1. 연구대상 연구대상및방법 2. 연구방법 Table 1. Classification of diagnosis for No. of dystonic No. of non-dystonic Bipolar disorder Schizophrenia Schizo

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1 KISEP Original Articles 생물정신의학 Vol. 5, No. 2, December 1998 정신과입원환자에서항정신병약물에의한급성근긴장이상증과혈청철농도와의관계 이동진 * 박인준 * 권영준 * 정희연 * 한선호 ** The Relation of Antipsychotic Drug Induced-Acute Dystonia and Serum Iron Level Dong-Jin Lee, M.D.,* In-Joon Park, M.D.,* Young-Joon Kwon, M.D.,* Hee-Yeon Jeong, M.D.,* Sun-Ho Han, M.D.** ABSTRACT O bjectthis study was performed in order to examine the correlation between acute neuroleptic-induced dystonic reactions and serum iron level. MethodSerum iron levels were measured in psychiatric in who had developed acute neuroleptic-induced dystonian41 and in control with no history of acute dystonic reactionsn37. Serum iron levels were compared in acute dystonic in before starting treatment with neuroleptics and after acute dystonic reaction. ResultsThe exhibiting acute dystonic reactions had significantly lower serum iron levels than the without acute dystonic reactions. ConclusionThis result supports an association between low serum iron and the occurrence of neuroleptic-induced acute dystonic reactions. KEY WORDSSerum ironacute dystonic reactionsantipsychotic drug. 서 Department of Psychiatry, College of Medicine, Soonchunhyang University, Chun-an, Korea Department of Psychiatry, College of Medicine, Soonchunhyang University, Seoul, Korea 론

2 1. 연구대상 연구대상및방법 2. 연구방법 Table 1. Classification of diagnosis for No. of dystonic No. of non-dystonic Bipolar disorder Schizophrenia Schizoaffective disorder 4 3 Schizophreniform disorder 3 2 Substance abuse 2 1 Total

3 연구결과 Table 2. Clinical and demographic characteristics of Dystonic Non-dystonic SexMen/Women 25/16 20/17 Ageyears* Dosechlorpromazine equivalent, mg/day** Duration of treatmentday *t-test, p0.05 **t-test, pns Table 3. Iron levels in dystonic and non-dystonic before and after neuroleptic treatment Irong/dl p-value* Before After Dystonic N p0.05 Non-dystonic N NS *t-test 고찰

4 요 중심단어 : 참고문헌 Addonizio G, Roth SD, Strokes PE(1988):Increased extrapyramidal symptoms with addition of Lithium to neruoleptics. J Nerv Ment Dis 176: Aguilar EJ, Keshavan MS, Martines-Quiles MD, Hernandez J, Gomez-Beneyto M, Schooler NR(1994):Predictors of acute dystonia in first-episode psychotic. Am J Psychiatry 151: American Psychiatric Association(1994):Diagnostic and statistical manual of mental disorders. 4th ed, Washington DC, American Psychiatric Association Ashkenazi R, Ben-Shachar D, Youdim MB(1982):Nutritional iron and dopamine binding sites in the rat brain. Pharmacol Biochem Behav 17 Suppl 1:43-47 Barnes TR, Halstead SM, Little PW(1992):Relationship between iron status and chronic akathisia in an in- population with chronic schizophrenia. Br J Psychiatry 161: Barton A, Bowie J, Ebmeier K(1990):Low plasma iron status and akathisia. J Neurol Neurosurg Psychiatry 53: Ben-Shachar D, Inberg JP, Youdim MB(1985):Effect of iron ch- 약

5 elators on dopamine D 2 receptors. J Neurochem 45: Ben-Shachar D, Livne E, Spanier I, Zuk R, Youdim MB(1993): Iron modulates neuroleptic-induced effects related to the dopaminergic system. Isr J Med Sci 29: Brown KW, Glen SE, White T(1987):Low serum iron status and akathisia. Lancet 30: Buckley PF, Meltzer HY(1995):Treatment of schizophrenia. In: Textbook of psychopharmacology. Ed by Schatzberg AF and Nemeroff CB, Washington, DC, American Psychiatric Press, pp 627 Garver DL, Davis DM, Dekirmenjian H, Ericksen S, Gosenfeld L, Haraszti J(1976):Dystonic reactions following neuroleptics: Time course and proposed mechanisms. Psychopharmacologia 47: Gershanik OS(1993):Drug-induced movement disorders. Curr Opin Neurol Neurosurg 6: Horiguchi J(1991):Low serum iron in with neuroleptic-induced akathisia and dystonia under antipsychotic drug treatment. Acta Psychiatr Acand 84: Limongi PJC(1996):Dystonia:concepts, classification, and physiopathology. Arq Neuropsiquiatr 54: Marsden CD, Jenner P(1980):The pathophysiology of extrapyramidal side-effects of neuroleptic drugs. Psychol Med 10:55-72 McEvoy JP(1983):The clinical use of anticholinergic drugs as treatment for extrapyramidal side effects of neuroleptic drugs. J Clin Psychopharmacol 3: Mazurek MF, Rosebush PI(1996):Circadian pattern of acute neuroleptic-induced dystonic reaction. Am J Psychiatry 153: O Loughlin V, Dickie AC, Ebmeier KP(1991):Serum iron and transferrin in acute neuroleptic induced akathisia. J Neurol Neurosurg Psychiatry 54: Remington GJ, Voineskos G, Pollock B, Reed K, Coulter K(1990): Prevalence of neuroleptic-induced dystonia in mania and schizophrenia. Am J Psychiatry 147: Sachdev P, Loneragan C(1991):Acute drug-induced akathisia is not associated with low serum iron status. Psychopharmacology (Berl) 103: Soland VL, Bhatia KP, Marsden CD(1996):Sex prevalence of dystonias. J Neurol neurosurg Psychiatry 60: Soni SD, Tench D, Routledge RC(1993):Serum iron abnormalities in neuroleptic-induced akathisia in schizophrenic. Br J Psychiatry 163: Spina E, Sturiale V, Valvo S, Ancione M, Di Rosa AE, Meduri M, Caputi AP(1993):Prevalence of acute dystonic reactions associated with neuroleptic treatment with and without anticholinergic prophylaxis. Int Clin Psychopharmacol 8:21-24 Spina E, Ancione M, Di Rosa AE, Artemisia A, Natoli C, Caputi AP(1994):Iron status in schizophrenic with acute neuroleptic-induced dystonic reactions. Prog Neuropsychophar-macol Biol Psychiatry 18: Tarao T, Yoshimura R(1991):Low plasma iron status and akathisia. J Neurol Neurosurg Psychiatry 54:

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