Treatment of Psoriasis Jai Il Youn, M.D. Department of Dermatology Seoul National University College of Medicine & Hospital E mail : jaiil@snu.ac.kr Abstract Psoriasis is a common, chronic skin disease. The goal of therapy is always to use the appropriate medication to achieve the desired effect while minimizing side effect. The three types of traditional therapies for treatment of psoriasis are topical therapies, phototherapies and systemic therapies. Topical steroid, vit D derivatives are frequently prescribed with other agents. Broad band UVB, PUVA and narrow band UVB therapies are most commonly used phototherapy. Three main systemic agents now used for moderate to severe psoriasis are retinoid, cyclosporine and methotrexate. Psoriasis is recently found to be an T cell mediated immunologic disease. This lead to the developing new targeted immunobiologic agents.the newer biologic agents appear to combine greater efficacy of treatments with less toxicity by targeting T cell activation or specific mediator, TNF. Keywords : Psoriasis; Phototherapy; Retinoid; Cyclosporine; Biologics 150
Type of psoriasis treatment Topical agents in the treatment of psoriasis Factors influencing choice of psoriasis therapy Side reactions of topical steroid 151
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Phototherapeutic agents in the treatment of psoriasis 153
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Systemic agents in the treatment of psoriasis 155
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Strategies for biologic therapies of psoriasis T alefacept T efalizumab, alefacept Th1/Th2 IL 10 TNF etanercept, infliximab 157
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