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Market Overview Biochip Technologies DNA Microarray Technologies Arrays Consumables Instrumentation Software Proteomics Array Technologies Instrumentation Consumables Microfluidics/ Lab-on-a-chip Technologies Direct Sales through Catalog, Web site and Distributor Pharmaceutical Companies Biotechnology Companies Agricultural Companies Clinical Laboratories Forensic Laboratories Government Agencies NIH NSF FDA CDC DOE DOD Academic Institutions Hospitals and Medical Schools Non-Profit Organizations - 437 -

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바이오칩기술경로도 1 단계 2 단계 3 단계 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 바이오칩컨텐츠개발 바이오칩용재료기술 바이오컨텐츠설계기술 기술 극미량바이오유체처리및제어기술 바이오칩표면화학및고효율고정화기술 생체물질상호작용고감도분석및이미징기술 생체물질초고집적어레이및바이오패터닝 신개념생체물질결합의검출기술 바이오칩통합용소프트웨어기술 바이오칩통합기술 바이오칩활용기술 HTS 용단백질칩, 펩타이드칩, 당쇄칩, 세포칩등 질병예측, 진단용 DNA 칩, 단백질칩등 제품 생체분자프로파일분석용바이오어레이칩 바이오 LOC 미래형통합바이오칩시스템 - 439 -

산업분야보건의료 환경정밀화학식품및생물공정정보 / 전자 응용범례혈액검사, 유전자분석, Functional Genomics, Proteomics 자가진단 ( 혈당, HIV 등 ), 임상용진단시약 /kit/ 센서, Animal 센서실험동물대체용독성시험, Prosthetic Vision 의료기기, 뇌연구 BOD 센서, 수질및해양오염감시, 오염물질검출및분석중금속 / 독성폐기물검출, 위험물 / 생화학무기검출 μ-tas (Total Analysis System), Bioremediation 생리활성의약원료개발 ( 항생제 / 항암제 / 호르몬제 / 백신류 / 진단제 ) 화장품제조및테스트, 효소및생화학시약류, 농약제조및분석 Combinatorial Chemistry, High Throughput Screening (HTS) 시스템식품 / 안정성검사, 동식물질병진단육류 / 농산물의품질관리생물공정계측및제어, 생물생산시스템가전응용, 개인식별 / 보안시스템, 가상현실시스템, Video Game Olfactory Interfaces, Home Telemetry, Artificial Neural Networks Neuromorphic Vision Chip, 생물전자소자, 바이오컴퓨터 - 440 -

1,600.0 16.0 1,400.0 14.0 매출액 ($ Million) 1,200.0 1,000.0 800.0 600.0 400.0 매출액 ($ Million) 매출액성장률 (%) 12.0 10.0 8.0 6.0 4.0 성장률 (%) 200.0 2.0 0.0 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 0.0 연도 - 441 -

100% 90% 80% 매출액비율 (%) 70% 60% 50% 40% 30% 20% 10% 0% 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 연도 DNA M icroarray 시장 M icrofluidics / L ab-on-a-chip 시장 Proteomics Arrays 시장 CAGR (2005 2012) 0% 5% 10% 15% 20% 25% 30% 35% U.S. Proteomics Arrays Markets $51.6 million U.S. Microfluidics/ Lab-on-a-chip Markets $84.3 million U.S. DNA Microarray Markets $446.8 million Development Segment Life Cycle Stage Growth - 442 -

시장참여기업수경쟁기업타입분배구조주요소비그룹경쟁요소 약 130 개기업생명공학기반기업연구목적기업신약개발기업 / 제약회사소비자직거래대리점협력및제휴경로제약회사 / 생명공학기반기업임상실험실대학연구실및정부산하연구소브랜드인식도컨텐츠구성가격및품질 - 443 -

Competitive Factors 2005 2002 Customer Priorities 1. Cost 2. Access to technology 3. Proof-of-principle Customer Priorities 1. Standardization & clinical approval 2. Data comparison across platforms 3. Flexibility in data analysis 2012 Customer Priorities 1. Regulated in vitro diagnostics 2. Multiple commercialized applications 3. Research workflows involve multiple biochip technologies Other, 40.3% Affymetrix, 25.8% Cepheid, 1.7% PerkinElmer, Caliper, 2.5% 1.9% Bio-Rad, 2.1% Agilent, 11.5% Molecular Devices, 7.4% GE Illumina, 3.6% Healthcare, 3.2% - 444 -

Tiers of Competition Tier I Tier II 2005 revenues exceed $40.0 mil Examples: Affymetix Agilent Molecular Devices Tier III 2005 revenues range from $10.0 mil to $40.0 mil 2005 revenues less Examples: than %5.0 mil Illumina Examples: Caliper Invitrogen/BioSource Bio-Rad Clontech - 445 -

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120 100 매출액 ($ Million) 80 60 40 20 0 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 연도 급성질환관련매출액 만성질환관련매출액 - 449 -

연도 매출액 ($ Million) 2005 5.0 2006 6.0 2007 7.1 2008 8.4 2009 9.8 2010 11.4 Compound Annual Growth Rate (2005-2010): 17.8% 매출액증가율 (%) --- 18.9 18.6 17.6 17.5 16.5-450 -

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32% 46% 미국영국일본한국기타 6% 6% 10% - 462 -

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30 25 논문편수 20 15 10 5 0 2005 년 2006 년 2007 년 2008 년 * 2008 년자료는 7 월까지만집계되었음. - 465 -

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