일반의약품 비타민 K 의진면목 (1) 저자김성철영남대임상약학대학원겸임교수약학정보원학술자문위원 개요 현재약국임상에서지용성비타민의일종인비타민 K 제제는전부전문의약품으로인식되어있으며, 일부종합비타민제제에함유되어있어도비타민 K의효능과새로이연구되고있는적응증에대해서는관심도가떨어진
|
|
- 종윤 후
- 5 years ago
- Views:
Transcription
1 일반의약품 비타민 K 의진면목 (1) 저자김성철영남대임상약학대학원겸임교수약학정보원학술자문위원 개요 현재약국임상에서지용성비타민의일종인비타민 K 제제는전부전문의약품으로인식되어있으며, 일부종합비타민제제에함유되어있어도비타민 K의효능과새로이연구되고있는적응증에대해서는관심도가떨어진것은주지의사실이다. 이번호에는지용성비타민 K의작용기전과새로이연구되고있는적응증및작용기전특히외용비타민 K 제제에대하여숙지하여약국경영에다소도움이되었으면한다. 키워드 비타민 K, 비타민 K 의종류, 비타민 K 가많이함유된음식 1. 비타민 K 의역사 비타민 K는 1929년덴마크의과학자인헨릭댐 (Henrik Dam) 이저콜레스테롤식을먹인닭에서의콜레스테롤의역할에대한연구중에발견하였다. 저콜레스톨식을시행한동물에서출혈경향이나타남을발견하고, 콜레스테롤식을시행하여도출혈이멈추지않음으로출혈에관여하는제2의물질이있음을확인하고이것을응고비타민이라고칭하였다. 이것을발표한독일학회에서본물질을독일어로응고즉 Koagulation 비타민이라하고비타민 K라고명명하였다. 이후미국세인트루이스대학의에드워드도이시가이물질의분자구조와화학적성질을발견하였다. 이것으로댐과도이시는 1943에노벨의학상을수상하였다. 이후비타민 K의연구가활발하게추진되어현재는천연비타민인 K 1 과 K 2 및합성비타민인 K 3, K 5, K 7 을발견하게되었다. 이후수십년동안비타민결핍모델닭을이용하여각종음식속에함유된비타민 K의함량을결정하는기준으로하게되었다. 전세계적으로본연구는덴마크의코펜하겐대학생물학과, 미국아이오와대학의병리학과및메이요크리닉에서활발하게연구를진행하였다. 1938년에프로트롬빈결핍증을수반한황달환자에있어서의생명을위협하는출혈경향에비타민 K를사용함으로써임상적성공을거두면서현재의료현장에널리사용하게되었다. 2. 비타민 K 의종류 비타민 K는분자구조적으로는모두유사하며혈액응고에관여하는특정단백질의후변환조절 (post-translational modification) 및뼈및타조직의대사경로에작용하는인체에필수적인지용성비타민이다. 비타민 K 1, 비타민 K 2 는 2-methyl-1,4-naphthoquinone 유도체인천연의비타민 K군이다. 1
2 (1) 비타민 K 1 비타민 K 1 은 phylloquinone, phytomenadione, 또는 phytonadione으로알려져있으며, 주로직접광합성이가능한짙은녹색잎을가진식물에서합성되어진다. 그러므로식물성비타민 K라고일컫는다. 비타민 K 1 은이것을섭취한동물에있어서도혈액응고작용을나타내게되며, 대부분의동물들에서비타민 K 1 은체내에서비타민 K 2 로전환된다. [ 그림 ] 비타민 K 1 및 K 2 (MK-4/MK-7) 구조식 (2) 비타민 K 2 비타민 K 2 는동물에있어서는저장형태로써 isoprenoid 측쇄의길이에따라몇개의아류로구분된다. 이것의동족체를 menaquinones라고일컫는다. 이것을줄여서 MK-n으로칭한다. M은 menaquinone을의미하며 K는비타민 K를뜻하며 n은 isoprenoid 측쇄의수를나타낸다. 즉 MK-4는측쇄에 4개의 isoprene 잔기가있는것임을의미한다. 통상 menatetrenone이라고일컬어지는 Menaquinone-4가동물에있어서는가장흔한비타민 K 2 의형태로써, 비타민 K 1 으로부터동맥벽, 췌장및고환에서합성되어지며, 이것은일종의효소기능을발휘하는것이비타민 K 1 과는상이한점이다. 동물의대장에존재하는세균의혐기성호흡과정을통하여비타민 K 1 은비타민 K 2 로변환된다. 이세균은 MK-7에서부터 MK-11까지더긴측쇄를형성할수있다. 현재까지알려진합성비타민 K는 K 3, K 4 와 K 5 이며이중 menadione이라고불리는비타민 K 3 의독성이임상에서보고되어지고있다. 3. 비타민 K 의섭취및흡수 비타민 K는소장또는대장의손상으로흡수불량이존재하거나광범위항생제의투여로장내정상세균총의살멸에의하여생성이저하되며, 연령에따라비타민 K의합성이저하되어혈중농도가낮아진다. 연구에의하면항생제를투여한쥐실험에서정상식사를한쥐보다약 74% 정도혈중농도가낮아졌음이보고되어있다. 최근연구에의하면와파린을계속투여한환자는동맥벽의석회화진행이되었다고보고하였다. 그러나비타민 K를투여한군에서는와파린유도성석회화는감소하였다. 2
3 4. 일일권장량및많이함유된음식 (1) 일일권장량 국내의 1일권장량은없지만미국의경우 1일권장량 (DRI : Dietary Reference Intake) 은다음과같다. - 남성 : 120 μg - 여성 : 90 μg - 유아 : μg - 소아및청소년 : μg - 1일최대량 : 1000 μg ( 비타민 K 1 ) osteocalcin의 carboxylation을최대화하기위함 (2) 많이함유된음식 요구르트, 알팔파, 노른자, 홍화유, 대두유, 물고기의간유, 해조류, 녹색잎야채, 민들레, 케일, 시금치, 브로컬리, 아스파라거스, 파슬리, 키위, 포도, 아보가도등에함유되어있다. 다음표는비타민 K 1 과 K 2 가많이함유된음식을표한다. ( 비타민 K 1 ) Food Serving Size Vit. K 1 Vit. K 1 Food Serving Size Kale, cooked 1/2 cup 531 Parsley, raw 1/4 cup 246 Spinach, cooked 1/2 cup 444 Spinach, raw 1 cup 145 Mustard greens, cooked 1/2 cup 210 Mustard greens, raw 1 cup 279 Broccoli, cooked 1 cup 220 Broccoli, raw 1 cup 89 Cabbage, cooked 1/2 cup 82 Green leaf lettuce 1 cup 71 Asparagus 4 spears 48 ( 비타민 K 2 ) Food 100 grams (3.5 oz) portion Vit. K 2 Proportion of vit. K 2 Food 100 grams (3.5 oz) portion Vit. K 2 Proportion of vit. K 2 Natto, cooked 1,103.4 (90% MK-7, 10% other MK) Chicken Leg 8.5 (100% MK-4) Goose liver pâté (100% MK-4) Ground beef (medium fat) 8.1 (100% MK-4) Hard cheeses (Dutch (6% MK-4, Chicken liver 76.3 Gouda style), raw 94% other MK) (braised) 6.7 (100% MK-4) Soft cheeses (French (6.5 MK-4, 56.5 Brie style) 93.5% other MK) Hot dog 5.7 (100% MK-4) Egg yolk, (98% MK-4, 32.1 (Netherlands) 2% other MK) Bacon 5.6 (100% MK-4) Goose leg 31.0 (100% MK-4) Calf s liver 6.0 (100% MK-4) Egg yolk (U.S.) 15.5 (100% MK-4) Sauerkraut 4.8 (100% MK-4) Butter 15.0 (100% MK-4) Whole milk 1.0 (100% MK-4) Chicken liver (raw) 14.1 (100% MK-4) Cow s liver 0.4 (100% MK-4) Chicken liver 12.6 (100% MK-4) Egg white 0.4 (100% MK-4) [ 출처 : Nutrition facts, calories in food, labels, nutritional information and analysis. Nutritiondata.com (13 February 2008). Retrieved on 21 April 2013.] 3
4 5. 독성 뚜렷이알려진독성은없다. 그러나알레르기가알려져있으며, 다만고용량 (1 일 135mg 이상 ) 투여시응 고성장애와용혈성빈혈, 간세포독성이보고되어있다. 약사 Point - 비타민 K는단순히혈액응고작용만있는것이아니라와파린또는아스피린의장기복용으로야기되는혈관석회화의예방에도도움이된다. - 비타민 K는항산화작용이있어서인슐린의저항성을낮춰줌으로당뇨병환자에게는비타민 K가함유된종합비타민제제를반드시추천하여야한다. - 비타민 K 외용제제는각종멍 ( 자반증 ) 에효과가입증되어있다. ( 멍소실의시간단축, 흉터최소화 ) - 아직연구중에있지만간암의예방, 전립선암에도효과가보고되어있다. 참고문헌 1. Dam, H. (1935). "The Antihæmorrhagic Vitamin of the Chick.: Occurrence And Chemical Nature". Nature 135 (3417): Will, BH; Usui Y, Suttie JW (1992). "Comparative Metabolism and Requirement of Vitamin K in Chicks and Rats". Journal of Nutrition 122 (12): Vermeer, C; Braam L (2001). "Role of K vitamins in the regulation of tissue calcification". Journal of bone and mineral metabolism 19 (4): Suttie, JW (1995). "The importance of menaquinones in human nutrition". Annual Review of Nutrition 15: Weber, P (2001). "Vitamin K and bone health". Nutrition17 (10): Sato, Y; Kanoko T, Satoh K, Iwamoto J (2005). "Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease". Bone36 (1): Inoue, T; Sugiyama T, Matsubara T, Kawai S, Furukawa S (2001). "Inverse correlation between the changes of lumbar bone mineral density and serum undercarboxylated osteocalcin after vitamin K 2(menatetrenone) treatment in children treated with glucocorticoid and alfacalcidol". Endocrine Journal 48 (1): Sasaki, N, Kusano E, Takahashi H, Ando Y, Yano K, Tsuda E, Asano Y; Kusano E, Takahashi H, Ando Y, Yano K, Tsuda E, Asano Y (2005). "Vitamin K 2 inhibits glucocorticoid-induced bone loss partly by preventing the reduction of osteoprotegerin(opg)". Journal of bone and mineral metabolism 23 (1): Yonemura, K; Fukasawa H, Fujigaki Y, Hishida A. (2004). "Protective effect of vitamins K 2 and D 3 on prednisolone-induced loss of bone mineral density in the lumbar spine". American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation 43 (1): Shiomi, S; Nishiguchi S, Kubo S (2002). "Vitamin K 2(menatetrenone) for bone loss in patients with cirrhosis of the liver". The American Journal of Gastroenterology 97 (4): Sato, Y; Kanoko T, Satoh K, Iwamoto J (2005). "Menatetrenone and vitamin D2 with calcium supplements prevent nonvertebral fracture in elderly women with Alzheimer's disease". Bone36 (1): Sato, Y; Honda Y, Kaji M (2002). "Amelioration of osteoporosis by menatetrenone in elderly female Parkinson's disease patients with vitamin D deficiency". Bone31 (1): Nishiguchi, S; Shimoi S, Kurooka H (2001). "Randomized pilot trial of vitamin K 2 for bone loss in patients with primary biliary cirrhosis". Journal of Hepatology 35 (4):
5 14. Viegas, C. S. B.; Cavaco, S.; Neves, P. L.; Ferreira, A.; João, A.; Williamson, M. K.; Price, P. A.; Cancela, M. L.; Simes, D. C. (2009). "Gla-Rich Protein is a Novel Vitamin K-Dependent Protein Present in Serum That Accumulates at Sites of Pathological Calcifications". The American Journal of Pathology175 (6): Binkley NC, Krueger DC, Kawahara TN, angelke JA, Chappell RJ, Suttie JW (2002). "A high phylloquinone intake is required to achieve maximal osteocalcin gamma-carboxylation". Am.J.Clin.Nutr.76 (5): Spronk, H. M. H.; Soute, B. A. M.; Schurgers, L. J.; Thijssen, H. H. W.; De Mey, J. G. R.; Vermeer, C. (2003). "Tissue-Specific Utilization of Menaquinone-4 Results in the Prevention of Arterial Calcification in Warfarin-Treated Rats". Journal of Vascular Research 40 (6): Nutrition Facts and Information for Parsley, raw. Nutritiondata.com. Retrieved on 21 April Nutrition facts, calories in food, labels, nutritional information and analysis. Nutritiondata.com (13 February 2008). Retrieved on 21 April Vitamin K. Vivo.colostate.edu (2 July 1999). Retrieved on 21 April Ikeda; Iki, M; Morita, A; Kajita, E; Kagamimori, S; Kagawa, Y; Yoneshima, H (2006). "Intake of fermented soybeans, natto, is associated with reduced bone loss in postmenopausal women: Japanese Population-Based Osteoporosis (JPOS) Study". The Journal of nutrition 136 (5): Katsuyama; Ideguchi, S; Fukunaga, M; Saijoh, K; Sunami, S (2002). "Usual dietary intake of fermented soybeans (Natto) is associated with bone mineral density in premenopausal women". Journal of nutritional science and vitaminology 48 (3): Gast, G. C. M.; De Roos, N. M.; Sluijs, I.; Bots, M. L.; Beulens, J. W. J.; Geleijnse, J. M.; Witteman, J. C.; Grobbee, D. E.; Peeters, P. H. M.; Van Der Schouw, Y. T. (2009). "A high menaquinone intake reduces the incidence of coronary heart disease". Nutrition,Metabolism and Cardiovascular Diseases 19 (7): Geleijnse; Vermeer, C; Grobbee, DE; Schurgers, LJ; Knapen, MH; van der Meer, IM; Hofman, A; Witteman, JC (2004). "Dietary intake of menaquinone is associated with a reduced risk of coronary heart disease: The Rotterdam Study". The Journal of nutrition 134 (11): Allison AC (2001). "The possible role of vitamin K deficiency in the pathogenesis of Alzheimer's disease and in augmenting brain damage associated with cardiovascular disease". Medical hypotheses 57 (2): Cohen, JL; Bhatia, AC (November 2009). "The role of topical vitamin K oxide gel in the resolution of postprocedural purpura". Journal of drugs in dermatology :JDD8 (11): Leu, S; Havey, J; White, LE; Martin, N; Yoo, SS; Rademaker, AW; Alam, M (September 2010). "Accelerated resolution of laser-induced bruising with topical 20% arnica: a rater-blinded randomized controlled trial". The British journal of dermatology 163 (3): "Vitamin K Found to Protect Against Liver Cancer". utraingredients.com (21 July 2004) 28. Nimptsch K, Rohrmann S, Linseisen J (2008). "Dietary intake of vitamin K and risk of prostate cancer in the Heidelberg cohort of the European Prospective Investigation into Cancer and Nutrition. (EPIC-Heidelberg)". Am.J.Clin.Nutr.87 (4): American Cancer Society: Vitamin K. Cancer.org. Retrieved on 21 April Ibarrola-Jurado, N.; Salas-Salvado, J.; Martinez-Gonzalez, M. A.; Bullo, M. (2012). "Dietary phylloquinone intake and risk of type 2 diabetes in elderly subjects at high risk of cardiovascular disease". American Journal of Clinical Nutrition 96 (5):
일반의약품_비타민 K의 진면목 (2)_편집완료_최종.hwp
일반의약품 비타민 K 의진면목 (2) 저자김성철영남대임상약학대학원겸임교수약학정보원학술자문위원 개요 현재약국임상에서지용성비타민의일종인비타민 K 제제는전부전문의약품으로인식되어있으며, 일부종합비타민제제에함유되어있어도비타민 K의효능과새로이연구되고있는적응증에대해서는관심도가떨어진것은주지의사실이다. 이번호에는지용성비타민 K의작용기전과새로이연구되고있는적응증및작용기전특히외용비타민
More information노인정신의학회보14-1호
제14권 1호 통권 제23호 www.kagp.or.kr 발행인 : 정인과 / 편집인 : 이동우 / 발행처 : 정인과 (152-703) 서울특별시 구로구 구로동 80번지 고려대학교 구로병원 정신과 / TEL : 02-818-6608 / FAX : 02-852-1937 발행일 : 2008년 4월 30일 / 제 작 : (주)엠엘커뮤니케이션 140-846 서울특별시
More information- i - - ii - - iii - - iv - - v - - vi - - 1 - - 2 - - 3 - 1) 통계청고시제 2010-150 호 (2010.7.6 개정, 2011.1.1 시행 ) - 4 - 요양급여의적용기준및방법에관한세부사항에따른골밀도검사기준 (2007 년 11 월 1 일시행 ) - 5 - - 6 - - 7 - - 8 - - 9 - - 10 -
More informationTreatment and Role of Hormaonal Replaement Therapy
Treatment and Role of Hormone Replacement Therapy Chung-Ang University Hospital Chee Jeong Kim 7.2 5.3 6.4 5.6 7.3 5.5 1 1 2 3 4 10 11 7 34 49 122 123 1.0 - - 10. 2001 1998 1998 Improvement of postmenopausal
More information½Ç°ú¸Ó¸®¸»¸ñÂ÷ÆDZÇ(1-5)¿Ï
실과056-094 2013.1.9 7:22 PM 페이지67 MDPREP_RipControl 2007 개정 5학년 검정 지도서 각론 알짜 정리 67 영양소 힘을 내는 일(탄수화물/지방/단백질) 몸의 조직 구성(지방/단백질/무기질/물) 몸의 기능 조절(단백질/무기질/비타민/물) 식품 구성 자전거의 식품과 영양소 식품군 곡류 탄수화물 우리가 활동하는데 필요한 힘을
More information(Microsoft PowerPoint - S13-3_\261\350\273\363\307\366 [\310\243\310\257 \270\360\265\345])
Cardiovascular Disease in Metabolic Syndrome 김상현 보라매병원내과 서울대학교의과대학내과학교실 Contents Metabolic syndrome and Cardiovascular system CVD Mortality Coronary artery disease Heart failure Atrial fibrillation Management
More informationPharmacotherapeutics Application of New Pathogenesis on the Drug Treatment of Diabetes Young Seol Kim, M.D. Department of Endocrinology Kyung Hee Univ
Application of New Pathogenesis on the Drug Treatment of Diabetes Young Seol Kim, M.D. Department of Endocrinology Kyung Hee University College of Medicine & Hospital E mail : ycell2@yahoo.co.kr Abstract
More information보고서_pdf로.hwp
9:30-10:00 10:00-10:10 INTRODUCTION 10:10-11:40 ISSUES IN DIETARY ASSESSMENT IN COHORT STUDIES Alan Kristal (Fred Hutchinson Cancer Research Center, U.S.A.) Developing adiet questionnaire for alarge cohort
More information지속가능경영보고서도큐_전체
C o n t e n t s 03 06 07 10 30 38 43 55 56 60 62 70 71 Korea Foundation for Women Annual Report 2010 SLOGAN VISION 2 3 MISSION 1 MISSION 3 MISSION 2 4 5 Korea Foundation for Women Annual Report 2010 Korea
More informationA 617
Special Issue Diabetic Retinopathy Won Ki Lee, M.D. Department of Ophthalmology The Catholic University of Korea College of Medicine Kangnam St. Mary s Hospital E mail : wklee@catholic.ac.kr Abstract R
More information2013........10
06 07 04 13 14 18 22 26 28 32 36 40 44 72 86 87 88 48 80 82 90 GongGam Human Rights Law Foundation 02+03 인사글 하늘은 욕망 없는 생명을 만들지 아니하고 대지는 이름 없는 풀을 키우지 아니한다. (天不 세월과 권력과 부침에 흔들리지 않고 한국 사회에 뿌리 깊이 내린 한 그루 나무가
More information레이아웃 1
대한위장관기질종양연구회 01 GIST 06 02 11 03 Imatinib 14 04 05 06 07 Sunitinib 32 40 44 48 GIST 6 01 7 GIST Guide book GIST 8 01 9 GIST Guide book GIST (CT) MRI FDG-PET 10 02 11 GIST Guide book 12 02 (Imatinib)
More information서론 34 2
34 2 Journal of the Korean Society of Health Information and Health Statistics Volume 34, Number 2, 2009, pp. 165 176 165 진은희 A Study on Health related Action Rates of Dietary Guidelines and Pattern of
More information슬라이드 1
이치호교수님 ( 동물생명과학대학 620 호식품화학실험실 / leech@konkuk.ac.kr) 학습목표 지용성비타민의종류 지용성비타민의효능 지용성비타민의섭취권장량 지용성비타민의함유식품 에대해학습 비타민의분류 Vitamin C 지용성 비타민 Vitamin A 수용성 비타민 Vitamin B1 ( 티아민 ) Vitamin B2 ( 리보플라빈 ) Vitamin D
More information칠레01-28p 6월27일3차
INERVIEW 04 06 08 09 11 12 14 16 17 19 20 22 25 2013 July FOOD JOURNAL 3 4 2013. 7 2013 July FOOD JOURNAL 5 6 2013. 7 2013 July FOOD JOURNAL 7 8 2013. 7 2013 July FOOD JOURNAL 9 10 2013. 7 2013 July FOOD
More information그렇기때문에혈액응고장애위험이증가할수있다. 따라서와파린을복용하고있는사람들은비타민 K 를과량함유하고있는식품 ( 녹색잎줄기채소류 ) 과비타민 K 보조제를피해야한다. 역으로, 비타민 K 는와파린의항응고효과가심하게나타날때, 혹은수술등에선행하여와파린의효과를역전시키기위해사용한다.
비타민 K Vitamin K Natural Standard Monograph, Copyright 2010 (www.naturalstandard.com). 상업적목적으로사용하는것을금합니다. 본글은오직정보전달을위해작성되었으며, 특정한의학용도로사용될수없습니다. 관련요법과건강상태에대해결정을내리기전에건강전문가와꼭상의하십시오. 일부보완대체요법은과학적으로연구되었지만, 대부분은안전성과유효성및작용기전에대한자료가제한적이거나서로상충되고있다.
More informationMay 10~ Hotel Inter-Burgo Exco, Daegu Plenary lectures From metabolic syndrome to diabetes Meta-inflammation responsible for the progression fr
May 10~12 2012 Hotel Inter-Burgo Exco, Daegu Plenary lectures From metabolic syndrome to diabetes Meta-inflammation responsible for the progression from obesity to metabolic syndrome originates in the
More information07.... 01V28.
National Election Commission 9 September S M T W T F S 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23/30 24 25 26 27 28 29 11 November S M T W T F S 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16
More informationAnalyses the Contents of Points per a Game and the Difference among Weight Categories after the Revision of Greco-Roman Style Wrestling Rules Han-bong
Analyses the Contents of Points per a Game and the Difference among Weight Categories after the Revision of Greco-Roman Style Wrestling Rules Han-bong An 1 & Kyoo-jeong Choi 2 * 1 Korea National Wrestling
More informationµðÇÃÇ¥Áö±¤°í´Ü¸é
Review 2 2013 JAN.FEB. vol. 23 Display Focus 3 Review 4 2013 JAN.FEB. vol. 23 Display Focus 5 Review 6 2013 JAN.FEB. vol. 23 Display Focus 7 Review 8 2013 JAN.FEB. vol. 23 Display Focus 9 Preview 2013.1
More information페링야간뇨소책자-내지-16
야간뇨의진단과치료 - 실제적접근 - Reference 1. Choo MS, Ku JH, Park CH et al. Prevalence of Nocturia in a Korean Population Aged 40 to 89 Years. Neurourol Urodyn 2008; 27:60-64. 2. Weiss JP. Prevalence
More information#유한표지F
www.yuhan.ac.kr www.yuhan.ac.kr 대 학 요 람 2008 422-749 경기도 부천시 소사구 경인로 636(괴안동 185-34) Tel : 02)2610-0600 / 032)347-0600 유 한 대 학 대학요람 2008 2008 대학요람 설립자 유일한 박사의 숭고한 정신과 철학을 실천하는 대학 눈으로 남을 볼 줄 아는 사람은 훌륭한
More information한국성인에서초기황반변성질환과 연관된위험요인연구
한국성인에서초기황반변성질환과 연관된위험요인연구 한국성인에서초기황반변성질환과 연관된위험요인연구 - - i - - i - - ii - - iii - - iv - χ - v - - vi - - 1 - - 2 - - 3 - - 4 - 그림 1. 연구대상자선정도표 - 5 - - 6 - - 7 - - 8 - 그림 2. 연구의틀 χ - 9 - - 10 - - 11 -
More informationMicrosoft PowerPoint - CNVZNGWAIYSE.pptx
서울대학교의과대학 가정의학과조희경 Contents Introduction Biological Mechanisms Epidemiologic Studies Randomized Controlled Trials Guidelines on vitamin D intake Known and Unknowns WE KNOW Vitamin D is important < 20
More informationNational Food & Nutrition Statistics 2011: based on 2008~2011 Korea National Health and Nutrition Examination Survey (Ⅱ) i ii iii iv v vi vii viii ix (N=33,745, 단위 : g) (N=33,745, 단위 : g) (N=33,745,
More information저품질낱장.pdf
Personal Advisor For A Better Life vol. 276 January 2015 January 2015 Contents 08 20 06 INTRO 08 STYLE 16 DRINK 18 NUTRITION 20 FOOD 26 26 PROJECT 32 HOBBY 34 MIND 36 SKIN CARE 42 MAKE-UP 44 HAIR 46 BODY
More information한국영양학회지 (Korean J Nutr) (3) 189 ~ 195 DOI /kjn 비타민 K 2 첨가식이가난소절제쥐의골밀도에미치는영향 최미자 김미성 계명대학교식품영양학과 Effect of Dietary Vitamin
한국영양학회지 (Korean J Nutr) 2011 44(3) 189 ~ 195 DOI 10.4163/kjn.2011.44.3.189 비타민 K 2 첨가식이가난소절제쥐의골밀도에미치는영향 최미자 김미성 계명대학교식품영양학과 Effect of Dietary Vitamin K 2 Supplementation on Bone Mineral Density in Ovariectomized
More information황지웅
Comparison of Laparoscopy and Exploration in the Distal Pancreatectomy BACKGROUND: To determine the benefits of laparoscopic surgery compared with exploration, the clinical outcomes of open and laparoscopic
More informationuntitled
FOR YOUR PREMIUM LIFESTYLE WINTER 2013 20 FOR YOUR PREMIUM LIFESTYLE 2013 Winter CONTENTS Wellness Beauty Living CONTENTS 2013 Winter FOR YOUR PREMIUM LIFESTYLE One for One Hyper Store [ 2074 ] 10-0394K
More information<30382EC0C7C7D0B0ADC1C22E687770>
대한내과학회지: 제 76 권 제 2 호 2009 의학강좌-개원의를 위한 모범처방(Current Clinical Practice) 간기능검사의 이해와 적용 인제대학교 의과대학 일산백병원 내과학교실 김 경 아 Understanding and application of liver function tests Kyung-Ah Kim, M.D. Department of
More information<31382D322D3420BDC5B1D4C8AF5FB3EDB9AE28C3D6C1BEBABB292E687770>
醫 史 學 제18권 제2호(통권 제35호) 2009년 12월 Korean J Med Hist 18ː57 72 18ː173-188 Dec. Dec. 2009 2009 C 大 韓 醫 史 學 會 ISSN ISSN 1225 505X 1225-505X 지방병 연구와 식민지배 : 1927년 영흥 및 해남지역 에메틴 중독사건을 중심으로 신 규 환* 1. 머리말 2. 일제의
More information노영남
Purpose: Delayed massive hemorrhages from pseudoaneurysm rupture of the peripancreatic large arteries, after pancreaticoduodenectomy, are fatal. We reviewed the clinical course and outcome of bleeding
More information처방정보 JW중외 제피드, 속도 안전성 개선 프리미엄 치료제 - 제피드, 발기 효과 최대 15분 환자 편의성 증대 - 내과-가정의학과 등으로 시장 확대 블록버스터 육성 JW중외제약(대표 이경하)이 출시한 국내 17호 신 약 제피드 는 기존 치료제의 불편함인 느린 발현
처방정보 해외의료 의료계이슈 뉴트렌드 보건정책 신간안내 CLINICAL ISSUE 01 02 03 04 05 06 처방정보 - 제피드 / JW중외 해외의료 의료계이슈 - 의료분쟁조정중재원의 역할 및 향후 추진방향 Medical Concert / 피부예술학 - 동 서양인의 출생 표시는 차이가 있을까? 보건정책 신간안내 - 마음아프지마 - 소아심초음파 처방정보
More informationKjcg007( ).hwp
25 Elderly People are the Major Target for Risk Reduction to Prevent Atherosclerotic Disease 동맥경화의정도 증상 (+) 증상 (-) 뇌졸중심근경색 위험인자 Hypercholesterolemia Hypertension Diabetes Mellitus Smoking Others 심장질환의고위험군이란?
More information590호(01-11)
T H E K O R E A N D O C T O R S W E E K L Y www.docdocdoc.co.kr I N S I D E 38 3 5 6 7 10 13 28 29 30 31 38 41 42 2 Advertisement Government & Medicine 3 Government & Medicine 4 Government & Medicine Government
More information여름호-내지원본
Watermelon C O N T E N T S 04 06 08 10 12 14 16 18 20 23 24 25 26 FOODMERCE 4 5 FOODMERCE 6 7 FOODMERCE 8 9 FOODMERCE 10 11 3 MON 4 TUE 5 WED 6 THU 7 FRI 18 TUE 19 WED 20 THU 21 FRI 24 MON 3 MON 4
More information김범수
Analysis of Outcomes after Resection of Sarcomatous Hepatocellular Carcinoma Purpose: Sarcomatous hepatocellular carcinoma (HCC) is rare. Therefore, the clinicopathologic characteristics and prognosis
More information13.12 ①초점
12 2013 Health and Welfare Policy Forum 2 3 4 5 Income Distribution of the Elderly and Desirable Income Support Directions 7 8 9 10 11 12 13 14 15 16 17 A Poverty Solution of Low-lncome Elderly Women
More information<5B31362E30332E31315D20C5EBC7D5B0C7B0ADC1F5C1F8BBE7BEF720BEC8B3BB2DB1DDBFAC2E687770>
2016 지역사회 통합건강증진사업 안내 - 지역사회 중심 금연지원 서비스 - 2016. 3. 주요변경사항 5 1부 국가 금연정책 추진 및 현황 Ⅰ. 국가 금연정책 개요 1. 금연정책의 배경 및 필요성 11 2. 세계 금연정책 동향 20 3. 우리나라 금연정책 추진경과 24 4. 2016년도 금연정책 추진방향 31 Ⅱ. 국가 금연사업 현황 1. 흡연자 금연지원서비스
More information1. Korea Centers for Disease Control and Prevention. The fifth Korea National Health and Nutrition Examination Survey (KNHANES V-1) 2010. Cheongwon: Korea Centers for Disease Control and Prevention; 2012.
More information08년요람001~016
Challenge to the Greatness, Beautiful Leader 2008 2009 06 07 JANUARY 01 JUNE 06 FEBRUARY MARCH 02 03 JULY AUGUST 07 08 APRIL MAY 04 05 SEPTEMBER OCTOBER 09 10 2008 schooling schedule 08 09 2008 schooling
More informationRheu-suppl hwp
Objective: This paper reviews the existing Korean medical and public health, and nursing academy articles on disease-specific and domain-specific quality of life, and provides recommendations for the universally
More information<C8DEB0A1C0CCBFEB20BDC7C5C2C1B6BBE720B9D720C8DEB0A1B9AEC8AD20B0B3BCB12DC6EDC1FD2E687770>
연구책임 이 성 태 (한국문화관광연구원 책임연구원) 연구보조 김 수 아 (서울시립대학교 조경학 석사) 서 문 우리나라는 국토에 매장되어 있는 천연자원은 물론 축적기술의 부족으 로 인하여 근로자의 근면과 성실을 통한 노동집약적 압축 성장을 추진한 역사가 있습니다. 보다 발전된 미래 청사진의 실현을 위해서 국민 모두가 쉬지 않고 일한 결과, 대한민국은 자동차
More information04_이근원_21~27.hwp
1) KIGAS Vol. 16, No. 5, pp 21~27, 2012 (Journal of the Korean Institute of Gas) http://dx.doi.org/10.7842/kigas.2012.16.5.21 실험실의 사례 분석에 관한 연구 이근원 이정석 한국산업안전보건공단 산업안전보건연구원 (2012년 9월 5일 투고, 2012년 10월 19일
More information<3034C0D3BBF3C3E1B0E8C7D0BCFABCBCB9CCB3AA2E687770>
2004년 대한임상건강증진학회 춘계학술대회 Korean Society for Health Promotion and Disease Prevention [세미나 Ⅱ] 병 의원에서 건강 증진의 활성화 선우 성 울산의대 서울아산병원 가정의학과 우리 개원가의 현실은 구조적으로 일차진료의의 중요한 기 능 중의 하나인 건강증진 상담을 제대로 할 수 없도록 짜여 져 있다.
More information종합물가정보 2016년 4월호
April 21 26 28 30 34 38 40 42 46 53 54 56 58 60 61 61 62 62 63 64 66 69 397 523 617 695 875 929 959 1 19 157 069 070 071 071 072 072 073 074 075 075 076 077 078 079 080 081 082 083 084 084 085 086 088
More information005- 4¿ùc03ÖÁ¾š
210 212 213 214 215 218 219 223 224 226 4 228 229 230 231 232 233 236 238 240 241 244 245 _ April 1 210 1946 1970 211 _ April 212 1946 1970 _ April 4 213 _ April 3. 3 214 1946 1970 _ April 5 215 216 1946
More information<C7D1B1B9C0CEC0C720B4EBC7A5BDC4B4DCBAB8B0EDBCAD2E687770>
(Mean group portion in gram) (weekly mean group frequency)/7days =average daily intake (g/day) :, 1998, 1999 ꀻ 9.4% 90.6% 해조류 어패류 7.9% 1.5% 1.2% 0.8% 28.0%
More informationSheu HM, et al., British J Dermatol 1997; 136: Kao JS, et al., J Invest Dermatol 2003; 120:
Sheu HM, et al., British J Dermatol 1997; 136:884-890 Kao JS, et al., J Invest Dermatol 03; 1:446-464 1 10 0 3 Day Normal MLE Lotion Lotion MLE Cream Cream 80 7 70 6 3 Day Normal MLE Lotion Lotion MLE
More information전립선암발생률추정과관련요인분석 : The Korean Cancer Prevention Study-II (KCPS-II)
전립선암발생률추정과관련요인분석 : The Korean Cancer Prevention Study-II (KCPS-II) 전립선암발생률추정과관련요인분석 : The Korean Cancer Prevention Study-II (KCPS-II) - i - - ii - - iii - - iv - - v - - vi - - vii - - viii - - ix - -
More informationFebruary
February 3 8 10 12 14 18 22 24 26 28 30 37 38 40 42 44 45 45 46 46 47 48 50 51 155 379 503 763 867 955 1031 1061 1 171 051 052 053 053 054 054 054 055 056 057 058 059 060 061 062 063 064 064 065 066 068
More information식료
BREAKFAST I 07:00~11:00 I MORNING BUFFET Adult 29,800 (07:00~10:00) Child 22,000 AMERICAN BREAKFAST 23,000 A Choice of Chilled Juice(Orange, Tomato, Pineapple) Two Eggs with Choice of Side Dish(Ham, Bacon,
More information심장2.PDF
(Treatment of Hypertension with Associated Diseases) 1.. (140/90 mmhg). 80 mmhg. ( ). (atenolol ), (amlodipine ) 1. -1 nitrate. ACE diltiazem, verapamil. ACE. ( )., ACE diltiazem,, diltiazem, verapamil.
More informationµµÅ¥¸àÆ®1
ISSN 1976-4294 JOURNAL OF DISASTER PREVENTION 10 11 12 2012 Vol. 14 No. 5 53 D.W.M : Deep Wing Mixing YEOMYUNG Co., Ltd. 2012 10 11 12 Vol.14 No.5 www.kodipa.or.kr 04 07 11 22 30 40 48 56 64 88 92 114
More information½Å³âÈ£-³»ÁöÀμâ
Potato C O N T E N T S 04 06 08 10 12 14 16 18 20 23 24 25 26 FOODMERCE 4 5 FOODMERCE 6 7 Total hygiene service 3HS FOODMERCE 8 9 FOODMERCE 10 11 4 MON 5 TUE 6 WED 7 THU 8 FRI 19 TUE 20 WED 21 THU 22
More informationuntitled
FOR YOUR PREMIUM LIFESTYLE CONTENTS 2014 AUTUMN FOR YOUR PREMIUM LIFESTYLE One for One [ 2074 ] 10-0394K Gift Set Business Support Tools sabn Telecom Amway TV s BEST OF NATURE. BEST OF
More information저작자표시 - 비영리 - 변경금지 2.0 대한민국 이용자는아래의조건을따르는경우에한하여자유롭게 이저작물을복제, 배포, 전송, 전시, 공연및방송할수있습니다. 다음과같은조건을따라야합니다 : 저작자표시. 귀하는원저작자를표시하여야합니다. 비영리. 귀하는이저작물을영리목적으로이용할
저작자표시 - 비영리 - 변경금지 2.0 대한민국 이용자는아래의조건을따르는경우에한하여자유롭게 이저작물을복제, 배포, 전송, 전시, 공연및방송할수있습니다. 다음과같은조건을따라야합니다 : 저작자표시. 귀하는원저작자를표시하여야합니다. 비영리. 귀하는이저작물을영리목적으로이용할수없습니다. 변경금지. 귀하는이저작물을개작, 변형또는가공할수없습니다. 귀하는, 이저작물의재이용이나배포의경우,
More informationLumbar spine
Lumbar spine CT 32 111 DOI : 10.3831/KPI.2010.13.2.111 Lumbar Spine CT 32 Received : 10. 05. 23 Revised : 10. 06. 04 Accepted : 10. 06. 11 Key Words: Disc herniation, CT scan, Clinical analysis The Clinical
More informationuntitled
FOR YOUR PREMIUM LIFESTYLE SPRING 2012 Vol.17 FOR YOUR PREMIUM LIFESTYLE 2012 Spring CONTENTS Wellness Beauty Talk Talk Talk in Spring CONTENTS 2012 Spring FOR YOUR PREMIUM LIFESTYLE Living One for One
More informationuntitled
2012 Winter FOR YOUR PREMIUM LIFESTYLE 16 CONTENTS Wellness 006 Best of Nature, Best of Science 008 010 Nutrition Supplement 014 Double X 016 Vitamin Mineral Supplement 019 Herb Functional Supplement 028
More informationȸº¸13È£
The Korean Society of Women Composers The Korean Society of Women Composers The Korean Society of Women Composers The Korean Society of Women Composers The Korean Society of Women Composers The Korean
More informationhwp
심사위원 심사위원 심사위원 인 인 인 - i - - ii - - iii - - iv - - v - Ⅰ. 서 - 1 - - 2 - - 3 - - 4 - - 5 - - 6 - - 7 - - 8 - - 9 - - 10 - - 11 - - 12 - - 13 - - 14 - - 15 - - 16 - - 17 - - 18 - 항목 건강하지못하다 주관적구강상태 보통이다
More information현재도 피운다. (a) Half pack a day (b) half to one pack a day 반 갑 미만 반 갑 ~ 한 갑 (c) one to two packs a day (d) more than 2 packs a day 한 갑 ~ 두 갑 두 갑 이상 5. Ho
Name: Preliminary Medical Examination (Female) 문진표(여성) 1. Have you ever suffered from or been treated for below diseases for more than 3 months? 과거에 다음과 같은 질병으로 3개월 이상 앓았거나 진단(치료)을 받은 적이 있습니까? 1 diabetes
More information12권2호내지합침
14 OPTICAL SCIENCE AND TECHNOLOGY April 2008 15 16 OPTICAL SCIENCE AND TECHNOLOGY April 2008 17 18 OPTICAL SCIENCE AND TECHNOLOGY April 2008 19 20 OPTICAL SCIENCE AND TECHNOLOGY April 2008 21 22 OPTICAL
More informationJournal of Educational Innovation Research 2017, Vol. 27, No. 1, pp DOI: * The
Journal of Educational Innovation Research 2017, Vol. 27, No. 1, pp.243-268 DOI: http://dx.doi.org/10.21024/pnuedi.27.1.201703.243 * - 2001 2015 - The Research Trends on Peer Counseling in Elementary and
More information*165호_전체
www.lisa.or.kr 165 2011 11 11 www.lisa.or.kr November 165 2011.11 2011 September 2011 September 12,094,000 3,000,000 15,094,000 17,627,960 10,100,000 27,727,960 41,967,320 35,000 10,000 42,012,320
More information( )Kju269.hwp
만성세균성전립선염모델흰쥐에서 의항염효과 Anti-inflammatory Effect of Lycopene on Chronic Bacterial Prostatitis Rat Model Cho Hwan Yang, Dong Wan Sohn, Yong-Hyun Cho From the Department of Urology, The Catholic University
More information식료
LUNCH & DINNER I I KOREAN TABLE D'HOTE Beef Bone & Vegetable soup with Rice 20,000 and 4Kinds of side dish Boiled Ox-Tail Soup with Steamed Rice 24,000 Sliced and Marinated Beef Ribeye Barbecued on a Bulgogi
More information歯1.PDF
200176 .,.,.,. 5... 1/2. /. / 2. . 293.33 (54.32%), 65.54(12.13%), / 53.80(9.96%), 25.60(4.74%), 5.22(0.97%). / 3 S (1997)14.59% (1971) 10%, (1977).5%~11.5%, (1986)
More information01 Lee SK, Kim SH, Cho GY, Baik I, Lim HE, Park CG, Lee JB, Kim YH, Lim SY, Kim H, Shin C. Obesity phenotype and incident hypertension: a prospective community-based cohort study. J Hypertens. 2013 Jan;31(1):145-51.
More informationuntitled
Safety Kids, send your drawing with an electrical safety tip to your local electric cooperative (address found on Page receive a prize. All entries must include your name, age, mailing address and the
More informationA Study on Married Female Immigrants Life Style and Marriage Satisfaction in Terms of Preparing Their Old Age in Chungcheongnam-do Department of Gerontology, Hoseo University Doctoral Student : Hi Ran
More informationuntitled
Case Report : Asan Medical Center Cardiac Rehabilitation AACVPR (http://www.aacvpr.org/) KACVPR (http://www.kacvpr.com/) Backgrounds PCI 2,395 consecutive patients in Minnesota (Mayo Clinic) Between1994
More information386-390.hwp
386 HANYANG MEDICAL REVIEWS Vol. 29 No. 4, 2009 우리나라 미숙아의 통계와 의료비용 Statistics and Medical Cost of Preterm in Korea 윤혜선 을지대학교 노원을지병원 소아청소년과학교실 Hye Sun Yoon, M.D., Ph.D., Department of Pediatrics, Nowon
More information00약제부봄호c03逞풚
경희대학교 동서신의학병원 약품 정보지 2 0 0 7. S P R I N G. V O L. 0 1 신약 소개 02 Journal Review 03 Special Subject 04 복약 지도 06 의약품 안전성 정보 07 약제부 알림 07 약제부 업무 소개 08 E A S T - W E S T N E O M E D I C A L C E N T E R 본 약품
More informationuntitled
CONTENTS 2013 Autumn FOR YOUR PREMIUM LIFESTYLE One for One [ 2074 ] 10-0394K Gift Set Business Support Tools sabn Telecom 630 TIP BEST OF NATURE. BEST OF SCIENCE. BEST OF NATURE BEST OF
More informationYI Ggodme : The Lives and Diseases of Females during the Latter Half of the Joseon Dynasty as Reconstructed with Cases in Yeoksi Manpil (Stray Notes w
497 의사학 제24권 제2호(통권 제50호) 2015년 8월 Korean J Med Hist 24 ː497-532 Aug 2015 c대한의사학회 http://dx.doi.org/10.13081/kjmh.2015.24.497 pissn 1225-505X, eissn 2093-5609 역시만필( 歷 試 漫 筆 ) 의 사례로 재구성한 조선후기 여성의 삶과 질병
More information16(1)-3(국문)(p.40-45).fm
w wz 16«1y Kor. J. Clin. Pharm., Vol. 16, No. 1. 2006 x w$btf3fqpsu'psn û w m w Department of Statistics, Chonnam National University Eunsik Park College of Natural Sciences, Chonnam National University
More information스포츠과학 143호 내지.indd
https simtk.org,, sanghyuk0620@kspo.or.kr.... 48 SPORT SCIENCE . 33 55% 1 2 Iwamoto and Takeda 2003 3 1 3.......?... 4 SPORT SCIENCE 1. 2 3 12 16 3 6.. 5 strain gauge. 1970. 6 1) Brukner, P., Bradshaw,
More information(Exposure) Exposure (Exposure Assesment) EMF Unknown to mechanism Health Effect (Effect) Unknown to mechanism Behavior pattern (Micro- Environment) Re
EMF Health Effect 2003 10 20 21-29 2-10 - - ( ) area spot measurement - - 1 (Exposure) Exposure (Exposure Assesment) EMF Unknown to mechanism Health Effect (Effect) Unknown to mechanism Behavior pattern
More informationMicrosoft PowerPoint - SS2_Dr.LeeHY(fiber).ppt
DRIs for Koreans Update of Scientific Issues Dietary Fiber DRIs for Fiber Korea 005 US/Canada 00 Australia/ NewZealand 00 Adequate Intake(AI) for dietary fiber AI for total fiber AI(& DG) for dietary fibre
More informationOverview -ingredient - mechanism 2. Biomarker 3. In vitro study 4. In vivo study 5. Human study 6. 기능성 인정서 7.기준규격 인정서
*CJ standard Mw 40500 standard Mw 8000 CJ CJ Chitosan 1. 70g Sprague Dawley 1 2. Stainless steel cage 3. Ingredient Basal Control CJ Sucrose Starch Casein DL-methionine Corn oil Lard Choline bitartarate
More informationuntitled
FOR YOUR PREMIUM LIFESTYLE SUMMER 2014 26 CONTENTS 2014 SUMMER FOR YOUR PREMIUM LIFESTYLE One for One [ 2074 ] 10-0394K Gift Set Business Support Tools sabn Telecom Amway TV TM EXACT FI T PRESSED
More information육화원_카다로그시안_수정22_최종검토용2
Fresh Meat Fresh Meat Yukhwawon s fresh meat division conducts the whole process of preparing all kinds of chicken meats. This process includes fat removing, deboning, and preparing the chicken cut meat.
More information???? 1
The Korean Journal of Applied Statistics (2014) 27(1), 13 20 DOI: http://dx.doi.org/10.5351/kjas.2014.27.1.013 Maximum Tolerated Dose Estimation by Stopping Rule and SM3 Design in a Phase I Clinical Trial
More informationJkbcs016(92-97).hwp
Expression of bcl-2 and Apoptosis and Its Relationship to Clinicopathological Prognostic Factors in Breast Cancer - A Study with Long Term Follow-up correlated with the survival rate.(journal of Korean
More information어린이기호식품1회제공량표시-결과보고서-줄임.hwp
우리는소비자와함께행복한세상을만든다 어린이기호식품 1 회제공량표시조사보고서 2010. 11 식품미생물팀 차례 Ⅰ. 조사개요 1 1. 추진배경 1 2. 조사기간및조사내용 2 Ⅱ. 조사결과 2 1. 어린이기호식품 2 2. 가공식품의영양표시제도 4 3. 1회제공량표시 9 4. 영양성분앞면표시제 12 5. 신호등표시제 14 6. 고열량 저영양식품 16 7. 어린이기호식품품질인증
More information2009;21(1): (1777) 49 (1800 ),.,,.,, ( ) ( ) 1782., ( ). ( ) 1,... 2,3,4,5.,,, ( ), ( ),. 6,,, ( ), ( ),....,.. (, ) (, )
Abstract Kim Dal-Rae, Kim Sun-Hyung* Dept. of Sasang Constitutional Medicine, College of Oriental Medicine, Kyung-Hee Univ. *Dept. of Sasang Constitutional Medicine, East-West Neo Medical Center, Kyung-Hee
More information02 로봇수술센터 300례 달성 캄보디아 현지 수술로 유방암, 갑상선암 22건 집도 현지 외과의사 양성 프로그램도 적극 지원 예정 <1면에 이어서> 수술은 오전 8시부터 저녁 7시까지 계속됐다. 이번 캠프에 참여한 장여구 교수는 "NGO단체인 헤브론병원이 정부로부터 외
生命尊重, 人間사랑을 實踐하는 世界 속의 海雲臺白病院 끊임없이 硏究하는 最尖端 病院 地域에 奉仕하는 信賴받는 病院 인제대학교 患者에게 感動주는 親切한 病院 仁濟大學校 海雲臺白病院 消息紙 해운대백병원 소식지 INJE UNIVERSITY HAEUNDAE PAIK HOSPITAL NEWS 부산광역시 해운대구 해운대로 8 7 5 No.31 대표전화 051-797-0100,
More information