25(1)-13(이규식).fm

Size: px
Start display at page:

Download "25(1)-13(이규식).fm"

Transcription

1 Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 25, No. 1, 76-82, $.4.4wxEVUBTUFSJEF ûxáû Á ÁÁ Áy Á½kÁ» Á k ÁxÁŸyÁ³, ttsƒ twsƒ, 1 sƒ Analysis of dutasteride in human serum by LC-MS/MS Hye-Seon Nam, Kyong-Hee Nam, Su Hee Jung, Jang Woo Lee, Jin Yeong Kang, Soon Keun Hong,G Tae Sung Kim, Ki Kyung Jung, Tae Seok Kang 1, Hae-Jung Yoon, Kwang Ho Lee and Gyu-Seek Rhee Food Safety Evaluation Department, 1 Toxicology Evaluation and Research Department, National Institute of Food and Drug Safety Evaluation, Korea Food and Drug Administration Osong Health Technology Administration Complex, 187 Osongsaengmyeong 2(i)-ro, Gangoe-myeon, Cheongwon-gun, Chungcheongbuk-do , Korea (Received October 14, 2011; Revised November 15, 2011; Accepted December 16, 2011) : x kl y w LC-ESI-MS/MS w wš, k wš ww. üt jk ƒw x methyl tert-butyl ether (MTBE) w (liquid-liquid extraction, LLE) w. LC-MS/MS MRM (multiple reaction monitoring) yw kl jk mass transition ƒƒ m/z , m/z , ƒƒ 6.45, ~30.0 ng/ml R 2 = ù kü, w z ƒƒ 0.5 ng/ml 66~72%. ü w 3.5~5.5%, y 85.7~89.9%, 3 ww 4.2~5.8%, y 90.8~95.8%. Abstract: The determination and confirmation of dutasteride in human serum was performed by a liquid chromatography-electrospray ionization tandem mass spectrometry (LC-ESI/MS/MS). Beclomethasone as an internal standard (I.S.) was added to the serum and the mixed sample was pretreated by liquid-liquid extraction (LLE) with methyl tert-butyl ether (MTBE). The mass transitions of dutasteride and I.S. monitored in multiple reaction monitoring (MRM) were m/z and m/z , respectively, and the retention times were 6.45 and 5.46 min, respectively. The calibration curve was linear in the concentration range of 0.5~30.0 ng/ml (R 2 = ) and the limit of quantitation (LOQ) was found to be 0.5 ng/ml. The recovery of dutasteride was shown to be 66~72%. The intra-day assay precision and accuracy were in the range 3.5~5.5% and 85.7~89.9%, respectively, and the interday assay precision and accuracy were in the range 4.2~5.8% and 90.8~95.8%, respectively. Key words: Dutasteride, LC-MS/MS, human serum Corresponding author Phone : +82-(0) Fax : +82-(0) gsrhee@kfda.go.kr 76

2 LC-MS/MS w x dutasteride 77 kl(dutasteride, Fig. 1a) 4-l (azasteroid) wyw 5-α-reductase z y g ûy lml(testosterone) wlml(dihydrotestosterone, DHT) w.kl p (Avodart) 2001 t (FDA) (benign prostatic hyperplasia, BPH) e, z w û w y w(lower urinary tract symptom, LUTS) ûx k(male pattern baldness, MPB) ew zƒ šš. 1-9 w» ùkü FDA e(proscar, 1992) ûx k e (Propecia, 1997) vùl (finasteride)ƒ 5-α-reductase z Type 2 isoenzyme k j w, kl Type 1 Type 2 isoenzyme j. w vùl kl z w vùl klƒ 5-α-reductase z z w šwš, p k lƒ vùl Type 2 isoenzyme y 3 jš Type 1 isoenzyme , kš šwš. ù kl x¾ y. w ûy DHT y w w» kl û k»»x ƒ w, ù ƒ kl kl e ƒ w. w û 5-α-reductase Type 2 w ù kú, û»»,, x ùkú , kl x mw ù ƒ w» k l n š 6 w û xx w x wš kl š k»x ƒ ƒw w x w xx š, x kl w. ù kl 17 Ramakrishna et al. (2004) w x(plasma) LC-MS/MS w z k (Tamsulosin) y t(alfuzosin) x kl w, ü y LC-ESI/MS/MS w x kl dw wš, k w š ww. kl(99%, Fig. 1a) t jk(99%, Fig. 1b) üt ƒƒ AKSci(CA, USA) Sigma-Aldrich(St. Louis, MO, USA)t wš, tx(human serum) PAA Laboratories(Cölbe, Germany)t w. LC-MS/MS w HPLC š wš, mp Merck(Darmstadt, Germany), k (formic acid) ƒƒ J.T. Baker(Phillipsburg, NJ, USA)t w. methyl tert-butyl ether (MTBE) ke(k 2 CO 3 ) ƒƒ Sigma-Aldrich(St. Louis, MO, USA), Wako (Junyaku, Japan)t w. x Fig. 1. Chemical structures of (a) dutasteride and (b) beclomethasone (I.S). Vol. 25, No. 1, 2012

3 78 ûxáû Á ÁÁ Áy Á½kÁ» Á káxáÿyá³»» e w LC-MS/MS Agilent 1200 Series HPLC (Agilent Technologies, Palo Alto, CA, USA) triple quadruple l»(api 4000, Applied Biosystems, USA) w. HPLC e Imtakt Corporation(Kyoto, Japan) Unison UK-C18 column (2 mm i.d 75 mm length, 3 µm particle size) w.» Beckman Coulter(Fullerton, CA, USA) Allegra 6R w š, vortex-mixer Scientific Industries(Bohemia, NY, USA) Vortex-Genie 2 w. Shaker IKA Labortechnik(Staufen, Germany) HS 250 basic wš,» Zymark(CA, USA) Turbovap LV evaporator w. Fig. 2. Schematic diagram of the sample preparation. x t kl tt k 1000 µg/ mlƒ t(stock solution) wš t 200, 100, 50, 20, 10, 2, 1 ng/ml ƒ k w t w. ütt jk k 1000 µg/mlƒ t w z k w 100, 50 ng/ml t w. -70 C þ w w o w z w. x 200 µl üt (jk) 20 µl ƒw z(vortexing, 30 sec), mp 400 µl e g.» ke ƒw z MTBE 5 ml š 20 wš, 3000 rpm 10 w w z N 2 evaporator (30 C) o w šw. š LC-MS/MS Table 1. Experimented conditions of LC-MS/MS LC conditions HPLC Agilent 1200 series Column Unison UK-C18 (2 75 mm, 3 µm) Column oven 35 o C Flow Rate 250 µl/min Injection 5 µl Mobile phase A: 0.1% formic acid in water, B: acetonitrile Gradient: B 10% (0 min) B 10% (1 min) B 97% (4 min) B 97% (6 min) B 10% (6.1 min) B 10% (11 min) MS/MS conditions MS/MS API 4000 Curtain gas (psi) 10 Ion source ESI Collision gas (psi) 5 Detection mode Positive Ion spray voltage (V) 4500 Source temperature ( o C) 300 Declustering potential (DP) (V) 90 Dwell time (ms) 150 Entrance potential (EP) (V) 10 Ion source gas(gas1) (psi) 25 Collision energy (CE) (V) 46 Ion source gas(gas2) (psi) 50 Collision cell exit potential (CXP) (V) 13 Analytical Science & Technology

4 100 µl z(vortexing, 30 sec), micro-filtering (0.45 µl, PTEE)w LC-MS/MS 5 µl w w(fig. 2).»» e Table 1»» LC-MS/MS w w. e Unison UK-C18 column (2 mm i.d 75 mm length, 3 µm particle size) wš, 0.1% sw mp»» (gradient elution) w 250 µl/min w. e 35 C w o w. w MS/MS»y (electrospray ionization, ESI) kwš (+) MRM (multiple reaction monitoring) w.» ƒ w 300 o C, ion spray voltage 4500 V.»k MS/MS ql declustering potential 90 V, entrance potential 10 V, collision energy 46 V, collision cell exit potential 13 V w w. LC-MS/MS w x dutasteride 79 Bioanalytical Method Validation ww yw w (LOQ) y (signal) (noise) 10» w. kl t (0.5, 1.0, 2.0, 5.0, 10.0, 20.0, 30.0 ng/ml) w w w 5z ww z w. kl QC»,, š ƒƒ 1.5, 12.0, 24.0 ng/ml w w w x 5 ww ü (precision), y(accuracy) wš, w 3 x ww, y w k w. š -$.4.4 rp x kl w LC-MS/ MS wš, Table 1 ùkü. kl üt jk Fig. 3. Electrospray product ion mass spectra of (a) dutasteride and (b) beclomethasone (I.S). y w (+) Q1 scan wš, m/z [M+H] + ww vj yw z, y(quantitative optimization) ww (precursor ion) (product ion) yw., kl m/z 529.6m/z 461.5, üt jk m/z 409.3m/z d(fig. 3). k Blank w ƒw x w z LC-ESI/MS/MS w jm Fig. 4 ùkü. Fig. 4(a) üt blank üt jk 5.46 klƒ š, 0.5 ng/ml dutasteride klƒ 6.45 yw v j ùkü(fig. 4(b)). Vol. 25, No. 1, 2012

5 남혜선 남경희 정수희 이장우 강진영 홍순근 김태성 정기경 강태석 윤혜정 이광호 이규식 80 Fig. 4. Chromatogram of (a) blank (drug free spiked with internal standard) human serum and (b) 0.5 ng/ml spiked dutasteride with the internal standard 직선성 검량선 작성을 위해 혈청 중 농도가 0.5~30.0 ng/ ml의 범위가 되도록 표준물질을 가한 후 전처리 과 정을 거쳐 검량선을 작성하였으며, 표준용액의 농도범 위에서 상관계수 (R ) 의 우수한 직선성을 확인 하였다(Fig. 5) 정확도, 정밀도. 5. Linearity of the standard calibration curve of dutasteride. Fig 0.5~30.0 ng/ml의 농도범위에서 실시한 검량선 시 료의 일내 정밀도는 변동계수(coefficient of variation, CV)가 2.4~8.4%로 생체시료분석법 밸리데이션 가이 던스인 15%를 만족하였으며, 정확도는 92.5~103.8% 로 생체시료분석법 가이던스인 80~120%를 만족하였 Analytical Science & Technology

6 LC-MS/MS w x dutasteride 81 Table 2. Precision and accuracy data of backed-calculated concentration of calibration samples for dutasteride in human serum Spiked Conc. (ng/ml) MeanÛSD n=5 *Precision **Accuracy Û Û Û Û Û Û Û * C.V.=STDEV of measured concentration/means of measured concentration ** Accuray = Measured concentration/spiked concentration Table 3. Precision and accuracy for the determination of dutasteride in human serum Spiked Conc. (ng/ml) Inter-day (n=5) Precision Accuracy Intra-day (n=3) Precision Accuracy (Table 2).» ƒ ( 1.5 ng/ml, 12.0 ng/ml, š 24.0 ng/ml) w w x 5 ww w ü y 85.7~89.9%, w 3 ww y 90.8~95.8% ƒ w(table 3). w ƒ ( 1.5 ng/ml, 12.0 ng/ml, š 24.0 ng/ ml) w ü, ƒ ƒ ƒ 3.5~5.5%, 4.2~5.8% ƒ 15% w(table 3). kl w x w» w y ƒ š yw. z w z w» w w z e» z kl üt vj w w ng/ml d w z 65.6% 72.4% ƒƒ ùkü Table 4. Recovery of dutasteride from human serum Spiked Conc. (ng/ml) Recovery (Table 4). Ramakrishna et al.(2004) 17 (40.7%) w z ùkü. x kl w LC-MS/MS w yw, w w. kl w z ƒƒ 0.5 ng/ml, 66~72% š, 0.5~30.0 ng/ml w (R 2 = ) ùkü. LC-MS/MS x ü kl y w k, y ƒš, x w xx kl w». šx 1. C. G. Roehrborn, P. Boyle, J. C. Nickel, K. Hoefner and G. Andriole, Urol., 60, (2002). 2. H. C. Evans and K. L. Goa, Drugs Aging., 20(12), (2003). 3. K. K. Gaines, Urol. Nurs., 23(3), (2003). 4. G. L. Andriole and R. Kirby, Eur. Urol., 44, (2003). 5. F. Debruyne, J. Barkin, P. van Erps, M. Reis, T. L. J. Tammela and C. Roehrborn, Eur. Urol., 46(4), (2004). 6. R. V. Clark, D. J. Hermann, G. R. Cunningham, T. H. Wilson, B. B. Morrill and S. Hobbs, J. Clin. Endocrinol Metab., 89(5), (2004). 7. E. A. Olsen, M. Hordinskym, D. Whiting, D. Stough, S. Hobbs, M. L. Ellis, T. Wilson and R. S. Rittmaster, J. AM ACAD DERMATOL., 55(6), (2006). 8. M. Marberger, C. G. Roehrborn, L. S. Marks, T. Wilson and R. S. Rittmaster, J. Clin. Endocrinol. Metab., Vol. 25, No. 1, 2012

7 82 ûxáû Á ÁÁ Áy Á½kÁ» Á káxáÿyá³ 91(4), (2006). 9. C. G. Roehrborn, P. Siami, J. Barkin, R. Damião, K. Major-Walker, B. Morrill and F. Montorsi, CombAT Study Group, J. Urol., 179(2), (2008). 10. J. C. Nickel, Urol., 6(9), S31-39 (2004). 11. N. Makridakis and J. K. V. Reichardt, J. Mol. Endocrinol., 34, (2005). 12. J. K. Amory, C. Wang, R. S. Swerdloff, B. D. Anawalt, A. M. Matsumoto, W. J. Bremner, S. E. Walker, L. J. Haberer and R. V. Clark, J. Clin. Endocrinol. Metab., 92(5), (2007). 13. C. L. Foley, S. R. Bott, I. S. Shergill and R. S. Kirby, Drugs. Today., 40(3), 213 (2004). 14. A. M. Traish, J. Hassani, A. T. Guay, M. Zitzmann and M. L. Hansen, J. Sexual. Medicine., 8(3), (2011). 15. Blood Guidances, Food and Drug Administration, USA, Blood Regulation Law, Ministry of Health and Welfare, Korea, N. V. S. Ramakrishna, K. N. Vishwottam, S. Puran, M. Koteshwara, S. Manoj and M. Santosh, J. Chromatogr B., 809(1), (2004). 18. S. Agarwal, K. V. Gowda, A. K. Sarkar, D. Ghosh, U. Bhaumik, T. K. Chattarai and T. K. Pal, Chromatographia., 67, (2008). 19. N. A. Gomes, A. Pudage, S. S. Joshi, V. V. Vaidya, S. A. Parekh and A. V. Tamhankar, Chromatographia., 69, 9-18 (2009). 20. Bioanalytical Method Validation, National Institute of Food and Drug Safety Evaluation, Korea, Guidance for Industry, Bioanalytical Method Validation, Food and Drug Administration, USA, Analytical Science & Technology

한약재품질표준화연구사업단 강활 ( 羌活 ) Osterici seu Notopterygii Radix et Rhizoma 생약연구과

한약재품질표준화연구사업단 강활 ( 羌活 ) Osterici seu Notopterygii Radix et Rhizoma 생약연구과 한약재품질표준화연구사업단 강활 ( 羌活 ) Osterici seu Notopterygii Radix et Rhizoma 생약연구과 - 2 - - 3 - KP 11 Osterici seu Notopterygii Radix et Rhizoma Ostericum koreanum Maximowicz, Notopterygium incisum Ting, Notopterygium

More information

한약재품질표준화연구사업단 단삼 ( 丹參 ) Salviae Miltiorrhizae Radix 생약연구과

한약재품질표준화연구사업단 단삼 ( 丹參 ) Salviae Miltiorrhizae Radix 생약연구과 한약재품질표준화연구사업단 단삼 ( 丹參 ) Salviae Miltiorrhizae Radix 생약연구과 - 1 - KP 11 CP 2015 Salvia miltiorrhizae Radix Salviae Miltiorrhizae Radix et Rhizoma Salvia miltiorrhiza Bunge Salvia miltiorrhiza Bunge salvianolic

More information

한약재품질표준화연구사업단 작약 ( 芍藥 ) Paeoniae Radix 생약연구과

한약재품질표준화연구사업단 작약 ( 芍藥 ) Paeoniae Radix 생약연구과 한약재품질표준화연구사업단 작약 ( 芍藥 ) Paeoniae Radix 생약연구과 - 2 - KP 11 CP 2015 JP 16 Paeoniae Radix Paeoniae Radix Alba Paeoniae Radix Rubra Paeoniae Radix Paeonia lactiflora Pallas paeoniflorin, albiflorin 2.3% Paeonia

More information

DBPIA-NURIMEDIA

DBPIA-NURIMEDIA Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 18, No. 5, 425-430, 2005» 677*4 Ÿ w sƒ ½»x Á Á½ k w y w, w y œw Some considerations for the analytical approaches to measure atmospheric

More information

한약재품질표준화연구사업단 금은화 ( 金銀花 ) Lonicerae Flos 생약연구과

한약재품질표준화연구사업단 금은화 ( 金銀花 ) Lonicerae Flos 생약연구과 한약재품질표준화연구사업단 금은화 ( 金銀花 ) Lonicerae Flos 생약연구과 - 2 - KP 11 Lonicerae Flos Lonicera japonica Thunberg - CP 2015 JP 16 Lonicerae Japonicae Flos Lonicerae Folium Cum Caulis Lonicera japonica Thunberg - Lonicera

More information

14.531~539(08-037).fm

14.531~539(08-037).fm G Journal of the Korea Concrete Institute Vol. 20, No. 4, pp. 531~539, August, 2008 š x y w m š gj p { sƒ z 1) * 1) w w Evaluation of Flexural Strength for Normal and High Strength Concrete with Hooked

More information

한약재품질표준화연구사업단 고삼 ( 苦參 ) Sophorae Radix 생약연구과

한약재품질표준화연구사업단 고삼 ( 苦參 ) Sophorae Radix 생약연구과 한약재품질표준화연구사업단 고삼 ( 苦參 ) Sophorae Radix 생약연구과 - 1 - KP 11 Sophorae Radix Sophora flavescens Solander ex Aiton oxymatrine, matrine 1.0% CP 2015 Sophorae Flavescentis Radix Sophora flavescens Aiton - JP 16

More information

< DC1A4C3A5B5BFC7E22E666D>

< DC1A4C3A5B5BFC7E22E666D> ¼ (Jeong, Jung Chae)*, ý (Kim, Yoon Soo), (Shin, Woo Young), Þ Ñ (Park, Jong Man) ò ý ƒ Ð (Korea Evaluation Institute of Industrial Technology) (Shin, Jae-Heyg) Š æ (Ministry of Knowledge Economy) 1. :

More information

19(1) 02.fm

19(1) 02.fm Korean J. Crystallography Vol. 19, No. 1, pp.7~13, 2008 Ÿ (ICISS) w š t w (2): t w y w œw Surface Structure Analysis of Solids by Impact Collision Ion Scattering Spectroscopy (2): Atomic Structure of Semiconductor

More information

10(3)-09.fm

10(3)-09.fm w y wz 10«3y 253~258 (2010.12.) Journal of Korean Society of Urban Environment ³ w Á» Á Á y w y œw (2010 11 22, 2010 12 9 k) Study on Determine of Detention Pond in Small Developed Area In-Soo Chang ½

More information

26(1)-11(김기준).fm

26(1)-11(김기준).fm Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 26, No. 1, 80-85, 2013 http://dx.doi.org/10.5806/ast.2013.26.1.080 Study on the analytical method using GC-MS for the accident preparedness

More information

untitled

untitled [ ] œwz, 21«6y(2008) J. of the Korean Society for Heat Treatment, Vol. 21, No. 6, (2008) pp. 300~306 š y w p x*, **Á **Áy y* * ** w œ w œw, w» gœ Solid State Diffusion Brazing of the Aluminum Alloy Castings

More information

14.fm

14.fm Journal of the Korean Ceramic Society Vol. 44, No. 2, pp. 93~97, 2007. Preparation of High Purity Si Powder by SHS Chang Yun Shin, Hyun Hong Min, Ki Seok Yun, and Chang Whan Won Engineering Research Center

More information

(Microsoft PowerPoint - src.ppt [\300\320\261\342 \300\374\277\353] [\310\243\310\257 \270\360\265\345])

(Microsoft PowerPoint - src.ppt [\300\320\261\342 \300\374\277\353] [\310\243\310\257 \270\360\265\345]) LC/MS, LC/MS/MS 기초개론 LC LC/MS(Liquid Chromatography/Mass Spectrometry) 액상의분석물질을기화및이온화하여고진공관에서원하는질량 (m/z) 이나질량범위만검출하여정량 정성분석하는시스템 High vacuum PC/Software Ion source Mass Analyzer Detector ESI APCI APPI

More information

50(1)-09.fm

50(1)-09.fm 2006, Vol. 50, No. 1 Printed in the Republic of Korea 언빨래가마르는현상에대한중등학교화학전공교사들의인식조사 ½x Á» Á½ # Á x* w w yw y š w w # w w (2005. 5. 11 ) A Research of Secondary School Chemistry Major Teachers Perceptions

More information

51(2)-06.fm

51(2)-06.fm Journal of the Korean Chemical Society 2007, Vol. 51, No. 2 Printed in the Republic of Korea f p ƒ š w er elk yw ½ Á y*» l, w w ywœw (2006. 12. 5 ) Separation of Caffeine and Catechin Compounds from Green

More information

82-01.fm

82-01.fm w y wz 8«( 2y) 57~61, 2005 J. of the Korean Society for Environmental Analysis p w w Á Á w w» y l Analysis of Influence Factors and Corrosion Characteristics of Water-pipe in Potable Water System Jae Seong

More information

DBPIA-NURIMEDIA

DBPIA-NURIMEDIA Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 20, No. 2, 138-146, 2007 -$.4.4 w x q p š ³ Á Áw Á Á Á 1 g ( ), 2 ( ) w wq, 3 w w w Sensitive determination of paroxetine in canine plasma

More information

84-01.fm

84-01.fm w y wz 8«( 4y) 00~00, 2005 J. of the Korean Society for Environmental Analysis HPLC f y e t p»wá½»x w y w»y Detection Characteristics of a HPLC Method on Carbonyl-DNPH Derivatives in Relation with Column

More information

환경중잔류의약물질대사체분석방법확립에 관한연구 (Ⅱ) - 테트라사이클린계항생제 - 환경건강연구부화학물질연구과,,,,,, Ⅱ 2010

환경중잔류의약물질대사체분석방법확립에 관한연구 (Ⅱ) - 테트라사이클린계항생제 - 환경건강연구부화학물질연구과,,,,,, Ⅱ 2010 11-1480523-000702-01 환경중잔류의약물질대사체분석방법확립에 관한연구 (Ⅱ) - 테트라사이클린계항생제 - 환경건강연구부화학물질연구과,,,,,, Ⅱ 2010 목차 ⅰ ⅱ ⅲ Abstract ⅳ Ⅰ Ⅱ i 목차 Ⅲ Ⅳ i 목차 ii 목차 iii Abstract α β α β iv Ⅰ. 서론 Ⅰ 1 Ⅱ. 연구내용및방법 Ⅱ. 2 Ⅱ. 연구내용및방법

More information

10(3)-10.fm

10(3)-10.fm w y wz 10«3y 259~264 (2010.12.) Journal of Korean Society of Urban Environment w gj p p y Á Á½k * w m œw Á* w y œw (2010 9 28, 2010 10 12 k) Characteristics of Antiwashout Underwater Concrete for Reduction

More information

304.fm

304.fm Journal of the Korean Housing Association Vol. 20, No. 3, 2009 yw s w - û - A Study on the Planning of Improved-Hanok - Focused on Jeon-Nam Province - y* ** z*** **** Kang, Man-Ho Lee, Woo-Won Jeong, Hun

More information

12.077~081(A12_이종국).fm

12.077~081(A12_이종국).fm J. of Advanced Engineering and Technology Vol. 1, No. 1 (2008) pp. 77-81 y w» e wx Á w œw Fabrication of Ceramic Batch Composition for Porcelain by Using Recycled Waste Ceramic Powder Hyun Guen Han, and

More information

82.fm

82.fm Journal of the Korean Ceramic Society Vol. 44, No. 9, pp. 524~528, 2007. Determination of Critical Chloride Content of Ordinary Portland Cement Concrete by Linear Polarization Technique Hong-Sam Kim, Hai-Moon

More information

10(3)-12.fm

10(3)-12.fm w y wz 10«3y 273~280 (2010.12.) Journal of Korean Society of Urban Environment p yá xá½k w y œw (2010 9 15, 2010 12 2 k) Analysis of Characteristics of Delivered Nonpoint Source Pollution at Forested Watershed

More information

untitled

untitled ª Œª Œ 27ƒ 2B Á 2007 3œ pp. 193 ~ 199 ª ƒ w d w ƒ sƒ Methodology of Drought Assessment Using National Groundwater Monitoring Network Data «x Á½ Kwon, Hyung JoongÁKim, Seong Joon Abstract The objective

More information

83-07.fm

83-07.fm w y wz 8«( 3y) 137~142, 2005 J. of the Korean Society for Environmental Analysis sw n w Polychlorinated Biphenyls»y Áwx Á yá w w yw Analysis of Polychlorinated Biphenyls from Pohang and Gangseo, Busan

More information

08.fm

08.fm w y wz 9«( 4y) 261~267, 2006 J. of the Korean Society for Environmental Analysis SDB-RPS j š w 3-Chloro-4- (dichloromethyl)-5-hydroxy-2(5h)-furanone y Á Á l w œ Development of Disk-type Extraction of 3-Chloro-4-(dichloromethyl)-

More information

15.101~109(174-하천방재).fm

15.101~109(174-하천방재).fm w wz 8«4y 2008 8 pp. 101 ~ 109 w» m -,, - A Study on Warnning Criteria Investigation of Automated Rainfall Warning System -Focused on Realationship of Water Level, Discharge and Precipitation - Á Á Á Ahn,

More information

fm

fm [ ] w wz DOI: 10.3740/MRSK.2009.19.12.692 Kor. J. Mater. Res. Vol. 19, No. 12 (2009) y INCONEL 718w Gas Tungsten Arc Welding» p sƒ ½»y Á *Á *Á y** ( ) d lj p wœq, *w wœ» q **( ) d lj p t Mechanical Properties

More information

9(3)-4(p ).fm

9(3)-4(p ).fm w wz J. Kor. Soc. Cloth. Ind. 9«3y, 2007 Vol. 9, No. 3, pp.319-326(2007) w xk x p w q w Analysis of Foot Characteristics According to the Classification of Foot Types of Junior High School Girls Ji-Young

More information

10(3)-02.fm

10(3)-02.fm w y wz 10«3y 203~211 (2010.12.) Journal of Korean Society of Urban Environment w ù p yá k«áyw *Á xá½k w y œw Á* y w (2010 9 15, 2010 12 2 k) Characterization of Nonpoint Source Pollutant Loads from the

More information

19(1)-3(09-02)p fm

19(1)-3(09-02)p fm w wz 19«1y Kor. J. Clin. Pharm., Vol. 19, No. 1. 2009 w p 35 mg w m w Á½ Á Á Á y Á w œw w w (2009 2 12 Á2009 4 15 Á2009 5 11 ) Pharmacokinetic Comparison of Actonel and Risenel Tablet Containing Risedronate

More information

16(2)-7(p ).fm

16(2)-7(p ).fm w wz 16«2y Kor. J. Clin. Pharm., Vol. 16, No. 2. 2006 ü t xy y w tœ ½ BÁ x BC B y w w w C y w w w Current Status and Expectations of Orphan Drugs in Korea -In point of supplying medicines for the rare

More information

605.fm

605.fm Journal of the Korean Housing Association Vol. 19, No. 6, 2008 y k y p w sƒ Care-giver s Needs and Evaluation on the Actual Condition of the Playgrounds in Child Care Facilities y* Choi, Mock-Wha x **

More information

69-1(p.1-27).fm

69-1(p.1-27).fm 99 A 380 B 787 : wœ z w * w w wœ» A380 B787 wœ» w. wœ» ww r. w wœ» p j y w r» w. I. II. z III. A380 B787 IV. A380 V. wœ» : x VI. z VII. I. A380 B787»ƒ z wœ w, w w p j w w ƒ r. t wœ w ƒ w w wœ» š œm wš,

More information

- 2 -

- 2 - 한약재품질표준화연구사업단 인동 ( 忍冬 ) Lonicerae Folium et Caulis 생약연구과 - 2 - KP 11 Lonicera japonica Thunberg 0.1% CP 2015 JP 16 Lonicera japonica Thunberg chlorogenic acid 0.10% Lonicera japonica Thunberg - β α - 3

More information

12(2)-04.fm

12(2)-04.fm J. Korean. Soc. Living. Environ. Sys. Vol. 12, No. 2, pp 106~111(2005) w y y w z œ k üœ» p ½ Á Á Á ³ Á Á½Ÿ w w w, *g», ** w w Effects of Strategies to Improve Indoor Air Quality at Pre-occupancy Stage

More information

07.051~058(345).fm

07.051~058(345).fm w wz 8«3y 2008 6 pp. 51 ~ 58 m qp yp š w k sƒ Evaluation of Dynamic Modulus based on Aged Asphalt Binder y*á **Á***Á**** Lee, Kwan-HoÁCho, Kyung-RaeÁLee, Byung-SikÁSong, Yong-Seon Abstract Development

More information

개최요강

개최요강 55 2009. 5. ( ) ( ) < > 1. 1 2. 2. 2. 3 1) 3 2) 3 3) GC-MS 4. 5 1) 5 2) 5 3) ICP-OES 6 3. 7. 7 1) 7 2) 10. 13 1) 1g 13 2),,, 14 3), 15 4),, 15 4. 17 19 < > [ 1] 2 [ 2] ICP-OES 6 [ 3] 13 [ 4] 1g 13 [ 5]

More information

패션 전문가 293명 대상 앙케트+전문기자단 선정 2010.1 Fashionbiz CEO Managing Director Creative Director Independent Designer

패션 전문가 293명 대상 앙케트+전문기자단 선정 2010.1 Fashionbiz CEO Managing Director Creative Director Independent Designer READY-TO-WEAR Fashionbiz 2010.1 패션 전문가 293명 대상 앙케트+전문기자단 선정 2010.1 Fashionbiz CEO Managing Director Creative Director Independent Designer READY-TO-WEAR Fashionbiz 2010.1 1 2 3 4 5 6 7 8 9 9 2010.1 Fashionbiz

More information

10(1)-08.fm

10(1)-08.fm w y wz 10«( 1y) 47~52, 2007 J. of the Korean Society for Environmental Analysis œ w t y ½ xá Á x Á½ Á x* Ÿ œ, * w œw Optimization of Coagulation In The Conventional Water Treatment Plant Jun-Hyun Kim,

More information

12(3) 10.fm

12(3) 10.fm KIGAS Vol. 12, No. 3, September, 2008 (Journal of the Korean Institute of Gas) ü LP ƒ š Database w š Á Á½z w ywœw (2008 6 10, 2008 8 12 (1 ), 2008 9 5 (2 ), 2008 9 5 k) Constructing a Database Structure

More information

한약재품질표준화연구사업단 맥문동 ( 麥門冬 ) Liriopis Tuber 생약연구과

한약재품질표준화연구사업단 맥문동 ( 麥門冬 ) Liriopis Tuber 생약연구과 한약재품질표준화연구사업단 맥문동 ( 麥門冬 ) Liriopis Tuber 생약연구과 Fig.1 ( ) ( ) Table 1. The origin of the Liriopis Tuber in KP, ChP and JP β α β α βα αβ α aster saponin Hb methyl ester H H H H H H H liriope glycoside Lm-3

More information

11(5)-12(09-10)p fm

11(5)-12(09-10)p fm w wz J. Kor. Soc. Cloth. Ind. 11«5y, 2009 Vol. 11, No. 5, pp.799-807(2009) w w * k ƒm w pg p w, ƒm w q w A Qualitative Research on Pursuing Image and Appearance Management Behavior of Brides Eun-Joo Bae

More information

16(5)-04(61).fm

16(5)-04(61).fm Journal of Korean Powder Metallurgy Institute DOI: 10.4150/KPMI.2009.16.5.326 ƒ w Fe œ w Cu wy SPS (II) II. w SPS p ½ *Á½ Á½{ a Á½ š b w œw, a w» gœ, b y œ Production of Fe Amorphous Powders by Gas-Atomization

More information

21(4)-02.fm

21(4)-02.fm J. Fd Hyg. Safety 21(4), 204 212 (2006) ŸŸ w» ƒ, ƒ, w ½ Á Á½ ¼Á½ Á Á½ Ášy Á» y Quantitative Analysis of Acid Value, Iodine Value and Fatty Acids Content in Sesame Oils by NIRS Jae-Kwan Kim, Myung-Jin Lee,

More information

16(5)-03(56).fm

16(5)-03(56).fm Journal of Korean Powder Metallurgy Institute DOI: 10.4150/KPMI.2009.16.5.316 ƒ w Fe œ w Cu wy SPS (I) I. ƒ wy y Á xá½ Á½ *Á½{ a w œw, a w» gœ Production of Fe Amorphous Powders by Gas-atomization Process

More information

82-02.fm

82-02.fm w y wz 8«( 2y) 00~00, 2005 J. of the Korean Society for Environmental Analysis Calix[6]arene w k š w *Á x Á Á«ƒm w yw, *w w yw Cesium Ion Selective Solid Contact Electrodes Based on Calix[6]arene Won-sik

More information

50(4)-10.fm

50(4)-10.fm 2006, Vol. 50, No. 4 Printed in the Republic of Korea 칼코겐이도핑된망간산화물의저온합성연구 k Á z Á, *Áy, * y w ù w yw x ù l w» ww (2006. 7. 13 ) Chimie Douce Synthesis of Chalcogen-Doped Manganese Oxides Seung Tae Lim,GDae

More information

16(1)-3(국문)(p.40-45).fm

16(1)-3(국문)(p.40-45).fm w wz 16«1y Kor. J. Clin. Pharm., Vol. 16, No. 1. 2006 x w$btf3fqpsu'psn û w m w Department of Statistics, Chonnam National University Eunsik Park College of Natural Sciences, Chonnam National University

More information

49(6)-06.fm

49(6)-06.fm Journal of the Korean Chemical Society 2005, Vol. 49, No. 6 Printed in the Republic of Korea 중학교과학교과서불꽃반응실험에서선스펙트럼관찰의문제점분석및개선연구 ½ Á Á * w w yw (2005. 10. 4 ) An Analysis and Improvement of the Line Spectrum

More information

16(2)-3(p ).fm

16(2)-3(p ).fm w wz 16«2y Kor. J. Clin. Pharm., Vol. 16, No. 2. 2006 k v p w w sƒ B Á z C Á½ k B Á B Á B Á x B Á x D Á x C Á ³ C Á E B w w w C w w D ƒm w w w E œw Bioequivalence Study on Two Talniflumate Preparations

More information

03-서연옥.hwp

03-서연옥.hwp 농업생명과학연구 49(4) pp.31-37 Journal of Agriculture & Life Science 49(4) pp.31-37 Print ISSN 1598-5504 Online ISSN 2383-8272 http://dx.doi.org/10.14397/jals.2015.49.4.31 국가산림자원조사 자료를 적용한 충남지역 사유림경영율 추정 서연옥

More information

26(1)-03(명승운).fm

26(1)-03(명승운).fm Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 26, No. 1, 19-26, 2013 http://dx.doi.org/10.5806/ast.2013.26.1.019 Analysis of gibberellic acid from fruits using HPLC/UV-vis Kyung Na

More information

14(2) 02.fm

14(2) 02.fm J. Korean. Soc. Living. Environ. Sys. Vol. 14, No. 2, pp 117~125(2007) w y y w z sm Ÿ š w œ l ³Á½ * w, **w w w Impact of Photosensor Sensitivity on the Control Performance of a Daylight Dimming System

More information

16(5)-06(58).fm

16(5)-06(58).fm Journal of Korean Powder Metallurgy Institute DOI: 10.4150/KPMI.2009.16.5.336 y-y w Sm-Fe w ƒ w zá *Á w»» The Effect of Excess Samarium Oxide on the PreparationG of Sm-Fe Alloy Powder by Reduction-diffusion

More information

50(5)-07.fm

50(5)-07.fm Printed in the Republic of Korea w 3w yû x w w w Á x* w w w yw (2006. 3. 14 ) A research of the Difference in Teaching Styles and Understanding of 9 th Grade Students About Lead-iodide Precipitation Reaction

More information

8(2)-4(p ).fm

8(2)-4(p ).fm w wz J. Kor. Soc. Cloth. Ind. 8«2y, 2006 Vol. 8, No. 2, pp.177-182(2006) x w e w 1) Á Ÿ 1) Á»û 2) 1) ƒm w q w 2) w w w The Effect of Media on Taking Plastic Surgery Chong-Hee Yun 1), Su-Kwang Sung 1) and

More information

12(4) 10.fm

12(4) 10.fm KIGAS Vol. 12, No. 4, December, 2008 (Journal of the Korean Institute of Gas) l x CNG» v m s w ½ Á y w» œw (2008 9 30, 2008 12 10, 2008 12 10 k) Numerical Analysis for Temperature Distribution and Thermal

More information

16(1)-5(국문)(p.52-56).fm

16(1)-5(국문)(p.52-56).fm w wz 16«1y Kor. J. Clin. Pharm., Vol. 16, No. 1. 2006 j rù k w y B Áy k B Á½ C Á D B w C D ƒm w w w Pharmacokinetic Study of Aceclofenac and its Metabolites, and Application to Bioequivalence Study Chun-hwa

More information

14(4)-14(심고문2).fm

14(4)-14(심고문2).fm w» wz, 14«4y(2012) (ISSN 1229-5671) Korean Journal of Agricultural and Forest Meteorology, Vol. 14, No. 4, (2012), pp. 260~264 DOI: 10.5532/KJAFM.2012.14.4.260 Author(s) 2012. CC Attribution 3.0 License.

More information

93.fm

93.fm Journal of the Korean Ceramic Society Vol. 45, No. 10, pp. 625~630, 2008. Effect of Storage Conditions on the Setting Properties of Brushite Bone Cement Containing Granular β-tricalcium Phosphate Sun-Ae

More information

DBPIA-NURIMEDIA

DBPIA-NURIMEDIA Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 18, No. 5, 436-443, 2005,1"$ w Q) t p z Á 1w w œw 2 w œ yw Effects of surface properties and solution ph on the pollutants removal of

More information

84-07.fm

84-07.fm w y wz 8«( 4y) 00~00, 2005 J. of the Korean Society for Environmental Analysis CWPO œ w 1,4- s Á Á * û y, * w yœ lœw 1,4-Dioxane Treatment using Catalytic Wet Peroxide Oxidation Process Jong-min Kang,

More information

w w l v e p ƒ ü x mw sƒw. ü w v e p p ƒ w ƒ w š (½kz, 2005; ½xy, 2007). ù w l w gv ¾ y w ww.» w v e p p ƒ(½kz, 2008a; ½kz, 2008b) gv w x w x, w mw gv

w w l v e p ƒ ü x mw sƒw. ü w v e p p ƒ w ƒ w š (½kz, 2005; ½xy, 2007). ù w l w gv ¾ y w ww.» w v e p p ƒ(½kz, 2008a; ½kz, 2008b) gv w x w x, w mw gv ª Œª Œ 30ƒ 5A Á 2010 9œ pp. 475 ~ 484 gj p ª v e p p PSC ƒ gv : II. x w Precast Concrete Copings for Precast Segmental PSC Bridge Columns : II. Experiments and Analyses ½kzÁ½ Á zá x Kim, Tae-HoonÁKim,

More information

41(6)-09(김창일).fm

41(6)-09(김창일).fm 269 Ar v Na 0.5 K 0.5 NbO 3 t ½ t,, ½ w,, ½ w»œw Surface Reaction of Na 0.5 K 0.5 NbO 3 Thin Films in Inductively Coupled Ar Plasma w t œwz J. Kor. Inst. Surf. Eng. Vol. 41, No. 6, 2008. < > Dong-Pyo Kim,

More information

<312D303128C1B6BAB4BFC1292E666D>

<312D303128C1B6BAB4BFC1292E666D> k Ÿy y y + ûz m Ì ˆw k Ÿ ø ky w y y» wk Ÿ v w k w w ƒ Ÿ ew k Ÿy yø k Ÿ ý k z» w ƒ w Ÿ y k y w x mw w w ³Ÿ wšy v mw y w r œw yÿ ý w z»ÿ Ÿ»» Ÿ ¾ Ÿ 6TCXGN 9GGMN[ ýw k Ÿ Ÿ ƒ š wš y w k Ÿ ƒ m ³ w w y y y 'EQVQWTKUO

More information

Microsoft Word - KSR2013A320

Microsoft Word - KSR2013A320 k ƒ! YWXZ º º t rzyywxzhzyw k ep k Dynamic Behavior of Bridge considering Various Light Weight Rail Vehicles Õ äø ÐãäÕò ãã Sang-Su Kim, Yong-ul Park *, Man-Cheol Kim ** Abstract The purpose of this paper

More information

31(3B)-07(7055).fm

31(3B)-07(7055).fm ª Œª Œ 31ƒ 3B Á 2011 5œ pp. 265 ~ 276 ª w w s³ The Correlation Between the Moving Average of Precipitation and Groundwater Level in Korea Á½û» Yang, Jeong-SeokÁKim, Nam-Ki Abstract Precipitation data and

More information

, 66~67dB»e 55dB š 12dBù û»e(65db) w 70~71dB ñ. ù ü»» 35dB(ü), 45dB() r. w» w 1938 œk ³Ø w, 1960 Ø, 1968 ³Ø w. w 1972 ³Ø w w ³ ƒwš, ù y Ø w ³w

, 66~67dB»e 55dB š 12dBù û»e(65db) w 70~71dB ñ. ù ü»» 35dB(ü), 45dB() r. w» w 1938 œk ³Ø w, 1960 Ø, 1968 ³Ø w. w 1972 ³Ø w w ³ ƒwš, ù y Ø w ³w ª Œª Œ 26ƒ 1D Á 2006 1œ pp. 1~11 ª qp md w An Analysis of the Traffic Noise Measurement Plans of Apartment Complexes A Case on the North Riverside Expressway in Seoul Á Kang, Jun MoÁLee, Sung Kyung Abstract

More information

THE JOURNAL OF KOREAN INSTITUTE OF ELECTROMAGNETIC ENGINEERING AND SCIENCE. vol. 29, no. 10, Oct ,,. 0.5 %.., cm mm FR4 (ε r =4.4)

THE JOURNAL OF KOREAN INSTITUTE OF ELECTROMAGNETIC ENGINEERING AND SCIENCE. vol. 29, no. 10, Oct ,,. 0.5 %.., cm mm FR4 (ε r =4.4) THE JOURNAL OF KOREAN INSTITUTE OF ELECTROMAGNETIC ENGINEERING AND SCIENCE. 2018 Oct.; 29(10), 799 804. http://dx.doi.org/10.5515/kjkiees.2018.29.10.799 ISSN 1226-3133 (Print) ISSN 2288-226X (Online) Method

More information

93-09.fm

93-09.fm w y wz 9«( 3y) 199~206, 2006 J. of the Korean Society for Environmental Analysis sƒ(i) ½» *Áx Á * w yw w, w y œw Evaluation of Manual and Automated Methods in Total Nitrogen (TN) and Total Phosphorus (TP)

More information

15(2)-07.fm

15(2)-07.fm J. Korean. Soc. Living. Environ. Sys. Vol. 15, No. 2, pp 145~154(2008) w y y w z 15 «2 y 2008 ³ l w sm ½ Á yáy * w y w, ** w w Recommended Sensitivity of a Fully-shielded Photosensor for a Daylight Dimming

More information

3.fm

3.fm Journal of the Korean Ceramic Society Vol. 44, No. 1, pp. 12~17, 2007. A Study on the Preparation of Bone Ash and Celadon Bone Body Using Pig Bone Jae-Jin Jeong, Sang-Hee Lee, Yong-Seok Lee,* and Byung-Ha

More information

626_636의학강좌_김청수

626_636의학강좌_김청수 Continuing Education Column Benign Prostatic Hyperplasia Choung Soo Kim, MD. Department of Urology, Ulsan University College of Medicine E mail : cskim@amc.seoul.kr J Korean Med Assoc 2007; 50(7): 626-636

More information

fm

fm J. Fd Hyg. Safety 20(4), 253 257 (2005) ü w w w Áy»xÁ Á Á Á«Á Áw Á x Á yx Á½ Á½ Á½ t t» t t ƒ q Study on Management of Artificial Flavors in Korea Tal-Soo Lee, Young-Mi Jang, Ki-Hyoung Hong, Sung-Kwan

More information

페링야간뇨소책자-내지-16

페링야간뇨소책자-내지-16 야간뇨의진단과치료 - 실제적접근 - Reference 1. Choo MS, Ku JH, Park CH et al. Prevalence of Nocturia in a Korean Population Aged 40 to 89 Years. Neurourol Urodyn 2008; 27:60-64. 2. Weiss JP. Prevalence

More information

14(4) 09.fm

14(4) 09.fm J. Korean. Soc. Living. Environ. Sys. Vol. 14, No. 4, pp 343~350(2007) w y y w z 14 «4 y 2007 yw» l s p»xá ³ *w w w œw, **w w w The Property of Pressure Distribution of Hybrid Underfloor Air Distribution

More information

17(2)-00(268).fm

17(2)-00(268).fm w ywz 17«2y(2012)/ 1 AMESim» CRDi l 2 p w if * Á le * Áfld ** Analysis of Dynamic Characteristics in Two-stage Injection for CRDi Injectors Based on AMESim Environment Insu Jo, Jiwon Kwon and Jinwook Lee

More information

Lumbar spine

Lumbar spine Lumbar spine CT 32 111 DOI : 10.3831/KPI.2010.13.2.111 Lumbar Spine CT 32 Received : 10. 05. 23 Revised : 10. 06. 04 Accepted : 10. 06. 11 Key Words: Disc herniation, CT scan, Clinical analysis The Clinical

More information

416.fm

416.fm Journal of the Korean Housing Association Vol. 20, No. 4, 2009 œ qp œ y An Analysis of Change on the Apartment Unit Plans and the Interior Spaces Related to Women * Choi, ByungSook ** Park, JungA "CTUSBDU

More information

책임연구기관

책임연구기관 2009. 2. 책임연구기관 - i - - ii - - iii - - iv - 6.3.1 Sample Collection and Analysis 161 6.3.1.1 Sample Collection 161 6.3.1.2 Sample Analysis 161 6.3.2 Results 162 6.3.2.1 Dalian 162 6.3.2.2 Xiamen 163 6.3.3

More information

18(3)-10(33).fm

18(3)-10(33).fm Journal of Korean Powder Metallurgy Institute Vol 18 No 3 011 DOI: 10150/KPMI01118383 e x 5Mg(OH) MgSO 3H O x w MgO NH OH w a báv y aá½xk aá½ aá½ cá½ bá½ a * aw» l bš w œw ck Effect of MgO and NH OH on

More information

04_이근원_21~27.hwp

04_이근원_21~27.hwp 1) KIGAS Vol. 16, No. 5, pp 21~27, 2012 (Journal of the Korean Institute of Gas) http://dx.doi.org/10.7842/kigas.2012.16.5.21 실험실의 사례 분석에 관한 연구 이근원 이정석 한국산업안전보건공단 산업안전보건연구원 (2012년 9월 5일 투고, 2012년 10월 19일

More information

25(6)-21(김유곤).fm

25(6)-21(김유곤).fm Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 25, No. 6, 483-491, 2012 http://dx.doi.org/10.5806/ast.2012.25.6.483 Study on stability test of in process sample of recombinant Protein

More information

26(3D)-17.fm

26(3D)-17.fm 26ƒ 3D Á 2006 5œ pp. ~ ª y w qp yw k d Predictive Equation of Dynamic Modulus for Hot Mix Asphalt with Granite Aggregates yá½x Á Lee, Kwan-HoÁKim, Hyun-OÁJang, Min-Seok Abstract The presented work provided

More information

<30332DB9E8B0E6BCAE2E666D>

<30332DB9E8B0E6BCAE2E666D> kœw» y w k p y w k» z wš ye z w mdkqvqrg üœ» y» Ÿ w kœwgeqgpikpggtkpiy glj GEQVGEJPQNQI[ œw w k w yz š y j œ w m w y ˆ mw y» kœ w k û ³ y ƒ ƒ» ƒ w œw w w y ƒƒ» k z w» %NGCP 9CVGT #EV wšw y ù» œ w w w t

More information

10.063~070(B04_윤성식).fm

10.063~070(B04_윤성식).fm J. of Advanced Engineering and Technology Vol. 1, No. 1 (2008) pp. 63-70 Mg-3%Al-1%Zn w ƒœ» y Á x*á **Á Á w œw *w s l I ûer ** t Effect of Thermomechanical Treatment on Microstructure and Mechanical Properties

More information

18211.fm

18211.fm J. of the Korean Sensors Society Vol. 18, No. 2 (2009) pp. 168 172 p k ù p p l xá xá ³ Á *Á w * Fabrication of the CNT-FET biosensors with a double-gate structure Byunghyun Cho, Byounghyun Lim, Jang-Kyoo

More information

6À嵶¼º¿¬±¸ºÐ¾ß

6À嵶¼º¿¬±¸ºÐ¾ß Korea Food & Drug Administration 6 01 K o r e a F o o d & D r u g A d m i n i s t r a t i o n 504 505 년들도 친숙하게 독성물질에 대한 정보들에 접근할 수 있도록 하였다. 그림6-1-3 국립독성연구원 홈페이지 K o r e a F o o d & D r u g A d m i n i

More information

Microsoft Word - KSR2012A038.doc

Microsoft Word - KSR2012A038.doc YWXY º º t rzyywxyhwz_ º zƒ A Study on the Relation of Railroad System and Energy Saving ö ä ø ã ä ãã In Moon, Han-Min Lee *, Jong-Eun Ha * * Abstract Now the world, such as the impact of fossil energy

More information

Statistical Data of Dementia.

Statistical Data of Dementia. Screening of Prolyl Endopeptidase Inhibitors from Medicinal Plants. Lee Si-young, Lee Jung-han, Paik Young-Sook College of Environment and Applied Chemistry, Kyung Hee University. Statistical Data of Dementia.

More information

07.045~051(D04_신상욱).fm

07.045~051(D04_신상욱).fm J. of Advanced Engineering and Technology Vol. 1, No. 1 (2008) pp. 45-51 f m s p» w Á xá zá Ÿ Á w m œw Image Retrieval Based on Gray Scale Histogram Refinement and Horizontal Edge Features Sang-Uk Shin,

More information

25(6)-12(조윤아).fm

25(6)-12(조윤아).fm Printed in the Republic of Korea "/"-:5*$"- 4$*&/$& 5&$)/0-0(: Vol. 25, No. 6, 416-420, 2012 http://dx.doi.org/10.5806/ast.2012.25.6.416 Characteristics of heavy metals's exposure from playground flooring

More information

11(1)-15.fm

11(1)-15.fm w y wz 11«1y 73~80 (2011.8.) Journal of Korean Society of Urban Environment SWMM 을이용한도시지역비점오염부하저류시설용량산정 Áw«Á *Áy **Á½ yá½ Á x w w Á* û w y œw Á** w y lœw (2011 6 13, 2011 6 27 k) Determine Capacity of

More information

THE JOURNAL OF KOREAN INSTITUTE OF ELECTROMAGNETIC ENGINEERING AND SCIENCE Nov.; 26(11),

THE JOURNAL OF KOREAN INSTITUTE OF ELECTROMAGNETIC ENGINEERING AND SCIENCE Nov.; 26(11), THE JOURNAL OF KOREAN INSTITUTE OF ELECTROMAGNETIC ENGINEERING AND SCIENCE. 2015 Nov.; 26(11), 985991. http://dx.doi.org/10.5515/kjkiees.2015.26.11.985 ISSN 1226-3133 (Print)ISSN 2288-226X (Online) Analysis

More information

(JBE Vol. 21, No. 1, January 2016) (Regular Paper) 21 1, (JBE Vol. 21, No. 1, January 2016) ISSN 228

(JBE Vol. 21, No. 1, January 2016) (Regular Paper) 21 1, (JBE Vol. 21, No. 1, January 2016)   ISSN 228 (JBE Vol. 1, No. 1, January 016) (Regular Paper) 1 1, 016 1 (JBE Vol. 1, No. 1, January 016) http://dx.doi.org/10.5909/jbe.016.1.1.60 ISSN 87-9137 (Online) ISSN 16-7953 (Print) a), a) An Efficient Method

More information

목차 ⅰ ⅲ ⅳ Abstract v Ⅰ Ⅱ Ⅲ i

목차 ⅰ ⅲ ⅳ Abstract v Ⅰ Ⅱ Ⅲ i 11-1480523-000748-01 배경지역 ( 백령도 ) 에서의 대기오염물질특성연구 (Ⅲ) 기후대기연구부대기환경연구과,,,,,,, Ⅲ 2010 목차 ⅰ ⅲ ⅳ Abstract v Ⅰ Ⅱ Ⅲ i 목차 Ⅳ ii 목차 iii 목차 iv 목차 μg m3 μg m3 v 목차 vi Ⅰ. 서론 Ⅰ μm μg m3 1 Ⅰ. 서론 μg m3 μg m3 μg m3 μm 2

More information

04.fm

04.fm w y wz 9«( 2y) 91~96, 2006 J. f the Krean Sciety fr Envirnmental Analysis üy wƒ w y k p ½» w w œw Adsrptin Prperties f the Activated Carbns fr Remving Harmful Gases in Indr Envirnments In-Ki Kim Department

More information