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1 소식지 주소 : 부산광역시금정구장전동산 30 번지부산대학교약학대학약학연구동 435 호 / 전화 :051) 팩스 :051) agingbank@pusan.ac.kr hyjung@pusan.ac.kr Homepage : Content 3 월호 알기쉬운노화의기초지식 암후성유전체학의연구동향 (Recent progress in Cancer Epigenetics) 이주미, 정해영 ( 동남권원자력의학원, 부산대학교약학대학약학과 ) 1. 암후성유전체학의배경 2012 년 03 월호 발행인 : 발행처 : 편집인 : 정해영한국연구재단지원정기웅, 김대현, 박준환, 정유리, 임수경 Roth, G. (Gerontech Co.) Ishigmi, A. ( 일본 Toho대 ) Shimokawa, I. ( 일본 Nagasaki 대학 ) 자문위원 : Maruyama, N. ( 일본동경도립노화연구소 ) Yu, Byung Pal ( 미국텍사스대학 ) 정해영 ( 부산대 ) 김남득 ( 부산대 ) 김규원 ( 서울대 ) 운영위원 : 최재수 ( 부경대 ) 윤식 ( 부산대 ) 이은경 ( 동남권원자력의학원 ) 하영미 ( 부산대 ) 1

2 Aging Tissue Bank 2. 암과 DNA methylation 3. 후성유전학 연구 방법과 최신 기술의 발달 : Next Generation Sequencing (NGS) 2

3 Aging Tissue Bank 4. 후성유전체학의 미래 연구동향 ( 노화와 혈관질환의 기전 분자염증은 3월호에 계속 연재됩니다. ) 3

4 Aging Tissue Bank 노 화 소 식 동맥 노화에서의 Wnt/beta-catenin pathway 의 발현 Photoaging of human skin Marchand A et al.: Aging Cell,10: (2011) 4

5 Aging Tissue Bank 노 화 소 식 M. Berneburg et.al.: Photodermatol Photoimmunol Photomed 16: (2002) 여러 질환에서 Forkhead transcription factor (FoxO)의 최근 연구동향 김대현 Ph.D. (부산대학교 분자염증 노화제어 연구센터 연구원) 5

6 Aging Tissue Bank 노화조직을활용한최근연구논문 1. Choi. J., Kwon, S., Park, K., Yu, B.P., Kim, N.D., Jung, J.H., and Chung, H.Y.: The Anti-Inflammatory Action of Fermented Soybean Products in Kidney of High-Fat-Fed Rats. J Med. Food, 14 (3), (2011) (IF=1.309) 2. Lee. E.K., Kim, J.M., Choi, J., Jung, K.J., Kim, D.H., Chung, S.W., Ha, Y.M., Yu, B.P., Chung, H.Y.: Modulation of NF-κB and FOXOs by baicalein attenuates the radiation-induced infl ammatory process in mouse kidney. Free Radical Res, 45(5), (2011) (IF=2.805) 3. Kim, J.M., Heo, H.S., Choi, Y.J., Ye, B.H., Seo, A.Y., Yu, B.P., Leeuwenburgh, C., Chung, H.Y., and Carter, C.S.: Inhibition of NF-κB-induced inflammatory responses by angiotensin II antagonists in aged rat kidney. Exp. Gerontol, 46(7), (2011) (IF=3.804) 4. Ha, Y.M., Kim, J.A., Park, Y.J., Park, D., Kim, J.M., Chung, K.W., Lee, E.K., Park, J.Y., Lee, J.Y., Lee, H.J., Yoon, J.H., Moon, H.R., and Chung HY.: Analogs of 5-(substituted benzylidene)hydantoin as inhibitors of tyrosinase and melanin formation. Biochim Biophys Acta, 1810(6), (2011) (IF=4.663) 5. Ha, Y.M., Park, J.Y., Park, Y.J., Park, D., Choi, Y.J., Kim, J.M., Lee, E.K., Han, Y.K., Kim, J.A., Lee, J.Y., Moon, H.R., Chung HY.: Synthesis and biological activity of hydroxy substituted phenyl-benzo[d]thiazole analogues for antityrosinase activity in B16 cells. Bioorg. Med. Chem. Lett,21(8), (2011) (IF=2.661) 6. Young Jun Lee Mee Young Ahn Hyung Sik Kim Seung Jun Kwack Kul Lea Park Sik Yoon Dosik Min : Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague Dawley rats treated with di(2-ethylhexyl)phthalate. Arch. Toxicol., 85(8), (2011) (IF=4.041) 7. Choi, Y.J., Kim, D.H., Lee, E.K., Kim, J.M., Ha, Y.M., Kim, N.D., Jung, J.H., Choi, J.S., Yu, B.P., Chung,H.Y. : Attenuation of age-related changes in FOXO3a activity and the PI3K/Akt pathway by short-term feeding of ferulate. AGE, 34, (2012) (IF=6.28) 8. Hyun Ah Jung, Seong Eun Jin, Ran Joo Choi, Hung Tran Manh, Yeong Shik Kim, Byung-Sun Min, You Kyung Son, Bo Ra Ahn, Byung-Woo Kim, Hee Sook Sohn, and Jae Sue Choi : Anti-Tumorigenic Activity of Sophoflavescenol against Lewis Lung Carcinoma In Vitro and In Vivo. Arch Pharm Res. 34(12), (IF=1.593) 9. Hae Young Chung, Eun Kyung Lee, Yeon Ja Choi, Ji Min Kim, Dae Hyun Kim, Yani Zou, Chul Hong Kim, Jaewon Lee, Hyung Sik Kim, Nam Deuk Kim, Jee H. Jung, and Byung Pal Yu. : Molecular Inflammation as an Underlying Mechanism of the Aging Process and Age-related Diseases. Journal of dental research, 90(7), (2011) (IF=3.773) 10. Lee, Y.J., Ahn, M.Y., Kim, H.S., Kwack, S.J., Park, K.L., Yoon, S., Min, D.: Role of phospholipase D in regulation of testicular Leydig cell hyperplasia in Sprague-Dawley rats treated with di(2-ethylhexyl) phthalate. Arch. Toxicol. 85(8), (2011) (IF=4.041) 11. You Jung Kim, Young Ae Kim, Takako Yokozawa : Pycnogenol modulates apoptosis by suppressing oxidative stress and inflammati.on in hige glucose-treated renal tubular cells. Food Chem. Toxicol. 49(9), (2011) (IF=2.602) 12. Jae-Eun Lee, Jee-In Heo, Seong-Hoon Park, Jeong-Hyeon Kim, Yoon-Jung Kho, Hong-Jun Kang, Hae Young Chung, Jong-Lull Yoon, Jae-Youg Lee : Calorie restriction (CR) reduces age-depender decline of non-homologous end joining (NHEJ) activity in rat tissues. Exp. Gerontol. 46(11), (2011) (IF=3.804) 13. Li C, Sun S, Park D, Jeong HO, Chung HY, Liu XX, Zhou HM.: Hydrogen peroxide targets the cysteine at the active site and irreversibly inactivates creatine kinase. Int J Biol Macromol. 49(5), (2011) (IF=2.502) 14. Lim HA, Lee EK, Kim JM, Park MH, Kim DH, Choi YJ, Ha YM, Yoon JH, Choi JS, Yu BP, Chung HY.: PPARγ activation by baicalin suppresses NF-κB-mediated inflammation in aged rat kidney. Biogerontology, (in press) (2011) (IF=3.411) 15. Hossain M.A., Kim D.H., Jang J.Y., Kang Y.J., Yoon J.H., Moon J.O., Chung H.Y., Kim G.Y., Choi Y.H., Bryan L. Copple and Kim N.D.: Aspirin induces apoptosis in vitro and inhibits tumor growth of human hepatocellular carcinoma cells in nude mice xenograft model. INT J ONCOL., (in press) (2011) (IF=2.571) 16. Hossain M.A., Kim D.H., Jang J.Y., Kang Y.J., Yoon J.H., Moon J.O., Chung H.Y., Kim G.Y., Choi Y.H., Bryan L. Copple and Kim N.D.: Aspirin enhances doxorubicin-induced apoptosis and reduces tumor growth in human hepatocellular carcinoma cells in vitro and in vivo. INT J ONCOL., (in press) (2011) (IF=2.571) 17. Dae Hyun Kim, Ji Min Kim, Eun Kyeong Lee, Yeon Ja Choi, Chul Hong Kim, Jae Sue Choi, Nam Deuk Kim, Byung Pal Yu, Hae Young Chung: Modulation of FOX01 phoshporylation/acetylation by baicalin during aging. J NUTR BIOCHEM., (in press) (2011) (IF=4.538) 18. Wootae Kim, Ranah Kim, Geunyeong Park, Jong-Wan Park, and Ja-Eun Kim: Deficiency of H3K79 Histone Methyltransferase Dot1-like Protein(DOT1L) Inhibits Cell Proliferation. J BIOL CHEM., 287(8), ,(2011) (IF=5.328) 6

Aging Tissue Bank < 홍보 > 노화 수명연장연구에필요한시료를찾으십니까? 부산대 Aging Tissue Bank 로오십시오 본은연구자들에게노화기전및노화제어에필요한연구시료와정보를신속하게제공하여노화연구를원활히지원하는것을목적으로하고있습니다. 노화조직과노화쥐이미지 1) 노화조직의연구소재분양 1.

유전자변이모델동물 (GH결손, mini rat) 조직 7. 노화촉진모델동물 (SMP-30 유전자변이마우스 ) 8. 각종항산화물질투여노화조직 (SD) 구체적인것은 homepage를방문하시기를바랍니다. www.agingbank.or.kr / http://agingbank.pharm.pusan.ac.

Resveratrol 9. Ursodeoxycholic acid 3) 노화관련 Data Base 구축을통한통합정보제공 a) http://aging.pharm.pusan.ac.kr b) http://bionet.inje.ac.kr/massprophet c) http://bionet.inje.ac.kr/trep_db d) http://aging.

7 Aging Tissue Bank < 홍보 > 노화 수명연장연구에필요한시료를찾으십니까? 부산대 Aging Tissue Bank 로오십시오 본은연구자들에게노화기전및노화제어에필요한연구시료와정보를신속하게제공하여노화연구를원활히지원하는것을목적으로하고있습니다. 노화조직과노화쥐이미지 1) 노화조직의연구소재분양 1. Fisher 344 rat (AL) 연령별노화조직 2. Fisher 344 rat (DR) 연령별노화조직 3. LPS처리노화조직 (F344 rat) 4. Wistar rat 및 SD rat (AL) 연령별노화조직 5. Wistar rat 및 SD rat (DR) 연령별노화조직 6. 유전자변이모델동물 (GH결손, mini rat) 조직 7. 노화촉진모델동물 (SMP-30 유전자변이마우스 ) 8. 각종항산화물질투여노화조직 (SD) 구체적인것은 homepage를방문하시기를바랍니다. / 2) 노화제어 ( 유기합성물 / 천연물유래순수화합물 ) 물질분양 1. Total saponin 2. Ginsenoside Rb2 3. Ginsenoside Rbe 4. Ginsenoside Rbc 5. Ginsenoside Rg1 6. Lithospermate B 7. Oligonol 8. Resveratrol 9. Ursodeoxycholic acid 3) 노화관련 Data Base 구축을통한통합정보제공 a) b) c) d) e) 1), 2) 의연구소재가필요하시면다음으로연락주십시오 Tel : H.P : Fax : agingbank@pusan.ac.kr; hyjung@pusan.ac.kr 7

8 소식지

Aging Tissue Bank κ κ κ κ (9 월호에계속...) 2

Aging Tissue Bank κ κ κ κ (9 월호에계속...) 2 소식지 주소 : 부산광역시금정구장전동산30번지부산대학교약학대학 / 전화 :051)510-2814 팩스 :051)518-2821 E-mail:agingbank@pusan.ac.kr hyjung@pusan.ac.kr Homepage : www.agingbank.or.kr http://aging.pharm.pusan.ac.kr/ Content 6 월호 알기쉬운노화의기초지식