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1 Since 1978 S U N J I N 자외선차단화장품의최근동향및원료개발전망 For more information, please visit our home page: or sungholee@sunjinchem.co.kr or call office tel: (700) or call mobile: SUNJIN CHEMICAL R&D

3 자외선차단제시장전망

4 오드리헵번처럼 ' 우아한노화 ' 원하십니까? 흰머리를두려워말라 " 등 CNN 10 가지비결소개

5 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 5 무인도에갈때화장품을딱 1 개만가지고간다면 망설일것없이자외선차단제다. 자외선은피부노화의최대적이다. 요즘은공해도피부건강에큰영향을미친다. 공해로인한피부오염을막아주는기능이포함된자외선차단제를고르기바란다. 자외선차단제는 10대부터발라주는게좋다 중앙일보인터뷰 베로니크델비뉴랑콤과학연구소장, 피부생물학박사

6 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 6 자외선 (UV) 은다시파장에따라 UVB 와 UVA 로구분 Leathery skin Wrinkles UVB = 280~320nm 파장이짧아서에너지가큼 SUN BURN( 홍반 ) 을일으킴 SPF 로차단정도표시 UVA = 320~400nm 파장이길어서진피까지침투해서 SUN TAN( 흑반 ) 과광노화 (photo-aging) 을일으킴 PA 로차단정도표시

7 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 7 일상생활자외선노출정도 UV exposure (amount of penetration) Clouds >> 90% Clothing, wet >> 50% Swimming >> 90% Sand (white, higher) >> 4% Snow (reflects up) >> 90% Window glass UVA >> 100% UVB >> 0% 흐린날 ( 구름 ) 에서도자외선은 90% 투과되고, 실내에있어도 UVA 는 100% 실내유리를투과합니다

13 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 13 국내피부암환자늘고있다한국일보 서구에서주로발생했던피부암이지난 5 년 새 44% 가량증가해우리나라도더이상안전지 대가아닌것으로나타났다. 대한피부과학회는피부건강의날 (5월 13일 ) 을맞아건강보험심사평가원의최근 5년간전체피부암실태를분석결과, 악성흑색종을포함한피부 암환자가 2009 년 1 만 980 명에서 2013 년 1 만 5,826명으로 44.1% 나늘어한해평균 9.6% 나증가했다고밝혔다. 신규피부암발병건수는 2010년 6,739건에서 2013년 7,677건으로 4년간 938건 (13.9%) 이늘어연평균 3% 씩증가했다. 2013년악성흑색종의조발생률 ( 인구 10만명당환자수 ) 은 3.0건이었고, 기타피부암의조발생률은 12.0 건이었다. 특히 2013년악성흑색종의조발생률은 7.4명, 악성흑색종을제외한기타피부암 ( 편평상피세포암, 기저세포암등 ) 의조발생률은 23.6명으로나타났다. 특히피부암중악성도가높은악성흑색종도꾸준히늘어 2009 년 2,819명에서 2013년 3,761명으로 33.4% 증가했다. 윤정숙화순전남대병원피부과교수는 인구고령화와자외선노출빈도가높아지면서국내에서도피 부암환자가늘고있다 며 초기에피부과전문의의정확한진단을받아치료하는것이중요하다 고했다.

15 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 15 아시아에서의하얀피부란? 중국등아시아에서는하얀피부는아름다움을넘어서흔히사회적지위와연관됩니다 자외선차단화장품은미백, 주름방지의기초입니다 즉자외선을차단하여미백의기본인색소침착을방지하고주름방지의기본인광노화현상을방지하는것입니다 즉자외선차단은일정소득수준에이르면그사용이지속적으로크게늘어나는속성이있습니다

Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 17 세계자외선화장품매년 6.5% 로성장이예측됨 http://www.reedexpomobile.

18 중국시장전망 Facial Skin Care 시장규모로는중국이 127 억달러로세계최대이나, 1 인당소비금액은 9.4 달러로한국 1 인당소비금액의인 139 달러의 6.7% 수준임 Sources: Fuji-Keizai Group, Korea Health Industry Development Institute, U.S. Census Bureau, Information Resources, Inc./Mintel Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 18

20 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 20 국내자외선차단제시장전망 자외선차단제는미백, 주름개선화장품과함께기능성화장품으로분류되며, 2013 년자외 선차단기능성화장품으로판매된금액은 9 천 2 백억원 이는기능성화장품법에따라기초및메이크업제품에서도자외선차단기능이있을경우 자외선차단제품으로분류되기때문이며, 최근의추세는기초및메이크업제품에서도자외 선차단은화장품의필수기본기능으로소비자들이요구하기때문임

21 In vivo test In vitro SPF & PA SUNJIN Optometrics 290AS Installed at SUNJIN in 2014 In vivo SPF & PA SUNJIN SPF Testing W Multiport UV Solar Simulator Installed at SUNJIN in 2009 Sample Report from SUNJIN All Formulas from SUNJIN, With in vivo test results

22 자외선차단화장품의최근동향

23 Big Sun Screen Trends in High SPF & PA 2. 낮은처방원가 3. 차별화된사용경험 4. 차별화된컨셉

24 Big Sun Screen Trends in 2015 HIGH SPF & PA SPF 50, PA +++

27 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 27 SPF 와자외선차단능력의관계 Amount of UVB protection based on SPF SPF 10 blocks 90% of UVB SPF 20 blocks 95% of UVB SPF 33 blocks 97% of UVB SPF 40 blocks 97.5% of UVB SPF 50 blocks 98% of UVB SPF 100 blocks 99% of UVB

28 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 28 Measurement system of UVA protection In Asia, PA system are based on the PPD method PA++++ PPD= 16 or above(especially in Japan) PA+++ PPD = 8 or above PA++ PPD = 4 to less than 8 PA+ PPD = 2 to less than 4 In EU 2006, EU Commission UVA: 1/3 of SPF, Critical Wavelength > 370 nm UVA protection testing: PPD method

29 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 29 How to measure UVA protection? PPD: Measurement of UVA protection Persistent pigment darkening (PPD) The persistent pigment darkening (PPD) method is a method of measuring UVA protection, similar to the SPF method of measuring UVB light protection. Originally developed in Japan, it is the preferred method used by manufacturers such as L'Oréal. Instead of measuring erythema or reddening of the skin, the PPD method uses UVA radiation to cause a persistent darkening or tanning of the skin. Theoretically, a sunscreen with a PPD rating of 10 should allow a person 10 times as much UVA exposure as would be without protection. The PPD method is an in vivo test like SPF. In addition, Colipa has introduced a method that, it is claimed, can measure this in vitro and provide parity with the PPD method <MPPDu> (BMDBM:3.0%) <MPPDp> PORT UV Power 1 : 16.70mw/cm^ 2 : 20.88mw/cm^ 3 : 26.10mw/cm^ 4 : 32.62mw/cm^ 5 : 40.78mw/cm^ 6 : 51.00mw/cm^ MPPDu : 40.78mw/cm^ * 420sec = mw * s/cm^ = 17.1 j/cm^ MPPDp : 40.78mw/cm^ * 420sec * 7 = mw * s/cm^ = j/cm^ 3 PAF Result : MPPDp / MPPDu : j/cm^ / 17.1 j/cm^ = 7.0 PA 2 1

30 Big Sun Screen Trends in 2015 Formula Cost 낮은처방원가

31 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 31 UVA Filters Product INCI Approval Status (max%) Remark EU JP US Kor Uvinul A Plus Tinosorb S DHHB (Diethylamino hydroxybenzoyl hexyl benzoate) BEMT (bisethylhexyloxyphenol methoxyphenyl triazine) Not approved in US Not approved in US Parsol 1789 BMDBM Globally approved Multiple suppliers Mexoryl XL Drometrizole trisiloxane Captive used only by L OREAL Mexoryl SX Terephtalidene dicamphor sulfonic acid Captive used only by L OREAL Neo helipan AP disodium phenyl dibenzimidazole tetrasulfonate Zinc Oxide Zinc Oxide <100nm ZnO is not listed as UV Filter in EU

32 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 32 UVA Filters Tinosorb-S INCI : bis-ethylhexyloxyphenol methoxyphenyl triazine(bemt) Broad-spectrum UV absorber, absorbing UVB as well as UVA rays. It has two absorption peaks, 310 and 340 nm. Highly photostable. Even after 50 MEDs (minimal erythemal doses), 98.4% remains intact. It helps prevent the photodegradation of other sunscreen actives like avobenzone Not approved in US Uvinul A plus INCI: Diethylamino hydroxybenzoyl hexyl benzoate (DHHB) Absorption maximum of 354 nm Excellent photostability and compatibility with other UV absorbers DHHB has been approved for the use in sunscreens in the European Union since 2005 with a maximum of 10 per cent and is also approved in South America, Mexico, Japan and Taiwan Not approved in US(in US, only for product protection)

33 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 33 UVA Filters Mexoryl XL Drometrizole trisiloxane Oil soluble Broad-spectrum UV absorber with two absorption peaks, one at 303 nm (UVB) and one at 344 nm (UVA). Just like Mexoryl SX (ecamsule), it is used exclusively in products by L'Oréal owned brands. Drometrizole trisiloxane and ecamsule are often used together, because they show a synergistic effect in protection

34 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 34 UVA Filters Mexoryl SX INCI: Terephthalylidene dicamphor sulfonic acid Water soluble UVA Filter Excellent photostability Together with Mexoryl XL (INCI Drometrizole trisiloxane, oil soluble), they show a synergistic sun protection Patented by L'Oréal. Sunscreens containing ecamsule are exclusive to L'Oréal and its brands. Neo Heliopan AP INCI disodium phenyl dibenzimidazole tetrasulfonate water soluble Bisdisulizole disodium is not approved in the United States by the FDA, but it has been approved in the European Union since the year 2000[3] and other parts of the world.[4][5]

35 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 35 Parsol 1789 Avobenzone INCI Butyl Methoxydibenzoylmethane(BMDBM) Oil soluble UVA filter λ max = 357nm Avobenzone was patented in 1973 and was approved in the EU in It was approved by the FDA in Its use is approved worldwide Avobenzone has been shown to degrade significantly in light, resulting in less protection over time. Avobenzone is sensitive to the properties of the solvent, being relatively stable in polar protic solvents and unstable in nonpolar environments

36 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 36 UVA Filters(FDA) Dioxybenzone benzophenone-8 λmax = 327nm Sulisobenzone benzophenone-4 λmax = 324nm Oxybenzone benzophenone-3 λmax = 325nm

37 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 37 Cost Efficient UVA system for PA+++ Water, Ethylhexyl Methoxycinnamate, Glycerin, Ethylhexyl Palmitate, Titanium Dioxide(CI 77891), Cyclopentasiloxane, 4-Methylbenzylidene Camphor, Butyl Methoxydibenzoylmethane, Ethylhexyl Salicylate, Octocrylene, Cyclohexasiloxane, Silica, Aloe Barbadensis Leaf Juice, Lavandula Angustifolia (Lavender) Water, Chamomilla Recutita (Matricaria) Flower Water, Prunus Mume Fruit Extract, Citrus Aurantium Dulcis (Orange) Fruit Extract, Codium Tomentosum Extract, Enteromorpha Compressa Extract, Macrocystis Pyrifera Extract, Ecklonia Cava Extract, Gelidium Cartilagineum Extrac, Laminaria Japonica Extract, Nymphaea Alba Flower Extract, Chamaecyparis Obtusa Leaf Extrac, Viscum Album (Mistletoe) Fruit Extract, Sansevieria Trifasciata Leaf Extrac, Portulaca Oleracea Extract, Glyceryl Stearate, PEG-100 Stearate, Triceteareth-4 Phosphate, Glycol Stearate, Sorbitan Sesquioleate, Potassium Cetyl Phosphate, PEG-2 Stearate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Glyceryl Caprylate, Bis-Diglyceryl Polyacyladipate-2, Tromethamine, Caprylyl Glycol, Dimethicone, Butylene Glycol, Polydecene, Dipropylene Glycol, Sodium Palmitoyl Proline, Squalane, Coco-glucoside, Sorbic Acid, Ethylhexylglycerin, Acetyl Tetrapeptide-15, Cetearyl Alcohol, Xanthan Gum, Disodium EDTA, Phenoxyethanol, Benzyl Alcohol, Potassium Sorbate, Dehydroacetic Acid, Sodium Benzoate, Fragrence

38 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 38 Cost Efficient UVA system for PA+++ Water, Butylene Glycol, Ethylhexylmethoxycinnamate, Ethylhexyl Salicylate, Isoamyl p-methoxycinnamate, Butymethoxydibenzoylmethane, Phenethyl Benzoate, Cyclopentasiloxane, Octocylene, Ploymethylmethacylate, Niacinamide, Silica, Titanium Dioxide, Ceteacyl Alcohol, Glyceryl Stearate, Ethylhexyl Isononanoate, PEG-100 Stearate, Allantoin, PEG-150 Distearate, Sorbitan Sesquioleate, Polysorbate 60, Stearyl Behenate, Tocopheryl Acetate, Dimethicone, Cyclomethicone, Polyethylene, PEG/PPG-20/15 Dimethicone, Phenylmethicone, Polyacrylate-13, Polyisobutene, Polysorbate20, Glycerin, Nelumbium Speciosum Flower Extract, Nelumbo Nucifera Seed Extract, Nelumbo Nucifera Leaf Extract, Nelumbo Nucifera Root Extract, Ethylhexyl Glycerin, Portulaca Oleracea Extract, Adenosine, Sodium Hyaluronate, Xanthan Gum, Disodium EDTA, Caprylyl Glycol, Caprylhydroxamic Acid, Phenoxyethanol,, Fragrance

39 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 39 Formula cost for SPF50 PA+++ UVA Filters BEMT: bis-ethylhexyloxyphenol methoxyphenyl triazine BMDBMB: Butyl Methoxydibenzoylmethane(Avobenzone) DHHB: Diethylamino hydroxybenzoyl hexyl benzoate DPDT: disodium phenyl dibenzimidazole tetrasulfonate Zinc Oxide TiO2

40 Big Sun Screen Trends in 2015 차별화된사용자경험

41 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 41 Remarkable Products SPF50 PA+++ W/S SPF50 PA+++ O/W SPF25 PA++ Sun Gel SPF50 PA+++ Air Cushion O/W 인데지속성이우수한제품, W/O 인데사용감이우수한제품이 최근개발방향

43 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 43 Best W/S Shaking Sun Milk Ingredients: Cyclomethicone, Water, Zinc Oxide, ethylhexyl Methoxycinnamate,, Alcohol, Dimethicone, Ethylhexylpalmitate, Talc, Isododecane, Polymethylsilsesquioxane, Octocrylene, Polysilicone-15, Titanium Dioxide, Polybutylene Glycol/PPG-9/1 Copolymer, Trimethylsiloxysilicate, Methyl Gluceth-10, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Bisethylhexyloxyphenol Methoxyphenyl Triazine, C9-15 Flouroalcohol Phosphate, Dipotassium Glycyrrhizate, Gentiana Urnula Flower Extract, Sodium Hyaluronate, Thymus Serpillum Extract, Potentilla Erecta Root Extract, PEG-9 Polydimethylsiloxyethyl Dimethicone, Cyclopentasiloxane, Acrylates/ Dimethicone Copolymer, Isostearic Acid, Sodium Acryloyldimethyltaurate/ Methyacrylamindolauric Acid Copolymer, Disteardimonium Hectorite, Alumina, Butylene Glycol, Triethoxycaprylylsilane, Trisodium EDTA, BHT, Phenoxyethanol, Fragrance

44 깐깐한한국고객취향이, 세계食器까지바꾸다 조선일보 :24 [ 생활용품시장주도자변모 ] 로얄코펜하겐이만든韓食器, ' 코리안볼 ' 로유럽서출시한국인들 " 손잡이자주탄다 " 휘슬러, 냄비손잡이길게제작슈에무라 ' 강남핑크 ' 립스틱, 국내서반응좋자세계출시 비오템도 2006 년세계최초로남성전용자외선차단제를한국시장에출시해반응을본후전세계시장에내놨다. =twitter&d=

45 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 45 Best O/W INGREDIENTS : Water, Glycerin, Alcohol Denat., Dimethicone, Ethylhexyl Salicylate, Propylene Glycol, Terephthalylidene Dicamphor Sulfonic Acid, Silica, Drometrizole Trisiloxane, Titanium Dioxide, Triethanolamine, Phenylbenzimidazole Sulfonic Acid, Ethylhexyl Triazone, Tromethamine, Stearic Acid, Potassium Cetyl Phosphate, Plamitic Acid, PEG-100 Stearate, Glyceryl Stearate, Phenoxyethanol, Cetyl Alcohol,Carbomer, Tocopherol, Ammonium Polyacryldimethyltauramide/ Ammonium, Polyacryldimethyl Taurate, Vitreoscilla Ferment, Disodium Edta, Zea Mays Extract/ Corn Kernel Extract, Linalool, Lomonene, Arginne, Terminalia Sericea Extract, Menthoxypropanediol, Mannitol, Rna, Pyridoxine Hcl, Disodium Adenosine Triphosphate, Histidine Hcl, Phenylalanine, Tyrosine, Triticum Vulgare Germ Extract/ Wheat Germ Extract, Hydroxycitronellal, Benzyl Salicylate, Citronellol, Coumarin, Fragrance

47 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 47 SPF50 PA+++ SUN GEL SUN GEL SPF50+ PA+++ water resistant Water, Ethyhexyl Methoxycinnamate, Butylene Glycol, Propylen Glycol, Ethylhexyl Salicylate, C12-15 Alkyl Benzoate, Diethylamino Hydroxybenzoyl Hexyl Benzoate, Ethanol, Homosalate, Octocrylene, Titanium Dioxide, Cyclomethicone, 1,2-Hexanediol, Polymethylsilsesquioxane, Viscum Album (Mistletoe) Leaf Extract, Portulaca Oleracea Extract, Centella Asiatica Extract, Echium Plantagineum Seed Oil, Aloe Barbadensis Leaf Extract, Sodium Hyaluronate, Cardiospermum Halicacabum Flower/Leaf/Vine Extract, Helianthus Annuus (Sunflower) Seed Oil Unsaponifiables, Helianthus Annuus (Sunflower) Seed Oil, Citrus Unshiu Peel Extract, Orchid Extract, Camellia Sinensis Leaf Extract, Camellia Japonica Leaf Extract, Opuntia Coccinellifera Fruit Extract, Caprylic/Capric/Succinic Triglyceride, Aluminum Stearate, Polyacrylate-13, Glycerin, Bis-PEG-15 Dimethicone/IPDI Copolymer, Sorbitan Oleate, Polyhydroxystearic Acid, Polysorbate 20, Polyisobutene, Octyldodecanol, Behenyl Alcohol, Alumina, Inulin Lauryl Carbamate, Sodium Stearoyl Glutamate, Ethylhexylglycerin, Fragrance, Phenoxyethanol

48 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 48 SPF50 PA+++ SUN GEL INGREDIENTS Water, ethylhexyl methoxy cinnamate, ethylhexyl salicilate, Homosalate, diethylamino hydroxyl benzoyl hexyl benzoate, Dicarprylyl Carbonate, Alcohol Dent, 1.3-butylene Glycol, Bis Ethylhexyloxyphenol Methoxy Phenyl Triazine, Carlendula extract, carprylyl glycol, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Stearic Acid, vinyl alcohol, Carbomer, 2Na-EDTA, phenoxy ethanol, Sodium Benzoate, Potassium Sorbate, fragrance Emulsifier Free Translucent

50 Big Sun Screen Trends in 2015 차별화된컨셉

51 Natural, Safe & ECOCERT

52 Natural, Safe & ECOCERT

53 Non-nano, ECOCERT

54 Tinted Sun Cream

55 원료별개발전망및중요이슈

58 PA++++

60 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 60 UVA Filters Product INCI Approval Status (max%) Remark Uvinul A Plus Tinosorb S DHHB (Diethylamino hydroxybenzoyl hexyl benzoate) BEMT (bisethylhexyloxyphenol methoxyphenyl triazine) New EU JP US Kor Not approved in US Copy Not approved in US Stabilize Parsol 1789 BMDBM Globally approved Multiple suppliers Mexoryl XL Drometrizole trisiloxane Captive used only by L OREAL Modify Modify Mexoryl SX Terephtalidene dicamphor sulfonic acid Captive used only by Copy L OREAL Neo helipan AP disodium phenyl dibenzimidazole tetrasulfonate Zinc Oxide Zinc Oxide <100nm ZnO is not listed as UV Filter in EU

61 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 61 BMDBM Photo-stabilizer Quenches Avobenzone s singlet excited state. Stabilize Effective in photostabilizing Avobenzone even when OMC in formulation

63 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 63 Perfect Gel SPF50+ PA++++ Water, Alcohol, Zinc Oxide, Ethylhexylmethoxycinnamate, Isododecane, Caprylylmethicone, Dimethicone, Silica, Butylene Glycol, Octocrylene, Diethylamino Hydroxybenzoyl Hexylbenzoate(DHHB), Bisethylhexyloxyphenol Methoxyphenyltriazine (BEMT),Glycerin, PEG-60 Hydrogenated castor oil, PEG/PPG-14/7 Dimethyl Ether, Ethyl Ascorbic Acid, Dipotassium Glycyrrhizinate, Polymethyl Methacrylate, Potentilla Erecta Root Extract, Sodium Hyaluroate, PPG-17, Isostearic Acid, Triethoxycaprylylsilane, Dimethylacrylamide/Sodium Acryloyldimethyltauratecrosspolymer, Sorbitan Sesquiisostearate, Sodium Metasphate, Succinoglycan, Citric Acid, Disodium EDTA, BHT, Sodium Citrate, Tocopherol, Syzygium Jambos Leaf Extract, Sodium Laureth Sulfate, Aminomethyl Propanol, Fragrance, Mica, Iron Oxides. Zinc Oxide 11.8% DHHB 3% BEMT 2.2%

64 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 64 PA ++++ Shaking Sun Milk Dimethicone, Water, Isododecane, Ethylhexyl methoxycinnamate, Alcohol, Diisopropyl sebacate, Polymethylsilsequioxane, VINYL DIMETHICONE/METHICONE SILSESQUIOXANE CROSSPOLYMER, Pentaerythrityl tetraethylhexanoate, Zinc Oxide, Glycerin, Octocrylene, Polysilicone-15, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Isohexadecane, POLYBUTYLENE GLYCOL/PPG-9/1 COPOLYMER, Diethylamino Hydroxybenzoyl Hexyl Benzoate, *Bisethylhexyloxyphenol methoxyphenyl triazine, Phenylbenzimidazole Sulfonic Acid, Phytosteryl macadamiate, Hydrogenated polyisobutene, Aminomethyl propanol, PEG/PPG-14/7 dimethyl ether, Polymethyl Methacrylate, Ethyl Ascorbic Acid, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Potentilla erecta, Hydrated silica, Isostearic Acid, Silica, Trisodium EDTA, Butylene Glycol, Triethoxycaprylylsilane, Triethoxysilylethyl Polydimethylsiloxyethyl Dimethicone, BHT, Sodium Laureth Sulfate, Tocopherol, Syzygium Jambos Leaf Extract, Fragrance

65 A recent development is Tinosorb S Aqua, which is bemotrizinol in a PMMA matrix dispersed in water. This makes it possible to add bemotrizinol to the water phase Composition BEMT 20% PMMA 19% WATER 59% Surfactant

67 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 67 Hybrid AB from SUNJIN Core: Chemical UV Filters(30%) For UV protection Shell: PMMA Bead(70%) 1) For Sensorial Modification 2) Oil soluble UV filters can be used into water phase Hybrid AB Composition PMMA 70% Avobenzone * 30% Particle Size 5 um UVA Protection Hybrid S Composition PMMA 70% BEMT ** 30% Particle Size 5 um UVA+UVB Hybrid EHT Composition PMMA 70% EHT *** 30% Particle Size 5 um UVB Protection * Avobenzone: Butyl Methoxy dibenzoylmethane(bmdbm) ** BEMT: bis-ethylhexyloxyphenol methoxyphenyl triazine *** EHT: Ethyl Hexyl Triazone

68 TiO 2 & ZnO - EU 최신규제동향 - USA 최신규제동향 - ECOCERT 최신규정

69 SCCS opinion in EU

72 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 72 SCCS 는 EU 의공식적인과학자문기구입니다 EU (European Union) EC (European Commission) 대한민국 대한민국행정부 Health and Food Safety Department 보건복지부 SCCS (Scientific Committee On Consumer Safety) SCCS 에서제안된의견은 EC 에서공식적인절차를거쳐의안으로상정되어 European Parliament(EU 의회 ) 에서비준을하게되면실제적인 EU 의법령인 Regulation 이나 Directive 로 EU 회원국에법률로서효력발생 그러므로 EC 의공식자문기구인 SCCS 의 Opinion 은유럽의회에서법률승인이전에도, 실질적으로는 SCCS Opinion 자체로도업계영향력발생

73 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 73 SCCS opinion 발표의배경 2014 년 SCCS 에서 Revision of the opinion on Titanium Dioxide (Nano form) 발표 SCCS/1516/13 은 2009 년인준된 REGULATION (EC) No 1223/2009 을 대체하는의견 2009년 REGULATION (EC) No 1223/2009의주요내용 2009년현단계에서나노물질의위험성에대해보다심도있는연구가필요 나노물질의안정성이확인될때까지는 Nano 물질의사용여부를화장품용기에표시하여소비자에게정보를제공한다 Nano 물질의정의는용해되지않으며 (Insoluble) 안정적인 (Stable) 상태로존재하며, 입자사이즈의범위는 1에서 100nm로구성되는물질

75 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 75 SCCS opinion on TiO 2 요약 1. EU 에서사용가능한 Nano TiO 2 와 ZnO 입니 다 2. 처방에최대 25% 까지적용가능합니다 3. 유럽수출을염두에둔화장품은 SCCS 규격에 맞는 TiO 2 와 ZnO 를사용해야합니다. 4. 단, 다음의조건을만족하여야만사용가능합 니다

76 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 76 SCCS 가제안한 Nano TiO 2 규격은다음과같습니다 Purity >99%, Anatase <5% Median primary particle size 30~100nm by number based size distribution Aspect ratio <4.5 Volume specific surface area <460m 2 /cm 3 Photo-stable Approved coating ingredients ** * ** page 8, Table 1

79 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 79 SCCS 가제안한 Nano ZnO 규격은다음과같습니다 Purity >96% with impurities only of CO 2 and H 2 O, whilst any other impurities are less than 1% total Median primary particle size >30nm by number based size distribution Approved coating ingredients** Triethoxycaprlylsilane Dimethicone Dimethoxydiphenylsilanetritehoxycaprylyl silane cross-polymer Octyltriethoxy silane * f ** page 13

80 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 80 미국에서의최신규제동향 미국에서자외선차단제품은 OTC(over-the-counter) 의약품 (drug) 으로분류됨 자외선차단제품은 OTC monograph에따라제조, 판매, 유통되어야함 OTC monograph의주요한내용은다음과같음 cgmp에서제조되어야하며, Quality unit, Personnel, Facilities, Equipment, Control of materials 의세부적인내용을규정 자외선차단제품의 active ingredient들은 NDC(National Drug Code) Directory에등록관리됨을권장함 NDC란 FDA에서일반의약품및의약외품의허가및사후추적관리를위해만든코드로써, 제조사 (Labeler), 효능성분 (Drug), Package 형태및사이즈정보를관리하기위해서임

ingredient의경우, NDC가강제규정 (must have) 은아니나, 실질적으로업계에서 NDC코드를가진 active

81 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 81 Sunscreen Active Ingredients in USA 미국시장판매를계획한다면, 자외선차단제의 active ingredient의경우, NDC가강제규정 (must have) 은아니나, 실질적으로업계에서 NDC코드를가진 active ingredient사용이 FDA의 inspection에대비하기위한업계의관행이므로, NDC를가진 active ingredient 사용이필수적임

82 Copyright 2015 by SUNJIN Chemical Co. LTD ALL RIGHTS RESERVED. 82 NDC 사례 Product Name Product NDC Product Package NDC SUNSIL-Tin SUNSIL-Tin SunTitan LL SunTitan AS T T80AS T80LL TX TX85AQ Hybrid AB SFT85-CC SFT85-CCTG SUNSIL TIN 50 AS SunZnO - AS SunZnO - NAS TX

2009년의 REGULATION (EC) No 1223/2009의주요내용은아래와같다 년현단계에서나노물질의위험성에대해보다심도있는연구가필요하다. - 그러므로나노소재의안정성이확인될때까지는 Nano 소재의사용여부를화장품용기에표시하여소비자에게나노소재의사용정보를제공하

2009년의 REGULATION (EC) No 1223/2009의주요내용은아래와같다 년현단계에서나노물질의위험성에대해보다심도있는연구가필요하다. - 그러므로나노소재의안정성이확인될때까지는 Nano 소재의사용여부를화장품용기에표시하여소비자에게나노소재의사용정보를제공하 EU 및미국에서의무기자외선차단제최신규제동향 서론 정책에관한과학적의견을 EC 에제공한 다. 이번글에서지난 2014 년 European Union(EU) 의행정부에해당하는 European Commission (EC: EU 집행위원회 ) 산하의과학자문기관인 Scientific Committee on Consumer Safety (SCCS) 에서제안한무기자외선차단제관한최신의견인