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1 K O R E A C E N T E R S F O R D I S E A S E C O N T R O L & P R E V E N T I O N PHWR Vol. 6 No ISSN: X Animal bite cases in high-risk region of rabies, CONTENTS

2 466 PUBLIC HEALTH WEEKLY REPORT, KCDC Figure 1. The map showing animal rabies outbreak regions across the natural barrier(yeongdong expressway) in 2012(black). High-risk and suspect-risk regions indicated to gray and light gray colors Figure 2. Number of animal bite and incidence of rabies cases reported in high-risk region of rabies in Korea,

3 467 Table 1. The demographic characteristics of all the animal bite patients in high-risk region in Korea,

4 468 PUBLIC HEALTH WEEKLY REPORT, KCDC Table 2. Body site and animal species caused bite in high-risk region in Korea, Table 3. Analysis of factors influencing prophylaxis and treatment in the cases after animal bites patients in Table 4. Analysis of factors influencing prophylaxis and treatment in the cases after exposure category III to animal bites

Analysis of factors influencing prophylaxis and treatment in the cases after animal bites

5 469 Figure 3. The number of cases of rabies virus infection in animals and incidence of animal biting between 2005 and 2012 in Gyeonggi, Gangwon provinces

6 470 PUBLIC HEALTH WEEKLY REPORT, KCDC Analysis of antifungal susceptibility testing of Candida isolates by revised CLSI and EUCAST method

7 471 Table 1. Comparison of antifungal susceptibility testing method (CLSI and EUCAST method) of yeast species

8 472 PUBLIC HEALTH WEEKLY REPORT, KCDC Table 2. Distribution of yeasts recovered from clinical specimens during a year period(2011) Table 3. Source of clinical isolates of Candida species recovered from hospitals used for antifungal susceptibility testing

9 주간 건강과 질병 473 Table 4. Antifungal susceptibilities of 1,582 clinical isolates of Candida species from Korea 마이카펀진에 대한 감수성은 99.5%(1,275/1,281), 99.8% EUCAST 시험법은 적용이 가능한 C. albicans, C. tropicalis (1,534/1,536) 및 99.6%(1,511/1,516)로 높았다. 및 C. parapsilosis의 경우 CLSI법과 비교하여 항진균제 총 1,582주를 대상으로 두 가지 방법에 의한 5가지 주요 감수성시험 결과 일치율이 높았으나 C. glabrata 등의 다른 항진균제에 대해 감수성 시험을 실시한 결과 각 항진균제에 균종에서 적용 기준이 없어 CLSI법과 범주 일치율을 비교 대한 MIC 범위는 Table 5와 같다. CLSI M27-A3법에 하기는 어려웠다. 의한 24시간 방법으로 판정한 칸디다 종의 암포테리신 B, 플루코나졸, 보리코나졸, 카스포펀진, 마이카펀진에 대한 Ⅲ. 맺는 말 MIC는 각각 mg/ml, mg/ml, mg/ml, 및 mg/ml이었다. EUCAST에 최근 CLSI에서는 항진균제 감수성 시험 결과 판정 기준을 의한 결과도 매우 유사하여 두 방법은 모든 항진균제 감수성 칸디다 종 별로 달리 적용하는 새로운 Clinical breakpoints 시험에서 높은 일치률(2배 희석배수 내)을 보였다. 그러나 (CBPs)를 발표하였다. CBP는 항진균제 치료 반응을 예측

glabrata 등의 다른 항진균제에 대해 감수성 시험을 실시한 결과 각 항진균제에 균종에서 적용 기준이 없어 CLSI법과 범주 일치율을 비교 대한 MIC 범위는 Table 5와 같다. CLSI M27-A3법에 하기는 어려웠다. 의한 24시간 방법으로 판정한 칸디다 종의 암포테리신 B, 플루코나졸, 보리코나졸, 카스포펀진, 마이카펀진에 대한 Ⅲ.

10 474 PUBLIC HEALTH WEEKLY REPORT, KCDC Table 5. Antifungal MIC distribition of 1,582 clincial isolates of Candida species to amphotericin B, micafungin, caspofungin, vociconazole and fluconazole as determined with the 24-h CLSI and EUCAST methods

Candida species to amphotericin B, micafungin, caspofungin,

11 475 World Blood Donor Day, 14 June 2013 Figure 1. The 10th anniversary banner of World Blood Donor Day(WBDD) 2013

12 476 PUBLIC HEALTH WEEKLY REPORT, KCDC (A) (B) (C) Figure 2. A: WBDD 2013 posters, B: The Global host for 2013-France posters, C: Korean red cross blood services invitation for WBDD 2013

13 477 Current status of selected infectious diseases Figure 1. The weekly proportion of influenza-like illness visits per 1,000 patients from season to season Figure 1. The status of HFMD sentinel surveillance, Figure 1. The mean of patient visits to sentinel physicians for Epidemic keratoconjunctivitis by week, Figure 2. The mean of patient visits to sentinel physicians for A cute hemorrhagic conjunctivitis by week,

Figure 1. The status of HFMD sentinel surveillance, 2010-2013 Figure 1.

14 478 PUBLIC HEALTH WEEKLY REPORT, KCDC Table 1. Provisional cases of reported notifiable diseases-republic of Korea, week ending Jun 8, 2013(23th week) -: No reported cases. Cum: Cumulative counts of the year from 1st week to current week. EHEC: Enterohemorrhagic Escherichia coli. HFRS: Hemorrhagic fever with renal syndrome. CJD/vCJD: Creutzfeldt-Jacob Disease / variant Creutzfeldt-Jacob Disease. * Incidence data for reporting year 2012, 2013 is provisional, whereas data for 2008, 2009, 2010 and 2011 are finalized. Reported cases contain all case classifications(confirmed, Suspected, Asymptomatic carrier) of the disease respectively. Excluding Hansen's disease, diseases reported through the Sentinel Surveillance System(Data for Sentinel Surveillance System are available in Table III), and diseases no case reported(diphtheria, Poliomyelitis, Epidemic typhus, Anthrax, Plague, Yellow fever,viral hemorrhagic fever, Smallpox, Severe Acute Respiratory Syndrome, Avian influenza infection and humans, Novel Influenza, Tularemia, Newly emerging infectious disease syndrome, Tick-borne Encephalitis, Chikungunya fever) Surveillance system for Viral hepatitis A, Viral hepatitis B, Syphilis, CJD/vCJD, West Nile fever was altered from Sentinel Surveillance System to National Infectious Disease Surveillance System as of December 30,2010. Calculated by summing the incidence counts for the current week, the 2 weeks preceding the current week, and the 2 weeks following the current week, for a total of 5 preceding years(for Viral hepatitis A, Viral hepatitis B, Syphilis, CJD/vCJD, West Nile fever, Lyme Borreliosis, Melioidosis, this calculation used 2 year data(2011, 2012) only, because of being designated as of December 30,2010). **Viral hepatitis B comprises acute Viral hepatitis B, HBsAg positive maternity, Perinatal hepatitis B virus infection. Scarlet fever's case classifications added suspected cases in addition to confirmed cases. Cases who have not Korean citizenship were excluded.

CJD/vCJD: Creutzfeldt-Jacob Disease / variant Creutzfeldt-Jacob Disease. * Incidence data for reporting year 2012, 2013 is provisional, whereas data for 2008, 2009, 2010 and 2011 are finalized.

15 479 Table 2. Provisional cases of selected notifiable diseases, Republic of Korea, weeks ending Jun 8, 2013(23th week) -: No reported cases. Cum: Cumulative counts of the year from 1st week to current week. * Incidence data for reporting years 2012, 2013 is provisional, whereas data for 2008, 2009, 2010 and 2011 are finalized. Reported cases contain all case classifications (Confirmed, Suspected, Asymptomatic carrier) of the disease, respectively. Surveillance system for Viral hepatitis A was altered from Sentinel Surveillance System to National Infectious Disease Surveillance System as of December 30,2010. Calculated by averaging the cumulative counts from 1st week to current week, for a total of 5 preceding years.

* Incidence data for reporting years 2012, 2013 is provisional, whereas data for 2008, 2009, 2010 and 2011 are finalized.

16 480 Table 2. Provisional cases of selected notifiable diseases, Republic of Korea, weeks ending Jun 8, 2013(23th week) -: No reported cases. Cum: Cumulative counts of the year from 1st week to current week. * Incidence data for reporting years 2012, 2013 is provisional, whereas data for 2008, 2009, 2010 and 2011 are finalized. Reported cases contain all case classifications (Confirmed, Suspected, Asymptomatic carrier) of the disease, respectively. Surveillance system for Viral hepatitis A was altered from Sentinel Surveillance System to National Infectious Disease Surveillance System as of December 30,2010. Calculated by averaging the cumulative counts from 1st week to current week, for a total of 5 preceding years. Scarlet fever's case classifications added suspected cases in addition to confirmed cases.

Reported cases contain all case classifications (Confirmed, Suspected, Asymptomatic carrier) of the disease, respectively.

17 481 Table 2. Provisional cases of selected notifiable diseases, Republic of Korea, weeks ending Jun 8, 2013(23th week) -: No reported cases. Cum: Cumulative counts of the year from 1st week to current week. * Incidence data for reporting years2012, 2013 is provisional, whereas data for 2008, 2009, 2010 and 2011 are finalized. Reported cases contain all case classifications (Confirmed, Suspected, Asymptomatic carrier) of the disease, respectively. Calculated by averaging the cumulative counts from 1st week to current week, for a total of 5 preceding years.

Cum: Cumulative counts of the year from 1st week to current week.

18 482 Table 2. Provisional cases of selected notifiable diseases, Republic of Korea, weeks ending Jun 8, 2013(23th week) -: No reported cases. Cum: Cumulative counts of the year from 1st week to current week. * Incidence data for reporting years 2012, 2013 is provisional, whereas data for 2008, 2009, 2010 and 2011 are finalized. Reported cases contain all case classifications (Confirmed, Suspected, Asymptomatic carrier) of the disease, respectively. Surveillance system for Syphilis, CJD/vCJD was altered from Sentinel Surveillance System to National Infectious Disease Surveillance System as of December 30,2010. Calculated by averaging the cumulative counts from 1st week to current week, for a total of 5 preceding years.

19 483 Table 3. Provisional cases of reported sentinel surveillance disease, Republic of Korea, weeks ending June 1, 2013(22nd week) -: No reported cases. Cum: Cumulative counts of the year from 1st week to current week. * Above data for reporting years 2012 and 2013 are provisional. Reported cases contain all case classifications (Confirmed, Suspected, Asymptomatic carrier) of the disease, respectively. Calculated by averaging the cumulative counts from 1st week to current week, for a total of 5 preceding *

reported cases. Cum: Cumulative counts of the year from 1st week to current week.

20 PUBLIC HEALTH WEEKLY REPORT, KCDC Tel. (043) , 7164Fax. (043) http://

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°Ç°�°úÁúº´6-2È£ K O R E A C E N T E R S F O R D I S E A S E C O N T R O L & P R E V E N T I O N PHWR Vol. 6 No. 2 www.cdc.go.kr 2013 1 11 6 2 ISSN:2005-811X Flavivirus surveillance in mosquitoes collected from the quarantine