KISEP Case Report 대한간질학회지 2003;7(2):125 7(2):125-129 129 발작과 의식저하를 동반한 급성 Methyl Bromide 중독 2예 3 조광덕 1 임수빈 1 이순금 1 최성훈 2 김태훈 2 한군희 3 송경일 Two Cases of Methyl Bromide Intoxication with Seizures and Altered Mental State Kwang Deog Jo, M.D. 1, Soo-Bin Yim, M.D. 1, Soon Keum Lee, M.D. 1, Seong Hoon Choi, M.D. 2, Tae Hoon Kim, M.D. 2, Koon Hee Han, M.D. 3 and Kyung Il Song, M.D. 3 Department of Neurology, 1 Internal Medicine, 3 Kangnung Asan Hospital, Department of Family Medicine, 2 Seoul Asan Hospital, Asan Medical Center, University of Ulsan College of Medicine Methyl bromide is presently used as a fumigant for insects in soil, grains or fruit in storage or transport. It is a neurotoxic agent and has been responsible a number of deaths or acute poisonings among occupationally exposed persons. We report 2 patients, who had worked fumigation warehouse, presented with seizures and altered mental state. The serum concentrations of bromide were elevated 32.9 and 42.5 mg/l, respectively. Brain MRI showed bilateral symmetric high signal intensities in the splenium of corpus callosum, the globus pallidus, the quadrigeminal plate, the periaqueductal gray matter, the red nucleus, the substantia nigra, the medial lemniscus, the pontine tegmentum, the dentate nucleus, and the medulla. There was no brain lesion in the other patient. Appropriate and supervised handling of the chemical and regular education to workers are important to avoid the risk of methyl bromide poisoning. J Korean Epilep Soc 2003; 72:125-129 KEY WORDSMethyl bromideneurotoxicityseizure. - 증 례 1: 증 례 대한간질학회지 2003;7(2):125-129 125
Methyl Bromide 중독 2예 시간을 훈증하였고 송풍기로 약 10분간 환기시킨 후에 이 뇌염의 병력은 없었고 사회력 및 가족력에는 특이 사항이 송 작업을 진행하였다. 내원 2일 전에는 평소보다 작업양 없었다. 이 많고 일하는 인원이 적어 약 3~4분간만 환기시킨 후 이학적검사상 활력징후는 정상이었고 피부 발진은 없었 에 작업을 하였다. 과거력상 두부 외상이나 열성경련 및 다. 신경학적검사상 의식은 혼돈상태로 시간과 장소에 대 A B C D E 126 대한간질학회지 2003;7(2):125-129 F Fig. 1. T2 weighted axial MRI of case 1, obtained on the 5th hospital day, show bilateral symmetric high signal intensities in the splenium of corpus callosum (A), the globus pallidus (B), the quadrigeminal plate (C, closed arrow), the periaqueductal gray matter (C, closed arrow), the red nucleus (C, open arrow), the substantia nigra (C, open arrow), the medial lemniscus (C, open arrow), the pontine tegmentum (D), the dentate nucleus (E), and the medullar (F).
조광덕임수빈이순금 등 증 례 2: - - 대한간질학회지 2003;7(2):125-129 127
Methyl Bromide 중독 2예 고 찰 128 대한간질학회지 2003;7(2):125-129
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