[ 별지 19] ( 뒷면 ) 1 1 3 0 6 0 1 5cm ( 앞면 ) 주 의 ( 편집순서 8) (15 포인트고딕계열 ) 6cm 가축생산성 증대를 위한 광기술응용 기반의 광파동에너지 발생장치 개발 농림축산식품부 9cm 4cm
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,,. R&D,,,. BEP (Biological Energy Projector; ) ( ),,. (ultra-weak photon). BEP ( ) (Biophoton theory).,, BEP (2H₂O H₃O₂+ H+ +e-),.. (BEP), BEP,., ( ) 3
, ( ), ( ). 4
SUMMARY ( 영문요약문 ) 5
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CONTENTS ( 영문목차 ) 7
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1, 1..,,...,. (metabolomics) /.,...,., NMR (Nuclear Magnetic Resonance) (Structural Biology), PCR (Polymerase Chain Reaction) (Genomics)..,. R&D,,,. 2.. BEP ( ),,.,,,. 9
(ultra-weak photon). BEP 관련각종시험결과및임상실험검증결과. BEP () (Biophoton theory). 1920 (Gurwitsch). biophoton, photon.. Biophoton chemi-luminescence UV IR. 10
10 8 biophoton ~ photon/cm 2 /s.. biophoton.., (Spontaneous ultraweak photon emission imaging of oxidative metabolic process in human skin : effect of molecular oxygen and antioxidant defense system, 2011), BEP (2H₂O H₃O₂+ H+ +e-),.. BEP,,,..,,. 2 1..,,.., (3 ).., ( ),,, / 11
, ( ) 12
.,....,. (1) : Effect of Polarized Light Treatment on Milk production and Milk Somatic Cell Count Cows (ACTAVET BRNO 2008, 77: 225-229) (2) : Effect of 710-nm visible light irradiation on neuroprotection and immune function after stroke (Neuroimmunomodulation 2012, 19(5) 267-276) (3) : The effect of lighting conditions on the rhythmicity of growth hormone secretion in Holstein steers (Anim. Sci. J. 2012 83(3) 238-44) (4) UV : Ultraviolet irradiation and the mechani underlying its inactivation of infectious agents (Anim. Health Res. Rev. 2011 12(1) 15-23) : Ultraviolet A radiation: its role in immunosuppression and carcinogenesis (Semin. Cutan. Med. Surg. 2011 30(4) 214-21) (5) UV : Laboratory-scale investigation of UV treatment of ammonia for livestock and poultry barn exhaust applications (J. Environ. Qual. 2012 41(1) 281-8) : Disinfection of swine wastewater using chlorine, ultraviolet light and ozone (Water Res. 2006 40(10) 2017-26) (6) LED 13
: Photocatalytic oxidation of NOx under visible LED light irradiation over nitrogen-doped titania particles with iron or platinum loading (J. Phys. Chem. C 2008 112(32) 12425-12431)., electromagnetic wave (EM).,.,. (1) (Multi-Wave Oscillator) :, Georges Lakhovsky (resonator) (receiver)., 1941,. (2) VIBE (Vibrational Integrated Bio-photonic Energizer) :, Antoine Priore Plasma wave,,, (3) PAP IMI (Ion magnetic Inductor) :, Panos Pappas. (4) Microcurrent Electrical therapy ( ) MET : ; 1000 (10 600μA) 0.5Hz 2,500 (<2 ). APS : ;, DC, ATP,, SCENAR (Self-Controlling Energy-Neuro-Adapting Regulator) : ; CE, 1.. (, ),.,, 14
... 15
. ( ) (, ),,. BEP.,. (1) ( ) - : - : - : 9 - BEP : 2012 9 - :, 12 (2011 10 ~2013 10 ) 낙농, 양돈농가의 BEP 기기실시예 16
( ) ( ) - ( ). -. -. (2) ( ) - :, - : - : 2 - BEP : 2013 4 - BEP : 4,5,6 - :, 12 (2011 10 ~2013 10 ) ( ) - ( 109 ) - B 80g, K 120g 17
- (CAT) 245.43±57.516nmol/ml/min 174.57±51.47 nmol/ml/min (p<0.05). - Glutathion S-transferase(GST) 3.12±1.37 unit/mg protein 2.85±1.16unit/mg protein. - Superoxide dismutase(sod) 0.22±0.04 unit/ml 0.16±0.06 unit/ml (p<0.05). - MDA, GSH, GST, Catalase, SOD. GSH, SOD, GST Catalase, MDA. ( ) -. -. - 4 ( ). -. (3) ( ) - : S - BEP : 2013 4 - BEP : 4,5,6 - :, 6 (2013 2 ~2013 10 ) 18
( ) - / : 0% ( 9% ) - :, / 14.9% 10.4% ) ( ) -. -, -.,,.,.,,.,,. BEP.., BEP (ultra-weak),,. (retrospective analysis), / / /. 19
BEP..,.,, /,.. (1) BEP (2) BEP ( ) ( ),.. 3,. 20
(1) ( ) (2) ( ) (3) ( ) (1) ( ) ( ) BEP ( QC ) ( ) BEP ( QC ) ( ) (,,, ) (2) ( ) ( ) BEP ( ) ( ) BEP ( ) BEP (3) ( ) ( ) BEP (, ) ( ) ( ), ( ),. BEP, 1995 BEP, BEP ph.. /,.,.. BEP (1) : BEP ( ) 21
(2) : ( ) seeding ( ) ( ) (ph=7.4 ) ( ) 48 ph (3) : ( ) BEP. ( ) ph BEP.pH. (4) ( ) BEP PH. ( ) - - ( ) - speceis, 22
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80 %...... Gilbert Ling.,.. Pollack (, Lippincott ER, Stromberg RR, Grant WH, Cessac GL, Polywater, Science, 164, pp.1482-1487, 1969) 2H2O H3O2.. 26
mv.. 70 mv. Ling Association-Induction Hypothesis....,... BEP. 27
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특허, 논문, 제품 ( 시장 ) 분석보고서 1. 본연구관련국내외기술수준비교 50% 50% 80% 50% 50% 80% 2. 특허분석가. 특허분석범위 DB KR, US, JP, EP, (PCT) WIPS ON 1983.03.25~2014.07.04,, 나. 특허분석에따른본연구과제와의관련성 Keyword,,,,,, 126 102 31 14, JP KR 1991 (% ) 70% 50%,,,, BEP, 29
3. 논문분석가. 논문분석범위 DB,, Pubmed DB(www.ncbi.nlm.nih.gov) 5, 나. 논문분석에따른본연구과제와의관련성 ( 1) ( 2) Keyword low-level light therapy Growth hormone, light, holstein 1640 3 347 3 Low-power laser irradiation promotes cell proliferation by activating PI3K/Akt pathway The effect of lighting conditions on the rhythmicity of growth hormone secretion in Holstein steers. Journal of cell physiology Animal Science Journal Zhang et al Kasuya et al. 2009 2012 (% ) 80% 60% 30
4. 제품및시장분석 ( 최신의자료로작성하되, 반드시출처명시 ) 가. 생산및시장현황 (1) /.. Ÿ Ÿ Ÿ Ÿ,,,, B&F, CJ,,,,, CJ Ÿ Ÿ Ÿ Ÿ ( ), Ÿ Ÿ Ÿ Ÿ K9 K9,,,,,,,,,,,,,, 31
, BEP. (2) 국외제품생산및시장현황 - /,. 나. 개발기술의산업화방향및기대효과 (1) 산업화방향 ( 제품의특징, 대상등 )..,,,.,. (2) 산업화를통한기대효과 32
5. 3P( 특허, 논문, 제품 ) 분석을통한연구추진계획 가. 분석결과향후연구계획 ( 특허, 논문, 제품측면에서연구방향제시 ) (1) 특허분석측면 현재가축생산성향상목적으로일부특허에서자력선펄스를조사를하였지만, 본연구를통해서광에너지를좀더안정적으로방출하고, 현장적용기반으로장비를개발함으로써관련기술을특허로출원할예정이다. 본연구를통해서가축의세포및배아에광에너지를주사함으로써세포및배아의생존율을증가시킨다면관련기전을밝힘으로써관련부분을특허로출원할예정이다. (2) 논문분석측면. (, circadian rhythm), /,., /. / (,..). BEP. (3) 제품및시장분석측면 / BEP,,.,. 33
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본문작성요령 가. 본문의순서는장, 절, 1, 가, (1), ( 가 ), 1, 가등으로하고, 장은 17 포인트고딕계열, 절은 15포인트명조계열, 본문은 11 포인트명조계열로합니다. 다만, 본문의내용중중요부문은고딕계열을사용할수있습니다. 나. 장은원칙적으로페이지를바꾸어시작합니다. 다. 본문은 11 포인트횡으로작성합니다. 라. 쪽번호는하단중앙에표기하되, 11 포인트로합니다. 마. 각주는해당쪽하단에 8포인트로표기하며, 본문과구분하도록합니다. 바. 쪽수는편집순서 2의제출문부터시작합니다. 이경우삽입물이있을때에는그삽입물의크기에관계없이 1면을한쪽으로하여일련번호룰붙입니다. 사. 한글 한문 영문을혼용합니다. 아. 뒷면지에주의문을넣습니다. 자. 참고문헌 (reference) 인용의경우본문중에사용처를반드시표시하여야합니다. 차. < 첨부 > 자료는협약시연구계획서별첨으로제출한특허, 논문및시장분석보고서를기준으로연구완료후변동내용을작성하시기바랍니다. 35
보고서겉표지뒷면하단에다음문구삽입 36
인쇄내용 Ⅰ. 인쇄규격 1. 크기 : A4 신판 ( 가로 210mm * 세로297mm) 2. 제본 : 좌철 3. 용지가. 표지 200g/ m2양면아트지나. 내용 80g/ m2모조지 4. 인쇄방법가. 표지 : 바탕백색, 활자흑색나. 내용 : 흑색지정활자다. 양면인쇄 Ⅱ. 편집순서 1. 표지 2. 제출문 3. 요약문 4. 영문요약서 (Summary) 5. 영문목차 (Contents) 6. 목차 7. 본문 8. 뒷면지 Ⅲ. 참고사항 전자조판인쇄시에는이에준한다. 37