Sweet BV 85 DOI : 10.3831/KPI.2010.13.2.085 Sweet BV Received : 10. 05. 24 Accepted : 10. 06. 07 Clinical Analysis about Treatment of Myofascial Pain Syndrome(MPS) with Sweet Bee Venom on Hand Paresthesia based on Thoracic Outlet Syndrome Key Words: Hand Paresthesia, Myofascial Pain Syndrome, Sweet Bee Venom, Osteoporosis Sung-Won Oh 1), Byoung-Woo Kim 1), Joong-chul An 2) *, Hye Chul Yoon 2), Jae Seuk Park 2), Ki-Rok Kwon 2) 1) Department of Internal Medicine, Oriental Hospital of Sangji University, Wonju, Korea 2) Department of Acu. & Mox., Oriental Hospital of Sangji University, Wonju, Korea ABSTRACT Objectives: The objective of this study was to compare the effects of Sweet Bee Venom(Sweet BV) Therapy between the hand paresthesia patients with Osteoporosis and without Osteoporosis. Methods: This study was carried out to established the clinical criteria of hand parethesia. The patients who had past history of diabeics, neuropathy induced by alcohol or drug and was positive on Myofacial Pain Syndrome Theory were excluded. 32 patients who had hand paresthesia related with unknown-reason was selected by the interview process. And the effects of treatment were analyzed using VAS score before treatment, after treatment, after 1 month and after 3 months. Results and conclusion: After treatment, While Osteoporosis group decrease from 64.81 17.81 to 27.21 17.32, Non-Osteoporosis group decrease from 58.76 11.43 to 24.74 13.81 by VAS scores. and After 3 months, While Osteoporosis group increase from 27.21 17.32 to 54.96 19.40, Non- Osteoporosis group increase from 24.74 13.81 to 32.43 15.57. Non-Osteoporosis group was accordingly more effective than Osteoporosis group after 3 months. So Sweet BV therapy for hand numbness patients without Osteoporosis was effective than patients with Osteoporosis. I 60 Corthami-Flos, CF BUM 2 Corresponding author: Joong-chul An, Okgye Public Health Clinic, Hyeonnae-ri,Okgye-myeon, Gangneung-si, Gangwon-do, South Korea. Tel.+82-33-534-0437, E-mail. fouth1@hanmail.net
86 Journal of Pharmacopuncture 13 2 2010 6 CF BUM Sweet Bee Venom, Sweet BV Sweet BV melittin Gel filtration chromatography propionic acid/urea polyacrylamide gel electrophoresis 2008 4 2009 10 Sweet BV X-ray II 1 6 Fig. 1 point 1 middle scalene muscle sternocleidomastoid muscle trapezius muscle point 2 middle scalene muscle trapezius muscle clavicle point 3 anterior scalene muscle clavicular head of sternocleidomastoid muscle clavicle point 4 subclavius muscle clavicle Sternal head of pectoralis major muscle point 5 pectoralis minor muscle clavicle coracoid process point 6 transverse carpal ligament palmaris longus tendon 1.5 5 point 6 point 6 2 (Inclusion criteria) 2008 4 2009 10 3
Sweet BV 87 1 6 1 2 1 3 VAS 3. (Exclusion criteria) 49 17 32 4 X-ray Dual energy X-ray Absorptiometry T value -2.5 5 SPSS Statistical Program for Social Science 10.0 Kolmogorov-Smirnov P-value>0.05 paired T-test p-value 0.05 1) VAS Visual Analogue Scale 0 100 2) 3 2 2 1 6 Sweet BV sterile hypodermic syringe 26GX1/2, 1 1ml, Point 1 6 syringe 1 1.5 Sweet BV 0.1 3) 3 2 III 1 0 13 59.89 3.27 4 8 1 5 8 7 2 3 1 0 19 61.68 3.80 4 12 2 9 10 10 5 3
88 Journal of Pharmacopuncture 13 2 2010 6 1 Table 1. 2 VAS 64.81 17.81, 58.76 11.43 Table 1. 3 2 VAS 27.21 17.32 37.60 15.73 p-value<0.01 24.74 13.81 34.02 14.13 p-value<0.01 p-value>0.05 1 44.31 17.73 29.36 16.25 3 54.96 19.40 32.43 15.57 Table 2. & Fig. 2 IV anaphylactic shock allergen phospolipase A2 histamine melittin Sweet BV Sweet BV 99 melittin TV CF BUM Sweet BV X-ray Dual energy X- ray Absorptiometry T value -2.5 3 CF BUM 50 Sweet BV VAS score 37.60 15.73 34.02 14.13 3 54.96 19.40 32.43 15.57
Sweet BV 89 Sweet BV 6 point 5 point thoracic outlet syndrome 3 anterior scalenic triangle posterior scalenic triangle costoclavicular space coracothoracopectoral space point Sweet BV Sweet BV CF BUM 37.53 17.76 student T-test p-value>0.05 CF BUM 50 Sweet BV 50 chi-square test p-value 1 V Sweet BV 2008 4 2009 10 32 2 1 3 VAS score 1. 2. 2 VAS score 3. 3 VAS score Sweet BV 3 Sweet BV VI 1. Chung MS, Kim HJ, Bin SI, Yeo BG, Kim YM. Nerve compression Syndromes of the Upper Extremities. Journal of Korean Orthop. Assoc. 1990; 25(3): 899-907. 2. Oh SW, Jeong JJ, Kim SY, Han IS, Kang HM, Kim BW, Kwon KR. Clinical Analysis about Diagnosis and Treatment of 86 Hand Paresthesia Cases Using MPS Theory and Pharmacopuncture Therapy. The Journal of Korean Acupuncture & Moxibustion Society. 2007; 10(3): 121-126. 3. Kwon KR, Choi SH, Cha BC. Component Analysis of Sweet BV and Clincal Trial on Antibody Titer and Allergic Reactions. The Journal
90 Journal of Pharmacopuncture 13 2 2010 6 of Korean Acupuncture & Moxibustion Society. 2006; 9(2): 79-86. 4. Lee JS, Lee JY, Kwon KR, Lee HC. A Study on Allergic responses Between Bee Venom and Sweet Bee Venom Pharmacopuncture. J. of KPI. 2006; 9(3): 105-112. 5. An JC, Kwon KR, Lee SB, Rhim TJ. Experimental Study on the comparison of antibacterial and antioxidant effects between the Bee Venom and Sweet Bee Venom. J. of KPI. 2006; 9(3): 97-104. 6. Kwon KR, Koh HK, Kim YS, Park YB, Kim CH, Kang SK. The Effect of Bee Venom Aqua-acupuncture on the Antitumor and Immune Response in the Epithelioma by 3-MCA. The Journal of Korean Acupuncture & Moxibustion Society. 1997; 14(2): 151-172. 7. Ko HK. Experimental Studies on the Effect of Bee Venom Theraphy on the analgesic, Antipyretic and Anti-inflammatory Action. Koren Journal of Oriental Medicine. 1992; 13(1): 283-292. 8. Lee SN, Hong SY, Jo HC, Byeon IJ, Song HS, Kim GH. The Clinical Study on Bee Venom Acupuncture Treatment on Osteoarthritis of Knee Joint. The Journal of Korean Acupuncture & Moxibustion Society. 2003; 20(5): 73-78. 9. Kim TH, Kong KS, Kwon KR. Three cases of affections of the hip treated with Korean Bee Venom Therapy. Journal of Korean Pharmacopuncture Institute. 2001; 4(3): 122-130. 10. Lee SH, Lee HJ, Baek YH, Kim SY, Park JK, Hong SJ, Yang HI, Kim Ks, Choi DY, Lee DI. Effects of Bee Venom on the pain, edema and acute inflammatory reactant of Rheumatoid Arthritis patients. The Journal of Korean Acupuncture & Moxibustion Society. 2003; 20(2): 77-84. 11. Kim KU, Seo BM, Yun JS, Lee YK, Choi SH, Lee KM, Lim SC, Seo JC, Jung TY, Han SW. The Comparison of Bee Venom Herbalacupuncture Therapy between Neighboring Acupuncture Points and Neighboring-Remote Acupuncture Points on the Treatment of Lumbar Spine Herniation of Nucleus Pulpous. The Journal of Korean Acupuncture & Moxibustion Society. 2005; 22(6): 181-187. 12. Kang KS, Kwon KR. Clinical Studies on 5 Cases of Multiple Sclerosis by Acupuncture Therpies. The Journal of Korean Acupuncture & Moxibustion Society. 2003; 20(1): 209-217. 13. Kwon KR. Clinical Studies of Amyotrophic Lateral Sclerosis(ALS) through Korean Medicine. The Journal of Korean Acupuncture & Moxibustion Society. 2003; 20(3): 209-216. 14. Lim CS, Park WP, Jang SB, Choi YC, Park DI, Kwon KR, Lee HC, Clinical Studies of Sweet Bee Venom to the Effect of Abdominal Fat Accumulation. The Journal of Korean Acupuncture & Moxibustion Society. 2008; 11(2): 55-62.
Sweet BV 91 Table 1. General characteristics Osteoporosis Group Non-Osteoporosis Group Sex (n)* Male Female 0 13 0 19 Age (mean SD)* 59.89 3.27 61.68 3.80 Age group (n)* 40-50 1 1 50-60 6 7 60-70 4 8 70-80 2 3 Job (n)* Housekeeper 4 4 Farmer 8 12 Other 1 3 Numbness area 1 (n)* Unilateral 5 9 Bilateral 8 10 Numbness area 2 (n) All hand 7 10 1 2 3 finger 2 5 4 5 finger 3 3 Palmar 1 1 * P-value 1(Statistical significance test was done by chi-square test) Table 2. The Comparison of VAS between Osteoporosis Group and Non-Osteoporosis Group Time Osteoporosis Group Non-Osteoporosis Group Before Treatment 64.81 17.81 58.76 11.43 Treatment End 27.21 17.32 24.74 13.81 1 month After Treatment 44.31 17.73 29.36 16.25 3 month After Treatment 54.96 19.40 32.43 15.57*
92 Journal of Pharmacopuncture 13 2 2010 6 Fig. 1 The point at diagnosis and treatment by MPS theory for hand Paresthesia related with unknown-reason Fig 2. The comparsion of VAS between osteoporosis group and non-osteoporosis group