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1 Chapter 19 진정세균 : Deinococci와프로테오박테리아외그람음성세균 1

2 Chlamydiae 문 Obligate intracellular parasite ( 절대세포내기생체 ) 주요한대사산물을숙주세포에의존 유전체크기가 Mb 에불과 2

3 Chlamydiae 문 Chlamydia Trachomatis Non gonococcal urethritis (NGU, 비임균성요도염 ) The most common sexually transmitted disease (STD, 성병 ) in human Pelvic inflammatory disease ( 골반염 ) Trachoma ( 결막염 ) The single most important infectious agent associated with blindness 3

4 Chlamydial Reproduction 1 RB EB Elementary body (EB, 기본소체 ) Non replicating infectious particle Reticulate body (RB, 망상체 ) Replicating non infectious particle 4

5 Spirochaetes 문 Slender, long with flexible helical shape ( 나선모양 ) Creeping (crawling) motility due to a structure called an axial filament ( 축사 ) Axial fibril ( 축세사 ) 5

6 Spirochaetes 문 Treponema pallidum ( 매독균 ) Syphilis ( 매독 ) 성병 Borrelia burgdorferi 생합성에필요한유전자가없음 Lyme disease ( 라임병 ) The most common tick ( 진드기 ) borne disease 6

7 Chapter 20 진정세균 : 프로테오박테리아 (Phylum Proteobacteria) 7

8 프로테오박테리아 그람음성균 16s ribosomal RNA sequence에의한분류 프로테오박테리아강 프로테오박테리아강 프로테오박테리아강 프로테오박테리아강 프로테오박테리아강 8

9 프로테오박테리아강 빈영양생물 영양물질이적은상태에서자랄수있는생물 9

10 Rickettsia 속 Very small, gram negative, non flagellated, diverse morphology Obligate intracellular parasite ( 절대세포내기생체 ) Parasitic ( 기생 ) or mutualistic ( 상리공생 ) Grows in vertebrate erythrocytes ( 적혈구 ), macrophages ( 대식세포 ), vascular endothelial cells ( 내피세포 ) Lives in blood sucking arthropods ( 절지동물, 벼룩진드기 ) vectors or primary hosts Genome sequence similar to mitochondria 10

11 Rickettsia 속 식세포작용 (phagocytosis) 을유도 숙주세포로침투 파고솜 (phagosome) 에서빠져나와세포질로이동 이분법으로분열 11

12 Rickettsia ( 리케치아 ) 속 R. prowazekii and R. typhi 이와쥐를통한 typhus fever ( 발진열 ) R. rickettsii Rocky mountain spotted fever ( 로키산홍반열 ) 12

13 Agrobacterium 속 Agrobacterium tumefaciens 식물병원균 종양세포로변형시킴 근두암종 (crown gall tumor) Ti (tumor inducing) plasmid 13

14 Brucellaceae 속 B. abortus ( 소브루셀라균 ) B. melitensis ( 산양브루셀라균 ) B. suis ( 돼지브루셀라균 ) B. canis ( 개브루셀라균 ) 인수공통전염병 부루셀라증 (brucellosis) 파상열 (undulant fever) 정기적으로고저를반복하는고열 14

15 프로테오박테리아강 산소가없는서식처 유기물이부패되면서나오는물질을이용 수소, 암모니아, 메탄, 휘발성지방산 15

16 Neisseria 속 Non motile, gram negative cocci ( 구균 ) Inhabitants of mucous membranes( 점막 ) of mammals ( 포유류 ) N. gonorrhoeae ( 임질균 ) Gonorrhea ( 임질 ) N. meningitidis Meningitis ( 세균성뇌수막염 ) 16

17 Bordetella 속 Coccobacilli ( 간구균 ) Multiply in respiratory epithelial cells ( 호흡상피 ) Non motile ( 비운동성 ), encapsulated ( 협막 ) species B. pertussis Pertussis or whooping cough ( 백일해 ) 17

18 프로테오박테리아강 가장생리적으로다양한집단 프로테오박테리아중가장큰집단 18

19 Legionellales 속 Legionella pneumophilia 특수한유형의폐렴 Causative agent of Legionnaire s disease 재향군인회병, 레지오넬라증 Transmission through aerosols 19

20 Legionellales 목 Intracellular pathogen of protozoa ( 원생동물 ) 축축한토양, 냉각탑, 에어컨, 냉각탑 Gram negative rods that replicates by binary fission 복제형 (replicative form, RF) replication 성숙한세포내형 (mature intracellular form, MIF) infectious 20

21 Coxiella 속 곤충, 물고기, 조류, 설치류, 양, 염소 에어로졸을통한급성수인성감염 Coxiella burnetti 독감과유사한 Q 열 (Q fever) 을일으킴 작은세포변이형 (small cell variant, SCV) Infectious 거대세포변이형 (large cell variant, LCV) Replication 21

22 Pseudomonadales 목 Pseudomonas aeruginosa ( 녹농균 ) 생물막 (biofilm) 낭포성섬유증 (cystic fibrosis) 와같은질병에걸려면역력이약화된사람에게감염 화상부위또는요도관을감염 22

23 Vibrionales 목 A comma shaped Vibrio cholerae 콜레라 Vibrio parahaemolyticus 오염된해산물에의한위장병 23

24 Vibrionales 목 Acquired by ingesting food or water contaminated by fecal matter ( 배설물 ) from patients or carriers Shellfish ( 패류 ) Adhere to intestinal mucosa ( 점막 ) of small intestine ( 소장 ) and secrete the cholera toxin 24

25 Enterobacteriales 목 장내세균 (enterobacteria) Escherichia coli ( 대장균 ) Probably best studied bacterium Inhabitant of intestinal tracts of many animals 25

26 Enterobacteriales 목 Used as indicator organisms for testing water for fecal contamination ( 배설물오염 ) Some strains are pathogenic Gastroenteritis( 위장염 ) Urinary tract infections( 요도염 ) 26

27 Enterobacteriales 목 Salmonella enterica Salmonellosis 장티푸스 (typhoid fever) 와위장염 Shigella sonnei, and Shigella flexneri Bacillary dysentery ( 세균성설사 ) Klebsiella pneumoniae 폐렴 Yersinia pestis 흑사병 (plague) 27

28 Pasteurellales 목 P. multocida 가금류콜레라 P. haemolytica 소와닭폐렴 Haemophilus influenzae type B 뇌수막염, 부비동염 (sinusitis, 축농증 ), 폐렴, 기관지염 28

29 프로테오박테리아강 그람음성간균 곧은모양이거나굽은모양, 나선모양 29

30 Campylobacter 속 Campylobacter foetus 소와양에서생식질환과유산 사람에게패혈증 (septicemia) 혈액에병원균과독소가존재 30

31 Campylobacter 속 Campylobacter jejuni Found in intestinal tract of animals (e.g., chickens, turkey, and cattle) Transmitted to humans by contaminated food or water, contact with infected animals Invades epithelium of small intestine ( 소장상피세포 ) and secretes an exotoxin ( 외독소 ) Campylobacteriosis Gastroenteritis ( 위장염 ), ulceration ( 궤양 ), and bloody stools ( 혈변 ), 설사 31

32 Helicobacter 속 Helicobacter pylori Gastritis ( 위염 ) and peptic ulcer ( 소화기궤양 ) Motility important for colonization Does not grow below ph 4.5 Produces urease ( 요소분해효소 ) Converts urea to ammonia(nh 3 ) and CO 2 by hydrolysis Provides a local alkaline environment Releases toxins that damage epithelial mucosal cells ( 표피점막 ) Class I carcinogen 32

(1-5장)바이오백서8.6-최종

(1-5장)바이오백서8.6-최종 Biosafety white paper 2011 Ministry of Knowledge Economy Korea Research Institute of Bioscience and Biotechnology www.kribb.re.kr issue issue 2011 Biosafety white paper issue 2011 Biosafety white paper