간질과산화스트레스 - 발작으로인한산화스트레스 아코니타제 (Aconitase) 의비활성 (Inactivation) - 지방과산화 (Lipid peroxidation) DNA 산화 (DNA oxidation) SOD 변이생쥐 (SOD mutant mice)

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재황 해
6 years ago
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1 KISEP Review 대한간질학회지 2004;8( 8(2): ): 간질과산화스트레스 김원섭 Epilepsy and Oxidative Stress Won Seop Kim, M.D. Department of Pediatrics, Chungbuk National University College of Medicine, Cheongju, Korea Epilepsy is arising from many molecular and biochemical events. In the underlying mechanisms of epilepsy, oxidative stress plays an important role in seizure-induced brain damage and neuronal death. Also epileptic seizures are noted in mitochondrial diseases with problems in oxidative phosphorylation. So oxidative stress is an important emerging cause of seizure-induced neuronal death as well as a result of epileptic seizure event. J Korean Epilep Soc 2004;82: KEY WORDSEpilepsyOxidative stressneuronal death Mitochondri. 서 론 간질성발작의산화스트레스증거 대한간질학회지 2004;8(2):

2 간질과산화스트레스 - 발작으로인한산화스트레스 아코니타제 (Aconitase) 의비활성 (Inactivation) - 지방과산화 (Lipid peroxidation) DNA 산화 (DNA oxidation) SOD 변이생쥐 (SOD mutant mice) 대한간질학회지 2004;8(2):

3 김원섭 경련에기인한산화세포사망 (Seizure-induced oxidative cell death) - 미토콘드리아질환과간질 Sod2 Sod2 - 결론 대한간질학회지 2004;8(2):

4 간질과산화스트레스 REFERENCES 1. Beal MF. Mitochondrial dysfunction in neurodegenerative diseases. Biochem Biophys Acta 1998;1366: Halliwell B. Reactive oxygen species and the central nervous system. J Neurochem 1992;59: Turrens JF, Freeman BA, Levitt JG, Crapom JD. The effect of hyperoxia on superoxide production by lung submitochondrial particles. Arch Biochem Biophsys 1982;217: MacGregor DG, Higgins MJ, Jones PA, et al. Acsorbate attenuates the systemic kainate-induced neurotoxicity in the rat hippocampus. Brain Res 1996;727: Sun AY, Cheng Y, Bu Q, Oldfield E. The biochemical mechanisms of the excitotoxicity of kainic acid. Free radical formation. Mol Chem Neuropathol 1992;17: Bruce AJ, Baudry M. Oxygen free radicals in rat limbic structures after kainate-induced seizures. Free Radic Biol Med 1995;18: Tan D, Manchester LC, Reiter RJ, Qi W, Kim SJ, EI-Sokkary GH. Melatonin protects hippocampal neurons in vivo against kainic acidinduced damage in mice. 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J Clin Investig 1984;74: Kondo T, Sharp FR, Honkaniemi J, Mikawa S, Epstein CJ, Chan PH. DNA fragmentation and prolonged expression of C-Fos, C- Jun, and Hsp70 in kainic acid-induced neuronal cell death in transgenic mice over-expressing human CuZn-superoxide dismutase. J Cerebral Blood Flow Metabol: Official J Int Soc Cerebral Blood Flow Metabol 1997;17: Liang LP, Chang L, Crapo JM, Patel M. Modulation of excitotoxic injury in extra cellular super oxide dismutase mutant mice. Free Radic Biol Med 2001;31(suppl 1):133. Abstract. 36. Hirata H, Cadet JL. Kainate-induced hippocampal DNA damage is attenuated in superoxide dismutase transgenic mice. Brain Res Mol Brain Res 1997;48: Patel M, Liang LP. Exacerbation of kainite-induced excitotoxicity in SOD2 deficient mice. Soc Neurosci 2001; Patel M. Oxidative stress, mitochondrial dysfunction, and epilepsy. Free Radic Res 2002;36: Schauwecker PE, Steward O. 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5 김원섭 Cell 1990;61: Cock H, Schapira AHV. Mitochondrial DNA mutations and mitochondrial dysfunction in epilepsy. Epilepsia 1999;40: Naviaux RK, Nyhan WL, Barshop BA, et al. Mitochondrial DNA polymerase gamma deficiency and Mtdna depletion in a child with Alpers syndrome. Ann Neurol 1999;45: Balentine JD. Experimental pathology of oxygen toxicity. In: Jobsis FF. Oxygen and Physiological Function. Dallas: Professional Information Library, 1977; Willmore LJ, Sypert GW, Munson JB, Hurd RW. Chronic focal epileptiform discharges induced by injection of iron into rat and cat cortex. Science 1978;200: Zuchora B, Turski WA, Wielosz M, Urbanska EM. Protective effect of adenosine receptor agonists in a new model of epilepsy-seizures evoked by mitochondrial toxin, 3-nitropropionic acid, in mice. Neurosci Lett 2001;305: Jensen FE, Holmes GL, Lombroso CT, Blume HK, Firkusny IR. Age-dependent changes in long-term seizure susceptibility and behavior after hypoxia in rats. Epilepsia 1992;33: Patel MN, Day BJ, Wallace DC, Liang LP. SOD2-deficient mice exhibit spontaneous age-related seizures and increased susceptibility to kainate-induced oxidative damage and apoptosis. Epilepsia 2001;42: Sorensen L, Ekstrand M, Silva JP, et al. Late-onset corticohippocampal neurodepletion attributable to catastrophic failure of oxidative phosphorylation in milon mice. J Neurosci: Official J Soc Neurosci 2001;21: 대한간질학회지 2004;8(2):

신하영 이두재 조경주등 Kainate 유발간질모델 - - 크레질바이올렛 (cresyl violet) 염색 Kainate 유발간질모델에서의뇌파검사 대상과방법 산소음이온라디칼 (superoxide anion radical, O.- 2 ) 검출 in situ- - 대한간질학

신하영 이두재 조경주등 Kainate 유발간질모델 - - 크레질바이올렛 (cresyl violet) 염색 Kainate 유발간질모델에서의뇌파검사 대상과방법 산소음이온라디칼 (superoxide anion radical, O.- 2 ) 검출 in situ- - 대한간질학 KISEP Original Article 대한간질학회지 2004;8(2):108 8(2):108-115 115 Kainate 유발간질모델에서 Apurinic/Apyrimidinic Endonuclease 의빠른소실과이에따른세포고사 신하영 이두재 조경주 김미애 이용현 허경 김경환 이병인 Rapid Loss of Apurinic/Apyrimidinic Endonuclease