Review Key Words : Stroke; Thrombolysis; Revasculaization treatment; Mechanical thrombolysis Received May 8, 2006; accepted after revision July 15, 2006. Correspondence to: Deok Hee Lee, MD, Department of Radiology, Research Institute of Radiology, Asan Medical Center, University of Ulsan College of Medicine, 388-1, Poognap-dong, Sonpa-gu, Seoul 138-736, Korea Tel. 82-2-3010-4325 Fax. 82-2-476-0090 E-mail: dhlee@amc.seoul.kr Neurointervention 2006;1:18-29 18 Neurointervention 1, August 2006
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Fig. 1. Functional outcome represented as mrs and comparison of current domestic results with those of control and treated groups of major thrombolysis trials. Table 1. Univariate Relationships of Significant Hemorrhage after Thrombolysis Variable Odds Ratio P value Demographic Age (>65y) 0.70 0.46 Sex (male) 0.32 0.08 Diabetes 0.96 0.95 Hypertension 3.03 0.044 Cardioembolism 1.38 0.51 Initial NIHSS score 15 3.75 0.046 CT findings Positive early CT sign 1.80 0.38 Violation of one-third rule 4.42 0.08 Basal ganglia involvement 4.08 0.03 Hyperdense MCA sign (+) 1.21 0.73 MR findings DWI lesion over 1/3 of MCA territory 0.86 0.81 DWI lesion over 1/2 of MCA territory 1.55 0.51 Basal ganglia involvement 3.93 0.042 Presence of diffusion-perfusion mismatch 0.84 0.88 Visible dark clot on T2*-weighted images 8.63 0.08 Procedure and post-procedure imaging findings Within working hours 2.82 0.038 Within 3 hours after symptom onset 1.64 0.46 Within 6 hours after symptom onset 0.39 0.22 Combined IV thrombolysis 0.79 0.62 Combined mechanical thrombolysis 0.93 0.88 Failed recanalization 0.86 0.77 Any contrast staining on post-ct 15.8 <0.0001 Contrast extravasation on post-ct 14.9 <0.0001 Table 2. Univariate Relationships with Poor Functional Outcome (mrs > 3) Variable Odds Ratio P value Demographic Age (>65y) 2.27 0.01 Sex (male) 0.87 0.68 Diabetes 1.52 0.35 Hypertension 1.12 0.73 Cardioembolism 0.88 0.70 Initial NIHSS score 15 4.88 <0.0001 CT findings Positive early CT sign 1.57 0.37 Violation of one-third rule 5.8 0.12 Basal ganglia involvement 1.26 0.68 Hyperdense MCA sign (+) 1.21 0.73 MR findings DWI lesion over 1/3 of MCA territory 2.35 0.04 DWI lesion over 1/2 of MCA territory 6.14 0.001 Basal ganglia involvement 3.22 0.01 Presence of diffusion-perfusion mismatch - 0.003 Visible dark clot on T2*-weighted images 2.10 0.33 Procedure and post-procedure imaging findings Within working hours 2.41 0.01 Within 3 hours after symptom onset 0.98 0.97 Within 6 hours after symptom onset 0.93 0.87 Combined IV thrombolysis 1.08 0.80 Combined mechanical thrombolysis 0.96 0.89 Failed recanalization 0.31 0.003 Any contrast staining on post-ct 2.33 0.03 Contrast extravasation on post-ct 4.00 0.007 Significant hemorrhage 26.7 0.002 20 Neurointervention 1, August 2006
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