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목 차 - 2 -

과제명 중심단어 β 주관연구기관 연구기간 β β β β β - 1 -

Title of Project Key Words Prion, Neurodegenerative disease, biomarker, β-amyloid, albumin Institute Kyungwon University Project Leader Seong Soo A.An Project Period 2010. 01. - 2010. 11. β β β β β - 2 -

학술연구용역사업연구결과 β β β β β β β β β - 3 -

β β β β γ β α α - 4 -

β α Disease Creutzfeldt Jakob Disease Alzheimer s Disease Parkinson sdisease Huntington disease Amyotrophic lateral sclerosis Type-II Diabetes Protein biomarker Prion protein Aβ-peptide, Tau α-synuclein Huntingtin Superoxide dismutase Amylin 아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β - 5 -

아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β 아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg 아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β β β α - 6 -

β β β - 7 -

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아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β β β β β β β - 13 -

β β β β β β - 14 -

β 아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β β β β 아미노산번호 Albumin, Aβ의 PrP에대한결합중복부위 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β β β β β β β - 15 -

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아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β 아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β β β - 18 -

147-151 번 23-40 번 β - 19 -

β - 20 -

β β - 21 -

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아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β 아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β 아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg - 23 -

아미노산번호 Sequence 1 manlgcwmlv lfvatwsdlg lckkrpkpgg wntggsrypg qgspggnryp 51 pqggggwgqp hgggwgqphg ggwgqphggg wgqphgggwg qgggthsqwn 101 kpskpktnmk hmagaaaaga vvgglggyvl gsamsrpiih fgsdyedryy 151 renmhrypnq vyyrpmdeys nqnnfvhdcv nitikqhtvt tttkgenfte 201 nitikqhtvt tttkgenfte tdvkmmervv eqmcitqyer esqayyqrgs 251 smvlfssppv illisflifl ivg β β 147-151 번 23-40 번 β β β - 24 -

ε ε ε β β α β α β α β - 25 -

α β α - 26 -

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β (Table 18) 사람혈청알부민과그제조회사 - 29 -

제 5 장연구성과 5.1 활용성과 과제명 과제책임자 번호논문제목저자명저널명집 ( 권 ) 페이지 Impact 국내 / factor 국외 SCI여부 1 2 번호발표제목발표형태발표자학회명연월일발표지 1 2 국내 / 국제 번호출원 / 등록 1 2 특허명출원 ( 등록 ) 인출원 ( 등록 ) 국출원 ( 등록 ) 번호 IPC 분류 - 30 -

5.2 활용계획 제 6 장기타중요변경사항 - 31 -

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제 8 장첨부서류 - 35 -