Microsoft PowerPoint - (Juvic) Korean-Swiss Life Science Symposium
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1 Application of Microneedles in Cosmetic and Medicine Hyungil Jung, Professor, Department of Biotechnology, Yonsei University Founder and CEO, Juvic Inc.
2 Microneedle is referred to micro dimensioned needles It is a novel delivery method to deliver drugs across the skin in a minimally invasive manner Microneedle patch Skin Application Delivery 2
3 Microneedle can be utilized in various fields of beauty, medical, cell therapy and beauty clinics. Beauty Anti wrinkle Whitening Alopecia treatment Beauty Clinic Acne Alopecia treatment Botox Medical Insulin patch PTH EPO Microlancet Cell Therapy Influenza Vaccine Arthritis treatment 3
4 According to analysis of Frost & Sullivan, Microneedle was selected as top 10 technologies of Healthcare & Wellness in 2016 Microneedle market Billion dollar "Drug delivery technology market has continued to grow rapidly due to impressive sales growth and trends." (BBC Research) "Micro-needles are likely to replace existing syringes, which will increase demand for micro-needles in the future." (Frost & Suliivan) Frost & Sullivan,
5 Currently, microneedle fabrication technologies are focused on cosmetics field. Main elements of dissolving microneedle delivery systems You want to deliver 1. Your valuable drugs 2. Maintains its activity 3. With high efficacy Drug Loading Fabrication Application
6 Activity of EGF Activity of Ascorbic acid Centrifugal Lithography 6
7 Drug Drug Polymer solution MN Centrifugal Lithography MN Delivery Solvent Drug Activity Preparation Storage Delivery efficacy Fabrication Process time
8 Formulation Technology Innovative polymer system (Any drugs) Fabrication Technology Centrifugal lithography (Various conditions) Delivery Technology Micro injector (Perfect delivery) Can load all type of drugs by amphipathic polymer system Can control easily the conditions to conserve the activity of drug Can deliver DMN in high efficacy by shooting DMN into skin All technologies are combined Into innovative products through JUVIC JUVIC provides Total solution for Healthcare with Microneedle
9 Juvic is a technology based start-up. Representative Hyungil Jung, Junbae Kim Founded on Publications and patents Various patents on microneedle fabrication and delivery methods (5 registered, 40 applied) Advanced Materials (2010, 2012), Scientific Reports (2015) etc. about 30 publications Location Main owners Yonsei University, Engineering Park Hyungil Jung Yonsei University, etc. Achievements Yonsei University Industry-University Cooperation Excellence Award (2009) Yonsei University Award of Excellent Achievement The 1st Yonsei University startup Award (2016) Awarded from Ministry of the Future Creation Science Prize for Excellent Technology Commercialization (2015) Technology transfer 7 transfers, 2 successful production 9
10 We are carrying out various national R&D projects in both cosmetics and medical fields. Projects Project Title Department Our role Assignment amount Duration New Industry Creation Project Future Creation Science Division Beauty patch development $ 1.5 Million ~ Social problem solving technology development Future Creation Science Division Korea Research Foundation Insulin needle development $ 0.2 Million ~ Private investment-led technology start-up support Small and Medium Business Administration Micro type patch development $ 0.5 Million ~
11 Ready for beauty patch for production 11
12 High efficiency and stability of biopharmaceuticals Dissolving microneedles Hollow microneedles Pharmaceutical Patch (Insulin and vaccine) Tuberculosis Patch Painless anesthesia patch Alopecia patech Insulin microneedles Smart tdiagnosis patch 12
13 OEM/ODM Business Our primary business target is to develop and commercialize dissolving microneedle beauty products and medical products in long term. Early business model: OEM/ODM for cosmetics Order from cosmetic partner Beauty patch production A Long term business: Medical Collaboration Medical patch production
14 No.1 Bio & Pharma Technology Pharmaceutics World best drug delivery & microneedle Technology Vaccination Cosmetics Lead in the Next Generation Medical & Cosmetics Field
15 Thank You 15
16 Various beauty / medical patches and smart touch patches for diagnosis based on our novel fabrication technique Cosmetics patch Controlled release Bio Patch 마이크로구조체 Micro structure Medical patch Implantable Micro-capsule Micro-injector Alopecia treatment Painless needles Diagnostic systems Microfluidics chip 16
17 We are planning to enter biopharmaceutical industry in near future. Polymer biopharmaceutical technology polymer Drug No activity loss during fabrication Fabrication High efficiency and stability of biopharmaceuticals Potential of delivering lipophilic drugs (arthritis etc. Maximization effect of anti-metabolism Drug encapsulating microneedle 17
18 Based on the target site, Microneedles are fabricated in solid, hollow and dissolving types. Microneedle types SOLID HOLLOW DISSOLVING Drugs are coated over the outer layer of microneedle Drugs are delivered by creating channels into skin Delivers liquid drugs via hollow channels Dissolves inside the skin upon penetration and releases the encapsulated drug 18
19 Currently, microneedle fabrication technologies are focused on cosmetics field. Our manufacturing technology can be extended to medical field. From cosmetics to medical field Competitors Comparison Our technology Local competitors International competitors Technology Centrifugal lithography DAB Micromolding Micromolding Company Juvic A Endo derma, Wellage, other companies Georgia tech Cos medi Fabrication time Less than 10 min Less than 10 min Over 3 hours Manufacturing process 2 steps Dispensing > Fabrication 3 steps Dispensing > drawing > air blow More than 3 steps Mold fabrication > Substanse insertion > centrifuge > drying > separation Target drug Unstable protein drugs can be utilized Mainly applicable to small molecule chemicals and is difficult to apply biopharmaceuticals due to fabrication temperature and air drying. Microneedle fabrication pattern Technology development time Flexible Micro mold should be re-designed
20 We have developed biodegradable micro-fabrication technology using Centrifugal Lithography and also developed an applicator technology that can deliver various drugs such as water-soluble / lipid-free with high efficiency. Main elements of dissolving microneedle delivery systems Drug Loading Fabrication Application Capable of loading all sort of substances 2 related patents applied Capability of fabrication in short time and at low temperature 2 related patents applied High delivery efficiency 2 related patents applied Scalability of drugs No activity loss High efficiency 20
21 Contents 21
22 JUVIC Through a variety of applicator technologies, we can effectively deliver encapsulated substances to the target site. Sticky Film Microneedle Microneedle Painless anesthesia patch Pharmaceutical Patch (Insulin) Tuberculosis Patch 22
23 Juvic has developed an innovative polymer system that can mix lipid soluble drugs (more than 50% of drugs) in microneedles. Traditional microneedles were not capable of encapsulating lipid soluble drugs Innovative polymer system Capable of encapsulating lipid soluble drugs 23
24 Dissolving microneedles fabricated via centrifugal lithography showed lower drug activity loss compared with other manufacturing processes (such as DAB) Comparison of centrifugal lithography and DAB fabrication methods Activity of EGF Activity of Ascorbic acid 24
25 Microneedle applicator device Microlancer shooting device Alopecia treatment 25
26 Juvic is a start up company founded in October 2015 Company Representative Juvic, Inc. Founded on Address Hyungil Jung, Junbae Kim Seoul, Yonsei University, Engineering Building Investment 204 Million won ( ) Main owners Hyungil Jung Yonsei University, etc. Government Project Selected for Small and Medium Business Administration project Transferred 45 patents related to microneedles from Yonsei University Awarded the 1st Prize of startup at Yonsei University Selected for social problem solving technology development project Founded Juvic Selected for new industrial project 26
27 Based on our innovative biodegradable micro-fabrication technology, we have developed a beauty patch using lab scale pilot equipment. Our technology Centrifugal Lithography Lab-Scale Pilot Cosmetic patch fabrication 27
28 II. 기술개발준비현황 ( 창업팀 ) JUVIC 논문게재및연구결과를 45 건의특허로권리화, 기술권리를확보함. < 마이크로니들관련핵심특허보유 > < 특허분석수행 > 마이크로니들저온제작관련핵심특허를자체보유하고있으며, 보유특허를통한미세돌기스킨케어시스템을이용한셀프필러제품구현가능함. IP컨설팅수행을통해기존지식재산권과침해여부분석완료했으며, 연세대학교산학협력단을통한기술유출방지대책마련완료함. 28
29 II. 기술개발준비현황 ( 창업팀 ) JUVIC 주빅공동대표이사정형일 1993 연세대학교졸업 1995 연세대학교식품공학석사 2002 미코넬대학교생명공학박사 2004~ 현재연세대학교생명공학과교수 2015~ 현재연세대학교최초교원창업기업주식회사주빅설립 미용및의약품경피전달체기술관련원천기술및특허다수보유성공적기술이전 ( 총 7건 ) 및사업화 ( 총 2건 ) 이력보유 미래융합의료기기개발 ( 한국보건산업진흥원 ) GMP 인증및사업화 서울전략산업지원사업 ( 서울산업통상진흥원 ) 화장품패치사업화및수출 미래창조과학부장관우수기술사업화성과표창장수상 사업화컨설팅수행 29
30 II. 기술개발준비현황 ( 창업팀 ) JUVIC 주빅공동대표이사김준배 1996 연세대학교졸업 2000 미퍼듀대학교경영학과석사 2004 KTB 네트워크투자심사역 2010 셀루메드 CFO 2012 코렌텍 CFO 2016~ 현재연세대학교최초교원창업기업주식회사주빅공동대표 국책과제수행벤처기업경영, 내부통제시스템구축및운영경험보유 국책과제수행기관 ( 벤처기업 ) 경영총괄 (3 개사 ) 재무 / 회계 / 자금등내부통제시스템구축및운영 30
31 II. 기술개발준비현황 ( 창업팀 ) JUVIC 논문게재및연구결과를 45 건의특허로권리화, 기술권리를확보함. < 마이크로니들관련핵심특허보유 > < 특허분석수행 > 마이크로니들저온제작관련핵심특허를자체보유하고있으며, 보유특허를통한미세돌기스킨케어시스템을이용한셀프필러제품구현가능함. IP컨설팅수행을통해기존지식재산권과침해여부분석완료했으며, 연세대학교산학협력단을통한기술유출방지대책마련완료함. 31
32 II. 기술개발준비현황 ( 창업팀 ) JUVIC 주빅공동대표이사정형일 1993 연세대학교졸업 1995 연세대학교식품공학석사 2002 미코넬대학교생명공학박사 2004~ 현재연세대학교생명공학과교수 2015~ 현재연세대학교최초교원창업기업주식회사주빅설립 미용및의약품경피전달체기술관련원천기술및특허다수보유성공적기술이전 ( 총 7건 ) 및사업화 ( 총 2건 ) 이력보유 미래융합의료기기개발 ( 한국보건산업진흥원 ) GMP 인증및사업화 서울전략산업지원사업 ( 서울산업통상진흥원 ) 화장품패치사업화및수출 미래창조과학부장관우수기술사업화성과표창장수상 사업화컨설팅수행 32
33 II. 기술개발준비현황 ( 창업팀 ) JUVIC 주빅공동대표이사김준배 1996 연세대학교졸업 2000 미퍼듀대학교경영학과석사 2004 KTB 네트워크투자심사역 2010 셀루메드 CFO 2012 코렌텍 CFO 2016~ 현재연세대학교최초교원창업기업주식회사주빅공동대표 국책과제수행벤처기업경영, 내부통제시스템구축및운영경험보유 국책과제수행기관 ( 벤처기업 ) 경영총괄 (3 개사 ) 재무 / 회계 / 자금등내부통제시스템구축및운영 33
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