검색및활용 2019.9.27. 박은선 peunsun@snu.ac.kr 목차 I. PubMed 소개및기본검색 II. MeSH Database 검색 III. 검색전략수립및예시 IV. MY NCBI 활용 1
I. PubMed 소개및기본검색 PubMed 레코드수 PubMed 색인된 (Indexed for MEDLINE) 논문 색인전 (In process, as supplied by publisher) 논문포함 Out of the scope of Medline journals. MEDLINE Index Medicus Non-Index Medicus ( 간호학, 치의학, 보건학등포함 ) 29,756,498 건 25,942,967 건 Medline 87% PMC 16% 4,997,858 건 PMC (PubMed Central) PubMed 의 Open Access Repository 무료원문 DB 2019.6.28 기준 MEDLINE 이란? 미국국립의학도서관이개발한의학 (Index Medicus), 간호학, 치의학, 수의학등 (Non Index Medicus) 보건과임상을망라하는최고의의학문헌서지색인데이터베이스 1944년도이후출판된 Biomedical and Clinical분야의 저널 15,107종 (Currently 5,235종 ) 이색인됨 온라인을통해 MEDLINE을검색하는온라인검색시스템 2
I. PubMed 소개및기본검색 Index Medicus - 1879 년부터미국국립의학도서관에서발간한의학문헌색인집 < 초창기 Index Medicus 표제지 > <PubMed 에등재된 Index Medicus 학술지예 > 3
PubMed 검색 - 기본검색 ATM 이란? 기본검색창에입력하는검색어 ( 자연어 ) 가 PubMed 에색인된통제어로바뀌검색어 자동변환 예시 : Phenytoin should not be used to treat epilepsy in pregnant women -> 임산부에게간질치료를목적으로페니토인을사용해서는안된다. 검색필드 https://www.nlm.nih.gov/bsd/mms/medlineelements.html 4
PubMed 검색 - 기본검색 Shaded areas indicate retrieval Search Statement stress AND anxiety Types of records retrieved Documents that have both stress AND anxiety stress OR anxiety Documents that have either stress OR anxiety stress NOT anxiety Documents that have stress but NOT anxiety AND, OR, NOT 검색 lung AND cancer : lung과 cancer가모두포함된논문검색 lung OR cancer: lung이나 cancer 둘중하나만포함되어있으면검색 lung NOT cancer: lung 검색결과에서 cancer가포함된논문은제외 Phrase 검색단어구로검색하기위해서는 사이에구를입력 Nesting 검색 ( ) 가있으면우선검색 Truncation 절단검색을원할때는 * 를사용하여검색예 : child* (child, children, childhood 등 ) 5
기본검색 Memory consolidation in the cerebellum PubMed.com 에서 Memory consolidation in the cerebellum 넣어검색한다면? 6
기본검색 ( 예시 ) ("memory consolidation"[mesh Terms] OR ("memory"[all Fields] AND "consolidation"[all Fields]) OR "memory consolidation"[all Fields]) AND ("Cerebellum"[Journal] OR ("the"[all Fields] AND "cerebellum"[all Fields]) OR "the cerebellum"[all Fields]) 7
저널명연도 ; 권 ( 호 ): 페이지. doi:. 원문배너링크 저자명 저자소속기관 관련논문 PMID(PubMed Identification Number)-[ 인덱싱상태 ] 이논문을인용한 PMC 논문 MeSH Terms Substances LinkOut-more resources 8
PubMed 검색 - Advanced 검색 특정필드키워드검색 여러필드를조합하여검색 검색 history 9 Text Words [tw] TW 검색은아래와같은 Field 에서검색된다 Title Abstract MeSH headings and Subheadings author-supplied keywords Chemical Names of Substances Secondary Source Identifier, which identifies a secondary source that supplies information (e.g., GenBank; ClinicalTrials.gov beginning in July 2005) 9
II. MeSH Database 검색 MeSH란? Medical Subject Headings 의약자로한글로는 의학주제명표목 이라고부름 시소러스 : 어휘를개념상으로분류하여유의어, 반의어및상하위관계를정의해놓은일종의사전 자연어 / 통제어 통제어검색 : Indexing term 검색으로적절한문헌검색에정확도를높여주고, 부적절한문헌을배제할가능성을높여줌 자연어검색 : 논문이색인전단계인경우, 저자키워드가 MeSH 용어에없는경우, MeSH Indexing 오류로인해검색결과가없는경우 민감도 / 특이도검색 민감도검색 : 제한을하지않고검색해서많은검색결과를얻기위한방법 Ex) Mouse vs Mice, Cancer vs Tumor vs Neoplasms 특이도검색가능 : 제한을최대한으로해서정확한검색결과를얻기위한방법 시소러스가없는 DB 의예 stress 의경우, Distress, Mental suffering 등빠짐, Stress incontinence, stress fracture 등필요없는논문검색 특이도검색 - 부적절한문헌을배제 - 정확하고빠른문헌검색 - 특정주제대한중요한논문포함검색 민감도검색 - 연구를위한방대한문헌검색 - 주제분야의논문모두포함검색 활용 : Focused Searching / 근거중심진료 를위한검색 활용 : SR( 체계적고찰 ), 연구계획서쓰기 임상진료지침개발 10
MeSH 검색 1 2 11
MeSH Term, definition Select Subheadings 유사어관련용어 (Free term 으로채택 ) MeSH Tree 12
1 2. 3 4. 1 MeSH 검색어넣기 ( 예시 lung cancer) 2 선정 subject heading 3 클릭 add to search builder 연산자활용 OR AND NOT 4 클릭 Search PubMed 검색결과보기 13
검색예시 1 주제 : Psychological aspects of gastritis in Children Subheadings gastritis[mesh Terms] child[mesh Terms] ATM 확인 Psychological[All Fields] AND aspects[all Fields] AND ("gastritis"[mesh Terms] OR "gastritis"[all Fields]) AND ("child"[mesh Terms] OR "child"[all Fields] OR "children"[all Fields]) MeSH 검색 Gastritis MeSH 검색 -> Subheadings psychology 선택 Check tags 필터이용 Child / check tag Human/ Check tag 검색예시 2 주제 : An outbreak of Shellfish poisoning in Canada disease outbreaks[mesh Terms] shellfish poisoning[mesh Terms] canada[mesh Terms] ATM 확인 ("disease outbreaks"[mesh Terms] OR ("disease"[all Fields] AND "outbreaks"[all Fields]) OR "disease outbreaks"[all Fields] OR "outbreak"[all Fields]) AND ("shellfish poisoning"[mesh Terms] OR ("shellfish"[all Fields] AND "poisoning"[all Fields]) OR "shellfish poisoning"[all Fields]) AND ("canada"[mesh Terms] OR "canada"[all Fields]) MeSH 검색 shellfish poisoning[mesh Terms] or Shellfish[MeSH Terms] : Poisoning or disease, foodborne[mesh Terms] : epidemiology Canada[MeSH Terms] : epidemiology Check tags 필터이용 14
통제어 & 자연어검색이란 통제어검색 : Indexing term 검색으로적절한문헌검색에정확도를높여주고, 부적절한문헌을배제할가능성을높여줌자연어검색 : 논문이색인전단계인경우, 저자키워드가 MeSH 용어에없는경우, MeSH Indexing 오류로인해검색결과가없는경우 통제어 = 시소러스 데이터베이스 PubMed Embase OVID Medline Cochrane Library CINAHL 시소러스 MeSH Emtree MeSH MeSH CINAHL Subject Headings Title/keyword/ MeSH(Major Topic) Title/Abstract/MeSH Text word[tw] 특이도검색 민감도검색 - 부적절한문헌을배제 - 정확하고빠른문헌검색 - 특정주제대한 key가되는논문검색활용 : Focused Searching 근거중심진료를위한검색 - 연구를위한방대한문헌검색 - 주제분야의논문이모두포함된검색활용 : 체계적고찰 연구계획서쓰기 임상진료지침개발 15
III. 검색전략수립및예시 질문부터검색까지 5 단계적용 Question Step 1. 임상질문의구조화 Term Harvesting Step 2. 검색어선정 Boolean Logic/ Truncation/Phrase Search Step 3. 검색전략수립 Search Interface Step 4. 검색데이터베이스선정 Search Step 5. 검색 16
STEP 1. Question PICO-TS ( 질문의구조화 ) - 컨셉추출 Patient : teenagers Intervention: patient education Comparison or Control : - Outcome : blood sugar Type of studies : RCT 질문유형 질문유형의정의 Template Interventio Questions addressing the n treatment of an illness or In ----(P), how does --------(I) compa red to ----(C) affect ----------(O) withi n -----(T)? disability Therapy In ----(P), what is the effect of ------- (I) compared to ----(C) on----(o) wit hin --(T)? Diagnosis or Diagnostic test Etiology Prognosis /Prediction Meaning Questions addressing the act or process of identifyi ng or determining the nat ure and cause of a disease or injury through evaluati on Questions addressing the causes or origins of diseas e (i.e., factors that produc e or predispose toward a certain disease or disorde r) Questions addressing the prediction of the course o f a disease Questions addressing how one experiences a pheno menon In ----(P) are/is--------(i) compared w ith --- -(C) more accurate in diagnos ing --------- -(O)? Are ----(P), who have --------(I) comp ared with those without ----(C) at -- --- risk for/of -----(O) over -----(T)? In ----(P), how does --------(I) compa red to ----(C) influence ----------(O) o ver ----- (T)? How do ----(P) with --------(I) perceiv e---- -------(O) during -----(T)? https://www.aaacn.org/sites/default/files/documents /misc-docs/1e_picot_questions_template.pdf 17
STEP 2. Term Harvesting 키워드유사어선정 Concept 1 teenagers, teens, adolescent Concept 2 - patient education, patient information Concept 3 - blood sugar, blood glucose, hypoglycaemia, hyperglycaemia Concept 4 - RCT Concept 1 (patient) Concept 2 (Interventio n) Concept 3 (Outcome) Indexing Term ( 통제어 ) Adolescent Patient Education Blood Glucose FreeTerm ( 자연어 ) Adolescents, Adolescence, Teens, Teen, Teenagers Teenager, Youth, Youths, Adolescents, Female Adolescent, Female. Education of Patients, Education, Patient, Patient Education Blood Sugar, Sugar, Blood, Glucose, Blood 시소러스 MeSH, emtree 등검색 [Text Word] 또는 [Title/Abstract] 로검색 18
STEP 3. Boolean Logic, Truncation, Phrase Search 두개의키워드모두출현하는검색결과 AND 다른개념끼리의조합은 AND 로연결 teenage and patient education teenage patient education 두키워드중어느하나만출현해도모두검색결과로나타남 OR 같은개념의키워드는 OR 로연결 teenage or adolescent teenage adolescent 각각의검색각각 concept 의검색커리를 AND 로검색하면최종검색결과도출함 Concept 1 AND AND Concept 2 Concept 3 AND 19
DB 별검색연산자 PubMed EMBASE Cochrane Library 기본연산자 AND, OR, NOT AND, OR, NOT AND, OR, NOT 근접검색연산자 없음 NEAR, NEXT NEAR, NEXT 구검색, [TITLE], - 절단검색 * * * NEAR : cancer NEAR/n lung : 앞뒤두단어사이에어떤단어가들어가던지 n 개단어안에서모두검색해줌 NEXT : cancer NEXT/n lung : 앞단어바로다음오는어떠한단어이든 n 개단어안에서모두검색해줌 검색커리수정 teenagers OR teens OR adolescent AND patient education OR patient information AND blood sugar OR blood glucose OR hypoglycaemia OR hyperglycaemia 검색식 1 teenagers OR teens OR adolescent AND 2 patient education OR patient information AND 3 blood sugar OR blood glucose OR hypoglycaemia OR hyperglycaemia 20 검색식 - 수정 1 Teenage*OR teen*or adolescent AND patient education OR patient information AND blood sugar OR blood glucose OR hypoglycae* OR hyperglycae* 검색식 - 수정 2
STEP 4. 검색데이터베이스선정 < 의학문헌색인집 (Index Medicus)> Index Medicus (MEDLINE) ( 미국 NLM, 1944~) Excerpta Medica (EMBASE) ( 네덜란드, 1947~) PubMed OVID EMBASE 각 DB 마다검색시스템이다르므로검색결과도다름 <PubMed, Embase, Central 의수록레코드 > PubMed Embase Cochrane Library - MEDLINE (1966~ 현재 ) -OLDMEDLINE (1944-1965) - PubMed - As supplied by Publisher - In Process - EMBASE (1974~ 현재 ) -EMBASE Classic (1947~1973) - MEDLINE (1950~ 현재 ) - Only Controlled Trials (MEDLINE, Embase, Handsearch results 등 ) 21
포괄적인문헌검색을위한주요데이터베이스 Probably Search Might Search Might Search Clinical Trials PubMed EMBASE Cochrane Library(CENTRAL) Web of Science ClinicalTrials.gov BIOSIS Previews CINAHL PsycINFO POPLILNE LILACS WPRIM WHO Global Health Library Sociological Abstracts NLM Gateway SIGLE GreyNet ClinicalTrials.gov European Union Clinical Trials Registry Current Controlled Trials International Clinical Trials Registry Platform (ICTRP) 상세정보및링크 - http://guides.library.harvard.edu/metaanalysis, http://libguides.snu.ac.kr/databasesatoz STEP 5. 검색 P P I P AN D I C Keywords ( 연구자 ) subungual mela noma, Nail unit melanoma "melanoma" "nails" "Melanoma/surgery" Functional surg "general surgery" ery, conservativ "amputation e surgery, wide "disarticulation" excision, local e xcision MeSH 동의어자연어 "Operative Surgical Procedu re" Melanomas Malignant Melanoma Malignant Melanomas Melanoma, Malignant Melanomas, Malignant Nail, Fingernails, Fingern ail, Toenails, Toenail Surgery general surger* amputation* excision* disarticulation* 삭제, 추가키워드 subungual melanoma #1 conservative surger* Functional surger* wide excision* local excision* wide local excision* total nail excision* #2 #3 #4 #5 #1 AN D #2 #3 AN D #4 검색커리 O local recurrenc e "Recurrence" overall survival Recurrence* Recrudescence* Relapse* #6 O disease free sur "Disease-Free Survival" vival, Disease Free Survival Event-Free Survival Event Free Survival Event-Free Survival* 22
V. MY NCBI Register : ID를등록한후사용가능하므로처음이용시에는 NCBI에 ID 신청 My Bibliography : 자신의논문을관리 Recent Activity : 최근 6개월간 PubMed에서실행한검색기록확인 Save Search : 관심주제어저장, 설정한기간에따라새로추가된논문정보메일로발송 Collections : 검색결과저장 NCBI site Preferences 1) Account settings: e-mail 주소, password 수정 2) Common Preferences : Links Display, Highlighting 3) PubMed Preferences : Result Display Settings 1 23
로그인 1 Sign in to NCBI 클릭 2 계정만들기 Collection 1 2 3 24
Collection 영구보존컬렉션 내가만든컬렉션 URL 을생성하여리스트공유 1 Favorites 관심있는논문을쉽게저장하는공간 2 Other Citations 특정한목적으로특정저자의논문또는내가참여한연구물수집 3 My Bibliography 내연구물수집 My Bibliography, Other Citations 링크클릭 - 공유 url 결과페이지 다양한 Citation 업로드방식 25
Creat alert (Save Searches) 2 1 1 관심키워드검색식만들기 2 2 2Create alert 클릭 3 Creat alert (Save Searches) 3 1 Search Name 검색식에해당하는전체 PubMed 결과를확인 2 What s New 마지막검색결과조회일이후신규논문갯수와결과확인 3 Last Searched 마지막으로검색결과를조회한날짜 26
Preferences 하이라이트 검색어하이라이트기능 27