표지완전최종

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1 봉약침을이용한전염성연속종의임상치험례보고 127 중례 봉약침을이용한전염성연속종의임상치험례보고 박사한 * ㆍ이종영 ** ㆍ권기록 ** * 사랑이꽃피는한의원 ** 상지대학교한의과대학침구학교실 Clincal Report on Treating Molluscum Contagiosum using Bee Venom Pharmacopuncture Sa Han, Park* Jong Young Lee** Ki Rok, Kwon** * Korean Medical clinics of Blooming Love ** Dept. of Acupuncture & Moxibustion, Oriental Medical College, Sangji University ABSTRACT Objectives Methods Results Conclusion key words This study observed the efficacy of bee venom pharmacopuncture on the treatment of Molluscum Contagiosum commonly manifesting in children. 104 patients admitted for Molluscum Contagiosum at Love Blossoming Oriental medicine clinic from August 2005 to August 2006 were administered with Bee Venom Pharmacopuncture and measured and analyzed changes in symptoms. 1. Regardless of age or duration of Molluscum Contagiosum, all 104 patients showed improvement. 2. Recurrence of Molluscum Contagiosum was not noticeable when treated with Bee Venom Pharmacopuncture, and the duration of treatment was significantly shorter than treating with conventional allopathic ointment. 3. Regardless of size or location of Molluscum Contagiosum, most cases improved with one or two treatments. Based on above findings, we can deduce Bee Venom Pharmacopuncture has superior anti-viral effects on the pox virus of molluscum contagiosum (MCV1,2). Bee Venom, Pharmacopuncture, Molluscum Contagiosum I. 서론 전염성연속종은 DNA 바이러스군에속하는 pox 바이러스인 Molluscum Contagiosum 바이러스 (MCV-1,2) 에의해일어나는양성질환으로전체인구의약 1-5% 에서발생하며 1-2) 최근에는후천성면역결핍증환자나면역억제제를투여받고있는장기이식환자등과같이전신면역기능이저하되어있는환자에서의발생이증가되고있다 3-4). 이바이러스는현저한표피친화성이있어사람의피부에중심부함몰이보이는특징적인반원형구진상으로나타나며, 이병변은 MCV의 DNA로가득찬연속종소 체 (Molluscum body) 로이루어져있다 1). 주로소아에서호발하며성인에서항문이나성기부위에발생할경우성인성질환으로간주되기도하고특별한자각증상은없으나소양증을동반할수도있다 3). 병소는자가접종, 피부접촉및성교에의해전파되고, 임상양상은전형적인경우직경 2-5mm크기의둥근반구형의피부색구진이다발성으로발생하며호발부위는안면, 손, 구간부의피부와점막을침범하며드물게는손바닥이나발바닥에도발생한다 1-2). 특히후천성면역결핍증환자의경우 18% 의높은발생률을나타내었다는보고가있으며, 특히 AIDS 환자들의경우임상양상이더욱광범 교신저자 : 권기록, 강원도원주시우산동 283 상지대학교부속한방병원침구과 (Tel: FAX: beevenom@paran.com)

2 128 대한약침학회지제 10 권제 3 호 (2007 년 12 월 ) 위하고만성적으로심하게나타난다고한다. 또한아토피피부염환자의 8.9% 에서동반되어나타나고, 전염성연속종환자의 29.1% 에서아토피피부염이발견되는등상관관계가보고되고있다 4). 전염성연속종은한방에서, 目의범주에들어가고, 樞 經脈篇 에서 手太陽之別名曰支正... 虛則生. 라하였으며 5) 風熱毒盛이나肝鬱痰凝, 腎氣不榮등으로발생한다고하고있다 6-7). 따라서진통, 소염, 항균효과가있는봉약침이바이러스성질환인전염성연속종 (Molluscum Contagiosum) 에효과가있는가를알아보고자이를주소로하는 104명의환자를대상으로봉약침을시술한결과유의한결론을얻어보고하는바이다. Fig. 1 시술할연속종을선택한다. Ⅱ. 연구대상및방법 1. 연구대상 생후 13개월부터 40세에이르기까지전염성연속종을호소하며사랑이꽃피는한의원을래원한 104명의환자들을대상으로하였다. 104명의환자중남자는 48명이었고여자는 56 명이었으며, 90% 이상이 8세이하의유 소아였다. Fig. 2 선택되어진연속종의내부에봉약침을적정량주입한다. 2. 시술방법 0.1mg / ml (10%, 순수 2호 ) 봉약침을연속종의내부에주입하는방식으로, 개수가적은경우에는 1회시술량으로 0.1ml에서광범위하게분포된경우에는최대 3.0ml까지연속종의내부에봉약침을시술하였다 (Fig. 1-3). 시술후환자에게환부가가려워도감염이발생할수있으므로긁지말라는주의를준후 20 여일지난후다시래원하게하였다. 재진시에완전히소멸된경우는다시치료를시행하지않았고, 연속종이발견된경우에는동일한방법으로시술하여완전히소멸될때까지시술하였다. 그리고그결과를관찰하였다. Fig. 3 시술부위주위가발적된다.

3 봉약침을이용한전염성연속종의임상치험례보고 129 Ⅲ. 결과 2. 치료결과분석 1. 임상양상남자 48명과여자 56명의전염성연속종환자를대상으로하여임상양상을분석하였다. 대부분의환자들은전신성구진의양상을나타내고있었고, 만 4세에서 6세가가장많은분포를나타내고있었다 (Fig. 4). 발병기간은평균 5개월로 3-4개월이환된경우가가장많았고, 11개월이상이환된경우도 13명으로비교적많은분포를나타내고있었다 (Fig. 5). 66명의환자에서단 1회의봉약침시술로전염성연속종이소멸되었고, 31명은 2회에서, 4명은 3회에서, 3명은 4회시술로소멸되었다 (Fig. 6). 전염성연속종의평균치료횟수는 1.5회를나타내어봉약침이 molluscum contagiosum 바이러스 (MCV-1,2) 에대단히뛰어난항바이러스작용이있음을알수있었다. Fig. 6 Molluscum Contagiosum was disappeared by the treatment of Bee Venom Pharmacopuncture. The average of treated time is one and half. 3. 시술과정에서의임상례 Fig. 4 Age distribution of 104 patients 모든환자에서시술전에는전염성연속종이투명한수포의형태를나타내고있었으나봉약침을시술한후에는붉은색혹은갈색으로변하면서고사되었고이과정을거치면서점차사라지는것을확인할수있었다 (Fig. 7). 4. 시술후의결과 모든환자에서시술후의기간경과에따라약간의차이는있었지만거의모든예에서만족할만한결과를얻었다. 또한재발이나타날경우래원하여재치료를권유하였으나 1례에서도재발로인한재치료를시행한경우가발생하지않았다. Ⅳ. 고찰 Fig. 5 Duration of Molluscum conagiosa 봉약침요법은살아있는꿀벌의독낭안에들어있는봉독을전기자극등 8) 으로추출하여건조한후, 정제가공하여辨證施治하는新鍼 法으로항염 9), 진통 10), 면역기능강

4 130 대한약침학회지제 10 권제 3 호 (2007 년 12 월 ) <Before> <After treatment> Fig. 7 The aspects of Molluscum Contagiosum before and after treatment

5 봉약침을이용한전염성연속종의임상치험례보고 131 <Before> <After treatment> Fig. 8 The aspects of Molluscum Contagiosum before and end of treatment

6 132 대한약침학회지제 10 권제 3 호 (2007 년 12 월 ) <Before> <After treatment> Fig. 8 The aspects of Molluscum Contagiosum before and end of treatment

7 봉약침을이용한전염성연속종의임상치험례보고 133 <Before> <After treatment> Fig. 8 The aspects of Molluscum Contagiosum before and end of treatment 화 11) 그리고항암작용 12) 등이있으며그효능또한뛰어난것으로알려져있다. 전염성연속종은 1-5세의소아와젊은성인에서주로발생하는 poxviridae과에속하는 DNA 바이러스에의한표피질환으로유일하게인간에게만전염되는특징이있다 1). 잠복기는 2-7주이고자가접종이나피부접촉, 성교에의하여전파되며다른바이러스성질환처럼기계적자극에의해전파가촉진된다. 일반적으로소아에서얼굴이나목에주로분포하는것은매개물이나접촉에의한감염에의한것으로생각되며, 드물게는손바닥이나발바닥, 입술, 혀, 협부점막이나안구및안구주위등의무모부위와두피에서도발생할수있다 2). 어른에서성기주위나하복부, 허벅지등에분포한것은성적인접촉에기안한것으로여겨지며 13) 후천성면역결핍증환자에서얼굴이나목 에호발하는것은면도시생기는미세한상처에기인한것으로추정된다 4). 병인은확실치않으나면역기능저하와의연관성이제시되고있는데, 특히활성화된 T임파구가매개하는면역이질병을조절하는데중요한역할을할것으로생각된다. 최근후천성면역결핍증후군이나신장이식 14), 비장절제 15) 를받은환자등에서단발성으로거대형의전염성연속종의발생보고와아토피환자에서발생률이높은것 16), 특히후천성면역결핍증후군의환자에서종양의크기가면역결핍의정도를추정하는임상적지표가된다는보고 4) 등이면역과의연관성을뒷받침하고있다. 임상적으로전염성연속종은사마귀, 수두, 편평태선, 유두종, 상피종, 그리고옹종등과감별이필요하다 1-2). 특히단발성의비교적큰결절혹은종양의형태로발생되는

8 134 대한약침학회지제 10 권제 3 호 (2007 년 12 월 ) 경우임상적으로심상성사마귀, 표피낭종, 화농성육아종, 한공증, 기저세포암, 그리고각화극세포증등으로진단하기쉬우므로주의를요한다 17). 양방에서는전염성연속종을치료하기위하여액화질소를이용한냉동치료법, 전기소작, 소파술, 절제, cantharidine 등다양한방법이시도되고있으며, 치료를하지않는경우에도흉터없이 6개월에서 3년사이에자연적으로소실될수도있다 1-2) 고보는견해도있지만외관상의문제가심한경우에는적극적인치료를통하여병변의수나크기를줄이는치료가진행되어야한다고보고있다 18). 본연구는봉약침이전염성연속종에어떠한효과가있는지를알아보기위하여 2005년 8월부터 2006년 8월까지사랑이꽃피는한의원에래원한생후 13 개월부터 40세에이르는환자 104명을대상으로봉약침을시술한후그결과를관찰하였다. 전염성연속종을치료하기위하여 10%(0.1mg / ml ) 봉약침을적게는한부위에 0.01ml부터많게는 0.03ml까지, 총주입량은 1회시술에적게는 0.1ml에서많게는 3.0ml까지환부의내부에주입한후 20 여일전후에래원하여관찰하는방법을사용하였다. 그결과대부분의환자들은전신성구진의양상을나타내고있었고, 만 4세에서 6세의연령대에서가장많은분포를나타내고있었다. 발병기간은평균 5개월로 3-4개월이환된경우가가장많았고, 11개월이상이환된경우도 13명으로비교적많은분포를나타내고있었다. 모든환자에서시술전에는전염성연속종이투명한수포의형태를나타내고있었으나봉약침을시술한후에는붉은색혹은갈색으로변하면서고사되었고, 이과정을거치면서점차사라지는것을확인할수있었다. 전체의 65% 인 66 명의환자에서단 1회의봉약침시술로전염성연속종이소멸되었고, 31 명은 2회에서, 4명은 3 회에서, 3명은 4회시술로소멸되었으며평균치료횟수도 1.5회를나타내어매우우수한소멸효과를나타내었다. 이러한결과는양방의소파술이나 DPCP의면역치료등에비하여대단히뛰어난결과임을알수있었다. 치료또한모든예에서만족할만한결과를얻었고재발로인한재치료를시행한경우도발생하지않아봉약침이 Molluscum Contagiosum 바이러스 (MCV-1,2) 에대단히뛰어난항바이러스작용이있음을알수있었다. 그동안전염성연속종에대한기존의보고가많지않았고, 자료또한희귀하여적극적인치료가쉽지않았으나본연구를바탕으로향후이에대한연구가더욱활성화되기를기대한다. V. 結論 소아에호발하는전염성연속종 (Molluscum Contagiosum) 의치료에봉약침을이용한효능을관찰하고자 2005년 8월부터 2006년 8월까지사랑이꽃피는한의원에래원한 104명의환자들을대상으로봉약침을시술하여그변화를관찰, 분석한결과다음과같은결론을얻었다. 1. 전염성연속종을호소한 104명의환자모두연령이나발병일에상관없이호전되었다. 2. 봉약침으로전염성연속종을치료한결과재발이거의관찰되지않았고, 치료기간도양방의연고치료등에비하여현저히짧은결과를나타내었다. 3. 연속종의크기나부위의다소에상관없이 1-2회의치료로대부분호전되었다. 이상의결과를바탕으로봉약침은 pox virus인 Molluscum Contagiosum 바이러스 (MCV1,2) 에대하여우수한항바이러스효능이있음을추정할수있었다. 參考文獻 1. Lowy DR. Molluscum contagiosum. In: Fitzpatric TB, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, et al., editors. Fitzpatrick's Dermatology in general medicine. 5th ed. New York: McGraw-Hill, 1999: Arnold HL, Odem RB, James WD. Andrew's diseases of the skin. 9th ed. Philadelphia: WB Saunders 2000: Schwartz JJ, Myskowski PL. Molluscum contagiosum in patients with human immunodeficiency virus infection: a review of twenty seven patients. J Am Acad Dermatol: 1992; 27: Vozmediano JM, Manrique A. Giant Molluscum contagiosum contagiosum in AIDS. Int J Dermatol. 1996; 35: 楊維傑編. 黃帝內經 樞譯解, 성보출판사, 1980.

9 봉약침을이용한전염성연속종의임상치험례보고 전국한의과대학피부외과학교재편찬위원회. 한의피부외과학, 도서출판선우, 謝觀, 동양의학대사전, 고문사, 1986, 대한약침학회. 약침요법시술지침서. 대한약침학회. 1999; 권기록, 고형균. 봉독약침요법의항염, 진통작용에미치는효능에관한실험적연구, 대한침구학회지, 1998; 15(2): 고형균. 봉독약침요법의항염, 진통작용에미치는효능에관한실험적연구, 대한한의학회지. 1992; 13(1): 권기록, 고형균. 봉약침요법의면역반응에관한임상적연구. 대한침구학회지. 2000; 17(1): 권기록, 고형균, 김용석, 박영배, 김창환, 강성길. 봉독약침자극이 3-MCA 유발상피종에대한항암및면역반응에미치는영향, 대한침구학회지 1997; 14(2): Lynch PJ, Minkin W. Molluscum contagiosum of the adult: probable veneral transmission. Arch Dermatol. 1968; 98: Taskpan O, Yenicesu M, Aksu A. A giant solitary molluscum contagiosum resembling nodular basal cell carcinoma in a renal transplant recipient. Acta Dermatol Venereol(Stockh) 1996; 76: Linberg JV, Blaylock WK. Giant molluscum contagiosum following splenectomy. Arch Opthalmol 1990; 108: 홍황표, 김정원, 허원. 아토피성피부염과전염성연속종의연관성에대한통계학적고찰, 대한피부과학회지, 1978; 16: Funt TR. Solitary molluscum contagiosum - clinical histopathological study of nine cases. Cutis 1967; 3: 윤춘식, 서대헌, 권오상, 박병순, 조광현, 오명돈등. AIDS 환자에서비전형적이고심한양상으로나타난전염성연속종 2례. 대한피부과학회지, 1999; 37:

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