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1 Comparison of physical fitness, indices of lifestyle disease, and biochemical property of muscle according to sarcopenia and obesity in elderly women Won-Sang Jung, Hyun-Seok Cho, & Man-Gyoon Lee* Kyung Hee University [Purpose] [Methods] m2 [Results] [Conclusion] Key words: ㆍ

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3 m2 ㆍ cm kg kg m2 kg kg Table 1. Physical characteristics of subjects Variables +obesity F value P value Age(yrs) 77.55± ± ± ± Height( cm ) ± ± ± ± Body weight( kg ) 55.73±0.96a 47.66±0.93b 61.00±1.06c 53.80±1.12a *** BMI( kg / m2 ) 24.12±0.33a 20.73±0.32b 26.45±0.35c 23.59±0.39a *** Fat-free mass( kg ) 32.80±0.55a 31.62±0.44a 36.40±0.65b 35.65±0.66b *** Fat mass( kg ) 21.98±0.71a 14.77±0.58b 23.31±0.59a 16.70±0.55b *** Percent body fat(%) 39.43±0.80a 30.93±0.83b 38.06±0.49a 30.88±0.59b *** ASM( kg / m2 ) 5.06±0.11a 5.24±0.04a 6.12±0.07b 6.15±0.10b ***

4 ml µ ml l α

5 Table 2. Comparison of physique and body composition among four groups Variables +obesity F values P value Height( cm ) ± ± ± ± Body weight( kg ) 55.73±0.96 a 47.66±0.93 b 61.00±1.06 c 53.80±1.12 a *** BMI( kg m -2 ) 24.12±0.33 a 20.73±0.32 b 26.45±0.35 c 23.59±0.39 a *** Waist circumference( cm ) 90.75±1.37 a 80.66±1.21 b 92.67±1.30 a 86.16±0.97 c *** Hip circumference( cm ) 93.80±1.09 a 88.12±1.07 b 95.12±0.87 a 90.86±0.52 c *** Waist-hip ratio 0.97±0.01a c 0.92±0.01 b 0.97±0.01 a 0.95±0.01 c *** Fat-free mass( kg ) 32.80±0.55 a 31.62±0.44 a 36.40±0.65 b 35.65±0.66 b *** Fat mass( kg ) 21.98±0.71 a 14.77±0.58 b 23.31±0.59 a 16.70±0.55 b *** Percent body fat(%) 39.43±0.80 a 30.93±0.83 b 38.06±0.49 a 30.88±0.59 b *** Table 3. Comparison of daily living fitness among four groups Variables +obesity F values P value Left grip strength( kg ) 20.08±1.06 a 19.73±0.72 a 23.36±0.62 b 24.27±0.56 b *** Right grip strength( kg ) 21.04±0.86 a 21.25±0.82 a 23.96±0.69 b 25.22±0.67 b *** Upper arm flexion(times) 20.52±1.10 a 21.04±0.90 a 23.39±0.63 b 23.41±0.59 b * Chair sit to stand(times) 17.60±1.31 a 18.99±0.92 ab 20.43±1.16 ab 21.54±0.64 b * Sit-and-reach( cm ) 10.54±1.93 a 11.12±1.48 a 11.81±1.38 a 15.47±1.09 b * Back scratch( cm ) 16.70± ± ± ± One leg standing: left (sec) 10.91± ± ± ± One leg standing: right(sec) 9.00± ± ± ± Functional reach( cm ) 26.91± ± ± ± Tandem test(sec) 11.94±0.74 a 10.91±0.67 b 10.31±0.58 ab 9.46±0.54 b * Up and go(sec) 7.12±0.41 a 6.88±0.25 a 6.50±0.20 ab 6.14±0.17b * Foot stepping(times) 26.95± ± ± ± Carrying beans using chopsticks 12.43± ± ± ± Pegboard 33.69± ± ± ± VO2max(ml kg -1 min -1 ) 23.65±1.01 a 24.41±1.11 a 25.84±0.54 ab 27.14±0.88 b * Table 4. Comparison of isokinetic function(60 /sec) among four groups Variables +obesity F values P value Peak torque(nm) 62.11±4.54 a 62.51±3.03 a 73.11±2.40 b 77.70±4.17 b ** Peak torque per BW(%BW) ±8.68 a ±6.69 ab ±4.54 a ±7.36 b * Extension Total work(nm) ± ± ± ± Total work per BW(%BW) ± ± ± ± Average power(w) 37.75±2.76 a 38.49±1.63 a 42.29±1.57 ab 46.44±2.75 b * Average power per BW(%BW) 67.38±5.38 a 78.45±3.63 ab 70.23±2.53 a 83.89±4.69 b * Peak torque(nm) 35.14± ± ± ± Peak torque per BW(%BW) 62.85±5.38 a 72.20±4.56 ab 64.31±3.57 a 78.45±4.54 b * Flexion Total work(nm) 80.81± ± ± ± Total work per BW(%BW) ± ± ± ± Average power(w) 23.24±2.05 a 24.53±1.38 a 27.01±1.83 ab 30.47±1.90 b * Average power per BW(%BW) 41.43±3.84 a 49.77±3.15 ab 45.70±2.98 a 55.45±3.35 b *

6 Table 5. Comparison of variables related to hypertension among four groups Variables +obesity F values P value Heart rate(beats min -1 ) 79.72±2.46 a 74.80±2.31 ab 77.04±2.23 a 70.45±1.83 b * SBP(mmHg) ± ± ± ± DBP(mmHg) 85.92± ± ± ± MAP(mmHg) ± ± ± ± PP(mmHg) 49.01± ± ± ± RPP ± a ± ab ± a ± b * Table 6. Comparison of variables related to diabetes mellitus among four groups Variables +obesity F values P value FPG( mg dl -1 ) ± ± ± ± FPI(μU ml -1 ) 7.86±0.85 a 5.52±0.56 b 7.33±0.69 a 5.60±0.41 b * HOMA-IR 2.26±0.27 a 1.51±0.19 bc 2.09±0.27 ac 1.41±0.10 b * Table 7. Comparison of variables related to hyperlipidemia among four groups Variables +obesity F values P value TC( mg dl -1 ) ± ± ± ± TG( mg dl -1 ) ± ± ± ± LDL-C( mg dl -1 ) ± ± ± ± HDL-C( mg dl -1 ) 43.20±2.18 a 51.72±2.64 bc 48.07±1.68 ac 53.99±2.41 b ** Table 8. Comparison of variables related to atherosclerosis among four groups Variables +obesity F values P value TC/HDL-C ratio 4.62±0.28 a 3.68±0.23 b 3.97±0.22 ab 3.47±0.21 b ** TG/HDL-C ratio 3.46± ± ± ± LDL-C/HDL-C ratio 2.93±0.22 a 2.18±0.21 b 2.39±0.18 ab 1.98±0.17 b ** Table 9. Comparison of biochemical property of muscle among four groups Variables +obesity F values P value hs-crp( mg l -1 ) 1.44± ± ± ± IL-6(pg ml -1 ) 1.95±0.26 a 1.60±0.29 ab 1.67±0.21 a 1.13±0.10 b * IGF-1(ng ml -1 ) ± ± ± ±

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15 from fasting plasma glucose and insulin concentrations in man. Diabetologia, 28(7), Milanović, Z., Pantelić, S., Trajković, N., Sporiš, G., Kostić, R., & James, N.(2013). Age-related decrease in physical activity and functional fitness among elderly men and women. Clinical Interventions in Aging, 8, Pisciottano, M. V. C., Pinto, S. S., Szejnfeld, V. L., & de Moura Castro, C. H.(2014). The relationship between lean mass, muscle strength and physical ability in independent healthy elderly women from the community. The Journal of Nutrition, Health & Aging, 18(5), Poggiogalle, E., Lubrano, C., Gnessi, L., Mariani, S., Lenzi, A., & Donini, L. M.(2016). Fatty liver index associates with relative sarcopenia and GH/IGF-1 status in obese subjects. PLoS One, 11(1), e Pouliot, M. C., Després, J. P., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Nadeau, A., & Lupien, P. J.(1994). Waist circumference and abdominal sagittal diameter: best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. The American Journal of Cardiology, 73(7), Rikli, R. E. & Jones, C. J.(2001). Senior Fitness Test Manual. Human Kinetics: Champaign, IL. Sanada, K., Iemitsu, M., Murakami, H., Gando, Y., Kawano, H., Kawakami, R., Tabata, I., & Miyachi, M.(2012). Adverse effects of coexistence of sarcopenia and metabolic syndrome in Japanese women. European Journal of Clinical Nutrition, 66(10), Sara, J. D., Prasad, M., Zhang, M., Lennon, R. J., Herrmann, J., Lerman, L. O., & Lerman, A.(2017). High-sensitivity C-reactive protein Is an independent marker of abnormal coronary vasoreactivity in patients with non-obstructive coronary artery disease. American Heart Journal, 190, e1-e8. Schmitz, K. H., Hannan, P. J., Stovitz, S. D., Bryan, C. J., Warren, M., & Jensen, M. D.(2007). Strength training and adiposity in premenopausal women: strong, healthy, and empowered study. The American Journal of Clinical Nutrition, 86(3), Schrager, M. A., Metter, E. J., Simonsick, E., Ble, A., Bandinelli, S., Lauretani, F., & Ferrucci, L.(2007). Sarcopenic obesity and inflammation in the Invecchiare in Chianti Study. Journal of Applied Physiology, 102(3), Segal, N. A., Zimmerman, M. B., Brubaker, M., & Torner, J. C.(2011). and knee osteoarthritis are not associated with impaired quadriceps specific strength in adults. The Journal of Injury, Function, and Rehabilitation, 3(4), Serra, R. J.(2006). Clinical consequences of sarcopenia. Nutricion Hospitalaria, 21(1), Siparsky, P. N., Kirkendall, D. T., & Garrett, W. E.(2014). Muscle changes in aging: understanding sarcopenia. Sports Health, 6(1), Stenholm, S., Alley, D., Bandinelli, S., Griswold, M. E., Koskinen, S., Rantanen, T., & Ferrucci, L.(2009). The effect of obesity combined with low muscle strength on decline in mobility in older persons: results from the InCHIANTI study. International Journal of, 33(6), Taylor, V. H., Forhan, M., Vigod, S. N., McIntyre, R. S., & Morrison, K. M.(2013). The impact of obesity on quality of life. Best Practice and Research Clinical Endocrinology and Metabolism, 27(2), Thayer, J. F., Yamamoto, S. S., & Brosschot, J. F.(2010). The relationship of autonomic imbalance, heart rate variability and cardiovascular disease risk factors. International Journal of Cardiology, 141(2), Waters, D. L. & Baumgartner, R. N.(2011). and obesity. Clinics in Geriatric Medicine, 27(3), Whelton, S. P., Narla, V., Blaha, M. J., Nasir, K., Blumenthal, R. S., Jenny, N. S., Al-Mallah, M. H., & Michos, E. D.(2014). Association between resting heart rate and inflammatory biomarkers (high-sensitivity C-reactive protein, interleukin-6, and fibrinogen)(from the Multi-Ethnic Study of Atherosclerosis). The American Journal of Cardiology, 113(4), Williams, R. S., Heilbronn, L. K., Chen, D. L., Coster, A. C., Greenfield, J. R., & Samocha-Bonet, D.(2015). Dietary acid load, metabolic acidosis and insulin resistance Lessons from cross-sectional and overfeeding studies in humans. Clinical Nutrition, 2015, 1-7. Winer, D. A., Luck, H., Tsai, S., & Winer, S.(2016). The intestinal immune system in obesity and insulin resistance. Cell Metabolism, 23(3),

16 Yamada, M., Nishiguchi, S., Fukutani, N., Tanigawa, T., Yukutake, T., Kayama, H., Aoyama, T., & Arai, H.(2013). Prevalence of sarcopenia in community-dwelling Japanese older adults. Journal of the American Medical Directors Association, 14(12), Zhu, S., Wang, Z., Heshka, S., Heo, M., Faith, M. S., & Heymsfield, S. B.(2002). Waist circumference and obesity-associated risk factors among whites in the third National Health and Nutrition Examination Survey: clinical action thresholds. The American Journal of Clinical Nutrition, 76(4), m2

저작자표시 - 비영리 - 변경금지 2.0 대한민국 이용자는아래의조건을따르는경우에한하여자유롭게 이저작물을복제, 배포, 전송, 전시, 공연및방송할수있습니다. 다음과같은조건을따라야합니다 : 저작자표시. 귀하는원저작자를표시하여야합니다. 비영리. 귀하는이저작물을영리목적으로이용할

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