Medical POSTGRADUATES No. 5, Vol. 38, 2010 Morphologic Findings of Mixed Phenotype Acute Leukemia (MPAL) Fig. 1a Fig. 1b) Fig. 1c, d) Fig. 1e, f) 189

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1 M e d i c a l P O S T G R A D U A T E S Abstracts

2 Medical POSTGRADUATES No. 5, Vol. 38, 2010 Morphologic Findings of Mixed Phenotype Acute Leukemia (MPAL) Fig. 1a Fig. 1b) Fig. 1c, d) Fig. 1e, f) 189

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4 Table 1. Myeloid lineage T lineage B lineage (multiple antigens required) Myeloperoxidase(flow cytometry, immunohistochemistry or cytochemistry) or Monocytic differentiation(at least 2 of the following: NSE, CD11c, CD14, CD64, lysozyme) Cytoplasmic CD3(flow cytometry with antibodies to CD3 epsilon chain; immunohistochemistry using polyclonal anti-cd3 antibody may detect CD3 zeta chain, which is not T-cell specific) or Surface CD3(rare in mixed phenotype acute leukemias) Strong CD19 with at least 1 of the following strongly expressed; CD79a, cytoplasmic CD22, CD10 or Weak CD19 with at least 2 of the following strongly expressed; CD79a, cytoplasmic CD22, CD10 Table 2. B- T- 2 cyt CD79a CD3 (m/cyt) MPO cyt CD22 cyt IgM Anti-TCR 1 CD19 CD2 CD117 CD20 CD5 CD13 CD10 CD8 CD33 CD10 CD TdT TdT CD14 CD24 CD7 CD15 CD1a CD64 191

5 REFERENCES 1. Matutes E, Morilla R, Farahat N, Carbonell F, Swansbury J, Dyer M et al.(1997): Definition of Acute Biphenotypic Leukemia. H a e m a t o l o g i c a, 82: Swerdlow SH, Campo E, Harris NL, Jaffe ES et al. ( ): WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues. IARC: Lyon, pp (2009): 4. : E Public, pp

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16 Medical POSTGRADUATES No. 5, Vol. 38, 2010 What is an Autonomous Decision? - It s Criteria and Autonomy in Korea - 203

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20 3. < > (2008) 27 4., < > (2008)., 5., :,,. 101, Rovert Veatch. 6. Ronald Munson (2004): Intervention and Reflection: Basic Issues in Medical Ethics (7 th edition), W a d s w o r t h, pp Bruce Miller (1981): "Autonomy and the Refusal of Lifesaving Treatment: Four Cases, Four Senses of Autonomy," The Hastings Center Report, 11, pp i n t e g r i t y 13., :,,,. 101, V e a t c h (2003): The Basics of Bioethics (2 nd edition), pp Robert Veatch (2003): The Basics of Bioethics ( 2 n d edition), Prentice Hall, pp Keith Burton (2003): A Chronicle: Dax's Case As It Happened, in Bonnie Steibock, John D. Arras, and Alex john London, Ethical Issues in Modern Medicine ( 6 t h edition), McGraw-Hill, pp i n t e g r i t y

21 Medical POSTGRADUATES No. 5, Vol. 38, 2010 Principle of Non-maleficence and Communication between Physicians and Ethicists 208

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25 REFERENCES 1. Albert Jonsen (1977): Do No Harm: Axiom of Medical 2. (2005):, Ethics, in Philosophical Medical Ethics: Its Nature and 3. Howard B. Radest (1997): First, Do No Harm! Medical Significance, pp Ethics and Moral Education, Humanism Today, vol

26 Medical POSTGRADUATES No. 5, Vol. 38, 2010 Health Care and Fair Distribution 213

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29 REFERENCES 1. health care. Ritchy, Dictionary of Medical Sociology, <London :.. (Norman Daniels) health care h e a l t h - c a r e. h e a l t h c a r e h e a l t h - c a r e. health care. health care - safety regulationcertain social support services (Norman Daniels, Just Health Care <NY : Cambridge, 1985>, p. ). Daniels is Mary B. Saltonstall Professor of Population health care1. Behavioral definition: Medicinal and preventive measures taken by the self or others to maintain functional health status. 2. Institutional definition: A society's cultural and organizational arrangements directed at maintenance of the health status of its population, Oxford University Press, 2001), pp (W. C. Cockerham F. J. Greenwood Press, 1997>, p. 53.) h e a l t h care. Caring EthicsEthics of Care (), health care. health care,h e a l t h - c a r e -, right to health, right to health care ( ). 2. Norman Daniels PhD, is an American philosopher, 3. ethicist, and bioethicist at Harvard. Currently, Norman Ethics and Professor of Ethics and Population Health in the Department of Global Health and Population of the Harvard School of Public Health in Boston. Tom L. BeauchampJames F. Childress, Principles of Biomedical Ethics (Oxford :. 216

30 . Gillon 6. age relative species-typical normal function, (Norman Daniels, Just Health Care <NY : Cambridge ( R a a n a n Gillon, < :, 2005>, pp. 159) W H O,,. Gillon. Gillon, pp D. Callahan, 1973, The WHO Definition of 'Health',T h e Hasting Center Studies, :3: (negative) (positive) H. Tristram Engelhardt, JR, "Managed Care and the. Deprofessionaization of Medicine," W. B. Bondeson and J. W. Jones (ed.) Ethics of Managed Care: Professional.,, Integrity and Patient Rights (Boston : Kluwer Academic, 161(2010 ), pp University Press, 1985>, pp. 26). ()., (Roy Porter, The Greatest Benefit to Mankind, <NY : W. W. Norton & Company, 1977>, pp. 717). e n h a n c e m e n t. J u l i a n S avules cu an d Nick Bo str om (ed.), H u m a n E n h a n c e m e n t (NY : Oxford University Press, 2009). Publishers, 2002), pp

31 Medical POSTGRADUATES No. 5, Vol. 38, 2010 Utilitarianism, Meat Eating and Animal Experiment 218

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35 REFERENCES 1. (2005):, M. (2004):, 2. J. (2000):, 5. R. & J. (2005):, R. & J. (2006):, 6. P. (1999):, 222

36 Medical POSTGRADUATES No. 5, Vol. 38, 2010 An Ethical Understanding based on The Brain Science The Ethical Brain : Book Review (Written in Korean) 223

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38 REFERENCES 1. S. / (2010):, K. /, 2,, pp S. / (2010): 6. S. / (2010):, 2,, pp S. / (2010): 7. S. / (2010):, 2,, pp S. / (2010): 8. S. (2010):,, 2,, pp (2003):, 1,, pp.192, 2,, pp.194, 2,, pp.229 K. (2003):, 225

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46 Abstracts Medical POSTGRADUATES No. 5, Vol. 38, 2010 Use of Advanced Radiology During Visits to US Emergency Departments for Injury-Related Conditions, Frederick Kofi Korley et al. JAMA, 303(13): , 2010 Association of Telomere Length of Peripheral Blood Leukocytes With Hematopoietic Relapse, Malignant Transformation, and Survival in Severe Aplastic Anemia Phillip Scheinberg et al. JAMA, 304(12): ,

47 Outcome after Reduced Chemotherapy for Intermediate-Risk N e u r o b l a s t o m a David L. Baker et al. N Engl, 363: , 2010 Etiology and Diagnosis of Systolic Murmurs in Adults Steven McGee Am J Med, 123(10): ,

48 Adherence to Oral Contraception in Women on Category X Medications Amy Steinkellner et al. Am J Med, 123(10): , 2010 Incidence and Risk Factors of Venous Thromboembolic Events in Lymphoma Xiao Zhou MD et al. Lancet, 123(10): ,

49 Serum Uric Acid Levels and the Risk of Type 2 Diabetes: A Diabetes Enhances Hepatocarcinogenesis in Noncirrhotic, Interferon-treated Hepatitis C Patients Yusuke Kawamura MD et al. Am J Med, 123(10): , 2010 Prospective Study Vidula Bhole MD et al. Am J Med, 123(10): ,

50 Early versus delayed treatment of relapsed ovarian cancer (MRC OV05/EORTC 55955): a randomised trial Prof Gordon JS Rustin MD et al. Lancet, 376(9747): ,

51 Medical POSTGRADUATES No. 5, Vol. 38,

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7.Æ¯Áýb71ÎÀ¯È« š J KMA Special Issue Myelodysplastic Syndrome June Won Cheong, MD Yoo Hong Min, MD Department of Internal Medicine, Yonsei University College of Medicine E mail : jwcheong70@yumc.yonsei.ac.kr minbrmmd@yumc.yonsei.ac.kr