Mast Cells in Functional Gastrointestinal Disorders Sei Jin Youn, M.D. Department of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea 서 론. (effector cell).. mucosal mast cell (MMC) connective. mast cell (CTMC)..,.. CTMC,,, MMC (immunocompetent cells).. 1,2 MMC (5-10µm) CTMC (10-20µm). MMC. histamine, 5-hydroxytryptamine (5-HT), rat. mast cell protease II (RMCP II), prostaglandins, leukotrienes platelet-activating factor(paf). 2 Tumor Necrosis, Factor(TNF)-alpha, interleukin(il)-1, -3, -4, -5, -6, GM-CSF, MCP-1 cytokines chemokines MMC.. IgE/antigen substance P acetylcholine 점막비만세포. 3,4,5 protease tryptase. 2. IgE- (. ) -IgE- (, ) cytokines. 2,6,7 TNF-alpha, 접수: 2005년 6월 2일 IL-1, -5, -8, -16, -18 cytokines 책임저자 : 윤세진, 충북청주시흥덕구개신동 62(361-711) 충북대학교의과대학내과학교실 mrna. stem cell factor Tel: (043)269-6029, 6357 Fax: (043)273-3252 (SCF)-conditioned media IL-4 IgE-receptor E-mail: SJYoun@chungbuk.ac.kr
IL-3, IL-5, IL-9 cytokine. 6 2. Crowe. biogenic amine, TTX proteoglycans, protease TNF-alpha. 13 lipid-derived mediator cytokines RMCPII. 14. cytokines TTX RMCPII... 13 비만세포-신경-상피세포상호작용.. 스트레스에 의해 유발된상피기능장애모델. Nippostrongylus brasiliensis 67% ( water avoidance ). 8.. 47-78% (<1µm). 9 Newson. CL -. 15. 10 horseradish peroxidase ( ) endosomes.. 15 atropine 과민성모델 (Models of hypersensitivity). acetylcholine. 15,16 water avoidance stress,. 17. Castro T. spiralis worm antigen short-circuit current(isc) tetrodotoxin (TTX), atropine. 11. 18-9 histamine 5-HT cold pain stress MMC prostaglandin E2 histamine tryptase, histamine, PG D2. 20 5-HT. 11 기능성위장장애의 신경면역생리학적범례 Perdue. anti-ige TTX 50%,,. 12 -.
... 23. (paradoxical output).,,. - /.. serotonin, histamine, prostaglandins, leukotrienes, platelet-activating factor cytokines. (Fig. 1). histamine (Fig. 1). 21., Guinea pig. histamine (effector system) /.. 22, histamine.. 24,25.,, (propulsive histamine motor).. 기능성위장장애에서뇌-비만세포상호작용... 8,26,27 protease.. 20 Thyrotropin releasing hormone (TRH) -. 5 TRH cold-restraint stress. restraint stress histamine
. 28 corticotropin releasing factor (CRF) Compylobacter 25%. CRF. 34 CRF. 30-33.... 33. 29. -. 31,32,35-37.. (, ),.. 38 (secretory behavior)... 21, I.,,,, / ( ). 31,36,39,.. 36,40 substance P.. substance P,. 36,41. PAR-2 (proteinase activated receptor 2),.. 21. 21, 과민성장증후군에서비만세포. 33,34.
, (Fig. 2).. histamine, tryptase.,,. 44,45. 요 약, 42 Constantine substance P.. 43.,. /.. -.,,. -, 참고문헌 1. Crowe SE, Perdue MH. Gastrointestinal food hypersensitivity: basic mechanisms of pathophysiology. Gastroenterology 1992;103:1075-1095. 2. Metcalfe DD, Baram D, Mekori YA. Mast cells. Physiol Rev 1997;77: 1033-1079. 3. Shanahan F, Denburg JA, Fox J, Bienenstock J, Befus D. Mast cell heterogeneity: effects of neuroenteric peptides on histamine release. J Immunol 1985;135:1331-1337. 4. Bani-Sacchi T. The release of histamine by parasympathetic stimulation in guinea-pig aurical and rat ileum. J Physiol 1986;371:29-43. 5. Santos J, Saperas E, Mourelle M, Antolin M. Regulation of intestinal mast cells and luminal protein release by cerebral thyrotropin-releasing hormone in rats. Gastroenterology 1996;111:1465-1473.
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