35 1 Journal of the Korean Society of Health Information and Health Statistics Volume 35, Number 1, 2010, pp ) 1) 2) 1) 1) Cadherin-1 (CDH1) po

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35 1 Journal of the Korean Society of Health Information and Health Statistics Volume 35, Number 1, 2010, pp. 1 15 1) 1) 2) 1) 1) Cadherin-1 (CDH1) polymorphism and the risk of colorectal cancer: A meta-analysis Abstract Purpose: Conflicting results on the association between cadherin-1 (CDH1) gene -160C>A polymorphism and risk of colorectal cancer have been reported. In order to clarify the effect of CDH1 polymorphism on the risk of colorectal cancer, we intended to perform a meta-analysis using published data. Methods: We attempted to search English literatures for all literat of possible effects of CDH-1 gene on colorectal cancer in human published prior to February 2010. We used a random effect model to perform a meta-analysis of 6 case-control studies that provided information related to the effects of CDH1 gene on colorectal cancer. Results: In a meta-analysis, a total of 13,278 participants (case: 6,603, control: 6,675) were included from selected 6 studies. From 5 studies for CDH1-160C>A (rs16260) in relation to colorectal cancer, when compared with the reference genotype, the odds for CA genotype was 0.919 (0.858, 0.985; p = 0.017), whereas the odds for AA genotype was 0.800 (0.704, 0.909; p = 0.001). Similarly, from 2 studies for CDH1-347G>A (rs5030625) in relation to colorectal cancer was 1.331 (1.029, 1.722; p =0.029). Conclusion: Our findings support that CDH1-160C>A is significantly associated with colorectal cancer risk. Further studies are needed. Key words: Gene, Colorectal cancer, Cadherin-1, meta-analysis * (10526) (0920330). * : / E-mail : jsunha@yuhs.ac

2 2.1 연구논문의수집 35 1

CDH1-160C>A 3 Figure 1. Study flow diagram Figure 2. SNP map of the CDH1 promoter and 5' non-coding region. Locations of SNPs are indicated

4 2.2 분석정보의추출 2.3 통계적분석방법 35 1

CDH1-160C>A 5 ʈ

6 3.1 연구문헌의정성적메타분석 3.2 대장결장암발생에유전자다형성 -160C>A 의관련성분석 3.3 대장결장암발생에유전자다형성 -347G>A 의관련성분석 35 1

CDH1-160C>A 7 Table 1. Summary of general characteristic in case-control studies of CDH1 polymorphism and colorectal cancer Investigators Year Age Male (%) Ethnic group Colorectal cancer Percent of familial cases (%) Case Control Selection of cases Selection of control Nakamura et al 2002 40-73 50 Japanese Total NR 96 147 Porter et al 2002 36-68 60 European Sporadic 55.9 128 171 Shin et al 2004 22-85 45 Korean Sporadic 0 260 147 Cattaneo et al Grunhage et al 2006 17-87 47 European Sporadic NR 106 246 2007 44-68 54 European Familial 50.5 94 217 Zou et al 2009 27-85 52 Chinese Total NR 290 335 Pittman et al Hospital patient Hospital patient Hospital patient Hospital patient Healthy controls Healthy controls Healthy controls Healthy controls Populati Population on based based controls from cases from a a cohort cohort study study Hospital patient Healthy controls 2009 50-68 48 Caucasian Total 15.9 5679 5412 NSCCG NSCCG NR: not responded NSCCG: National study of Colorectal cancer genetics

8 Table 2. Summary of genetic characteristics in case-control studies of CDH1polymorphism and colorectal cancer Investigators, year HWE MAF (%) SNP Comparison Porter et al, 2002 Satisfied 24.9-160C/A CA vs CC AA vs CC Shin et al, 2004 Satisfied 27.9-347G/A GA vs GG Shin et al, 2004 Satisfied 22.4-160C/A Cattaneo et al, 2006 Grunhage et al, 2007 Satisfied 25.4-160C/A Satisfied 31-160C/A CA vs CC AA vs CC CA vs CC AA vs CC CA vs CC AA vs CC Zou et al, 2009 NR 47.2-347G/A GA vs GG Pittman et al, 2009 Satisfied 28-160C/A CA vs CC AA vs CC HWE: hardy-weinberg equilibrium MAF: minor allele frequency SNP: single nucleotide polymorphism NR: not respond 35 1

CDH1-160C>A 9 Figure 3. Forest plot for the association between CDH1-160C/A polymorphism and risk of colorectal cancer Figure 4. Forest plot for the association between CDH1-347G/A polymorphism and risk of colorectal cancer

10 Figure 5. Funnel plot of the published studies considered in the meta-analysis 35 1

CDH1-160C>A 11

12 35 1

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