16(2)-7(p ).fm

Size: px
Start display at page:

Download "16(2)-7(p ).fm"

Transcription

1 w wz 16«2y Kor. J. Clin. Pharm., Vol. 16, No ü t xy y w tœ ½ BÁ x BC B y w w w C y w w w Current Status and Expectations of Orphan Drugs in Korea -In point of supplying medicines for the rare diseases- Hee-Eun Kim a and Hye-Sun Gwak a,b a Graduate School of Clinical Health Sciences, Ewha Womans University, Seoul , Korea b College of Pharmacy, Ewha Womans University, Seoul , Korea This study was aimed to investigate the current status and expectations of orphan drugs in Korea. The Korea Orphan Drug Center was established to supply many medicines for the patients with rare diseases. Among the medicines supplied by the Center, the number designated as the orphan drugs by the KFDA is quite few. However, a few of medicines are not under circulation even if the items are designated as the orphan drugs. Neoplasm-related medicines, infectious and parasitic disease-related medicines, endocrine, nutritional and metabolic disease-related medicines are the ones circulated most. There are several unapproved drugs among the medicines supplied by the Center. It s because the director of the Center can import the goods without a process to getting an approval from the KFDA. The Korea Orphan Drug Center has contributed to the selection of the medicines for treating the rare disease. On the contrary, some problems remain in the supply process. The safety and effectiveness of the medicines supplied by the Center are not guaranteed. So far, rare diseases have no specific legal definition, and therefore are only referred to in terms of the population of patients, which prevent from establishing the range of medicines. The introduction of Special Access Program or Access to Unapproved Therapeutic Goods will be the solution of these problems. In addition, it is another solution to keep intimate relations with the Rare and Intractable Disease Center and the Medicine Safety Information Center which will be open soon. Key words Orphan Drugs, Korea Orphan Drug Center, Rare Disease t e w w w yw œ w» w. ú Á w w» t y w w t t» w Áœ š. wš y e t Á w n ù, t ƒ., y ù e ƒ š w. Correspondence to : x y w w w/ w w p x 11-1 Tel: , Fax: w, ú w» w» ƒ y w, wz w.» w y ƒw, y ƒ š v w t w ƒw 1). t w z» w ù w t wš. ù w t w y ù ƒ e w w. w t yw w w t l w. t l» ƒ, w t œ w ww w ù Õ y t 107

2 108 Kor. J. Clin. Pharm., Vol. 16, No. 2, 2006 t Ö š w ƒe t ww t l t ƒ w w³ e mw t l t y e t w ww x ƒ wš w. w 2002 œ t 72 t, y 748, 2003 œ t 93 t, y 1,619, 2004 œ t 110t, y 2, z œ t y ƒ w w ƒwš. w x t l t œ t t š t w t ww, ü ƒ t w w w w. w j ƒ wù ü w t xy w w ü m š t y e ƒ š w w w w. wù ü m t œ w ù w ƒ w t w œ.» y t ƒw t l t œ xy w w v». ù y w ƒ š w. w ƒ ƒ,,, e e w ƒ» 2). ¾ t l mw œ w t yw w». t l t t Õ t w³ Ö Áš t y e t œ wš. y e t, ³ w.» t Õ t w³ Ö» w, t l q w š w. ³ w t ü y ƒ 20,000 w w e t w y t x t w œ y e j w ƒ š t t w t. t l mw t œ ƒw, y š y ù ƒ e w t k y w d» w š. ù œ, y, t k y «, t sƒ z d üswš. t t w ü t xy r š t l mw œ t y t w, ù ƒ t œ ùkú ƒ ƒ d w š, m wz w wš w. t t t t l š w. t t š y m ü t xy q w. w t l š m l mw œ t t y y r., t œ ü w t œ q w š w. ù txy t t š y, Õ t w³ Ö 3) w ¾ t 107 w (»y421, 429, 617)ƒ 26 ƒ w (»y 629) 15,» (»y149) t l mxy w t 109 t t x ü m t m ùkû. t 28% w w m š w. m t xƒ 4 (4 t ), x ƒ w 1 (1 t ), 3 (6 t ), 2 (2t ), 19 (42 t ), ƒ 2 (2t ) 4). m ƒ xƒ, ƒ (8 ) wz m ƒ w ù 23 wz œ ƒ n w. t š ü m š w. t l tœ xy t l t œ xy t,

3 ü t xy 109 y 748, t, y 1,619, t 2,903 w ƒ t œ , , w w ƒ ùküš 4). t l œ w t w w w» (WHO) (ICD-10) 5)» w w 2002 t 25t œ t 35% wš, ü Á Á y t 13t 18%, Á» y t 12t 17% w t 28t 30%, Á» y t 18t 19%, ü Á Á y t 15 t 16% ùkü Á» y t 26t 24%, t 26t 24%, ü Á Á y t 15% w. t, Á» y t, ü Á Á y t œ wš, 3 t t w %, %, % wš (Table 1) l 2004 ¾ t lƒ œ w t r, œ» ƒ œ w t 2002 t(11, 84.28%), ü Á Á y t(9, 6.72%), Á Á y t (5, 4.08%) š, 2003 t(14, 53.08%), Á» y t(9, 33.71%), ü Á Á y t(1, 4.10%), 2004 t(28, 59.8%), Á» y t(11, 24.96%), ü Á Á y t(2, 5.73%). wr y» ƒ œ w t 2002 t(574, 72.94%), Á Á y t(62, 7.88%), ü Á Á y t(44, 5.59%) š, 2003 t(964, 56.14%), Á» y t(350, 20.38%), k w t(135, 5.88%) š, 2004 t(1,530, 44.37%), Á» y t(972, 28.19%),, z t(476, 13.81%). t l œ w t t œ y ƒ ùkû. y y k, w. t lƒ œ w t t t (17%), t (12%), t (12%) w. t l mw œ t xƒ t xƒ t r 2004 œ t 110 Table 1. Medication classification supplied by Korea Orphan Drug Center in 2002~2004 Disease Classification Medication Number (%) Year 2002 Year 2003 Year 2004 Certain infectious and parasitic diseases 12 (17) 18 (19) 26 (24) Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism 1 (1) 3 (3) 3 (3) Diseases of the circulatory system 4 (6) 3 (3) 3 (3) Diseases of the digestive system 1 (1) Diseases of the ear and mastoid process 1 (1) 1 (1) Diseases of the eye and adnexa 2 (3) 4 (4) 4 (4) Diseases of the genitourinary system 1 (1) Diseases of the musculoskeletal system and connective tissue 1 (1) 3 (3) Diseases of the nervous system 5 (7) 11 (12) 8 (7) Diseases of the respiratory system 1 (1) 1 (1) 2 (2) Diseases of the skin andgsubcutaneous tissue 1 (1) Endocrine, nutritional and metabolic diseases 13 (18) 15 (16) 17 (15) Factors influencing health status and contact with health services 1 (1) 2 (2) 3 (3) Injury, poisoning and certain other consequences of external causes 6 (8) 5 (5) 7 (6) Mental and behavioural disorders 1 (1) 1 (1) Neoplasms 25 (35) 28 (30) 26 (24) Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified 5 (5) Total 72 (100) 93 (100) 110 (100)

4 110 Kor. J. Clin. Pharm., Vol. 16, No. 2, 2006 t xƒ t ù t t 34t (23%) š, ü, x t m w œ w t 2t (1%), ü ƒ m ù xƒ œ yw w ù y ƒ w w œ w t 36t (25%). ü xƒ t w œ w 38t (35%) 6). xƒ t w» w t w Table 2 Á» y t 11t (29%), t 9t (24%), ü Á Á y t 6t (16%) ùkû. š t l t œ w t y e t š w. t t t š Õ t w³ Ö w t t w» š w. ù y e t» w», t l q w w. ƒ w ƒ. w t l mw t œ w t, Á z w t e w», y e t y w w w. Õ t w³ Ö w t ü y ( )ƒ 20,000 w w e t w y t Table 2. Disease classification of unapproved medications supplied by Korea Orphan Drug Center in 2004 Disease Classification Medication numberg(%) Certain infectious and parasitic diseases 11 (29) Neoplasms 9 (24) Endocrine, nutritional and metabolic diseases 6 (16) Diseases of the nervous system 4 (11) Factors influencing health status and contact with health services 3 (8) Diseases of the eye and adnexa 2 (5) Diseases of the blood and blood-forming organsgand certain disorders involving the immune mechanism 1 (3) Diseases of the digestive system 1 (3) Injury, poisoning and certain other consequencesgof external causes 1 (3) Total 38 (100) x t w œ y e j w ƒ š t t w t ùkù. y e t w q w š w. y w» 20,000 w ew œ m ƒ w. w ù ƒ y w, m ù 1 ƒ 20,000 w, m w y w w š w 1). t lƒ œ w t t w ù t w, y e t w. w ³ ƒe t w³e ùkù t l w t wš», w q w š w. y e t w w ƒ yw, y w» š. t l mw œ t t wš x ƒ. wr t œ y y ƒ, t l mw œ t w y»»ƒ. t lƒ xƒ ù ü ƒ xƒ t, w t l mw œ w t xw œ w., xƒ t w eù y t» yw v ƒ 7-9). ù t ƒ w,, y,,, y sww x k w w v ƒ. y k w w, xƒ e w xƒ t w» e û w y t v w w mw w w w. ü ü xƒƒ» t Á Á z w w w š y w y w t š w w sww w w. w y t Á Á z w w t l( t t ) w t

5 ü t xy 111 w w š, š l w ü y sww. w mƒ ó ù w m w z m w w w ü l yw w w. š ƒ xƒ t w mw œ w v ƒ, y z œ w xk ù,» l t w w w w ƒw. w v w, t w w w w w. š w t w t lƒ œ w, ü qxƒ ù w t œ ƒ w w mw. œ w w w w w l w y š w., w w œ m w w. w œ w œ w w» y 2z š w w, š ü œ ü š sww w, œ t xƒ w v w. œ w mw w v ƒ. Á z š t lƒ w, w t wš w ƒ w. m w Á z y w w, xƒ t w w, t z z» w. w z» w, w w, t y ƒ» œ w w w, š š w yw ³ w v ƒ. w œ y w t l w w» w v w. w mw t œ w w xƒ ³ ƒ. Áùe y l mw Áùe y œ t t t v w t lƒ t l mw t œ ƒwš œ w t t y ƒwš. w ƒƒ y šm š y ƒ, š e w t k s x wr q wš» w. w r» y w ü xy w. ù y w ƒ v w, y w xk w w v ƒ. š t w ü xy w, ù t w w t t š ü m š. t l mw t œ ƒ ùkùš. t l œ t, œ y «, t, t l š ƒ k» z. t l t œ w w w w š, eù y xƒ t w r. eù y w xƒ t w ùkú w w e wš. t l mw t œ w w ƒ w. w Áùe y l t ¼ w x w y w xk t œ ƒ w. w x ƒ» w Á w. š x 1.»Á Á k. y w y z w. w z, š. ù y p w. w y w 2000; 5: t t yr 4. w t l yr

6 112 Kor. J. Clin. Pharm., Vol. 16, No. 2, WHO International Classification of Diseases yr 6. t t t yr kfda.go.kr/ 7. Health Canada. Special access program. Therapeutic Products Directorate, Therapeutic Goods Administration. Access to unapproved therapeutic goods in Australia. Therapeutic Goods Administration, Therapeutic Goods Administration. Drugs designated as orphan drugs. Therapeutic Goods Administration, 2002

16(1)-3(국문)(p.40-45).fm

16(1)-3(국문)(p.40-45).fm w wz 16«1y Kor. J. Clin. Pharm., Vol. 16, No. 1. 2006 x w$btf3fqpsu'psn û w m w Department of Statistics, Chonnam National University Eunsik Park College of Natural Sciences, Chonnam National University

More information

605.fm

605.fm Journal of the Korean Housing Association Vol. 19, No. 6, 2008 y k y p w sƒ Care-giver s Needs and Evaluation on the Actual Condition of the Playgrounds in Child Care Facilities y* Choi, Mock-Wha x **

More information

304.fm

304.fm Journal of the Korean Housing Association Vol. 20, No. 3, 2009 yw s w - û - A Study on the Planning of Improved-Hanok - Focused on Jeon-Nam Province - y* ** z*** **** Kang, Man-Ho Lee, Woo-Won Jeong, Hun

More information

< DC1A4C3A5B5BFC7E22E666D>

< DC1A4C3A5B5BFC7E22E666D> ¼ (Jeong, Jung Chae)*, ý (Kim, Yoon Soo), (Shin, Woo Young), Þ Ñ (Park, Jong Man) ò ý ƒ Ð (Korea Evaluation Institute of Industrial Technology) (Shin, Jae-Heyg) Š æ (Ministry of Knowledge Economy) 1. :

More information

11(5)-12(09-10)p fm

11(5)-12(09-10)p fm w wz J. Kor. Soc. Cloth. Ind. 11«5y, 2009 Vol. 11, No. 5, pp.799-807(2009) w w * k ƒm w pg p w, ƒm w q w A Qualitative Research on Pursuing Image and Appearance Management Behavior of Brides Eun-Joo Bae

More information

69-1(p.1-27).fm

69-1(p.1-27).fm 99 A 380 B 787 : wœ z w * w w wœ» A380 B787 wœ» w. wœ» ww r. w wœ» p j y w r» w. I. II. z III. A380 B787 IV. A380 V. wœ» : x VI. z VII. I. A380 B787»ƒ z wœ w, w w p j w w ƒ r. t wœ w ƒ w w wœ» š œm wš,

More information

416.fm

416.fm Journal of the Korean Housing Association Vol. 20, No. 4, 2009 œ qp œ y An Analysis of Change on the Apartment Unit Plans and the Interior Spaces Related to Women * Choi, ByungSook ** Park, JungA "CTUSBDU

More information

12(3) 10.fm

12(3) 10.fm KIGAS Vol. 12, No. 3, September, 2008 (Journal of the Korean Institute of Gas) ü LP ƒ š Database w š Á Á½z w ywœw (2008 6 10, 2008 8 12 (1 ), 2008 9 5 (2 ), 2008 9 5 k) Constructing a Database Structure

More information

9(3)-4(p ).fm

9(3)-4(p ).fm w wz J. Kor. Soc. Cloth. Ind. 9«3y, 2007 Vol. 9, No. 3, pp.319-326(2007) w xk x p w q w Analysis of Foot Characteristics According to the Classification of Foot Types of Junior High School Girls Ji-Young

More information

15.101~109(174-하천방재).fm

15.101~109(174-하천방재).fm w wz 8«4y 2008 8 pp. 101 ~ 109 w» m -,, - A Study on Warnning Criteria Investigation of Automated Rainfall Warning System -Focused on Realationship of Water Level, Discharge and Precipitation - Á Á Á Ahn,

More information

16(2)-10(p ).fm

16(2)-10(p ).fm w wz 16«2y Kor. J. Clin. Pharm., Vol. 16, No. 2. 2006 w t w BÁ½ C B w w w C x sƒ Analysis of Perception on the Bioequivalence-assured Generic Drugs Eui Kyung Lee a G and Dong Sook Kim b a Graduate School

More information

82-01.fm

82-01.fm w y wz 8«( 2y) 57~61, 2005 J. of the Korean Society for Environmental Analysis p w w Á Á w w» y l Analysis of Influence Factors and Corrosion Characteristics of Water-pipe in Potable Water System Jae Seong

More information

50(1)-09.fm

50(1)-09.fm 2006, Vol. 50, No. 1 Printed in the Republic of Korea 언빨래가마르는현상에대한중등학교화학전공교사들의인식조사 ½x Á» Á½ # Á x* w w yw y š w w # w w (2005. 5. 11 ) A Research of Secondary School Chemistry Major Teachers Perceptions

More information

10(3)-09.fm

10(3)-09.fm w y wz 10«3y 253~258 (2010.12.) Journal of Korean Society of Urban Environment ³ w Á» Á Á y w y œw (2010 11 22, 2010 12 9 k) Study on Determine of Detention Pond in Small Developed Area In-Soo Chang ½

More information

untitled

untitled ª Œª Œ 27ƒ 2B Á 2007 3œ pp. 193 ~ 199 ª ƒ w d w ƒ sƒ Methodology of Drought Assessment Using National Groundwater Monitoring Network Data «x Á½ Kwon, Hyung JoongÁKim, Seong Joon Abstract The objective

More information

415.fm

415.fm Journal of the Korean Housing Association Vol. 20, No. 4, 2009 xw z œ p w A Study on the Spatial Characteristics of the Concept of Non-sedentary in Contemporary Multi-housing Planning ½ * Kim, Mi-Kyoung

More information

14.531~539(08-037).fm

14.531~539(08-037).fm G Journal of the Korea Concrete Institute Vol. 20, No. 4, pp. 531~539, August, 2008 š x y w m š gj p { sƒ z 1) * 1) w w Evaluation of Flexural Strength for Normal and High Strength Concrete with Hooked

More information

8(2)-4(p ).fm

8(2)-4(p ).fm w wz J. Kor. Soc. Cloth. Ind. 8«2y, 2006 Vol. 8, No. 2, pp.177-182(2006) x w e w 1) Á Ÿ 1) Á»û 2) 1) ƒm w q w 2) w w w The Effect of Media on Taking Plastic Surgery Chong-Hee Yun 1), Su-Kwang Sung 1) and

More information

12(2)-04.fm

12(2)-04.fm J. Korean. Soc. Living. Environ. Sys. Vol. 12, No. 2, pp 106~111(2005) w y y w z œ k üœ» p ½ Á Á Á ³ Á Á½Ÿ w w w, *g», ** w w Effects of Strategies to Improve Indoor Air Quality at Pre-occupancy Stage

More information

16(2)-9(p ).fm

16(2)-9(p ).fm w wz 16«2y Kor. J. Clin. Pharm., Vol. 16, No. 2. 2006 ù txƒ š x B Á xk B Á C Á z B B w w w C w Regulatory System of Quasi-drugs in Korea Hyun Soon Sohn a, Hyun Taek Shin a, In Sook Song b, and Hyo Jung

More information

<30332DB9E8B0E6BCAE2E666D>

<30332DB9E8B0E6BCAE2E666D> kœw» y w k p y w k» z wš ye z w mdkqvqrg üœ» y» Ÿ w kœwgeqgpikpggtkpiy glj GEQVGEJPQNQI[ œw w k w yz š y j œ w m w y ˆ mw y» kœ w k û ³ y ƒ ƒ» ƒ w œw w w y ƒƒ» k z w» %NGCP 9CVGT #EV wšw y ù» œ w w w t

More information

21(1)-5(10-57)p fm

21(1)-5(10-57)p fm w wz 21«1y Kor. J. Clin. Pharm., Vol. 21, No. 1. 2011 m w : w w B Á ³ C B û w w w C û w w w (2010 12 3 Á2011 3 21 Á2011 3 22 ) A Descriptive Research on Drug Use Pattern of Narcotic Analgesics: a Case

More information

32(4B)-04(7455).fm

32(4B)-04(7455).fm 32«4ByÁ 2012 7 pp. 233 ~ 242 œ w w w y œ r Estimation of Domestic Water Supply Benefit Using Demand Function Approach ³ Á Á½¼yÁ Yeo, Kyu DongÁYi, Choong SungÁKim, Gil HoÁLee, Sang Won Abstract In the past,

More information

21(1)-3(10-64)p fm

21(1)-3(10-64)p fm w wz 21«1y Kor. J. Clin. Pharm., Vol. 21, No. 1. 2011 3» y t sƒv e z t ½ Á x Á xk w w w (2010 12 31 Á2011 3 11 Á2011 3 13 ) Comparison of Drug Prescriptions Before and AfterG Computerized Drug Utilization

More information

10(3)-12.fm

10(3)-12.fm w y wz 10«3y 273~280 (2010.12.) Journal of Korean Society of Urban Environment p yá xá½k w y œw (2010 9 15, 2010 12 2 k) Analysis of Characteristics of Delivered Nonpoint Source Pollution at Forested Watershed

More information

17.393~400(11-033).fm

17.393~400(11-033).fm Journal of the Korea Concrete Institute Vol. 23, No. 3, pp. 393~400, June, 2011 GGGGG DOI 10.4334/JKCI.2011.23.3.393 x RC { sƒ y y 1) *Á½ 1) Á 2) 1) y w œw 2) w œw Bond Strength Evaluation of RC Beams

More information

fm

fm J. Fd Hyg. Safety 20(4), 253 257 (2005) ü w w w Áy»xÁ Á Á Á«Á Áw Á x Á yx Á½ Á½ Á½ t t» t t ƒ q Study on Management of Artificial Flavors in Korea Tal-Soo Lee, Young-Mi Jang, Ki-Hyoung Hong, Sung-Kwan

More information

50(5)-07.fm

50(5)-07.fm Printed in the Republic of Korea w 3w yû x w w w Á x* w w w yw (2006. 3. 14 ) A research of the Difference in Teaching Styles and Understanding of 9 th Grade Students About Lead-iodide Precipitation Reaction

More information

82.fm

82.fm Journal of the Korean Ceramic Society Vol. 44, No. 9, pp. 524~528, 2007. Determination of Critical Chloride Content of Ordinary Portland Cement Concrete by Linear Polarization Technique Hong-Sam Kim, Hai-Moon

More information

202.fm

202.fm Journal of the Korean Housing Association Vol. 19, No. 2, 2008 w w w w Physical Identities of Bukchon Hanok Area Viewed from Literary Geography * Park, Cheol-Soo "CTUSBDU This study explores the beneficial

More information

14(4) 09.fm

14(4) 09.fm J. Korean. Soc. Living. Environ. Sys. Vol. 14, No. 4, pp 343~350(2007) w y y w z 14 «4 y 2007 yw» l s p»xá ³ *w w w œw, **w w w The Property of Pressure Distribution of Hybrid Underfloor Air Distribution

More information

07.051~058(345).fm

07.051~058(345).fm w wz 8«3y 2008 6 pp. 51 ~ 58 m qp yp š w k sƒ Evaluation of Dynamic Modulus based on Aged Asphalt Binder y*á **Á***Á**** Lee, Kwan-HoÁCho, Kyung-RaeÁLee, Byung-SikÁSong, Yong-Seon Abstract Development

More information

10(1)-08.fm

10(1)-08.fm w y wz 10«( 1y) 47~52, 2007 J. of the Korean Society for Environmental Analysis œ w t y ½ xá Á x Á½ Á x* Ÿ œ, * w œw Optimization of Coagulation In The Conventional Water Treatment Plant Jun-Hyun Kim,

More information

, 66~67dB»e 55dB š 12dBù û»e(65db) w 70~71dB ñ. ù ü»» 35dB(ü), 45dB() r. w» w 1938 œk ³Ø w, 1960 Ø, 1968 ³Ø w. w 1972 ³Ø w w ³ ƒwš, ù y Ø w ³w

, 66~67dB»e 55dB š 12dBù û»e(65db) w 70~71dB ñ. ù ü»» 35dB(ü), 45dB() r. w» w 1938 œk ³Ø w, 1960 Ø, 1968 ³Ø w. w 1972 ³Ø w w ³ ƒwš, ù y Ø w ³w ª Œª Œ 26ƒ 1D Á 2006 1œ pp. 1~11 ª qp md w An Analysis of the Traffic Noise Measurement Plans of Apartment Complexes A Case on the North Riverside Expressway in Seoul Á Kang, Jun MoÁLee, Sung Kyung Abstract

More information

<30312D303720B9DAC1A4BCF62E666D>

<30312D303720B9DAC1A4BCF62E666D> wz (010), 40«1y J. Kor. Pharm. Sci., Vol. 40, No. 1, 1-7 (010) 생물학적동등성시험을위한통계처리프로그램 (BioEquiv) 의개발 z 1 Áyù Á 3 Á 4 Á 1 1 û w m w, w wx, 3 û w w w, 4 û w w w (009 11 0 Á09 1 11 Á010 1 6 ) Developmet of

More information

51(2)-09.fm

51(2)-09.fm 2007, Vol. 51, No. 2 Printed in the Republic of Korea xw yw w w» e w z Á Á y Áw # Á k * w yw w w w w w # w w w (2006. 10. 30 ) Influences of Current Education Programs for Preservice Chemistry Teachers

More information

w w l v e p ƒ ü x mw sƒw. ü w v e p p ƒ w ƒ w š (½kz, 2005; ½xy, 2007). ù w l w gv ¾ y w ww.» w v e p p ƒ(½kz, 2008a; ½kz, 2008b) gv w x w x, w mw gv

w w l v e p ƒ ü x mw sƒw. ü w v e p p ƒ w ƒ w š (½kz, 2005; ½xy, 2007). ù w l w gv ¾ y w ww.» w v e p p ƒ(½kz, 2008a; ½kz, 2008b) gv w x w x, w mw gv ª Œª Œ 30ƒ 5A Á 2010 9œ pp. 475 ~ 484 gj p ª v e p p PSC ƒ gv : II. x w Precast Concrete Copings for Precast Segmental PSC Bridge Columns : II. Experiments and Analyses ½kzÁ½ Á zá x Kim, Tae-HoonÁKim,

More information

<30312DC0CCC7E2B9FC2E666D>

<30312DC0CCC7E2B9FC2E666D> 균류의다양성과역할 이향범 û w œw 머리말 k w š ³ q š yw < Ð >» w ww k w w v š q w Á Á w tyw š 2QKPVKPI CPF *[FG ú ƒ x %QPXGPVKQP QP $KQNQIKECN &KXGTUKV[ %$&» w w ««wš y w» š x ƒ w œ ƒ» ƒ œsw w ³ wš ù š y š ƒ t š ƒ wš»ƒ

More information

15(1)-04(국)(p.27-33).fm

15(1)-04(국)(p.27-33).fm w wz «y Kor. J. Clin. Pharm., Vol., No.. y sƒ Áwx Á ³ Á Ÿ y w w w w w Analysis of Drug Use Reviews in Pediatirc Inpatients Eun Jeong Shin, Hun Joo Ha Wan Gyoon Shin and Kwang Jun Park Graduate School of

More information

49(6)-06.fm

49(6)-06.fm Journal of the Korean Chemical Society 2005, Vol. 49, No. 6 Printed in the Republic of Korea 중학교과학교과서불꽃반응실험에서선스펙트럼관찰의문제점분석및개선연구 ½ Á Á * w w yw (2005. 10. 4 ) An Analysis and Improvement of the Line Spectrum

More information

31(3B)-07(7055).fm

31(3B)-07(7055).fm ª Œª Œ 31ƒ 3B Á 2011 5œ pp. 265 ~ 276 ª w w s³ The Correlation Between the Moving Average of Precipitation and Groundwater Level in Korea Á½û» Yang, Jeong-SeokÁKim, Nam-Ki Abstract Precipitation data and

More information

fm

fm [ ] w wz DOI: 10.3740/MRSK.2009.19.12.692 Kor. J. Mater. Res. Vol. 19, No. 12 (2009) y INCONEL 718w Gas Tungsten Arc Welding» p sƒ ½»y Á *Á *Á y** ( ) d lj p wœq, *w wœ» q **( ) d lj p t Mechanical Properties

More information

10(3)-02.fm

10(3)-02.fm w y wz 10«3y 203~211 (2010.12.) Journal of Korean Society of Urban Environment w ù p yá k«áyw *Á xá½k w y œw Á* y w (2010 9 15, 2010 12 2 k) Characterization of Nonpoint Source Pollutant Loads from the

More information

69-1(p.1-27).fm

69-1(p.1-27).fm 28 wœ p y mw š * x yw x mw šƒ w ƒ š w x ƒ y y mw œw w w x v w š w. x mw w p j wš y y w ù wœ p y mw yw w ƒ w. I. II. wœ ü wœ xy III. wœp y mw š IV. I. 1. e w ƒ e w s x y e š p š w v. w x yw x mw šƒ w ƒ.

More information

01.01~08(유왕진).fm

01.01~08(유왕진).fm JOURNAL OF KOREA SOCIETY OF PACKAGING SCIENCE & TECHNOLOGY. Vol. 14, No. 1 1~8 (2008) s w Á w» w Comparative Study on the Changes and Prospects of Flexible Food Packaging Design Kyung Soo Noh and Wang

More information

51(4)-13.fm

51(4)-13.fm Journal of the Korean Chemical Society 2007, Vol. 51, No. 4 Printed in the Republic of Korea w x - w y *Á š w w w yw (2007. 3. 28 ) Case Study on Verbal Interactions of Teacher-Small Group StudentsG in

More information

11(5)-7(09-37)p fm

11(5)-7(09-37)p fm w wz J Kor Soc Cloth Ind 11«y 009 Vol 11 No pp73-763009) Ášw k ÁÁ w w Comparison of Actual Status and Satisfaction of School Uniform between Middle and High School Students Ji-Min Lee Jeong-Ran Lee and

More information

» t d» y w š q, w d» y ƒ ƒ w tree-ring t w d» y ƒ w š w. w tree-ring t mw»z y p q w š w. Tree-ring t mw, 500» ƒ wš p w» ƒ, y»z p wš»»z y. ù tree-ring

» t d» y w š q, w d» y ƒ ƒ w tree-ring t w d» y ƒ w š w. w tree-ring t mw»z y p q w š w. Tree-ring t mw, 500» ƒ wš p w» ƒ, y»z p wš»»z y. ù tree-ring ª Œª Œ 29ƒ 5B Á 2009 9œ pp. 409 ~ 417 ª»z t ùkù»z yp Synoptic Change Characteristics of the East Asia Climate Appeared in Seoul Rainfall and Climatic Index Data y yá½ zá Á Hwang, Seok HwanÁKim, Joong HoonÁYoo,

More information

ePapyrus PDF Document

ePapyrus PDF Document Introduction 373 374 Definition of Child Abuse 375 376 Current Status of Child Abuse 377 378 Causes of Child Abuse 379 Signs and Sequelae of Child Abuse 380 A B C 381 382 383 384 385 Clinical Evaluation

More information

< C0E5BFC1C0E72E666D>

< C0E5BFC1C0E72E666D> w wz 9«4y 2009 8 pp. 0 ~ 0 지역회귀분석을이용한홍수피해위험도산정 Flood Risk Estimation Using Regional Regression Analysis 장옥재 * 김영오 ** Jang, Ock-Jae ½ Kim, Young-Oh Abstract Although desire for living without hazardous

More information

10(3)-10.fm

10(3)-10.fm w y wz 10«3y 259~264 (2010.12.) Journal of Korean Society of Urban Environment w gj p p y Á Á½k * w m œw Á* w y œw (2010 9 28, 2010 10 12 k) Characteristics of Antiwashout Underwater Concrete for Reduction

More information

14(2) 02.fm

14(2) 02.fm J. Korean. Soc. Living. Environ. Sys. Vol. 14, No. 2, pp 117~125(2007) w y y w z sm Ÿ š w œ l ³Á½ * w, **w w w Impact of Photosensor Sensitivity on the Control Performance of a Daylight Dimming System

More information

4.fm

4.fm Journal of the Korean Ceramic Society Vol. 46, No. 1, pp. 30~34, 2009. Optimization of Glass Wafer Dicing Process using Sand Blast Won Seo, Young-mo Koo*, Jae-Woong Ko**, and Gusung Kim Department of Electronic

More information

(2)-02(최경자).fm

(2)-02(최경자).fm Res. Plant Dis. 16(2) : 148-152 (2010) Research in Plant Disease The Korean Society of Plant Pathology z w t w sƒ Á½ Á Á yá * w yw yw l Development of Effective Screening Method and Evaluation of Radish

More information

27(5A)-07(5806).fm

27(5A)-07(5806).fm ª Œª Œ 27ƒ 5A Á 2007 9œ pp. 753 ~ 758 gj pœw gj p { x A New Test Method for Pure Isotropic Flexural Tensile Strength of Concretes Ÿ Á y Á x Zi, GoangseupÁOh, HongseobÁChoi, Jinhyek Abstract Proposed is

More information

untitled

untitled G Journal of the Korea Concrete Institute Vol. 20, No. 3, pp. 345~356, June, 2008 p -k w gj p k k 1) Á y 2) * 1) ƒm w w 2) w w Direct Inelastic Design of Reinforced Concrete Members Using Strut-and-Tie

More information

16(1)-4(국문)(p.9-13).fm

16(1)-4(국문)(p.9-13).fm w wz 16«1y Kor. J. Clin. Pharm., Vol. 16, No. 1. 2006 w w w BÁy CÁ wšdá DÁ DÁ ³D B C û w w w D û w w w Survey Analysis of Familiarity and Willingness of the Use of Auxiliary Label in Community Pharmacists

More information

16(4)-05.fm

16(4)-05.fm w m y Vol. 16(4), p. 53~61, 2011 œ 광물찌꺼기에함유된오염물질의안정화를위한표면차폐재의성능평가 ½ ³ 1 Á 1 *Á½ 2 Á½ 2 Á 3 Á 3 1 w œ w œw, 2 ( ) f lp, 3 w Ÿw œ Ÿw» Evaluation of Surface Water-preventing Materials on Stabilization of

More information

100(4)-24(90).fm

100(4)-24(90).fm x» w e full name w.. Jour. Korean For. Soc. Vol. 100, No. 4, pp. 000~000 (2011) JOURNAL OF KOREAN FOREST SOCIETY» zœx y x 1 Á 2 Á 1 1 w w, 2 w w Governance Types of Corporate Philanthropic Forestry Activities

More information

10.063~070(B04_윤성식).fm

10.063~070(B04_윤성식).fm J. of Advanced Engineering and Technology Vol. 1, No. 1 (2008) pp. 63-70 Mg-3%Al-1%Zn w ƒœ» y Á x*á **Á Á w œw *w s l I ûer ** t Effect of Thermomechanical Treatment on Microstructure and Mechanical Properties

More information

한국성인에서초기황반변성질환과 연관된위험요인연구

한국성인에서초기황반변성질환과 연관된위험요인연구 한국성인에서초기황반변성질환과 연관된위험요인연구 한국성인에서초기황반변성질환과 연관된위험요인연구 - - i - - i - - ii - - iii - - iv - χ - v - - vi - - 1 - - 2 - - 3 - - 4 - 그림 1. 연구대상자선정도표 - 5 - - 6 - - 7 - - 8 - 그림 2. 연구의틀 χ - 9 - - 10 - - 11 -

More information

(163번 이희수).fm

(163번 이희수).fm Journal of the Korean Ceramic Society Vol. 48, No. 4, pp. 323~327, 2011. DOI:10.4191/KCERS.2011.48.4.323 Electrical Properties and Temperature Stability of Dysprosium and Erbium Co-doped Barium Titanate

More information

fm

fm Journal of the Korea Concrete Institute Vol. 24, No. 1, pp. 079~086, February, 2012 GGGGG http://dx.doi.org/10.4334/jkci.2012.24.1.079 섬유보강콘크리트에묻힌 GFRP 보강근의부착거동에대한섬유영향평가 1) Á½ 1) Á 2) Á 1) * 1) ³ w y lœw

More information

15(2)-07.fm

15(2)-07.fm J. Korean. Soc. Living. Environ. Sys. Vol. 15, No. 2, pp 145~154(2008) w y y w z 15 «2 y 2008 ³ l w sm ½ Á yáy * w y w, ** w w Recommended Sensitivity of a Fully-shielded Photosensor for a Daylight Dimming

More information

50(4)-10.fm

50(4)-10.fm 2006, Vol. 50, No. 4 Printed in the Republic of Korea 칼코겐이도핑된망간산화물의저온합성연구 k Á z Á, *Áy, * y w ù w yw x ù l w» ww (2006. 7. 13 ) Chimie Douce Synthesis of Chalcogen-Doped Manganese Oxides Seung Tae Lim,GDae

More information

15(2)-13.fm

15(2)-13.fm w wz 15«2y Kor. J. Clin. Pharm., Vol. 15, No. 2. 2005 ù xw t wš x Á Á½ Á x Á x Á xk w w w w w Current Drug Classification System in Korea and Its Improvement Hyun Soon Sohn 1, Ock Hee Oh 2, Jong Joo Kim

More information

3.fm

3.fm Journal of the Korean Ceramic Society Vol. 44, No. 1, pp. 12~17, 2007. A Study on the Preparation of Bone Ash and Celadon Bone Body Using Pig Bone Jae-Jin Jeong, Sang-Hee Lee, Yong-Seok Lee,* and Byung-Ha

More information

26(3D)-17.fm

26(3D)-17.fm 26ƒ 3D Á 2006 5œ pp. ~ ª y w qp yw k d Predictive Equation of Dynamic Modulus for Hot Mix Asphalt with Granite Aggregates yá½x Á Lee, Kwan-HoÁKim, Hyun-OÁJang, Min-Seok Abstract The presented work provided

More information

50(6)-04.fm

50(6)-04.fm Journal of the Korean Chemical Society 2006, Vol. 50, No. 6 Printed in the Republic of Korea m w MBL x x y p *Á yá Á Á w w yw w w yw (2006. 8. 16 ) Characteristics of Verbal Interactions AccordingG to

More information

27(5A)-15(5868).fm

27(5A)-15(5868).fm ª Œª Œ 27ƒ 5A Á 2007 9œ pp. 701 ~ 711 ª x 3 k w Radial 3-D Elastodynamic Infinite Elements Á Á½ Seo, Choon-GyoÁYun, Chung-BangÁKim, Jae-Min Abstract This paper presents new three dimensional radial infinite

More information

12.077~081(A12_이종국).fm

12.077~081(A12_이종국).fm J. of Advanced Engineering and Technology Vol. 1, No. 1 (2008) pp. 77-81 y w» e wx Á w œw Fabrication of Ceramic Batch Composition for Porcelain by Using Recycled Waste Ceramic Powder Hyun Guen Han, and

More information

82-02.fm

82-02.fm w y wz 8«( 2y) 00~00, 2005 J. of the Korean Society for Environmental Analysis Calix[6]arene w k š w *Á x Á Á«ƒm w yw, *w w yw Cesium Ion Selective Solid Contact Electrodes Based on Calix[6]arene Won-sik

More information

( )-83.fm

( )-83.fm Journal of the Korean Ceramic Society Vol. 8, No. 1, pp. 0~5, 011. DOI:10.191/KCERS.011.8.1.00 Solidification of Heavy Metal Ions Using Magnesia-phosphate Cement HunG Choi, Hyun Ju Kang, Myung Shin Song,

More information

16(5)-06(58).fm

16(5)-06(58).fm Journal of Korean Powder Metallurgy Institute DOI: 10.4150/KPMI.2009.16.5.336 y-y w Sm-Fe w ƒ w zá *Á w»» The Effect of Excess Samarium Oxide on the PreparationG of Sm-Fe Alloy Powder by Reduction-diffusion

More information

8(3)-15(p ).fm

8(3)-15(p ).fm w wz J. Kor. Soc. Cloth. Ind. 8«3y, 2006 Vol. 8, No. 3, pp.357-362(2006) w p k sƒ ½ Á Á w w w A Study on the Mechanical and Hand Properties of the Lining Fabrics Myung-Ok Kim, Mi-Kyung Uh and Myung-Ja

More information

untitled

untitled [ ] œwz, 21«6y(2008) J. of the Korean Society for Heat Treatment, Vol. 21, No. 6, (2008) pp. 300~306 š y w p x*, **Á **Áy y* * ** w œ w œw, w» gœ Solid State Diffusion Brazing of the Aluminum Alloy Castings

More information

<312D303128C1B6BAB4BFC1292E666D>

<312D303128C1B6BAB4BFC1292E666D> k Ÿy y y + ûz m Ì ˆw k Ÿ ø ky w y y» wk Ÿ v w k w w ƒ Ÿ ew k Ÿy yø k Ÿ ý k z» w ƒ w Ÿ y k y w x mw w w ³Ÿ wšy v mw y w r œw yÿ ý w z»ÿ Ÿ»» Ÿ ¾ Ÿ 6TCXGN 9GGMN[ ýw k Ÿ Ÿ ƒ š wš y w k Ÿ ƒ m ³ w w y y y 'EQVQWTKUO

More information

3-15(3)-05(이주희).fm

3-15(3)-05(이주희).fm w CAD/CAM wz 15«3y 2010 6 pp. 189-203 œ w w *, **, x***, v ** The Conceptual Design of Semi-submersible Type Mobile Harbor Using Axiomatic Design Principles Joohee Lee*, Seongjin Yoon**, Hyun Chung***

More information

03-ÀÌÁ¦Çö

03-ÀÌÁ¦Çö 25 3 (2004 9 ) J Korean Oriental Med 2004;25(3):20-31 1), 2), 3) 1) 2) 3) Grope for a Summary Program about Intellectual Property Protection of Traditional Knowledge (TK)etc. Discussed in WIPO Hwan-Soo

More information

18211.fm

18211.fm J. of the Korean Sensors Society Vol. 18, No. 2 (2009) pp. 168 172 p k ù p p l xá xá ³ Á *Á w * Fabrication of the CNT-FET biosensors with a double-gate structure Byunghyun Cho, Byounghyun Lim, Jang-Kyoo

More information

27(3D)-07.fm

27(3D)-07.fm ª Œª Œ 27ƒ 3D Á 2007 5œ pp. 269~274 ª d x sƒ» w The Development of Safety Evaluation Criteria for the Alignment Design Consistency Methods on Rural Highways Á Á Lee, SooilÁWon, JaimuÁLee, Heeseung Abstract

More information

19(1) 02.fm

19(1) 02.fm Korean J. Crystallography Vol. 19, No. 1, pp.7~13, 2008 Ÿ (ICISS) w š t w (2): t w y w œw Surface Structure Analysis of Solids by Impact Collision Ion Scattering Spectroscopy (2): Atomic Structure of Semiconductor

More information

06.177~184(10-079).fm

06.177~184(10-079).fm Journal of the Korea Concrete Institute Vol. 23, No. 2, pp. 177~184, April, 2011 GGGGG DOI 10.4334/JKCI.2011.23.2.177 x w w MRS w p s y 1) Á z 2) Á x 3) * 1) wû w œw 2) w œw 3) w Nonlinear Analysis for

More information

DBPIA-NURIMEDIA

DBPIA-NURIMEDIA Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 18, No. 5, 425-430, 2005» 677*4 Ÿ w sƒ ½»x Á Á½ k w y w, w y œw Some considerations for the analytical approaches to measure atmospheric

More information

19(1)-1(09-01)p.1-17.fm

19(1)-1(09-01)p.1-17.fm w wz 19«1y Kor. J. Clin. Pharm., Vol. 19, No. 1. 2009 ü t y BÁ CÁ wc B Ÿ w w w C w w w (2009 2 5 Á2009 6 10 Á2009 6 25 ) Analysis of Drug Interaction Information Young Sook Lee, Ji Seon Lee and Sukhyang

More information

11(1)-15.fm

11(1)-15.fm w y wz 11«1y 73~80 (2011.8.) Journal of Korean Society of Urban Environment SWMM 을이용한도시지역비점오염부하저류시설용량산정 Áw«Á *Áy **Á½ yá½ Á x w w Á* û w y œw Á** w y lœw (2011 6 13, 2011 6 27 k) Determine Capacity of

More information

A 617

A 617 Special Issue Diabetic Retinopathy Won Ki Lee, M.D. Department of Ophthalmology The Catholic University of Korea College of Medicine Kangnam St. Mary s Hospital E mail : wklee@catholic.ac.kr Abstract R

More information

11(4)-13(09-12)p fm

11(4)-13(09-12)p fm w wz J. Kor. Soc. Cloth. Ind. 11«4y, 2009 Vol. 11, No. 4, pp.633-640(2009) 20Á30 û v k x k y ½z **Á* w w **, w w * Man's Hair style Preference according to Lifestyle in Age 20's and 30's Hyo-Jung Kim**

More information

04-46(1)-06(조현태).fm

04-46(1)-06(조현태).fm w œwz, 46«1y 2009 Textile Science and Engineering Vol. 46, No. 1, 2009 ù 2'6 wx xk Á «w œ w» Áq œw k 1PG $CVJ1PG 5VGR &[GKPI H 0[NP2'6 5RNKV 6[RG /KETHKDGT *[GP 6CG %J CPF%JWN-YP2CTM &GRCTVOGPV H 1TICPKE

More information

23(2) 71.fm

23(2) 71.fm J. of Korean Institute of Fire Sci. & Eng. [ ] Vol. 23, No. 2, 2009 w w w w w w Stud on the Fire Behaviour of Composite Beam with Loading and Unloading ½ *Á û**á½ ***Á½ Sung-Bae Kim* Chang-Nam Lee** Woo-Chul

More information

8.fm

8.fm wz (2009), 39 «2y J. Kor. Pharm. Sci., Vol. 39, No. 2, 127-131 (2009) t y»» w»» w s sƒ ½x»Á½ ká w 1 Á x 1 Á½ 1 Á½ 2 Áx 2 Á û w w w, 1 t t»»», 2 û w œ w (2009 3 25 Á2009 3 31 Á2009 4 1 ) Cytotoxicity Evaluation

More information

93.fm

93.fm Journal of the Korean Ceramic Society Vol. 45, No. 10, pp. 625~630, 2008. Effect of Storage Conditions on the Setting Properties of Brushite Bone Cement Containing Granular β-tricalcium Phosphate Sun-Ae

More information

DBPIA-NURIMEDIA

DBPIA-NURIMEDIA Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 18, No. 5, 436-443, 2005,1"$ w Q) t p z Á 1w w œw 2 w œ yw Effects of surface properties and solution ph on the pollutants removal of

More information

5/12¼Ò½ÄÁö

5/12¼Ò½ÄÁö 2010년 5월호 통권 제36호 이플 은 청순하고 소박한 느낌을 주는 소리의 장점을 살려 지은 순 한글 이름으로 고객 여러분께 좋은 소식을 전해드리고자 하는 국제이주공사의 마음입니다. 늦었습니다. 봄도 늦었고, 저희 소식지도 늦었습니다. 봄 소식과 함께 전하려던 소식지가 봄 소식만큼이나 늦어져 버렸습니다. 격월로 나가던 소식지를 앞으로 분기별로 발행할 예정입니다.

More information

(4)-03(박상철).fm

(4)-03(박상철).fm w CAD/CAM wz 15«4y 2010 8 pp. 271-278 w y» *, ¼ ** A Synthetic Enviornment Based Engagement Simulation Model Sang Chul Park* and Kil Young Seong** ABSTRACT Weapon systems for future war require operating

More information

삼교-1-4.hwp

삼교-1-4.hwp 5 19대 총선 후보 공천의 과정과 결과, 그리고 쟁점: 새누리당과 민주통합당을 중심으로* 윤종빈 명지대학교 논문요약 이 글은 19대 총선의 공천의 제도, 과정, 그리고 결과를 분석한다. 이론적 검증보다는 공천 과정의 설명과 쟁점의 발굴에 중점을 둔다. 4 11 총선에서 새누리당과 민주통합당의 공천은 기대와 달랐고 그 특징은 다음과 같이 요약될 수 있다. 첫째,

More information

10.123~130.fm

10.123~130.fm Atmosphere. Korean Meteorological Society Vol. 21, No. 1 (2011) pp. 123-130 w EUV-B p k D w w Á½ y* w»y w ( : 2010 12 1, : 2011 2 18, y : 2011 3 19 ) The Radiative Characteristics of EUV-B over the Korean

More information

43(5)-1.fm

43(5)-1.fm w œwz, 43«5y 2006 Textile Science and Engineering Vol. 43, No. 5, 2006 용융블렌드를이용한 PLA/PEG 블록공중합체의제조 Á w œw k Preparation of PLA/PEG Block Copolymer via Melt Blend %JGQN 5QQ ;QQP CPF &QPI 5WP,K 8q g yq r

More information

fm

fm w sw x w w w x y w w sw J[FTQRJ[VG w 5CVQƒw e UWDOGTIGF J[FTQRJ[VG šw z w w w w ù p w s w r w z w w kw p ³ w š w z w š w w kw mƒ w š w s w q 8CNNKUPGTKC FGPUGUGTTWNCVC½ ½ Õ 6[RJC NCZKOCPPK -KO CPF %JQK

More information