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1 13 1 ( 24 ) Korean J Med Hist Jun 2004 ISSN X * ** ** UN UN UN ) 1953 UN 1976 * 2003 ** 1) 1999 p

2 13 1 ( 24 ) ( 1) ( ) 20 2) ( 2) 2) (Rattus norvegicus) (Seoul SEO) (Clethrinomys gla-reolus) (Puumala PUU) (Microtus pennsylvanicus) (Prospect Hill PH) (Bandicota indica) (Thailand THAI) (Apodemus f lavicolis) (Belgrade BGD Dobraba DOB) (Suncus murinus) (Thottapalayam TPM) 1993 (Peromyscus manicula-tus) (Four Corner FCV) (Muerto Canyon MCV) (Sin Nombre SN) (Microtus arvalis Microtus rossiae-meridionalis) (Tula TUL) (Clethrinomys ruf o-canus) (Vladivostok VLA) (Microtus f ortis) (Khabarovsk KBR) (Peromyscus leucopus) (New York NY) (Reithrodonthomys megalotis) (El Moro Canyon ELMC) (Oryzomys palustris) (Bayou BAY) (Reithrodonthomys mexicanus) (Rio Segundo RIOS) (Microtus calif ornicus) (Isla Vista ILV) (Microtus ochrogaster) (Bloodland Lake BLLL) Cloudland (Peromyscus maniculatus) SN (Monongahela MON) (Sigmo-don hispidus) (Black Creek Canal BCC) (Oligo-ryzomys microtis) (Rio Mamore RM) ( (5) ) 38

3 < 1> Asia China Korea Japan USSR Hong Kong Malaysia Sri Lanka Europe Finland Sweden Denmark Bulgaria Hungary /year /year since ( ) ( ) 7 ( ) 6 (1985) 4 (1987) 609 ( ) Hundreds since 1964 Hundreds since ( ) 136 ( ) Europe Yugoslavia France Germany Italy Greece Belgium Great Britain America USA Africa Madagascar Hundreds/year since ( ) 8 ( ) 14 ( ) 37 ( ) 4 ( ( ) 1 (1986) 10 ( ) * (2) 146 < 2> (Hantavirus) Family Genus Serotypes Hantaan virus(1976 Korea) Seoul virus(1980 Korea) Puumala virus(1981 Finland) Dobrava virus(belgrade) Bunyaviridae Hantavirus Korea China USSR and Europe All over the world Scandinavia and Europe Balkan peninsula * (2)

4 13 1 ( 24 ) ( Q fever ) 3) ) ) 6) 2 1) 3) (8) 5 4) 1999 p 32 5) ( ) ) ( )

5 % 5 50% % 60-70% (bubonic type) (EL Tor type) S dysenteriae S sonnei 2)

6 13 1 ( 24 ) ) ( ) 7) (normal flora) 42

7 ( ) Seoul virus (WHO) 3 1) )9) 10) ( ) 1940 ( ) 8) p 39 9) ( ) ( ) ( ) ( ) ( ) ( ) ( ) ( ( ) 1977) 1989 p 4 10) ( ) 10 ( ) 43

8 13 1 ( 24 ) Amur ( ) Primorskaya 1930 Tula Tula Tula 1 1) ( ) ( ) ( ) ( ) ( ) 9 12 ( ) ( ) ( ) ) (Jiang 1981) 13) ( ) 1989 p 7 11) 1989 p 4 12) 1999 p

9 ) ( 731 ) (war nephritis) 15) (Flanders) (trench nephritis) (war nephritis) 16) 1940 Nephropathia epidemica Epidemic nephritis 1961 Gajdusek 1976 Hemorrhagic nephroso -nephritis Nephropathia epidemica ) p 8 14) 731 ( ) 1855 ( ) 1644 ( ) 8604 ( ) p ) (J R Bradford) p27 16) p 28 45

10 13 1 ( 24 ) (Apodemus agrarius) 17) ( ) ( ) ( ) % 18) 11-15% 19) 17) 74% 30% 18) No ) No

11 (Rattus norvegicus) 2) ) )

12 13 1 ( 24 ) ) 22) ? 23) ) p ) El Nino p )

13 ? ( ) ( ) 24) UN ? 24) 49

14 13 1 ( 24 ) ) < 3> UN ( ) UN ) 27)? 25) p 24 26) p )

15 < 3> 28) 28) p 50 51

16 13 1 ( 24 ) ) ) 3 1) 32) 1951? 406 ( ) 36 ( ) ( ) 135 ( ) ( ) 21 ( ) 246 ( ) ( ) 101 ( ) 32 ( ) 82 ( ) ) ) ( ) 2003 p ) 1950 Serratia marcescens DC 1996 p )

17 ) G )35) 33) p ) p p ) CIA (Takeoff Broadbrim ) (Hummer Affiliate ) (Kumquat) p

18 13 1 ( 24 ) ?? ) 37) ) ) 36) p ) p199 38) p ) p

19 ? 3) UN UN UN ) ( ) UN ( ) UN UN UN 33% 4 1) 40)

20 13 1 ( 24 ) % 42) 16 6% 43) % % % ( 4 5) < 4> (%) (%) (%) (%) < 5> (%) (%) (%) ) ) )

21 UN Sheer 5%(1952)-8%(1951) MGL report 44) 4 5% UN 45) UN UN ) 4 7) 1960 ( 1) km 10 44) US Army 406th MCL Annual Historical Report 1956 p 2 45) McClure( ) 1953 KATUSA p 39 46) ) p

22 13 1 ( 24 ) < 1> ( , 1973 ) * 58

23 160km 48) 1970 ( 2) < 2> ) 48) ( ) ) 59

24 13 1 ( 24 ) km

25 = ABSTRACT = H e m orrh ag ic F e v er w ith Re n al S y n drom e : H i s toric al A s p e ct s LEE Jae- kwang* HWANG Sang- ik* A mysterious disease was first reported from Korea when it had been observed during late spring 1951 in UN Forces operating in the central area close to the 38th parallel The disease showed distinctive features which included high fever low blood pressure hemorrhagic tendency and acute renal failure Historically it was apparently a similar disease to a clinical entity designated as Epidemic hemorrhagic fever in Manchuria or Hemorrhagic nephrosonephritis in Far Eastern Russia After Lee Ho-Wang succeeded in demonstrating Hantaan virus which caused hemorrhagic fever with renal syndrome(hfrs) many studies has revealed various biological and epidemiological aspects of the disease But the origin of the disease in Korea still remains unknown This article tests some hypotheses which explain the origin of the disease and reviews the relation between the Korean War and HFRS It is concluded that the emerging of HFRS would be closely related with the establishment of the munitions supply network in early 1951 in Chinese troop Key Words Hemorrhagic Fever with Renal Syndrome(HFRS) Epidemic Hemorrhagic Fever History of Disease Korean War * Department of the History of Medicine Corresponding author Seoul National University College of Medicine 61

歯kjmh2004v13n1.PDF

歯kjmh2004v13n1.PDF 13 1 ( 24 ) 2004 6 Korean J Med Hist 13 1 19 Jun 2004 ISSN 1225 505X 1) * * 1 ( ) 2) 3) 4) * 1) ( ) 3 2) 7 1 3) 2 1 13 1 ( 24 ) 2004 6 5) ( ) ( ) 2 1 ( ) 2 3 2 4) ( ) 6 7 5) - 2003 23 144-166 2 2 1) 6)

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歯kjmh2004v13n1.PDF