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National Institute of Food and Drug Safely Evaluation

C O N T E N T S 005 007 049 059 063 067 069 National Institute of Food and Drug Safely Evaluation

National Institute of Food and Drug Safely Evaluation

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National Institute of Food and Drug Safely Evaluation

National Institute of Food and Drug Safely Evaluation 9

(mg/100 ml) (C.paradisi) Naringin 4.5-60.2 4.8-119.7 Naringenin 0.98-8.00 0.40-16.2 Quercetin 0.17-0.21 0.2-0.9 Didymin Flavonoids 0.27-0.33 0.0-1.7 Poncirin 0.85-1.58 0.1-2.4 Hesperidin 0.25-1.79 0.2-16.4 Kaempferol - - 6,7- dihydroxybergamottin 0.8-34.7 - Bergamottin Furanocoumarins 7.2-10

National Institute of Food and Drug Safely Evaluation 200 mg 150 mg/3 ml 11

400 mg 0.25 mg CJ 50 /ml 0.25 mg/ml 12

National Institute of Food and Drug Safely Evaluation 10 mg 10, 20, 40, 80 mg 5/10 mg () 5/10, 5/20 mg () 5/10, 5/20 mg () 10, 20 mg 10, 40 mg 10, 20, 40, 80 mg 10, 20, 40, 80 mg 10, 20 mg / 10 mg 10, 20 mg 10, 20, 40, 80 mg / 5/10 mg 10 mg 10, 20, 40 mg 10, 20, 40 mg 5/10 mg 10 mg ()/ 10 mg 13

5/10 mg 10 mg () 10.36 mg 10 mg 10, 20, 40 mg 10 mg 5/10 mg 20 mg 10 mg 10, 40 mg 10 mg 10, 20 mg 10 mg - 10 mg 5/10, 5/20 mg 5/10 mg 5/10, 5/20, 5/40 mg / 5/10, 5/20 mg 5/10 mg 5/10, 5/20 mg 5/10 mg 5/10, 5/20 mg 10, 20 mg 10 mg 5/10, 5/20 mg 5/10, 5/20 mg 10 mg () 14

National Institute of Food and Drug Safely Evaluation 20 mg () 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg () 20 mg () 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 15

20 mg 20 mg 20, 40 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 20 mg () 20 mg 20 mg 10/10, 10/20 mg 10/10, 10/20 mg 10/10, 10/20, 10/40 mg 20 mg / 20 mg 20 mg () 20, 40 mg 16

National Institute of Food and Drug Safely Evaluation 10/10, 10/20 mg 20 mg 20 mg 20, 40 mg 20 mg () 20 mg () 20 mg () () 20 mg 10, 20 mg 20, 40 mg CJ () 20 mg () 20 mg 20 mg 20 mg 20, 40 mg 20, 40 mg 20 mg 20 mg 20 mg 10/10, 10/20 mg 20 mg 20 mg 20 mg 20 mg 20 mg 10/10, 10/20 mg () 20, 40 mg 20 mg 20, 40 mg 20 mg 10(), 20 mg 20 mg 17

20 mg 20 mg 20 mg 20 mg 20 mg () 40 mg 20 mg 40 mg 10/20 mg 20 mg 40 mg () 20 mg 20 mg 20 mg 20 mg 10/10, 10/20 mg 10/10, 10/20 mg 20 mg 20 mg 20 mg 20 mg 20, 40 mg 40 mg 20, 40 mg 20, 40 mg 20 mg 20 mg 10/10, 10/20 mg 20 mg 40 mg 20 mg 20, 40 mg () 18

National Institute of Food and Drug Safely Evaluation 50 mg 50 mg () 50 mg 50 mg 50, 100 mg 100 mg 50 mg 50 mg 50 mg 50 mg 100 mg 50 mg 50 mg 50 mg 19

100 mg 100 mg () 50 mg 50 mg 50 mg () 50 mg 50 mg 50 mg 50 mg 50 mg () 50 mg () 50, 100 mg 50 mg () 20

National Institute of Food and Drug Safely Evaluation 5 mg 5 mg () 2.5, 5 mg 2.5 mg 5 mg () 5 mg 2.5, 5 mg 5 mg 5 mg () 5 mg 5 mg / 5 mg 5 mg () 5 mg 2.5, 5 mg 21

5 mg 5 mg () 5 mg 5 mg 5 mg 2.5/2.5, 5.0/5.0 mg 5 mg 5 mg 5 mg 5 mg () 5 mg () () 5 mg () 5 mg 5 mg 5 mg 2.5, 5 mg 5 mg 5 mg 5 mg () 5 mg 5 mg 5 mg 5 mg 5 mg 5 mg 5 mg 22

National Institute of Food and Drug Safely Evaluation 10 mg 30 mg 30 mg 40 mg 20 mg 5 mg 30, 60 mg 10 mg 10 mg 20 mg() 10 mg 24 30 mg 30 mg 30 mg 10 mg/50 ml / 23

30 mg 10 mg/50 ml 10 mg 30 mg 30 mg 30 mg 10 mg/50 ml 10, 20 mg 20 mg 10, 20 mg /() 10/20 mg () 24

National Institute of Food and Drug Safely Evaluation 5, 10 mg 10, 20 mg 5 mg 5 mg 6.994 mg 5, 10 mg 5 mg 5, 10 mg 5/10 mg () 5 mg/10 mg, 5 mg/20 mg 5 mg 5/10, 5/20 mg () 5 mg 5, 10 mg 25

5, 10 mg 5 mg 5 mg/10 mg 5/10 mg 5 mg 5/20, 5/40, 10/40 mg / 5, 10 mg 5 mg/10 mg 5 mg/10 mg 5 mg 5 mg/10 mg 5 mg 5/160, 10/160, 5/80 mg / 5/10, 5/20 mg 6.94 mg 5 mg/10 mg 5/10 mg 5/10 mg 5/10 mg 5 mg/10, 5 mg/20 mg 5/10 mg 5/10, 5/20 mg 5 mg/10 mg, 5 mg/20 mg 40/10, 40/5, 80/5 mg 6.944 mg 5 mg/10 mg, 5 mg/20 mg 26

National Institute of Food and Drug Safely Evaluation 180, 240 mg 40, 80 mg 30, 90 mg 90 mg 180 mg 30 mg CJ / 50 mg 27

150, 300 mg 300 mg 200 mg 28

National Institute of Food and Drug Safely Evaluation 200 mg 200 mg 200, 300 mg 200 mg 2 % 20 mg/ml 100 ml 200 mg 200 mg 29

2 mg 10 mg/2 ml 10 mg/2 ml 5 mg/ml 2, 5, 10 mg 10 mg/2 ml 2, 5 mg / 5 mg 2, 5 mg 10 mg/2 ml 7.5 mg 5 mg/5 ml, 15 mg/3 ml 5 mg/5 ml, 15 mg/3 ml 3 mg/3 ml, 5 mg/5 ml, 15 mg/3 ml 3 mg, 5 mg/5 ml, 15 mg/3 ml 30

National Institute of Food and Drug Safely Evaluation 0.125, 0.25 mg 0.25 mg 0.125, 0.25 mg 5, 10() mg 5, 10, 15 mg 5, 10 mg 10 mg 5 mg 5 mg 5 mg 5 mg 31

50 mg 50 mg 50, 100 mg 50 mg 200, 1000 mg 500 mg 34

National Institute of Food and Drug Safely Evaluation 25 mg 100 mg/5 ml(vial) 100 mg/5 ml 100 mg/5 ml 2 % 100 mg/5 ml 100, 150, 500 mg 100 mg/5 ml, 150 mg/7.5 ml 20 mg/ml (2, 5 ml) 20 mg (2, 5 ml) 20 mg/ml(2.5, 25 ml) () 20 mg/ml (2, 5, 10, 15, 20 ml) 20 mg (2, 5, 7.5, 10, 12.5, 15, 20 ml) 35

20 mg/ml (2, 5 ml/v) 40 mg/2 ml 40, 100, 200 mg 20 mg/ml (2, 5, 10, 15 ml) 40 mg/2 ml, 100 mg/5 ml /CJ 20 mg/ml (40, 100, 200, 300 mg) () 36

National Institute of Food and Drug Safely Evaluation 250 mg 200 mg 12.5, 25, 50 mg 37

15, 45 mg 1 mg () 38

250 mg/5 ml - 100 mg/ml - 25, 100 mg/ml 100 mg/ml 25, 100 mg 250 mg/5 ml 25, 100 mg 25, 100 mg 40

National Institute of Food and Drug Safely Evaluation 30, 120, 180 mg () 120 mg 120 mg () 120 mg 30, 120, 180 mg 120 mg 120 mg 120 mg 41

0.5, 1, 2 mg 1, 2 mg () 0.6 mg 42

National Institute of Food and Drug Safely Evaluation 4, 8 mg 50, 100 mg 43

400 mg 400 mg 400 400 mg 400 mg () 400 mg () 20 mg/ml() 200, 400 mg 400 mg 400 mg 400 mg () 400 mg 400 mg 400 mg 400 mg 200, 400 mg 400 mg () 400 mg 400 mg 44

() 200 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100 mg 100, 200 mg 100 mg 100 mg 100 mg () 100 mg 100 mg JW 46

1/10, 2/10 1, 2 mg 1, 2 mg 4 mg 4 mg 4 mg () 4 mg 4 mg 4 mg 125, 500 mg 4 mg () 125, 500 mg 2, 4 mg 4 mg 125, 500 mg 4 mg () 4 mg 125 mg/80 ml, 500 mg/80 ml 4 mg 4 mg JW 48

National Institute of Food and Drug Safely Evaluation

Naringin (C.sinensis) (mg/100 ml) (C.aurantium) 21.0 0.20-7.54 1.97-9.0 Naringenin - 0.8 - Quercetin - - - Didymin Flavonoids 0.80-3.10 1.14-3.53 - Poncirin 0.49-1.59-0.73 Hesperidin 3.51-55.2 4.45-76.3 - Kaempferol - - 0.14 6,7- dihydroxybergamottin - - 10.3 Bergamottin Furanocoumarins - - 0.8 50

National Institute of Food and Drug Safely Evaluation Naringin (C.sinensis) (mg/100 ml) (C.aurantium) (C.paradisi) 21.0 1.97-9.0 4.5-60.2 Naringenin Flavonoids - - 0.98-8.00 Hesperidin 3.51-55.2-0.25-1.79 6,7- dihydroxybergamottin - 10.3 0.8-14.7 Bergamottin Furanocoumarins - 0.8 7.2 5 mg 5 mg () 2.5, 5 mg 2.5 mg 5 mg () 5 mg 51

2.5, 5 mg 5 mg 5 mg () 5 mg 5 mg / 5 mg 5 mg () 5 mg 2.5, 5 mg 5 mg 5 mg () 5 mg 5 mg 5 mg 2.5/2.5, 5.0/5.0 mg 5 mg 5 mg 5 mg 5 mg () 5 mg () () 5 mg () 5 mg 5 mg 5 mg 2.5, 5 mg 5 mg 5 mg 5 mg () 5 mg 5 mg 5 mg 5 mg 5 mg 5 mg 5 mg 52

National Institute of Food and Drug Safely Evaluation 7.5 mg 5 mg/5 ml, 15 mg/3 ml 5 mg/5 ml, 15 mg/3 ml 3 mg/3 ml, 5 mg/5 ml, 15 mg/3 ml 3 mg, 5 mg/5 ml, 15 mg/3 ml 53

() 30, 120, 180 mg 120 mg 120 mg () 120 mg 30, 120, 180 mg 120 mg 120 mg 120 mg 70 mg 70 mg () 5, 10 mg 54

National Institute of Food and Drug Safely Evaluation 70 mg 70 mg 70 mg 70 mg 70 mg 70 mg 91.37 mg 70 mg 70 mg () 5, 10 mg 70 mg 70 mg 70 mg () 70 mg () 70 mg 70 mg 70 mg 70 mg 70 mg () 70 mg 70 mg 70 mg 70 mg 70 mg 70 mg 70 mg 70 mg () 70 mg 70 mg 70 mg 70 mg 70 mg () 70 mg 70 mg 55

91.37 mg 70 mg 70 mg 70 mg 10, 70 mg / 70 mg 70 mg () 70 mg 70 mg () 56

National Institute of Food and Drug Safely Evaluation 50 mg 57

National Institute of Food and Drug Safely Evaluation

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National Institute of Food and Drug Safely Evaluation 300 mg 200 mg 200 mg 200 mg 200, 300 mg 200 mg 2 % 20 mg/ml 100 ml 200 mg 200 mg 2, 5 mg 5 mg 2, 5 mg 61

National Institute of Food and Drug Safely Evaluation

30 mg 64

National Institute of Food and Drug Safely Evaluation 15 mg 15 mg 15, 30 mg 15, 30 mg 15, 30 mg 15, 30 mg 30 mg 30 mg 30 mg 30 mg 30 mg 30 mg 30 mg 30 mg () 30 mg 30 mg 15 mg 30 mg 30 mg () 30 mg () 30 mg 30 mg 30 mg 30 mg 30 mg 30 mg () 30 mg 30 mg 30 mg 30 mg 30 mg 30 mg 65

2, 5 mg 5 mg 2, 5 mg 66

National Institute of Food and Drug Safely Evaluation

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National Institute of Food and Drug Safely Evaluation

70

National Institute of Food and Drug Safely Evaluation 71