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1 The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study Lim Hyun-Chang 1, Yang Jin-Hyuk 1, Chae Gyoung-Joon 1, Kim Sung-Tae 1, Jung Ui-Won 1, Kim Chang-Sung 1, Lee Yong-Keun 2, Choi Seong-Ho 1 1 Department of Periodontology, Oral Science Research Center, College of Dentistry, Yonsei University 2 Department and Research Institute of Dental Biomaterials and Bioengineering, College of Dentistry, Yonsei University Abstract The purpose of this study is to evaluate the effect of enamel matrix protein and -tricalcium phosphate(-tcp) which was applied into the surgically created gap defect around implants in mongrel dogs. Method and material: Two mongrel dogs were used. All mandibular premolars and first mandibular molar were extracted. After 8weeks, 3 implant osteotomies were prepared in each side of the mandible, gap defects were prepared by 4.8/6.5 profile drill. Standard plus implants(rt. side) and TE implants(lt. side) of SLA surface were installed. The width of gap defect was 1.25mm in Standard plus group and 0.5mm in TE group. Both groups were divided into three subgroups according to graft materials ; 1. No materials(control), 2. enamel matrix protein, 3. enamel matrix protein +-TCP. The dogs were sacrificed following an 8-week healing period. Specimens were analyzed histologically. Result: The primary stability of implants was mostly insufficient, due to removal of most of crestal cortical bone and implant design without self-cutting edge. Histologically, in subgroup 1 with no graft procedure, the gap defect was barely filled with new bone and remained as a wedge shaped defect. In subgroup 2 with enamel matrix protein graft, healing in the gap defect occurred up to the upper portion of rough surface. The healing of subgroup 3 with enamel matrix protein and - TCP graft, was relatively inferior to subgroup 2. Conclusion: In spite of limits of this study, it is suggested that the application of enamel matrix protein has favorable effects on the healing of peri-implant gap defect in dog. Further studies would be needed. Keyword : gap defect, enamel matrix protein, -tricalcium phosphate, primary stabilty 36 Implantology Vol. 12, No

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Implantology 2008 Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix

3 original article Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology 2008 Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology Implantology Vol. 12, No

4 Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology

5 original article Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology Implantology Vol. 12, No

6 Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology 2008 Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology

7 original article Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology 2008 Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology 2008 Lim Hyun-Chang et al; The histologic study of the effect of enamel matrix protein and -tricalcium phosphate in gap defect model in dogs : pilot study. Implantology Implantology Vol. 12, No

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9 original article 1. Akimoto K, Becker W, Persson R, et al. Evaluation of titanium implants placed into simulated extraction sockets: a study in dogs. Int J Oral Maxillofac Implants 1999;14: Botticelli D, Berglundh T, Buser D, Lindhe J. The jumping distance revisited: An experimental study in the dog. Clin Oral Implants Res 2003;14: Carlsson L, Rostlund T, Albrektsson B, Albrektsson T. Implant fixation improved by close fit. Cylindrical implant-bone interface studied in rabbits. Acta Orthop Scand 1988;59: Caudill RF, Meffert RM. Histologic analysis of the osseointegration of endosseous implants in simulated extraction sockets with and without e- PTFE barriers. 1. Preliminary findings. Int J Periodontics Restorative Dent 1991;11: Jung UW, Kim CS, Choi SH, et al. Healing of surgically created circumferential gap around non-submerged-type implants in dogs: a histomorphometric study. Clin Oral Implants Res 2007;18: Knox R, Caudill R, Meffert R. Histologic evaluation of dental endosseous implants placed in surgically created extraction defects. Int J Periodontics Restorative Dent 1991;11: Yoon HC, Choi JY, Jung UW, et al. Effects of different depths of gap on healing of surgically created coronal defects around implants in dogs: a pilot study. J Periodontol 2008;79: Becker W, Dahlin C, Becker BE, et al. The use of e-ptfe barrier membranes for bone promotion around titanium implants placed into extrac- 44 Implantology Vol. 12, No

10 tion sockets: a prospective multicenter study. Int J Oral Maxillofac Implants 1994;9: Hammerle CH, Lang NP. Single stage surgery combining transmucosal implant placement with guided bone regeneration and bioresorbable materials. Clin Oral Implants Res 2001;12: ,,, et al ;27: ,,, et al ;34: ,,, et al. 1 Emdogain Emdogain Calcium Sulfate Paste. 2000;30: Froum S, Lemler J, Horowitz R, Davidson B. The use of enamel matrix derivative in the treatment of periodontal osseous defects: a clinical decision tree based on biologic principles of regeneration. Int J Periodontics Restorative Dent 2001;21: Heijl L, Heden G, Svardstrom G, Ostgren A. Enamel matrix derivative (EMDOGAIN) in the treatment of intrabony periodontal defects. J Clin Periodontol 1997;24: Mellonig JT. Enamel matrix derivative for periodontal reconstructive surgery: technique and clinical and histologic case report. Int J Periodontics Restorative Dent 1999;19: Hammarstrom L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997;24: Boyan BD, Weesner TC, Lohmann CH, et al. Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. J Periodontol 2000;71: Schwartz Z, Carnes DL, Jr., Pulliam R, et al. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of preosteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 2000;71: E.Lynch S, Marx RE, Nevins M, Wisner-Lynch LA. Tissue Engineering, Application in oral and maxillofacial surgery and periodontics, 2nd ed. 2008: Artzi Z, Weinreb M, Givol N, et al. Biomaterial resorption rate and healing site morphology of inorganic bovine bone and beta-tricalcium phosphate in the canine: a 24-month longitudinal histologic study and morphometric analysis. Int J Oral Maxillofac Implants 2004;19: Zijderveld SA, Zerbo IR, van den Bergh JP, et al. Maxillary sinus floor augmentation using a beta-tricalcium phosphate (Cerasorb) alone compared to autogenous bone grafts. Int J Oral Maxillofac Implants 2005;20: Schulte W, Kleineikenscheidt H, Lindner K, Schareyka R. [The Tubingen immediate implant in clinical studies]. Dtsch Zahnarztl Z 1978;33: Cardaropoli G, Araujo M, Hayacibara R, et al. Healing of extraction sockets and surgically produced - augmented and non-augmented - defects in the alveolar ridge. An experimental study in the dog. J Clin Periodontol 2005;32: Casati MZ, Sallum EA, Nociti FH, Jr., et al. Enamel matrix derivative and bone healing after guided bone regeneration in dehiscence-type defects around implants. A histomorphometric study in dogs. J Periodontol 2002;73: Botticelli D, Berglundh T, Buser D, Lindhe J. Appositional bone formation in marginal defects at implants. Clin Oral Implants Res 2003;14:

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00)13-3목차1~3 An evaluation of marginal bone level change in single short implant : an 1-year follow up Tae-Hoon Lee, Joo-Hyun Kwon, Sunjai Kim, Chong-Hyun Han Department of Prosthodontics, Kangnam Severance hospital,