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newsletterno.2(0910)2007.9.1011:15am페이지1 약제부 알림 약품 제형 특성상 분쇄가 불필요한 약품 처방명칭 제형 처방명칭 제형 Almagel tab.500mg (Almagate) Prozac dispersible tab.20mg (Fluoxetine) 붕해정 Cal-D-vita tab. Remeron soltab.30mg (Mirtazapine) Harnal D tab.0.2mg (Tamsulosin) Risperdal quicklet tab.1mg (Risperidone) L-Carn tab.1g (L-Carnitine) Risperdal quicklet tab.2mg (Risperidone) Nasea OD tab.0.1mg (Ramosetron) Rulid D susp tab.for childn 50mg (Roxithromycin) 붕해정 Nitroglycerin tab.0.6mg (Nitroglycerin) 설하정 Singulair chew tab.4mg (Montelukast) Onseran tab.8mg (Ondansetron) Singulair chew tab.5mg (Montelukast) 경희대학교 동서신의학병원 약품 정보지 NEWS LETTER 2007. Vol 02. EAST-WEST NEO MEDICAL CENTER DRUG INFORMATION -contents약제부 업무소개 환자 대상 특정 약물 교육 업무 약물 교육은 처방의 의도와 필요성, 약의 올바른 복용 및 사용법 등을 교육 3. 흡입기 약물 교육 Respiratory Service, RS 하고 집중 관리함으로써 환자가 약물요법에 적극적으로 참여하게 하여 복약 1) 대상 환자 : 원내 모든 흡입기 약물 투여 환자 순응도를 높이고 사용법 미숙으로 인한 치료 실패를 예방하며, 약물 및 음식 2) 교육 내용 : 약물명, 효능, 흡입기 사용법, 용법 및 용량, 질병과 약물 요법 물과 약물의 상호작용에 대한 정보와 부작용에 대한 정보를 제공하여 환자 신약 소개 02 Journal Review 03 Special Subject 04 의약품 안전성정보 05 약제부 알림 06 약제부 업무소개 08 의 상관 관계에 대한 정보, 부작용 및 대처방안, 주의 사항 의 치료효과를 최대화하고자 하는 약제 서비스이다. 4. 암환자 약물 교육 1) 대상 환자 : 항암화학요법 환자 1. 약물 교육 항목 2) 교육 내용 : 약물명, 효능, 용법 및 용량, 화학요법schedule, 부작용 및 대 1) 항응고 약물 교육 처방안, 주의사항, 약물 상호작용, 음식물 상호작용 2) 흡입기 약물 교육 5. 이식환자 약물 교육 3) 암환자 약물 교육 1) 대상 환자 : 장기 이식환자 (장기 이식 후, 면역 억제제 투여 환자) 4) 이식환자 약물 교육 2) 교육 내용 : 약물명, 효능, 용량, 복용법 및 시간, 부작용 및 대처 방법, 약 2. 항응고 약물 교육 Anticoagulation Service, ACS 물 상호작용, 음식물 상호작용, 주의사항 1) 대상 환자 : warfarin 투여 환자 6. 약물 교육 의뢰 방법 2) 교육 내용 : 경구용 항응고제의 복용 이유와 약효, 복용법, 복용상 주의사 [서식리스트] [타과의뢰] 의뢰 구분에서 [약물상담] / [항응고 약물교 항, 혈액응고검사의 중요성, 약물 상호작용 및 약물 음식물 상호작용, 부 육 / 흡입기 약물교육 / 암환자 약물교육 / 이식환자 약물교육] 중 해당 약물 작용 및 부작용 발생시 대처방법, 의료진에게 연락해야 하는 경우 교육 선택 의뢰사유에서 TPL 을 클릭 [ 항응고 약물교육 의뢰 / 흡 3) PT, 복약순응도, drug-drug interaction, drug-food interaction, 부작용 입기 사용 환자 약물교육 의뢰 / 암환자 약물교육 의뢰 / 장기 이식환자 약 발현 여부를 통해 target INR 유지하도록 적정용량을 제시 물교육 의뢰 ] 중 선택 후, 의뢰 사유 작성 저장 추후 의무기록상 타과 의뢰에서 회신내용 확인 약품 관련 문의사항 및 건의사항은 약품정보실로 연락주시기 바랍니다. 팩스 02-440-6984 홈페이지 http://www.khnmc.or.kr 경희대학교 동서신의학병원 약제부 약품정보실 2007년 통권 제2호 비매품 전화 02-440-6977 발행일 2007년 9월10일 E-mail jkj93@khnmc.or.kr 발행인 김정태 편집위원 정경주, 예경남, 김정보 발행처 경희대학교 동서신의학병원(134-727 서울시 강동구 상일동 149번지) 디자인 디자인한(02-426-6810) 본 약품정보지는 경희대학교 동서신의학병원의 신약 및 최신 약물정보, 약물 상호작용, 철회 및 삭제약품, 의약품 안전성, 복약지도 등의 정보를 제공하기 위하여 연 4회 발행되는 정기간행물입니다. 경희대학교 동서신의학병원 약품 정보지 _ 8 약제부 약품정보실 제공

No 1 MLBUFMC [ ]Symbicort turbuhaler 160/4.5mcg 120dose (Budesonide, formoterol) 160/4.5MCG 120Dose( ) 60dose 2 MVSURGIA 1901GB Surgicel 1901GB 3 IAPMTX Alimta inj. 500mg/V(Pemetrexed) 500MG( ) 4 MBANRA Anorex cap. 25mg(Dantrolene) 25MG( ) 5 MBANRB Anorex cap. 50mg(Dantrolene) 50MG( ) 6 IAANZA Anzatax inj. 30mg /5ml (Paclitaxel) 30MG/5ML ( ) 7 IACAMOXB Augmentin inj. 0.6g(Amoxicillin, clavulanate) 0.6G( ) 8 MBBROM Bromidine tab.2.5mg(bromocriptine) 2.5MG( ) 9 IFCOML Combiflex lipid inj. 1450ml 1450ML( ) MG-TNA 10 IFCOMLP Combiflex lipid inj. Peri 1920ml 1920ML( ) MG-TNA 11 MYDHCD Cough syr. 1ml 500ML( ) S 12 MPDEPAA Depakine chrono sphere gran. 250mg/pk(Valproate) 250MG( - ) 13 MPDEPAB Depakine chrono sphere gran.500mg/pk(valproate) 500MG( - ) 14 MBDPKA Depakote ER tab. 250mg(Divalproex) 250MG( ) 15 MBDPKB Depakote ER tab. 500mg(Divalproex) 500MG( ) 16 MBDCAM DicaMax1000 tab. (Calcium, cholecalciferol) 1000 ( ) 17 IIELSP Elaspol inj. 100mg(Sivelestat) 100 ( ) 18 MTGATI Gatiflo eye drop 5ml(Gatifloxacin) 5ML( ) 19 IIHMR Humira inj.40mg/srg(adalimumab) 40MG( ) 20 PLO0041 IGFBP-3 IRMA IGFBP-3 IRMA(DSL) 21 EXDIOM400 Iomeron 400(Iomeprol) 400 ( ) 22 MYKASUT Kasut susp. 20ml/pk(Calcium polystyrene sulfonate) 20ML/PK( ) 23 MOKLB Kelobex gel 20g/tu 20G/TU( ) 24 MBKETO Ketosteril tab. 800mg ( ) 25 MBLVDP Levotuss tab. 60mg(Levodropropizine) 60MG( ) 26 MYMCG Mucalgel susp. 12g/pk 12G/PK( ) 27 IINOVOA Novorapid flexpen inj. 300IU/3ml(Insulin aspart) 300IU/3ML( ) 28 IINOVOB Novorapid inj. 1000IU/10ml (Insulin aspart) 1000IU/10ML( ) 29 IFOLCN4 Oliclinomel Peri N4-550 inj. 1500ml N4-550E 1500ML( ) MG-TNA 30 IFOLCN7 Oliclinomel N7-1000 inj. 1000ml N7-1000E 1000ML( ) MG-TNA 31 MBORFLA Orfil long retard cap. 150mg(Valproate) 150MG( ) 32 MBORFLB Orfil long retard cap. 300mg(Valproate) 300MG( ) 33 MPRAM Ramnos gran. 250mg/g(Lactobacillus casei variety rhamnosus) ( ) 34 MBRMCT Remicut SR cap. 2mg(Emedastine difumarate) 2MG( ) 1mg 35 MBREVA Revanex tab. 200mg(Revaprazan) 200MG( ) 36 MBRINO Rinoebastel cap.(ebastine, pseudoephedrine) ( ) 37 IJAGSGM Sagebrush Mugwort 1:20 W/V 10ml 1:20 W/V 10ML( ) 38 IJAGST Std. DP 10,000Au/ml 10ml DP 10,000Au/ML 10ML( ) 39 MBNSDPA Sysco ER tab. 10mg(Nisoldipine) 10MG( ) 40 MBNSDPB Sysco ER tab. 20mg(Nisoldipine) 20MG( ) 41 MBTLDM Thalidomide cap. 50mg(Thalidomide) 50MG( ) 42 MBTRCL Tracleer tab. 62.5mg(Bosentan) 62.5MG( ) 43 IJAGTM Tree Mix #11 1:20W/V 10 ml 1:20W/V 10ML( ) 44 MBTRENO Treno cap. 100mg(Tranilast) 100MG( ) 45 MBRMP10 Tritace protect tab. 10mg(Ramipril) 10MG( ) _ 2

No 1 MNOXY40 [ ]Oxycontin SR tab.40mg (Oxycodone) 40MG( ) 2 MBATVA [ ]Ativan tab.1mg (Lorazepam) 1MG( ) 3 MBACERT8 Acertil tab. 8mg (Perindopril) 8MG( ) 4 MBAMP50 Amcillin cap.500mg (Ampicillin) 500MG( ) 5 MBIRST30 Aprovel tab.300mg (Irbesartan) 300MG( - ) 6 MBBRFA Brufen tab.200mg (Ibuprofen) 200MG( ) 7 MBCRMA Claroma tab.500mg (Clarithromycin) 500MG( ) 8 MBLOST10 Cozaar tab.100mg (Losartan) 100MG(MSD) 9 MBMETC Diabex tab.1000mg (Metformin) 1000MG( ) 10 MBDQ10 Nobramin cap.10mg (Ubidecarenone) 10MG( ) 11 MBPROC Provera tab. 10mg (Medroxyprogesterone) 10MG( ) 12 MBPYA Pyrazinamide tab.500mg (Pyrazinamide) 500MG( ) 13 MBROPC Requip tab.2mg (Ropinirole) 2MG(GSK) 14 MBPRP30 Rytmonorm tab.300mg (Propafenone) 300MG( ) 15 MBSMV4 Simvalord tab.40mg (Simvastatin) 40MG( ) 16 MBMTLA Zaroxolyn tab.10mg (Metolazone) 10MG( ) Journal Review Rofecoxib and Cardiovascular Adverse Events in Adjuvant Treatment of Colorectal Cancer Background Selective cyclooxygenase inhibitors may retard the progression of cancer, but they have enhanced thrombotic potential. We report on cardiovascular adverse events in patients receiving rofecoxib to reduce rates of recurrence of colorectal cancer. Methods All serious adverse events that were cardiovascular thrombotic events were reviewed in 2434 patients with stage II or III colorectal cancer participating in a randomized, placebo-controlled trial of rofecoxib, 25 mg daily, started after potentially curative tumor resection and chemotherapy or radiotherapy as indicated. The trial was terminated prematurely owing to worldwide withdrawal of rofecoxib. To examine possible persistent risks, we examined cardiovascular thrombotic events reported up to 24 months after the trial was closed. Results The median duration of active treatment was 7.4 months. The 1167 patients receiving rofecoxib and the 1160 patients receiving placebo were well matched, with a median follow-up period of 33.0 months (interquartile range, 27.6 to 40.1) and 33.4 months (27.7 to 40.4), respectively. Of the 23 confirmed cardiovascular thrombotic events, 16 occurred in the rofecoxib group during or within 14 days after the treatment period, with an estimated relative risk of 2.66 (from the Cox proportional-hazards model; 95% confidence interval [CI], 1.03 to 6.86; P=0.04). Analysis of the Antiplatelet Trialists' Collaboration end point (the combined incidence of death from cardiovascular, hemorrhagic, and unknown causes; of nonfatal myocardial infarction; and of nonfatal ischemic and hemorrhagic stroke) gave an unadjusted relative risk of 1.60 (95% CI, 0.57 to 4.51; P=0.37). Fourteen more cardiovascular thrombotic events, six in the rofecoxib group, were reported within the 2 years after trial closure, with an overall unadjusted relative risk of 1.50 (95% CI, 0.76 to 2.94; P=0.24). Four patients in the rofecoxib group and two in the placebo group died from thrombotic causes during or within 14 days after the treatment period, and during the follow-up period, one patient in the rofecoxib group and five patients in the placebo group died from cardiovascular causes. Conclusions Rofecoxib therapy was associated with an increased frequency of adverse cardiovascular events among patients with a median study treatment of 7.4 months' duration. NEJM 2007 JUL26;357(4):360-69. Prophylaxis versus Episodic Treatment to Prevent Joint Disease in Boys with Severe Hemophilia Background Effective ways to prevent arthropathy in severe hemophilia are unknown. Methods We randomly assigned young boys with severe hemophilia A to regular infusions of recombinant factor VIII (prophylaxis) or to an enhanced episodic infusion schedule of at least three doses totaling a minimum of 80 IU of factor VIII per kilogram of body weight at the time of a joint hemorrhage. The primary outcome was the incidence of bone or cartilage damage as detected in index joints (ankles, knees, and elbows) by radiography or magnetic resonance imaging (MRI). Results Sixty-five boys younger than 30 months of age were randomly assigned to prophylaxis (32 boys) or enhanced episodic therapy (33 boys). When the boys reached 6 years of age, 93% of those in the prophylaxis group and 55% of those in the episodic-therapy group were considered to have normal index-joint structure on MRI (P=0.006). The relative risk of MRIdetected joint damage with episodic therapy as compared with prophylaxis was 6.1 (95% confidence interval, 1.5 to 24.4). The mean annual numbers of joint and total hemorrhages were higher at study exit in the episodictherapy group than in the prophylaxis group (P<0.001 for both comparisons). High titers of inhibitors of factor VIII developed in two boys who received prophylaxis; three boys in the episodic-therapy group had a life-threatening hemorrhage. Hospitalizations and infections associated with centralcatheter placement did not differ significantly between the two groups. Conclusions Prophylaxis with recombinant factor VIII can prevent joint damage and decrease the frequency of joint and other hemorrhages in young boys with severe hemophilia A. NEJM 2007 AUG9;357(6):535-44. _ 3

Special Subject 1. NovoRapid( ), Insulin aspart / 100U/ml, 10ml/V / 3ml/pen /, 1 (IDDM), 2 (NIDDM) / 15, 15, 1 1, iv PK/PD 10-20, 1-3, 3-5 (RI.),,,,, / 28.,. Pregnancy Risk Factor FDA C Drug( ) Onset (hrs) Peak effect (hrs) Duration (hrs) Insulin aspart(novomix) 0.17-0.33 1-3 3-5 Insulin lispro(humalog) 0.25 0.5-1.5 2-3 RI (Humulin R, Novolet R) 0.5-1 2-3 8-12 IV (2006 10 ) *Insulin aspart RI 72% (Diabetes med. 2004) * Insulin aspart RI, Insulin lispro HbA1c (Diabetes Care, 2002) 2. Humira inj.( ), Adalimumab / 40mg/SRG / Fully human monoclonal antibody, TNFalpha TNF receptor TNF. / (DMARDs ),, 40mg 2 1, MTX, DMARDs PK/PD BA: absolute: 64%, T1/2 : terminal: ~2wks(10-20days),,,,,,,,, (1-10%) /,, /, Pregnancy Risk Factor FDA B Fully human monoclonal antibody, 2 1. 3. Revanex tab.( ), Revaprazan / 200mg/T / K+ proton(h + ). proton pump inhibitor,,, /, : 1 1 200mg, 4-8, : 1 1 200mg 2 PK/PD Cyt P450 (3-4%),, (1-2%),, (1-2%), / :,,,. Pregnancy Risk Factor,,. 4. Syscor ER tab. ( ), Nisoldipine /10mg( 2/ 8mg)/T, 20mg ( 4/ 16mg)/T /,, / 1 1 10mg 40mg. 1...,,,,,,,,, BUN/Cr (<1%) / :,,,, 1,,,, Pregnancy Risk Factor FDA C (, ) * Amlodipine SBP, BP, non-dipper.(am J Hypertension, 2003) 5. Tracleer( ), Bosentan hydrate 62.5mg/T / Endothelin Receptor Antagonist (ERA), ETA ETB.,,,. WHO, / ( ) : 4 1 2 1 62.5mg. : 5 1 2 1 125mg. 1 250mg PK/PD Tmax : 3.5h, T1/2 : 5.4h, BA : 50%, Excretion : hepatic (urine < 6%),,,,,,,,,, /, -,,, Pregnancy Risk Factor FDA X 6. Ketostril( ), 4 +4 / Total 800mg/T(ketophenylalanin, ketoisoleucine, ketoleucine, ketovaline, hydroxymethionine, histidine, lysine, tryptophan, threonine) /, 1 40g, SCr 2-5mg/dl, 4.0g/dl, / 1 4, 1 3, /, / 25 1, 1.25mM, 7. Alimta inj. ( ), Pemetrexed / 500mg/V / Antimetabolite (antifolate), pyrrolopyrimidine 1. 2., / 1. : 500mg/m 2 10min iv D1 q3wks, Cisplatin 75mg/m 2 2hr iv D1 2. : 500mg/m 2 10min iv D1 q3wks PK/PD Vd: 16.1L, T1/2( normal renal function): 3.5hrs, Excretion: urine(70-90% unchanged),,,,,,,, A/N/V/D,,,,,,, (>10%) / Vit B12. : (,, ) / Reconstitution: 20ml NS 25mg/ml ( 24 ) Pregnancy Risk Factor FDA D 8. Thalidomide cap.( ), Thalidomide / 50mg/T /, - _ 4

Special Subject. Cytokine,. 1. 2., / (PRMP) : 1 200mg, 1 100mg, 800mg/d - : 1 100mg, 400mg/d PK/PD Vd : 120L, T1/2 : 5-7hrs, Time to peak, plasma : 3-6hrs, Excretion : Urine,,,,,,,,,,,,,,,,, ( >10%) /, 12,,,, Pregnancy Risk Factor FDA X 70% (Blood, 2001) 9. Elaspol ( 100 ), Sivelestat sodium hydrate / 100mg/V / (SIRS) (ALI) ( --> SIRS,, Sivelestat ) / 1 4.8mg/kg 24 ( NS 250-500ml 0.2mg/kg/hr ), 14. 72.,, (1-10%) /. / NS, 5D 24, ( ) * (SIRS) :,,,,,, 10. Anorex cap. ( ), Dantrolene / 25mg/T, 50mg/T /,,,,,. / 1 1, 1 25mg, 1 4, 1 200mg PK/PD Tmax 4hrs, T1/2 : 8.7hrs, Metabolism : hepatic, Excretion : Feces(45-50%), urine(25%),,,,,,,, (1-10%) /, :. Pregnancy Risk Factor FDA C 11. Tritace protect ( ), Ramipril / 10mg/T / ACE inhibitor : Angiotensin-converting enzyme(ace) : angiotensin angiotensin. RAS bradykinin bradykinin. 1. 55,, / 2. 55,, / :,, HDL,, / 1 1 2.5mg, 5mg, 3 10mg, 10mg/d. PK/PD BA : 60%, Tmax: ~1hr, T1/2 : Ramiprilat( ) : >50hrs, Excretion: urine(60%), feces(40%),,,,,,,,,,,, BUN/sCr (1-10%) /,,, Pregnancy Risk Factor FDA C(1 st trimester), D(2 nd, 3 rd trimester) *HOPE study ( ramipril 10mg, MI, ) 12. DicaMax 1000 tab. ( 1000 ), Calcium carbonate + Cholecalciferol / 1250mg + 1000U/T /, D (,,, ) / 12 : 1 1 1 /,, 12,, 13. Rino-Ebastel cap. ( ), Ebastine+Pseudoephedrine / 110+200.86mg /, Ebastine, pseudoephedrine. / 12 : 1 1 1, 1 2 1, 10.,,,,, /,,,,,, MAO, 12,, 07.8.17 Avandia tab. 4mg (Rosiglitazone) Actos tab.15mg (Pioglitazone) 2.,,,. FDA 07.8.14 (, )... (,, )... ( (NYHA) 3, 4 ). _ 5

[ ] Dicode tab. 60mg(Dihydrocodeine) O X [ ]MPS SR tab.10mg (Morphine) O X [ ]MPS SR tab.30mg (Morphine) O X [ ]Oxycontin SR tab.10mg (Oxycodone) X X [ ]Oxycontin SR tab.20mg (Oxycodone) X X [ ]Oxycontin SR tab.40mg (Oxycodone) X X [ ]Concerta oros tab.18mg (Methylphenidate) (OROS TYPE) X X [ ]Metadate CD SR cap.20mg (Methylphenidate) / X X Acamprosate whanin tab.333mg (Acamprosate) X X Adalat oros tab.20mg (Nifedipine) (OROS) X X Adalat oros tab.30mg (Nifedipine) (OROS) X X Adalat oros tab.60mg (Nifedipine) (OROS) X X Adalat soft cap.10mg (Nifedipine) X X Allaspan cap. (Alverine 60mg, Simethicone 300mg) X X Andriol soft cap.40mg (Testosterone) X X Asacol DR tab.400mg (Mesalazine) ` X X Aspirin protect tab.100mg (Aspirin) X X Astrix cap. 100mg (Aspirin enteric coated) O X ATP tab.20mg (Adenosine triphosphate) X X Austyn SR cap.200mg (Theophylline) O X Avodart cap. 0.5mg(Dutasteride) X X Bonky soft cap.0.25 (Calcitriol) X X Budenofalk cap. 3mg(Budesonide) O X Cardura-XL tab.4mg (Doxazosin) (OROS) X X Carmazepine CR tab.200mg (Carbamazepine) O X Cereticom tab.10mg (Cytochrome C) X X Cipol-N soft cap.100mg (Cyclosporin) X X Cipol-N soft cap.25mg (Cyclosporin) X X CiproUro tab.500mg (Ciprofloxacin) X X Clease tab.(trypsin, Ribonuclease ) X X Combizym tab. ( ) X X Depakine chrono tab.300mg(sod.valproate) O X Depakine chrono tab.500mg (Sod.valproate) O X Depakote ER tab. 250mg(Divalproex) X X Depakote ER tab. 500mg(Divalproex) X X Detrusitol SR cap 2mg (Tolterodine) X X Detrusitol SR cap 4mg (Tolterodine) X X Diamicron MR tab.30mg (Gliclazide) X X Dilopin tab.5mg (Felodipine) X X Diltelan SR cap.90mg (Diltiazem) O X Dulcolax-S TAB X X Dynacirc cap.5mg (Isradipine) O X Efexor XR SR cap 37.5mg (Venlafaxine) X X Efexor XR SR cap.75mg (Venlafaxine) X X Empynase-S tab.36mg (Pronase B) X X Epogam paediatric soft cap.80mg ( -Linolenic acid) X X Eryc cap.250mg (Erythromycin) O X Etheophyl 100mg cap.(theophylline) O X Evoprim for child soft cap. 80mg ( -linolenic acid) X X Evoprim for child soft cap.80mg ( -linolenic acid) X X Evoprim soft cap.40mg ( -linolenic acid) X X Feroba-U SR tab.256mg (Ferrous sulfate) X X Festal gold tab. X X Fludex SR tab.1.5mg (Indapamide) O X Glakay soft cap.15mg (Menatetrenone) X X Gliatilin soft cap.400mg (Choline) X X Herben SR Cap. 180mg (Diltiazem) O X Implanta soft cap.100mg (Cyclosporin) X X Implanta soft cap.25mg (Cyclosporin) X X Isoket retard SR cap.120mg (Isosorbide) O X Isoket retard tab.40mg (Isosorbide) O X Isoptin SR tab.180mg (Verapamil) O X Isotril ER tab.60mg (Isosorbide-5-mononitrate) O X K-contin continus SR tab.600mg (Pot.chloride) X X Ketas cap.10mg (Ibudilast) X X Klaricid XL tab. 500mg (Clarithromycin) O X Labopar SR cap.40mg (Ritodrine) O X Lancid cap.30mg (Lansoprazole) X X Lastet soft cap.25mg (Etoposide), X X Lescol XL SR tab.80mg (Fluvastatin) O X Liparoid tab.30u (Pancreatic sulfomucopolysaccharide) X X Lipidil supra tab.160mg (Fenofibrate) O X Lodine SR tab.600mg (Etodolac) X X Madopar HBS cap. (Levodopa 100mg, Benserazide 25mg) X X Medilac-DS enteric coated cap.250mg X X Munobal tab.5mg (Felodipine) X X Myfortic tab.180mg (Mycophenolic), X X Myfortic tab.360mg (Mycophenolic), X X Naxen-F CR tab.1000mg (Naproxen) O X Nexium tab. 20mg(Esomeprazol magnesium) X X Nexium tab. 40mg(Esomeprazol) X X Oldeca cap.10mg (Barnidipine), / X X Oldeca cap.5mg(barnidipine), / X X Omed tab.10mg (Omeprazole) X X OMP tab.20mg (Omeprazole) X X Orfil long retard cap. 150mg(Valproate) O X Orfil long retard cap. 300mg(Valproate) O X Orfil SR tab.300mg (Sod.valproate) O X Pancron tab. X X Panorin soft cap. 100mg (Pamidronate) X X Pantoloc tab.40mg (Pantoprazole) X X Pariet tab.10mg (Rabeprazole) X X Paxil CR tab.12.5m (Paroxetine) X X Pentasa SR tab.500mg (Mesalazine) X X Perdipine SR cap.40mg (Nicardipine) O X Phazyme tab. X X _ 6

Prozac weekly retard cap.90mg (Fluoxetine) X X Remicut SR cap. 2mg(Emedastine difumarate) O X Reminyl PR cap.16mg(galantamine) O X Reminyl PR cap.24mg(galantamine) O X Reminyl PR cap.8mg(galantamine) O X Rinoebastel cap.(ebastine, pseudoephedrine) X X Roaccutane soft cap.10mg (Isotretinoin) X X Rowachol cap. X X Roxan cap.75mg (Roxatidine) O X Sadenin tab.200mg (Ademetionine) X X Salofalk tab.250mg (Mesalazine) X X Sandimmun neoral soft cap.100mg (Cyclosporin) X X Sandimmun neoral soft cap.25mg (Cyclosporin) X X Suspen ER tab.650mg (Acetaminophen) X X Sysco ER tab. 10mg(Nisoldipine) X X Sysco ER tab. 20mg(Nisoldipine) X X Tagen F soft cap.170mg (Vaccinium myrtillus ext.) O X Tiorase tab.5mg (Serratiopeptidase) X X Topamax sprinkle cap. 50mg(Topiramate) O X Trittico CR tab.75mg (Trazodone) O X Urocitra-K S.R. tab. 540mg X X Utrogestan cap. 100mg(Micronized progesterone) X X Vesanoid soft cap.10mg (Tretinoin) X X Vessel due F soft cap.250lsu(sulodexide) X X Videx EC cap. 400mg(Didanosine) X X Videx EC cap.250mg (Didanosine) X X Viscozol cap.50mg (Letosteine) X X Wellbutrin SR tab.150mg (Bupropion) X X Xatral XL tab.10mg (Alfuzosin) X X Zanadipin tab.10mg (Lercanidipine) X X Zarontil soft cap.250mg (Ethosuximide) X X Zipan SR cap.100mg (Tramadol) O X Zopyrin enteric coated tab, 500mg (Sulfasalazine) X X Actonel tab.35mg (Risedronate) X X Actonel tab.5mg (Risedronate) X X Alend tab. 10mg(Alendronic acid) X X Alenmax tab. 70mg(Alendronate) X X Alkeran tab.2mg (Melphalan) O X Alkyloxan tab.50mg (Cyclophosphamide) O X Alocia tab.1mg (Finasteride) X X Amoclan duo tab.500mg (Amoxicillin/Pot.clavulanate(7:1)) X X Augmentin tab.375mg (Amoxicillin 250mg, Clavulanate 125mg) X X Azathioprine tab.50mg (Azathioprine) O X Carnitil tab 500mg(Acetyl-L-carnitine) X X Cellcept cap.250mg (Mycophenolate) X X Denol tab.300mg (Tripotassium dicitrate bismuthate) X X Doxiflu cap.200mg (Doxifluridine) X X Fosamax plus tab. 70mg/2800U (Alendronate/ cholecalciferol) X X Fosaqueen tab. 70mg/tab (alendronate) X X Glivec tab.100mg (Imatinib) X X Hydrea cap.500mg (Hydroxyurea) X X Iressa tab.250mg (Gefitinib) X X Lastet soft cap.25mg (Etoposide) X X Maxmarvil tab. (Alendronic acid 5mg, Calcitriol 0.5mcg) X X Meiact tab.100mg (Cefditoren) X X Methotrexate tab.2.5mg (Methotrexate) O X Myfortic tab.180mg (Mycophenolic), X X Myfortic tab.360mg (Mycophenolic), X X Neotigason cap.10mg (Acitretin) X X Nicetile tab.500mg(acetyl-l-carnitine) X X Orafridine cap.100mg (Doxifluridine) X X Pritor tab.40mg (Telmisartan) X X Pritor tab.80mg (Telmisartan) X X Prograf cap. 0.5mg(Tacrolimus) X X Prograf cap.1mg (tacrolimus) X X Propecia tab.1mg (Finasteride) X X Proscar tab. 5mg (Finasteride) X X Purinethol tab.50mg (Mercaptopurine) O X Renagel tab.400mg (Sevelamer) X X Renagel tab.800mg (Sevelamer) X X Starlevo tab.100mg (Levodopa 100mg, Carbidopa 25mg, Entacapone 200mg X X Starlevo tab.150mg (Levodopa 150mg, Carbidopa37.5mg, Entacapone 200mg X X Starlevo tab.50mg (Levodopa 50mg, Carbidopa 12.5mg Entacapone 200mg X X Sutene cap. 12.5mg (Sunitinib malate) X X Sutene cap. 25mg (Sunitinib malate) X X Sutene cap. 50mg (Sunitinib malate) X X Tambutol tab.400mg (Ethambutol) X X Temodal cap.100mg (Temozolomide) X X Temodal cap.20mg (Temozolomide) X X Temodal cap.250mg (Temozolomide) X X Thalidomide cap. 50mg(thalidomide) X X Thioguanine tab.40mg (Thioguanine) O X TS-1 cap.20(tegafur 20mg, Gimeracil 5.8mg, Oteracil Ca 19.6m X X TS-1 cap.25(tegafur 25mg, Gimeracil 7.25mg, Oteracil Ca 24.5 X X UFT cap. (Tegafur 100mg, Uracil224mg) X X Warfar tab.2mg (Warfarin) O X Warfar tab.5mg (Warfarin) O X Xeloda tab.150mg (Capecitabine) O X Xeloda tab.500mg (Capecitabine) O X _ 7

news letter No.2 10