소식지 주소 : 부산광역시금정구부산대학로 63번길 2( 장전동 ) 부산대학교약학대학 / 전화 :051)510-2814 팩스 :051)518-2821 E-mail:agingbank@pusan.ac.kr hyjung@pusan.ac.kr Homepage : www.atb.knrrc.or.kr http://aging.pharm.pusan.ac.kr/ Content 3 월호 알기쉬운노화의기초지식 Autophagy 와노화 정기웅 ( 부산대학교약학대학석박사통합과정 ) Autophagy 란무엇인가? 2015 년 3 월호 발행인 : 정해영 발행처 : 한국연구재단지원 편집인 : 정기웅, 문경미, 안혜진, 임수경 Autophagy 의기본적인기능 1
Aging Tissue Bank α Autophagosome 의형성 2
Aging Tissue Bank Autophagy 를조절하는상위 signaling α 3
Aging Tissue Bank Autophagy 가노화에서가지는의미 4
Aging Tissue Bank 결론 Reference 5
Aging Tissue Bank 노화소식 6
Aging Tissue Bank Elevated microrna-34a in obesity reduces NAD+levels and SIRT1 activity by directly targeting NAMPT. α κ 7
Aging Tissue Bank <은 행 동 향> 세미나 개최 1. 초청세미나 장소 및 일시 : 2015년 03월 24일 16:00 / 부산대 약대 세미나실 연 제 : Physiological and Clinical Implications of ANOCTAMIN 1, A Calcium-activated Chloride Channel 연 자 : 오우택 교수 (서울대학교 약학대학) 2. 노화조직 홍보 책자 발간 제 목 : 노화의 기전과 건강노화 발행처 : 목 차 : Ⅰ. 알기 쉬운 노화의 기초지식 Ⅱ. 건강장수의 비결 Ⅲ. 노화연구를 위한 소재와 정보 Ⅳ. 노화연구를 위한 소재은행() Ⅴ. 분자염증 노화제어 연구센터 8
Aging Tissue Bank 노화조직을활용한최근연구논문 1. Chung, K.W., Choi, Y.J., Park, M.H., Jang, E.J. Kim, D.H., Park, B.H., Yu, B.P., Chung, H.Y.: Molecular Insights into SIRT1,Protection Against UVB-Induced Skin Fibroblast Senescence by Suppression of Oxidative Stress and p53 Acetylation, J Gerontol A Biol Sci Med Sci, [Epub ahead of print] 2. Sung, B.K., Chung, H.S., Kim, M.J., Kang, Y.J., Kim, D.H. Hwang, S.Y., Kim, M.J., Kim, C.M., Chung, H.Y.,and Kim, N.D.: Cytotoxic effects of ethanol extract from Salvia miltiorrhiza BUNGE on human cancer cell lines, EXP THER MED, 9(4), 1421-1428 (2015) 3. Kim, M., Sung, B., Kang, Y.J., Kim, D.H., Lee, Y., Hwang, S.Y., Yoon, J., Yoo, M., Kim, C.M., Chung, H.Y., Kim, N.D.: The combination of ursolic acid and leucine potentiates the differentiation of C2C12 murine myoblastsn through the mtor signaling pathway, INT J MOL MED, 35(3),755-762 (2015) 4. Jung, K.J., Lee, E.K., Kim, S.J., Song, C.W., Maruyama, N.,Ishigami, A., Kim, N.D., Im, D.S., Yu, B.P., Chung, H.Y.: Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine Q1 kinase/phosphatase balance, J Mol Med(Berl), 93(3),343-356 (2015) 5. Jung, K.J., Lee, E.K., Kim, S.J., Song, C.W., Maruyama, N., Ishigami, A., Kim, N.D., Im, D.S., Yu, B.P., Chung, H.Y.: Anti-inflammatory activity of SMP30 modulates NF-κB through protein tyrosine Q1 kinase/phosphatase balance, J Mol Med, DOI 10.1007/s00109-014-1219-1(2014) 6. Cha, J.H., Wee, H.J., Seo, J.H., Ju, Ahn, B., Park, J.H., Yang, J.M., Lee, S.W., Lee, O.H., Lee, H.J., Gelman, I.H., Arai, K., Lo, E.H., Kim, K.W.: Prompt meningeal reconstruction mediat ed by oxygensensitive AKAP12 scaffolding protein after central nervous system injury, Nat Commun. 5:4952. doi: 10.1038/ncomms5952. (2014) 7. Kim D.H., Sung B., Chung H.Y., Kim N.D. : Modulation of Colitis-associated Colon Tumorigenesis by Baicalein and Betaine, J Cancer Prev, 19(3),153-160(2014) 8. Kim D.H., Park M.H., Lee E.K., Choi Y.J., Chung K.W., Moon K.M., Kim M.J., An H.J., Park J.W., Kim N.D., Yu B.P., Chung H.Y.: The roles of FoxOs in modulation of aging by calorie restriction, Biogerontology, 16(1):1-14(2014) 9. Jin, H., Lee, W.S., Eun, S.Y., Jung, J.H., Park, H.S., Kim, G., Choi, Y.H., Ryu, C.H., Jung, J.M., Hong, S.C., Shin, S.C., Kim, H.J.: Morin, a flavonoid from Moraceae, suppresses growth and invasion of the highly metastatic breast cancer cell line MDA-MB 231 partly through suppression of the Akt pathway.int J Oncol. 45:1629-1637(2014) 10. Kim, D.H., Park, M.H., Chung, K.W., Kim, M.J., Jung, Y.R., Bae, H.R., Jang, E.J., Lee, J.S., Im, D.S., Yu, B.P., Chung, H.Y.:The essential role of FoxO6 phosphorylation in aging and calorie restriction. Age. 36(4):9679 (2014) 11. Noh, K.K., Chung, K.W., Choi, Y.J., Park, M.H., Jang, E.J., Park, C.H., Yoon, C., Kim, N.D., Kim, M.K., Chung, H.Y.:β-Hydroxy β-methylbutyrate Improves Dexamethasone-Induced Muscle Atrophy by Modulating the Muscle Degradation Pathway in SD Rat. Plos one. 9(7):e102947 (2014) 9
Aging Tissue Bank 12. Choi, Y.J., Uehara, Y., Park, J.Y., Kim, S.J., Kim, S.R., Lee, H.W., Moon, H.R., Chung, H.Y.: MHY884, a newly synthesized tyrosinase inhibitor, suppresses UVB-induced activation of NF-κB signaling pathway through the downregulation of oxidative stress. Bioorganic & Medicinal Chemistry Letters. 24(5):1344-1348 (2014) 13. Kim, D.H., Sung, B., Kan,g Y.J., Jang, J.Y, Hwang, S.Y., Lee, Y., Kim, M., Im, E., Yoon, J.H., Kim, C.M., Chung, H.Y., Kim, N.D.: Anti-inflammatory effects of betaine on AOM/DSS induced colon tumorigenesis in ICR male mice. Int J Oncol. 45(3):1250-6(2014) 14. Park, C.H., Kim, D.H., Park, M.H., Kim, M.K., Kim, N.D., Kim, C.M., Tanaka, T., Yokozawa, T., Chung, H.Y., Moon, H.R.: Chinese Prescription Kangen-karyu and Salviae Miltiorrhizae Radix Improve Age-Related Oxidative Stress and Inflammatory Response through the PI3K/Akt or MAPK Pathways. The American Journal of Chineses Medicine. 42(4):1-19 (2014) 15. Kim S. R., Jung Y. R., Kim D. H., An H. J., Kim M. K., Kim N. D., Chung H. Y. : Caffeic acid regulates LPS-induced NF-κB activation through NIK/IKK and c-src/erk signaling pathways in endothelial cells, Arch Pharm Res., 37(4): 539-47(2014) 16. Lee, Y.J., Sung, B.K., Jang, Y.J., Kim, D.H., Kang, J.Y., Hwang, S.Y., Kim, M.J., Lim, H.S., Yoon, J.H., Chung, H.Y., Kim, N.D.: Apigenin-induced apoptosis is enhanced by inhibition of autophagy formation in HCT116 human colon cancer cells. Int J Oncol. 44(5):1599-1606(2014) 17. Sung, B., Kang, Y.J., Kim, D.H., Hwang, S.Y., Lee, Y., Kim, M., Yoon, J.H., Kim, C.M., Chung, H.Y., Kim, N.D.: Corosolic acid induces apoptotic cell death in HCT116 human colon cancer cells through a caspase-dependent pathway. Int J Oncol. 33(4):943-949(2014) 18. Lee, S.H., Kang, Y.J., Sung, B., Kim, D.H., Lim, H.S., Kim, H.R., Kim, S.J., Yoon, J.H., Moon, H.R., Chung, H.Y., Kim, N.D.: MHY-449, a novel dihydrobenzofuro [4,5-b][1,8] naphthyridin-6-one derivative, induces apoptotic cell death through modulation of Akt/FoxO1 and ERK signaling in PC3 human prostate cancer cells. Int J Oncol. 44(3):905-911(2014) 19. Lee, S.H., Kang, Y.J., Kim, D.H., Sung, B., Kang, J.A., Chun, P., Yoon, J.H., Moon, H.R., Kim, H.S., Chung, H.Y., Kim, N.D.: A novel oxiranylchromenone derivative, MHY336, induces apoptosis and cell cycle arrest via a p53- and p21-dependent pathway in HCT116 human colon cancer cells. Int J Oncol. 44(3):943-949(2014) 20. Kim, M.K, Kang, Y.J., Kim, D.H., Hossain, M.A., Jang, J.Y., Lee, S.H., Yoon, J.H., Chun, P., Moon, H.R., Kim, H.S., Chung, H.Y., Kim, N.D.: A novel hydroxamic acid derivative, MHY218, induces apoptosis and cell cycle arrest through downregulation of NF-κB in HCT116 human colon cancer cells. Int J Oncol. 44(1):256-264 (2014) 21. Park, M.H., Park, J.Y., Lee, H.J., Kim, D.H., Chung, K.W., Park, D., Jeong, H.O., Kim, H.R., Park, C.H., Kim, S.R., Chun, P., Byun, Y., Moon, H.R., Chung, H.Y.:The novel PPAR α/γ dual agonist MHY 966 modulates UVB-induced skin inflammation by inhibiting NF-κB activity. Plos one. 8(10):e76820(2013) 22. Kim, H.J., Lee, E.K., Park, M.H., Ha, Y.M., Jung, K.J., Kim, M.S., Kim, M.K., Yu, B.P., Chung, H.Y.: Ferulate Protects the Epithelial Barrier by Maintaining Tight Junction Protein Expression and Preventing Apoptosis in Tert-Butyl Hydroper oxide-induced Caco-2 Cells. Phytotherapy Res, 27(3):362-367(2013) 10
Aging Tissue Bank <홍보> 노 화 조 직 은 행 노화 수명연장 연구에 필요한 시료를 찾으십니까? 부산대 Aging Tissue Bank로 오십시오 본 은 연구자들에게 노화 기전 및 노화제어에 필요한 연구시료와 정보를 신속하게 제공하여 노화연구를 원활히 지원하는 것을 목적으로 하고 있습니다. 노화조직과 노화쥐 이미지 1) 노화조직의 연구소재 분양 1. 자유식이 Sprague Dawley(SD) rat(al) 연령별 노화조직 2. 식이제한 SD rat(cr) 연령별 노화조직 3. LPS처리 노화조직(SD rat) 4. AAPH처리 노화조직(F344 rat) 5. 자유식이 C57BL/6 mouse 연령별 노화조직 6. 유전자변이 모델동물(GH결손, mini rat)조직 7. 노화촉진 모델 동물(SMP30유전자변이 마우스) 8. 각종 항산화물질 투여 노화조직(SD rat) 구체적인 것은 homepage를 방문하시기를 바랍니다. www.agingbank.or.kr http://agingbank.pharm.pusan.ac.kr 2) 노화 제어 후보 물질 분양 1) 천연물 유래 활성물질 1. Lithospermate B 5. Ginsenoside Rb2 2. Oligonol 3. Resveratrol 4. Ursodeoxycholic acid 2) 합성물질 1. MHY1681 5. MHY1685 2. MHY1682 3. MHY1683 4. MHY1684 3) 비파유래 활성 분획 1. Ursolic acid-rich fraction 3) 노화관련 Data Base 구축을 통한 통합정보 제공 a) http://aging.pharm.pusan.ac.kr b) http://bionet.inje.ac.kr/massprophet c) http://bionet.inje.ac.kr/trep_db d) http://aging.pharm.pusan.ac.kr/agingdb e) http://aging.pharm.pusan.ac.kr:8080/dbpiat 1), 2)의 연구소재가 필요하시면 다음으로 연락주십시오 Tel : 051-510-2814 H.P : 010-6532-1569 Fax : 051-518-2821 E-mail: agingbank@pusan.ac.kr; hyjung@pusan.ac.kr 11
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