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1 만성세균성전립선염모델흰쥐에서 의항염효과 Anti-inflammatory Effect of Lycopene on Chronic Bacterial Prostatitis Rat Model Cho Hwan Yang, Dong Wan Sohn, Yong-Hyun Cho From the Department of Urology, The Catholic University of Korea College of Medicine, Seoul, Korea Purpose: Chronic bacterial prostatitis (CBP) is the most common urological disease in adult males, with antibiotic therapy being the gold standard for its treatment. However, long-term therapy results in many side effects as well as bacterial resistance. For these reasons, there is a need for a new treatment modality to replace traditional antibiotic therapy. Lycopene, an extract of tomatoes, has antioxidant effects against various bacteria and synergistic effects with antibiotics. We evaluate the synergistic effects of lycopene on the treatment of CBP in an animal model. Materials and Methods: Forty five rats demonstrating CBP were randomly divided into 4 groups; the control, lycopene, ciprofloxacin and lycopene with ciprofloxacin groups. All drug treatments were conducted over a period of 2 weeks. After treatment, the results were analyzed, with the microbiological cultures and histological findings of the prostate and urine samples compared with the control group and between each group. Results: The uses of ciprofloxacin, and lycopene with ciprofloxacin showed statistically significant decreases in bacterial growth and improvements in prostatic inflammation compared with the control group (p 0.05). The lycopene with ciprofloxacin group showed a statistically significant decrease in bacterial growth and improvements in prostatic inflammation compared with the ciprofloxacin group (p 0.05). Conclusions: These results suggest that lycopene may be an effective material in the treatment of CBP. Especially, the combination treatment of lycopene and ciprofloxacin has synergistic effects. Therefore, it is suggest that the combination of lycopene and ciprofloxacin may be effective in the treatment of CBP, and with a higher success rate. (Korean J Urol 2006;47: ) Key Words: Lycopene, Prostatitis, Antibiotics

양조환 외 만성 세균성 전립선염 모델 흰쥐에서 Lycopene의 항염효과 A B C D 1351 Fig. 1. Prostate section of a chronic bacterial prostatitis rat, obtained 2 weeks after each treatment (H&E, Bar=100μm).

(B) The acinar structures are moderately atrophied and obliterated. Moderate chronic inflammatory cell infiltration and interstitial fibrosis are seen (Group II).

(D) The acinar structures have a nearly normal appearance, with mild lymphocytic infiltration and focal fibrosis in the interstitial space (Group IV).

Ciprofloxacin 군과 lycopene과 ciprofloxacin 병용 투여 군의 비교에서 lycopene과 ciprofloxacin 병용 투여군에서 만 성 염증세포 침윤, 선 소포 변화 및 간질 섬유화가 통계학적 으로 유의하게 향상되었다 (p 0.05).

4 양조환 외 만성 세균성 전립선염 모델 흰쥐에서 Lycopene의 항염효과 A B C D 1351 Fig. 1. Prostate section of a chronic bacterial prostatitis rat, obtained 2 weeks after each treatment (H&E, Bar=100μm). (A) The acinar structures are severely atrophied and obliterated. Marked chronic inflammatory cell infiltration and interstitial fibrosis are seen (Group I). (B) The acinar structures are moderately atrophied and obliterated. Moderate chronic inflammatory cell infiltration and interstitial fibrosis are seen (Group II). (C) The acinar structures are mildly shrunken, with mild lymphocytic infiltration and fibrosis in the interstitial space (Group III). (D) The acinar structures have a nearly normal appearance, with mild lymphocytic infiltration and focal fibrosis in the interstitial space (Group IV). 만성 염증세포의 침윤, 선소포의 변화, 간질 섬유화 정도가 모두 감소하였으나 통계학적으로 유의하지 않았다 (p 0.05). Ciprofloxacin 군과 lycopene과 ciprofloxacin 병용 투여 군의 비교에서 lycopene과 ciprofloxacin 병용 투여군에서 만 성 염증세포 침윤, 선 소포 변화 및 간질 섬유화가 통계학적 으로 유의하게 향상되었다 (p 0.05). 결과적으로 ciprofloxacin과 lycopene 병용 투여군에서 다른 군에 비해 만성 염 증세포 침윤, 선소포의 변화 및 간질 섬유화가 통계학적으 로 유의하게 향상됨을 알 수 있었다 (p 0.05) (Fig. 2). 고 찰 만성 세균성 전립선염은 임상에서 흔히 접하는 질환으로 서 지속적으로 연구되고 있는 질환 중 하나이다. 임상 양상 이 비특이적이며 병인에 대해서도 아직까지 뚜렷이 밝혀진 바는 없어 이에 대한 여러 가지 병인론이 제기되고 있다. 만성 세균성 전립선염은 확진이 어렵고 치료 후에도 재발 하는 경우가 흔하다. 그래서 Stamey는 전립선염을 임상적 Fig. 2. Severity scores of chronic inflammatory cell infiltrations, acinar changes and interstitial fibrosis in each group. The values, expressed the means±sd, are compared with that of the control group. *: p 0.05, compared with the control group, : p 0.05, compared with the ciprofloxacin group, SD: standard deviation.

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untitled 만성세균성전립선염모델쥐에서 Ginsenoside 혹은 Urovaxom R 과 Ciprofloxacin 의상승효과 Synergistic Effect between Ginsenoside or Urovaxom R with Ciprofloxacin on Chronic Bacterial Prostatitis Rat Model Yong-Sun Choi, Yong-Hyun