Coronary atherosclerosis 109

Volumerendered (A) and maximum intensity

stenosis (arrows) in proximal left anterior

Shortaxial reformatted image (C) of the lesion

2 Choe YH A B C D Figure 1. 64yearold woman with chest pain. Volumerendered (A) and maximum intensity projection (B) images of 64slice CT show mild stenosis (arrows) in proximal left anterior descending branch. Shortaxial reformatted image (C) of the lesion shows an eccentric noncalcific plaque (arrow). Mean ROI of the plaque region was 46 HU suggestive of lipidrich content in the plaque. 110

Atherosclerotic Plaque Evaluation Using MDCT Coronary Aangiography A B C D

Volumerendered (A) and maximum intensity projection (B) images show stenosis

3 Atherosclerotic Plaque Evaluation Using MDCT Coronary Aangiography A B C D Figure 2. 64yearold male with chest pain. Volumerendered (A) and maximum intensity projection (B) images show stenosis (arrow) in the proximal left anterior descending branch, first diagonal branch and ramus intermedius. Shortaxial reformatted image (C) shows eccentric plaques (arrows) in these vessels. Also note hypoattenuated areas (arrowheads) suggestive of lipid content. Plaque volume was measured using a semiautomated method (D). It showed that plaque consisted of mostly fibrous component (50~130 HU) and the volume of the plaque was 13.13mm

4 Choe YH A B Figure 3. 48yearold male with acute myocardial infarction. CT reformatted images (A) show a noncalcific plaque (arrow) in left main coronary artery. Intravascular ultrasonography (B) confirmed presence of fibrous plaque (arrow) without foci of hypoechoic lipid component. 112

Atherosclerotic Plaques Evaluation Using MDCT Coronary

Volumerendered (A) and axial reformatted (B) images show

significant stenosis (arrow) with eccentric lumen and lipid

5 Atherosclerotic Plaques Evaluation Using MDCT Coronary Angiography A B C D Figure 4. 67yearold female with chest pain. Volumerendered (A) and axial reformatted (B) images show stenosis (arrow) in the proximal left anterior descending branch. Shortaxial reformatted image (C) of the vessel shows significant stenosis (arrow) with eccentric lumen and lipid area (arrowhead). Catheter angiography (D) correlated well with CT angiography in visual grading of stenosis (arrow) of the coronary artery. 113

6 Choe YH A B C Figure 5. 66yearold female with chest pain. Volumerendered (A) and maximum intensity projection (B) images show stenosis (arrow) in the mid left anterior descending branch. Semiautomatic quantitative approach (C) revealed a 55% stenosis. 114

Atherosclerotic Plaques Evaluation Using MDCT Coronary Angiography A B C D Figure 6.

There are multiple calcifications in proximal to mid left anterior descending branch.

calcifications (arrows) in mid left anterior descending branch adjacent to the origin

Shortaxial image (C) shows an almost obscured lumen in that segment.

7 Atherosclerotic Plaques Evaluation Using MDCT Coronary Angiography A B C D Figure 6. 65yearold male with previous myocardial infarction. There are multiple calcifications in proximal to mid left anterior descending branch. Volumerendered (A) and maximum intensity projection (B) images show dense tubular calcifications (arrows) in mid left anterior descending branch adjacent to the origin of 1st diagonal branch. Shortaxial image (C) shows an almost obscured lumen in that segment. However, catheter angiography reveals only mild stenosis in the same segment. This case illustrates an example of overestimation of the stenosis degree at CT angiography due to blooming artifact of calcium. 115

8 Choe YH 116

9 Atherosclerotic Plaques Evaluation Using MDCT Coronary Angiography 1. Naghavi M, Libby P, Falk E, Casscells SW, Litovsky S, Willerson JT, et al. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: Part I. Circulation 2003;108: Choe YH. Noninvasive imaging of atherosclerotic plaques using MRI and CT. Korean Circulation J 2005;35: VilesGonzalez JF, Poon M, Sanz J, Rius T, Nikolaou K, Fayad ZA, Fuster V, Badimon JJ. In vivo 16slice, multidetector row computed tomography for the assessment of experimental atherosclerosis: comparison with magnetic resonance imaging and histopathology. Circulation 2004;110: Nikolaou K, Becker CR, Muders M, Babaryka G, Scheidler J, Flohr T, Loehrs U, Reiser MF, Fayad ZA. Multidetectorrow computed tomography and magnetic resonance imaging of atherosclerotic lesions in human ex vivo coronary arteries. Atherosclerosis 2004;174: Schroeder S, Kuettner A, Wojak T, Janzen J, Heuschmid M, Athanasiou T, Beck T, Burgstahler C, Herdeg C, Claussen CD, Kopp AF. Noninvasive evaluation of atherosclerosis with 117

10 Choe YH contrast enhanced 16 slice spiral computed tomography: results of ex vivo investigations. Heart 2004;90: Becker CR, Nikolaou K, Muders M, Babaryka G, Crispin A, Schoepf UJ, Loehrs U, Reiser MF. Ex vivo coronary atherosclerotic plaque characterization with multidetectorrow CT. Eur Radiol 2003;13: Schroeder S, Kopp AF, Baumbach A, Meisner C, Kuettner A, Georg C, Ohnesorge B, Herdeg C, Claussen CD, Karsch KR. Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography. J Am Coll Cardiol 2001;37: Kopp AF, Schroeder S, Baumbach A, Kuettner A, Georg C, Ohnesorge B, Heuschmid M, Kuzo R, Claussen CD. Non invasive characterisation of coronary lesion morphology and composition by multislice CT: first results in comparison with intracoronary ultrasound. Eur Radiol 2001;11: Leber AW, Knez A, Becker A, Becker C, von Ziegler F, Nikolaou K, Rist C, Reiser MF, White C, Steibeck G, Boekstegers P. Accuracy of multidetector spiral computed tomography in identifying and differentiating the composition of coronary atherosclerotic plaques: a comparative study with intracoronary ultrasound. J Am Coll Cardiol 2004;43: Hoffmann U, Moselewski F, Nieman K, Jang IK, Ferencik M, Rahman AM, Cury RC, Abbara S, JoneidiJafari H, Achenbach S, Brady TJ. Noninvasive assessment of plaque morphology and composition in culprit and stable lesions in acute coronary syndrome and stable lesions in stable angina by multidetector computed tomography. J Am Coll Cardiol 2006;47: Leschka S, Wildermuth S, Boehm T, Desbiolles L, Husmann L, Plass A, Koepfli P, Schepis T, Marincek B, Kaufmann PA, Alkadhi H. Noninvasive Coronary Angiography with 64Section CT: Effect of average heart rate and heart rate variability on image quality. Radiology 2006;241: Cury RC, Pomerantsev EV, Ferencik M, Hoffmann U, Nieman K, Meselewski F, Abbara S, Jang IK, Brady TJ, Achenbach S. Comparison of the degree of coronary stenosis by multidetector computed tomography versus by quantitative coronary angiography. Am J Cardiol 2005;96: Leber AW, Knez A, von Ziegler F, Becker A, Nokolaou K, Paul S, Wintersperger B, Reiser M, Becker CR, Steinbeck G, Boekstegers P. Quantification of obstructive and nonobstructive coronary lesions by 64slice computed tomography. A comparative study with quantitative coronary angiography and intravascular ultrasound. J Am Coll Cardiol 2005;46: Caussin C, Larchez C, Ghostine S, PesentiRossi D, Daoud B, Habis M, SigalCinqualbre A, Perrier E, Angel CY, Lancelin B, Paul JF. Comparison of coronary minimal lumen area quantification by sixtyfourslice computed tomography versus intravascular ultrasound for intermediate stenosis. Am J Cardiol 2006;98: Busch S, Johnson TR, Nikolaou K, von Ziegler F, Knez A, Reiser MF, Becker CR. Visual and automatic grading of coronary artery stenoses with 64slice CT angiography in reference to invasive angiography. Eur Radiol 2006 Dec;16: [Epub ahead of print] 16. Khan MF, Wesarg S, Gurung J, Dogan S, Maataoui A, Brehmer B, Herzog C, Ackermann H, Assmus B, Vogl TJ. Facilitating coronary artery evaluation in MDCT using a 3D automatic vessel segmentation tool. Eur Radiol 2006;16: Marquering HA, Dijkstra J, de Koning PJH, Stoel BC, Reiber JHC. Towards quantitative analysis of coronary CTA. Int J Cardiovasc Imaging 2005;21: van der ZaagLoonen HJ, Dikkers R, De Bock GH, Oudkerk M. The clinical value of a negative multidetector computed tomographic angiography in patients with suspected coronary disease: a meta analysis. Eur Radiol 2006;16: Garcia MJ, Lessick J, Hoffmann MHK; CATSCAN Study Investigators. Accuracy of 16row multidetector computed tomography for the assessment of coronary artery stenosis. JAMA 2006;296: Raff GL, Gallagher MJ, O'Neill WW, Goldstein JA. Diagnostic accuracy of noninvasive coronary angiography using 64slice spiral computed tomography. J Am Coll Cardiol 2005;46: Ghostine S, Caussin C, Daoud B, Habis M, Perrier E, Pesenti Rossi D, SigalCinqualbre A, Angel CY, Lancelin B, Capderou A, Paul JF. Noninvasive detection of coronary artery disease in patients with left bundle branch block using 64slice computed tomography. J Am Coll Cardiol 2006;48: Nikolaou K, Knez A, Rist C, Wintersperger BJ, Leber A, Johnson T, Reiser MF, Becker CR. Accuracy of 64MDCT in the diagnosis of ischemic heart disease. Am J Roentgenol 2006; 187: Ehara M, Surmely JF, Kawai M, Katoh O, Matsubara T, Terashima M, Tsuchikane E, Kinoshita Y, Suzuki T, Ito T, Takeda Y, Nasu K, Tanaka N, Murata A, Suzuki Y, Sato K, Suzuki T. Diagnostic accuracy of 64slice computed tomography for detecting angiographically significant coronary artery stenosis in an unselected consecutive patient population: comparison with conventional invasive angiography. Circulation J 2006;70: Fine JJ, Hopkins CB, Ruff N, Newton FC. Comparison of accuracy of 64slice cardiovascular computed tomography with coronary angiography in patients with suspected coronary disease. Am J Cardiol 2006;97: Leschka S, Alkadhi H, Plass A, Desbiolles L, Grunenfelder J, Marincek B, Wildermuth S. Accuracy of MSCT coronary angiography with 64slice technology: first experience. Eur Heart J 2005;26: Mollet NR, Cademartiri F, van Mieghem CA, Runza G, Mc- 118

11 Atherosclerotic Plaques Evaluation Using MDCT Coronary Angiography Fadden EP, Baks T, Serruys PW, Krestin GP, de Feyter PJ. Highresolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography. Circulation 2005;112: Pugliese F, Mollet NR, Runza G, van Mieghem C, Meijboom WB, Malagutti P, Baks T, Krestin GP, defeyter PJ, Cademartiri F. Diagnostic accuracy of noninvasive 64slice CT coronary angiography in patients with stable angina pectoris. Eur Radiol 2006;16: Ropers D, Rixe J, Anders K, Kuttner A, Baum U, Bautz W, Daniel WG, Achenbach S. Usefulness of multidetector row computed tomography with 640.6mm collimation and 330ms rotation for the noninvasive detection of significant coronary artery stenoses. Am J Cardiol 2006;97: Scheffel H, Alkadhi H, Plass A, Vachenauer R, Desbiolles L, Gaemperli O, Schepis T, Frauenfelder T, Schertler T, Husmann L, Grunenfelder J, Genoni M, Kaufmann PA, Marincek B, Leschka S. Accuracy of dualsource CT coronary angiography: first experience in a high pretest probability population without heart rate control. Eur Radiol 2006;16: Sakuma H, Ichikawa Y, Chino S, Hirano T, Makino K, Takeda K. Detection of coronary artery stenosis with wholeheart coronary magnetic resonance angiography. J Am Coll Cardiol 2006; 48: Peer Reviewer Commentary 119

134~142특집_최병욱

134~142특집_최병욱 Focused Issue of This Month MDCT young Wook Choi, MD Department of Radiology, Yonsei University College of Medicine Email : bchoi@yumc.yonsei.ac.kr J Korean Med ssoc 2007; 50(2): 134-142 bstract Multidetector