슬라이드 1

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This specialized formulation will present more clean and

1 H Y D R O G E N S O A P 유셀라 TM 하이드로젠솝 ( 수소비누 ) EuːCELA HYDROGEN SOAP Hydrogen is a most effective anti-oxidant. This specialized formulation will present more clean and younger face by eliminating skin wastes and oxidative stresses.

2 INDEX HYDROGEN COSMETICS HYDROGEN SCIENCE (PUBLICATION) HYDROGEN GENERATING MATERIALS EuːCELA HYDROGEN SOAP 2

3 HYDROGEN COSMETICS HYDROGEN 수소 (Hydrogen) 란 원자번호 1 의지구상에서가장작은물질로서소량으로도효율적인항산화효능을발휘한다 활성산소와결합하여무해한물로변화시켜체외로배출시킨다 다른항산화제와는달리산화물이물이되어안전하며체내에남지않는다 산화력이가장강한하이드록실라디칼과도결합하여중화시킨다 피부항산화 피부내활성산소를억제하고피부의산화를억제하는작용 대표적인항산화물질비타민 C, E, 폴리페놀, 카테킨 ( 녹차 ), 플라보노이드, 코엔자임 Q10, SOD 단백질등 기존항산화제의단점 -. 상대적으로많은양을필요로함 -. 스스로산화물이되어인체에안좋은영향을미친다. ( 비타민 C 의산화 ) 3

skin from damage Free Radicals Neutralized Radicals

4 HYDROGEN COSMETICS HYDROGEN Pollution UV UV Exposure Allergen Stress Poor Nutrition Antioxidants like Hydrogen, Vitamin C & E, and SOD help protect the skin from damage Free Radicals Neutralized Radicals 수소의환원효과로산화된피부를건강하게환원시키는데도움을줍니다. 유해산소로부터피부를보호하는데도움을줍니다. 산화되어항산화제로서역할을하지못하는 Vitamin C, E 등항산화제를환원시켜항산화제로서재이용이가능하게해줍니다. 4

HYDROGEN SCIENCE (COSMETIC ASPECT) SCIENCE 항산화작용 (Antioxidant) -. 하이드록실라디칼제거. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Ref. Nat Med.

5 HYDROGEN SCIENCE (COSMETIC ASPECT) SCIENCE 항산화작용 (Antioxidant) -. 하이드록실라디칼제거. Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals Ref. Nat Med Jun;13(6): 산화스트레스완화. Molecular hydrogen is a novel antioxidant to efficiently reduce oxidative stress with potential for the improvement of mitochondrial diseases Ref. Biochim. Biophys. Acta May;1820(5): 항산화효능. The principle and the potential approach to ROS-dependent cytotoxicity by non-pharmaceutical therapies: Optimal use of medical gases with antioxidant properties Ref. Curr. Pharm. Des. 2011;17(22):

HYDROGEN SCIENCE (COSMETIC ASPECT) SCIENCE 콜라겐합성촉진 -. H 2 -rich electrolyzed warm water promotes the type-i collagen synthesis in fibroblasts Ref. J Photochem Photobiol B.

6 HYDROGEN SCIENCE (COSMETIC ASPECT) SCIENCE 콜라겐합성촉진 -. H 2 -rich electrolyzed warm water promotes the type-i collagen synthesis in fibroblasts Ref. J Photochem Photobiol B Jan 5;106:24-33 피부미백효능 (Whitening) -. 멜라닌생성저해. Inhibitions by hydrogen-occluding silica microcluster to melanogenesis in human pigment cells and tyrosinase reaction Ref. J. Nanosci. Nanotechnol Jan;13(1):52-59 아토피 (Atopic dermatitis) -. Positive effects of hydrogen water on 2,4-dinitrochlorobenzene-induced atopic dermatitis in NC/Nga mice Ref. Biol. Pharm. Bull. 2014;37(9):

7 HYDROGEN SCIENCE (MEDICAL ASPECT) SCIENCE 항염 (Anti-inflammation) -. Hydrogen gas improves survival rate and organ damage in zymosan-induced generalized inflammation model Ref. Shock Nov;34(5): 항암 (Anti-tumor) -. Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice Ref. Cancer Chemother. Pharmacol Sep;64(4): 항알러지 (Anti-allergic) -. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells Ref. Biochem. Biophys. Res. Commun Nov 27;389(4): 기타질환 -. 심근경색. Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury Ref. Biochem. Biophys. Res. Commun Aug 15;373(1): 파킨슨병. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease Ref. Neurosci. Lett Apr 3;453(2): 인지장애. Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice Ref. Neuropsychopharmacology Jan;34(2): 대사질환. Molecular hydrogen improves obesity and diabetes by inducing hepatic FGF21 and stimulating energy metabolism in db/db mice Ref. Obesity (Silver Spring) Jul;19(7):

8 HYDROGEN GENERATING MATERIALS

9 수소발생화장품원료 수많은가능성을지닌마이크로클러스터 ( 플래너수소 ) 마이크로클러스터는미국의패트릭플래너건 (Patrick Flanagan ) 박사가개발한나노실리카와미네랄성분을배합한분말입니다. 마이크로클러스터의원료는구연산칼륨탄산칼륨이산화규소 ( 실리카 ) 황산마그네슘등으로구성되어있으며, 수분과반응하면엄청난양의수소를발생시켜활성산소의중화 제거 ( 안티산화 ) 을자기면역력을높여줍니다. 건강식품, 화장품용수소흡입용등여러종류의마이크로클러스터를취급하고있습니다. 이름마이크로클러스터 J 마이크로클러스터 BHP 마이크로클러스터 구성성분 해바라기기름, 구연산칼륨, 탄산칼륨, 미립이산화규소, 황산마그네슘 구연산칼륨, 탄산칼륨, 실리카, 황산마그네슘, 향료 해바라기씨오일, 구연산칼륨, 탄산칼륨, 실리카, 황산마그네슘 원료원산지미국미국, 대만 ( 향료 ) 미국 형상분말분말분말 용도건강식품화장품화장품 특징 산화환원전위 -950mv 항산화에특화된소재. 용존수소량 : 1.608ppm. PH 를낮추고향료를더한소재. 산화환원전위 -950mv 항산화에특화된소재. 기대되는효능 항산화 멜라닌억제, 셀룰라이트억제, 콜라겐구축 멜라닌억제, 셀룰라이트억제, 콜라겐구축 9

장수의물 개발히스토리 헨리코안다박사와의만남위대한과학자이며노벨상수상자인앙리 Coanda 박사는유체역학의발견 ( 세계최초의제트기를제작 ) 과 600 개이상의특허의소유자입니다. 앙리 Coanda 박사는 100 세이상의사람들이건강한생활을하고있는카라코람산맥의북쪽파키스탄훈자 (Hunza) 지역식수에관심을가졌습니다.

10 장수의물 개발히스토리 헨리코안다박사와의만남위대한과학자이며노벨상수상자인앙리 Coanda 박사는유체역학의발견 ( 세계최초의제트기를제작 ) 과 600 개이상의특허의소유자입니다. 앙리 Coanda 박사는 100 세이상의사람들이건강한생활을하고있는카라코람산맥의북쪽파키스탄훈자 (Hunza) 지역식수에관심을가졌습니다. 코안다박사는미국국방부에서함께일하던 17 세의과학천재패트릭플래너건에연구데이터를제공하고장수의비밀탐구를계속하는것을패트릭에요구했습니다. 빙하우유의연구패트릭은그제안을받아연구를계속했습니다. 그는사람들이일상적으로 120 세가되어도놀라운건강한삶을살고있는세계의 5 개의토지를연구했습니다. 사람들은건강한생활은자신들이마시고있는물이라고합니다. 5 개지역에서는식수는녹은빙하에서와서물리적으로우리의마시는물과다릅니다. 그물은낮은표면장력을가지고우리몸의세포를둘러싼물과같은특성이있습니다. 그물은 " 빙하우유 " 라고최고의물로알려져있습니다. 기적의물을재현! 패트릭플래너건박사의목표는훈자지역물과같은물을만듦으로써전세계사람들에게장수를선물하는것이었습니다. 훈자물 " 속의콜로이드미네랄은지금까지알려져있지않았던특수한유형의 " 실리카 ( 규소 )" 임을파악하고, 나노기술을응용하여거의 10 년의세월을걸쳐높은마이너스전하를가진직경 5nm 의콜로이드입자를만들어내는것에성공하고드디어코안다박사의연구투입후거의 35 년의세월을걸쳐 훈자물 " 의재현에성공했습니다 년이기술 " 마이크로클러스터기술 로인해플래너박사는노벨상후보에까지올랐습니다. 수소를포함한마이크로클러스터마이크로클러스터 기술의개발이후플래너박사는실리카수소를개발하고미네랄의유효성을올려왔습니다. 마이크로클러스터기술은건강과삶의질향상을 21 세기에가져왔습니다. 마이크로클러스터개발자패트릭플래너건박사 1944 년미국오클라호마에서태어나 1955 년 11 세 ' 유도미사일탐지기 ' 개발 1958 년 14 세 ' 뉴로폰 ' 개발 1962 년 17 세잡지 ' 라이프 ' 에서가장잠재력있는과학자 10 명선정 * 1983 년훈자물재현 ' 크리스탈에너지 를개발 1994 년마이크로클러스터기술로노벨상후보 1997 년수소를함유한 241 번째실리카 " 마이크로클러스터 ' 개발이외에도 300 개이상의특허를가지고있습니다. 10

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12 Increasing amount of Melanin (%) Microcluster ( Flanagan hydrogen ) research report 현립히로시마대학생명환경학부세포사멸제어공학연구실교수三羽信比古 Study on melanin inhibitory effect in human pigment cells Purpose : Verification of melanin inhibitory effect of microcluster Verification Method : the human pigment cells irradiated with ultraviolet A wave measuring the increase in the amount of melanin Comparison : a. Untreated control b. Kojic acid ( existing whitening agent) administration c. Microcluster administration (low concentration of 1 ppm) % % 12.22% a b c 12

Study on melanin inhibitory effect in human pigment cells Inhibitory effect on melanin production of micro- cluster in human pigment cells (Presentation of cell characteristics due to an optical

pigment cells ( after ultraviolet A wave irradiation ) Melanin pigment cells are suppressed Pigment cell Melanin (Black granules) 멜라닌다산세포의특징인세포비대화 세포돌기다극화 핵인접부영역의멜라닌축적이관찰되었다.

13 Study on melanin inhibitory effect in human pigment cells Inhibitory effect on melanin production of micro- cluster in human pigment cells (Presentation of cell characteristics due to an optical microscope zoom up photo) No administration of human pigment cells ( after ultraviolet A wave irradiation ) Melanin increases in the interior of the pigment cells Microcluster administration of human pigment cells ( after ultraviolet A wave irradiation ) Melanin pigment cells are suppressed Pigment cell Melanin (Black granules) 멜라닌다산세포의특징인세포비대화 세포돌기다극화 핵인접부영역의멜라닌축적이관찰되었다. 멜라닌소산세포의특징인세포슬림화 소수의세포돌기가관찰되었다 Melanin increase of pigment cells by UV-A has been suppressed by 1 ppm (low concentration) of microcluster. This, we thought to be due to active oxygen derived from UV-A is the trigger of melanin production has been erased by the microcluster 13

A study report on the fat droplets / cellulite inhibitory effect Fat droplet accumulation suppression effect in the interior of the fat cell OP9 by the addition of microcluster Purpose : Verification

Untreated control b. Microcluster administration (1500 ppm) Note : What is cellulite formation (skin surface and uneven fat mass)?

14 A study report on the fat droplets / cellulite inhibitory effect Fat droplet accumulation suppression effect in the interior of the fat cell OP9 by the addition of microcluster Purpose : Verification of inhibitory effect of lipid droplets / cellulite of micro cluster Verification Method : The decomposition induced by such as insulin - adrenal cortex hormone fat cell OP9 Comparison : a. Untreated control b. Microcluster administration (1500 ppm) Note : What is cellulite formation (skin surface and uneven fat mass)? Cells lipid droplets have accumulated excess is easily die because of oxidative stress, lipid droplets are released extracellularly in association with cell death. cellulite is formed by receiving the lipid peroxidation Untreated (After induction of differentiation) 1500ppm of Microclusters (After induction of differentiation) Fat droplets Many of the fat droplets are generated Fat droplets is suppressed more than 90% 14

In human skin fibroblasts A study report on the collagen building effect Immunostaining of type I collagen in human skin fibroblasts Purpose : Verification of collagen building effect of microcluster

And validate the collagen production situation under suppression Comparison : a. Untreated control b. Retinol (existing anti-wrinkle agent) administration b.

15 In human skin fibroblasts A study report on the collagen building effect Immunostaining of type I collagen in human skin fibroblasts Purpose : Verification of collagen building effect of microcluster Verification Method : Immunostaining collagen by irradiating ultraviolet A wave in human dermal fibroblasts to suppress the building. And validate the collagen production situation under suppression Comparison : a. Untreated control b. Retinol (existing anti-wrinkle agent) administration b. Microcluster administration Blue : Nucleus Green : Collagen (a) (b) (c) Micro clusters increase type I collagen to 2.35 times that of untreated control in human skin fibroblasts and retinol, an existing anti-wrinkle agent, increase to 1.39 times Microclusters showed no cytotoxicity even at a considerable dose, is expected as friendly to the skin anti-wrinkle agent 15

16 EU: CELA HYDROGEN SOAP( 유셀라하이드로젠솝 )

This specialized formulation will present more clean and younger face by eliminating

17 EuːCELA HYDROGEN SOAP 유 ː 셀라하이드로젠솝 ( 수소비누 ) 100 g x 3 EA Hydrogen is a most effective anti-oxidant. This specialized formulation will present more clean and younger face by eliminating skin wastes and oxidative stresses. 주성분 H2, MK303, 100% 천연식물성지방산, 알로에베라추출물, 쉐어버터, 토코페롤, 라벤더오일, 티트리오일, 올리브오일, 호호바오일 사용방법세안이나전신사용시거품을충분히낸후, 1 분간마사지하듯문질러주신후미온수로충분히헹구어줍니다. 17

EuːCELA HYDROGEN SOAP ( 유셀라하이드로젠솝 ) INGREDIENT MK303( 발명특허제 0298832) 친환경천연물질로생체에이롭게합성시킨소재 과잉피지제거작용 신진대사촉진작용 콜라겐합성작용 음이온방사 천연식물성 100% 지방산 자연친화,

18 EuːCELA HYDROGEN SOAP ( 유셀라하이드로젠솝 ) INGREDIENT MK303( 발명특허제 ) 친환경천연물질로생체에이롭게합성시킨소재 과잉피지제거작용 신진대사촉진작용 콜라겐합성작용 음이온방사 천연식물성 100% 지방산 자연친화, 환경친화적이며피부에미치는트러블이없다. 라우릭산과미리스틱산이다량함유되어있어거품에차이가많다 알로에베라 피부진정작용, 보습작용, 비타민 1,2 가풍부하여피부에직접공급 쉐어버터 우수한모이스처라이저인시어버터의보습력은모든식물소재중가장뛰어납니다.. 피부에영양공급과보호역할을한다.. 18

19 EuːCELA HYDROGEN SOAP ( 유셀라하이드로젠솝 ) INGREDIENT 라벤더오일 피부에트러블, 문제성피부에도움을줍니다. 티트리오일 티트리오일은항균성이뛰어난식물추출물입니다. 문제성피부에효과적입니다. 올리브오일 탁월한보습효과. 거칠어진피부를촉촉하게한다. 호호바오일 무자극성, 보습효과, 피부를부드럽게만들며여드름을유발시키지않습니다. 토코페롤 세포막의투과성으로피로물질인젖산등을피부밖으로배출시켜피부에탄력과미백작용을합니다. 19

20 EuːCELA HYDROGEN SOAP ( 유셀라하이드로젠솝 ) EFFECTS 유셀라하이드로젠솝에함유된수소가피부의활성산소를제거하며피부면역력을회복하는데도움을줍니다. 풍부한거품은비누만으로도메이크업을피부자극없이깨끗이정리하며노화된피부의각질을효과적으로정리합니다. 풍성한거품으로얼굴을부드럽게마사지하면피부혈액순환과신진대사에도움을주어피부를부드럽고탄력있게가꿉니다.. 세안후로션, 앰플, 세럼, 에센스, 영양크림사용시효과와효능을더높이는부스터효과가있습니다. 헤어샴퓨대신사용하면잦은파머와염색으로손상된헤어와두피회복에도움을줍니다. 문제성피부에사용하면과도한피지분비를제거하고염증을예방할수있습니다. 합성계면활성제를사용하지않아서피부를자극시키지않으며환경친화적입니다. 20

21 CONTACT 디오셀 [DIOCELL Inc.] TEL. 02) FAX. 02)

Journal of Life Science 2011, Vol. 21. No μ μ

Journal of Life Science 2011 Vol. 21. No. 8. 1120~1126 ISSN : 1225-9918 DOI : http://dx.doi.org/10.5352/jls.2011.21.8.1120 μ μ μ α β Journal of Life Science 2011, Vol. 21. No. 8 1121 μ μ 1122 생명과학회지 2011,