fm

Transcription

1 ª ª (2009) 49ƒ 2 Korean J Vet Res(2009) 49(2) : 157~161 š xáá Á½zÁÁ Á½z 1w w, 2 ed j ( : ) Apocrine sweat gland adenocarcinoma in a cat Min-Hyeok Park 1, Ji-Youl Jung 1, Suk-Hee Jo 1, Jae-Hoon Kim 1, Jin-Yong Lee 2, Mi-Kyung Lee 2, Jae-Hoon Kim 1, * 1 College of Veterinary Medicine, Jeju National University, Jeju , Korea 2 Cats and Dogs Animal Clinic, Seoul , Korea (Accepted: April 15, 2009) Abstract : A 11-year-old female mixed cat with subcutaneous mass around the left 5th mammary glands was presented to local animal hospital. According to history taking, the mass recurred 2 times on the same site of abdomen. After surgical excision, subcutaneous mass was referred to Pathology Department of Veterinary Medicine in the Jeju National University. Grossly, round to oval, milky yellow or pale red nodules, measuring 0.1~1 cm in diameter, were occupied in the subcutis. Microscopically, the most neoplastic sweat glands were proliferated in the dermis and subcutis. Most tubules were lined by round to oval shaped epithelium with eosinophilic cytoplasm, hyperchromatic nuclei with high mitotic figures and severe central necrosis. The neoplastic epithelium also had periodic acid-schiff-positive diastase-resistant cytoplasmic granules, but was negative for Perl s iron stain. Based on the gross, histopathologic and special staining, this cat was diagnosed as apocrine sweat gland adenocarcinoma. In our best knowledge, this is the first report of apocrine sweat gland adenocarcinoma around abdominal mammary gland in a cat. Keywords : apocrine sweat gland adenocarcinoma, cat, diastase-resistant, PAS stain, tumor (sweat gland) xk» (apocrine sweat gland) (merocrine sweat gland). s w ƒ ù v sw. š (foot pads) pw v [3, 4]. w v w w xk, v w [3, 11, 14]. (apocrine adenocarcinoma) vsl y w wš, v 2.2% w [4]. š w 5~15 š wš, t Siamese š x ù domestic shorthaired š û [3]. š x, v w. 1~10 cm j» wš z xk v» w w x ùkú [3, 4]. š, ƒ *Corresponding author: Jae-Hoon Kim College of Veterinary Medicine, Jeju National University, Jeju , Korea [Tel: , Fax: , kimjhoon@jejunu.ac.kr] 157

2 158 xáá Á½zÁÁ Á½z, (eccrine adenocarcinoma), wû šƒ [1, 6, 7, 12]. ü [14] wx w š [11] ù, x¾ š w š. š d 5 w šwš, p mw w p wš w f šƒ d cm j» vw ƒ w üw, vw ƒ w w w. š d ƒ x fš 7 wù, 10 w 2 x. ù, w w w. 2 z s. 3 z doxorubin sw. yƒ w n w e w sw. w w 10% s š vw e qv swš 3~4 µm Ì r w hematoxylin-eosin(h&e) w z Ÿwx w. w w periodic acid-schiff(pas), diastase z PAS, Perl s iron Masson s trichrome w. ƒ vw, 0.5~1 cm x kx y ü (Fig. 1). w w j» x, kx ³ew xk š vd vw w swš v w. d d s, s w ü w (Fig. 2).»d y x x s s ƒ w, ü w s Õ» p (apical secretory Fig. 1. Round to oval subcutaneous masses around 5th mammary gland of 11-year-old mixed cat. Fig. 2. Apocrine adenocarcinoma, cat. Tumor cells formed glandular or tubular structure with central necrosis. Note typical apical blebs (arrows) and mitotic figures (open arrows). H&E, 200. blebs) ƒš. s w w wwš s w œsƒ tw y s ƒš, w ùküš (Fig. 2). y wì w ƒ ù y s û š. y 3~4 d dq š. s vw w w e ùküš, v x s (Fig. 3). xù v w» š ƒ wš. p wš s s PAS diastase ew PAS ƒš, Perl s iron

3 š 159 Fig. 3. Apocrine adenocarcinoma, dog. Note tumor cells emboli (arrows) in blood vessel. H&E, 200. Fig. 4. Apocrine adenocarcinoma, dog. Many tumor cells in neoplastic tubules show positive reaction for periodic acid-schiff (PAS) staining. PAS, 200. Insert: Note pink cytoplasmic granules in neoplastic cells. PAS stain after diastase digestion ùküš (Fig. 4). w š w Masson's trichrome t š. w p w. š š 7 d 5 vw ƒ w ù 2z ƒ w üw ww e ƒ. ù 3 w w,, w p m. w w s w ü w p ƒ xwš tubular type y.,, wû sw [2, 3, 10]. w š š [2, 3].»k 1, 3, wl 1 ƒ mö v ƒƒ 1ƒ š [3, 5, 8, 10, 15]. š v 0~6.5% w û š [7]. ww, ²i, Õ w š» wù [3, 7], p w ƒ š [7]. d x w p ùküš.,» w WHO w w solid, cystic, complex glandular, cribriform tubular xk y [2, 15]. ù solid, tubular cystic 3ƒ xkw p š [3, 15]. š y vs ü ü» w. d w» vw. Armed Forces Institute of Pathology w p y, s s PAS, diastase z PAS ƒ y s, Perl's iron, x, sw x wš [11, 15]. s PAS diastase w PAS ùküš, wš v s p ƒ y. w w, sw, y w ƒ. p œs ww y s ƒ v s œsƒ y s ƒš [15]. š x vw w yw. šƒ»

4 160 xáá Á½zÁÁ Á½z w p z q. Kalaher [7] š % vw v s e ù» yw, z š w 80%ƒ š 1 v» e [7]. w ƒ ƒ w 3 2 z 5 ¾ ù, w wl x 3z e š [15]. š 7 d w 2z e y. e wš, ƒ q. ƒ, v x w ƒ [2, 7, 9]. Simko [13] 44 w w ww w w (75%) s e š, e 5,» v e 28 y. ƒ ƒw 25 w w z s³» 30.» š w š z, ƒ(optic tracts), ƒ ù z w ƒ» w [9]. š 7 d 3z v w ƒ wš, w w 11 z sw. s š w yw s y. ù ƒ wš, 3 w e w v x sƒ e w p m q ƒ w y. y,, w w yw mw. š š w. { ƒ w w sw w ƒ. z w mw ywš yw, e yw z q wš. 11 f šƒ 7 d 5 ƒ 3 w. 3 w vw w, w yw p m. š p w ü š. šx 1. Fuentealba IC, Illanes OG, Haines DM. Eccrine adenocarcinoma of the footpads in 2 cats. Can Vet J 2000, 41, Goldschmidt MH, Dunstan RW, Stannard AA, von Tscharner C, Walder EJ, Yager JA. Histological Classification of Epithelial and Melanocytic Tumors of the Skin of Domestic Animals. 2nd series. Vol. III. pp , Armed Forces Institute of Pathology, Washington DC, Goldschmidt MH, Hendrick MJ. Tumors of the skin and soft tissues. In: Meuten DJ (ed.). Tumors in Domestic Animals. 4th ed. pp , Iowa State Press, Ames, Gross TL, Ihrke PJ, Walder EJ. Veterinary Dermatopathology: A Macroscopic and Microscopic Evaluation of Canine and Feline Skin Disease. pp , Mosby-Year Book, St. Louis, Gulbahar MY, Alkan I, Aslan L, Golen I. Mixed apocrine sweat gland tumor of the tail in a cow. Vet Pathol 2002, 39, Herráez P, Rodríguez F, Ramírez G, Aguirre- Sanceledonio M, Castro A, Espinosa de Los Monteros A. Multiple primary digital apocrine sweat gland carcinosarcoma in a cat. Vet Rec 2005, 157, Kalaher KM, Anderson WI, Scott DW. Neoplasms of the apocrine sweat glands in 44 dogs and 10 cats. Vet Rec 1990, 127, Miwa Y, Mochiduki M, Nakayama H, Shibuya N, Ogawa H, Sasaki N. Apocrine adenocarcinoma of possible sweat gland origin in a male rabbit. J Small

5 š 161 Anim Pract 2006, 47, Moise NS, Riis RC, Allison NM. Ocular manifestations of metastatic sweat gland adenocarcinoma in a cat. J Am Vet Med Assoc 1982, 180, Morandi F, Benazzi C, Simoni P. Adenocarcinoma of apocrine sweat glands in a mouflon (Ovis musimon). J Vet Diagn Invest 2005, 17, Park JS, Jung JY, Jo SH, Cheong J, Kang TY, Kim JH. Concurrent occurrence of apocrine sweat gland adenocarcinoma and mammary gland complex adenoma in a dog. Korean J Vet Res 2008, 48, Parry NMA. Anal sac gland carcinoma in a cat. Vet Pathol 2006, 43, Simko E, Wilcock BP, Yager JA. A retrospective study of 44 canine apocrine sweat gland adenocarcinomas. Can Vet J 2003, 44, Son YS, Chae CH. Histopathology of canine sweat gland neoplasms. Korean J Vet Res 1995, 35, Urayama F, Sato T, Shibuya H, Shirai W, Matsutani M, Yamazaki R. Apocrine adenocarcinoma in a golden hamster. J Vet Med Sci 2001, 63,