저작자표시 - 비영리 - 변경금지 2.0 대한민국 이용자는아래의조건을따르는경우에한하여자유롭게 이저작물을복제, 배포, 전송, 전시, 공연및방송할수있습니다. 다음과같은조건을따라야합니다 : 저작자표시. 귀하는원저작자를표시하여야합니다. 비영리. 귀하는이저작물을영리목적으로이용할수없습니다. 변경금지. 귀하는이저작물을개작, 변형또는가공할수없습니다. 귀하는, 이저작물의재이용이나배포의경우, 이저작물에적용된이용허락조건을명확하게나타내어야합니다. 저작권자로부터별도의허가를받으면이러한조건들은적용되지않습니다. 저작권법에따른이용자의권리는위의내용에의하여영향을받지않습니다. 이것은이용허락규약 (Legal Code) 을이해하기쉽게요약한것입니다. Disclaimer
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H : hairpin loop M: multiple loop I : internal loop U G C U A C C U U C G G G U G G C G G A C C C G G C G C C G H G U C M I U C G G C U C U C C U G C C G G C U Base pair Stem A G U C A U A A H G A G U C G C C U U U C U C G C G A A H C C U G G C C G H G U G G A A G A U G - 3 -
(A) (B) loop 2 loop 1 loop 2 stem 1 stem 2 loop 3 5' 3' y x stem 1 stem 2 5' 3' loop 3 (C) 3' (D) loop 1 stem 2 loop 2 stem 1 x stem 1 loop 3 loop 1 stem 2 5' 5' 3' - 4 -
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...(((((...)))))...((((...((((...))))..))))... - 6 -
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Book embedding Vertex Spine Edge Page Book thickness - 13 -
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5 3 a b c c' d d' b' e f f' e' g h g' h' a' i i' a root b e g i : pseudoknot h leaf stem-loop c d f (f,f ) (d,d ) (e,e ) (g,g ) (c,c') (b,b ) 5 3 (h,h ) (a,a ) (i,i ) - 17 -
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(A) (B) (C) (D) - 19 -
시작 서열, 구조데이터입력 염기쌍파악및반스템배열 A 생성 교차관계파악및페이지매핑 (3.2 절 ) 위상관계도생성 (3.6 절 ) Pseudoknot 파악및각 pseudoknot 을묶는가상반스템을반스템배열 A 에추가 i = A 의마지막반스템의인덱스 아니오 A[i] 는여는반스템이고페이지가 0 아니오 예 구조요소생성 i = i-1 i < 0 예 A[i] 는 psuedoknot 의가상반스템 아니오 H-type pseudoknot 예 스템과루프배치 아니오 Pseudoknot 스템정렬 (3.3 절 ) 자식이존재하는가 아니오 A[i] 와 partner(a[i]) 사이의모든반스템중페이지가 0 인반스템의페이지를 1 로지정 Convex hull 형태의루프생성 (3.4 절 ) 자식구조요소배치 (3.4 절 ) 예 Pseudoknot 스템정렬 (3.3 절 ) 구조요소간겹침이있는가 (3.5.1 절 ) 예 겹침해소및루프확장 (3.5.2 절, 3.5.3 절 ) 염기배치 끝 - 20 -
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Step 1 반스템배열 리스트 A B C D a E c e d F b f A B C D a E c e d F b f 여는스템? 교차관계 A - B - C - D - E - F - Step 2 A B C D a E c e d F b f a<b? A A - B B - A C - D - E - F - Step 3 A B C D a E c e d F b f 제거 닫는스템? A B C D A - B C D B - A C - A D D - A C E - F - Step 4 A B C D a E c e d F b f A - B C D B - A F C - A D E D - A C E - C F - B - 24 -
A B C D E F Page 2 Page 1 Page 1 A 1 2 B C 4 5 F E Page 3 D 3 6' D 6-25 -
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A B C a D c d E F e b f Step 1 반스템배열 A B C a D c d E F e b f Upper Upper R3 스템정렬 A B C a c D d E b e F f R5 Upper Step 2 A B C a D c d E F e b f R4 Under R4, 제거 A B b f C c Aa (1) D d E e F Step 6 Step 3 B C D c d E F e b f B C c Aa (1) D R3 d E R4 b e Ff (2) Step 4 B C D c d E e b Step 5 R4 R3 R5 B Dd (4) b C c Ee (3) Aa (1) Ff (2) Bb (6) Cc (5) Dd (4) Ee (3) Aa (1) Ff (2) - 33 -
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(A) (B) (C) - 36 -
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E r 1 I C I K F C L xa A x overlaps xd B D y d y c y overlaps r 2 G H d < r 1 + r 2 J π - 38 -
cos - 39 -
π θ arcsin arcsin (1) π arcsin (2) - 40 -
C A B D C A B D C A B D C A B D O O O O A C D B A C D B A C D B A C D B O O O O C B l 3 D B A a a 1 2 D A a 1 C l 2 l l 2 1 A' D' a b R O q = a + b l 1 A' R a O q = a D' - 41 -
θ θ π arccos (3) A r 2 B r 1 l 2 l 1 R q O - 42 -
B2 B1 B' B A C C r B3 A' A l c -r l c l c +r O O A 2 B 2 A 2 B 2 q 2 r q 2 r C B 1 C A 1 q 1 A 1 q 1 B 1 O O - 43 -
A l 3 B=D a r C A=D r C l 1 a b R O q = a + b l2 l 1 B l 2 q R O A a 1 B D r C l 1 l 2 q R O a 2 B' a 1 A l 1 C R r D B B' q F O l2 C - 44 -
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cos arcsin arccos (4) arccos (5) sin sin sin sin sin sin sin sin - 46 -
sin arcsin, (6) sin arcsin, (7) max (8) - 47 -
arccos arccos sin tan (9) sin tan (10) tan (11) - 48 -
(12) arccos sin (13) (14) sin tan cos, (15) sin tan cos, (16) - 49 -
C A B D C A B D C A B D C A B D O O O O A C D B A C D B A C D B A C D B O O O O A l 1 C l 2 a 1 a 2 D B A a 1 C a 2 D B A B r 1 r 2 dy d - 50 -
A l B a r dy C A r E dy d B d : a rsin(a) dy A l D r C rcos(a) d B : a dy rsin(a) A C D r B rcos(a) d - 51 -
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# TYMV 144 UUAGCUCGCCAGUUAGCGAGGUCUGUCCCCACACGACAGAUAAUCGGGUG CAACUCCCGCCCCUUUUCCGAGGGUCAUCGGAACCA...(((((...))))).((((((...))))))...((((.....))))(((...[[[[[[)))...]]]]]]... # TYMV 144 UUAGCUCGCCAGUUAGCGAGGUCUGUCCCCACACGACAGAUAAUCGGGUG...(((((...))))).((((((...))))))...((((.. CAACUCCCGCCCCUUUUCCGAGGGUCAUCGGAACCA...))))(((...[[[[[[)))...]]]]]]... - 59 -
# PKB128 (Bernevirus) 1045 UUUAAACUGUUGAGAGGUGCCUGGAGCGCCUGCAGGCAUCUCUGUU...(((((((((((...[[[[[)))))))))))... 1150 /UAUAAUGCAGGCA /...]]]]]. $ 1 UUAGCUCGCCAGUUAGCGAGGUCUGUCCCCACACGACAGAUAAUCGGGUG % 1...(((((...))))).((((((...))))))...((((.. $ 51 CAACUCCCGCCCCUUUUCCGAGGGUCAUCGGAACCA % 51...))))(((...[[[[[[)))...]]]]]]... - 60 -
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ASP input HTML input form ASP sender XML request SOAP request Client HTTP protocol HTML output with image G G A G C C C U C G C C A U A U Web application server XML response with image url SOAP response Web sevice server A G U G C C - 63 -
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WSPVRun Option {Scale, Output_name, Output_type} WSPVRequest 0 1 1 * Option WSPVInput 0 1 Option WSPVIn_data 0 1 0 1 Drawing_option Numbering {Interval} 0 1 0 1 Base_numbers Numbering_option Sequence {Name, Start_base} 0 1 0 1 Bracket_view Pair_info 1 * Pair WSPVIn_file_data PV_file WSPV_recall {serverid, format} - 71 -
WSPVRunResponse WSPVResponse 1 * WSPVOutput Name Images 0 1 0 1 0 1 0 1 WSPVOut_URL WSPVOut_EPS WSPVOut_raw_images Picture WSPVOut_Coordinates WSPV_Base {Base_type, x, y} - 72 -
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([)] ([)([)](]) ([)]([)] ([)([)]] ([)([)]([)]] ([)([)]([{)]}] ([)([)]([)]([)]] ([)([{<)]}>([)]] ([({({)[)]<[)]((])})>} ([[{({)((])([))<)(])((])})>} ([)(]) (([)]([))([)][([)][(]]{(([{<)]} >(([[)(]({)])(]))}))} (([)]([))[([)][([)][(]]]{(([{<) ]}>(([[)(]({)])(]))}))} ([)[([)][{[([)][(]]]}]{(([{<)]} >(([[)(]({)])(]))}))}([)] (([[)](])(([)]([)))[([)][([)][( ]]]{(([{<)]}>(([)(])(]))))}([)] (([)(])(([)]([)))[([)][([)][(]] ]{(([{<)]}>(([[)(]({)])(]))}))} ([)] (([[)](])(([)]([)))[([)][([)][( ]]]{(([{<)]}>(([[)(]({)])(]))}) )}([)] (([[)](])(([)]([)))[([)][([)][( ]]]{(([{<)]}>(([[{)](}({)])(])) }))}([)] - 88 -
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