- 685 -
- 686 -
- 687 -
- 688 -
- 689 -
- 690 -
- 691 -
- 692 -
- 693 -
실험군 대조군 - 694 -
- 695 -
- 696 -
개 자연살해세포활성 실험군 대조군 실험군 - 697 -
- 698 -
자연살해세포활성 실험군 군 대조군 - 699 -
- 700 -
- 701 -
- 702 -
- 703 -
- 704 -
체중 간무게 비장무게 - 705 -
체중 간무게 췌장무게 - 706 -
- 707 -
- 708 -
- 709 -
- 710 -
- 711 -
- 712 -
- 713 -
Proliferation (% ) 200 180 160 140 120 100 80 60 40 Control A B C D 20 0 0.001 0.01 0.1 1 Concentration (m g/m l) IF N γ (n - g /m l) 0.35 0.30 0.25 0.20 0.15 0.10 A B C D 0.05 0.00 0 0.001 0.01 0.1 C oncentration (m g/m l) - 714 -
IL -4 (n g /m l) 1. 0 0. 9 0. 8 0. 7 0. 6 0. 5 0. 4 0. 3 A B C D 0. 2 0. 1 0. 0 0 0. 0 0 1 0. 0 1 0. 1 1 C o n c e n t r a t io n ( m g / m l) - 715 -
IL -2 (n g /m l) 1. 4 1. 2 1. 0 0. 8 0. 6 0. 4 A B C D 0. 2 0. 0 0 0. 0 0 1 0. 0 1 0. 1 1 C o n c e n t r a t i o n ( m g / m l ) IL-12 (ng/ml) 1.0 0.8 0.6 0.4 A B C D 0.2 0.0 rifn-γ 0 rifn-γ 0.01 0.1 1 0.01 0.1 1 - + - - - + + + Concentration (mg/ml) - 716 -
Im m o b ility tim e 2 0 0 1 9 0 1 8 0 1 7 0 1 6 0 C o n t r o l A B 1 5 0 0.0 0 1 0.0 1 0.1 1 C o n c e n t r a t i o n ( m g / m l ) IL -2 (n g /m l) 0.55 A 0.50 B 0.45 C 0.40 0.35 0.30 0.25 0.20 0.15 0.10 0.05 0.00 N o rm a l B e fo r e A fte r - 717 -
IL -4 (n g /m l) 0.55 0.50 0.45 0.40 0.35 0.30 0.25 0.20 0.15 0.10 0.05 0.00 A B C N o rm a l B e fo re A fte r IL -6 (n g /m l) 0.25 0.20 0.15 0.10 0.05 A B C 0.00 N o rm a l B e fo re A fte r - 718 -
IF Nγ (-n g / m l) 0. 9 0. 8 0. 7 0. 6 0. 5 0. 4 0. 3 A B C 0. 2 0. 1 0. 0 N o rm a l B e fo re A fte r Nitrite µm () 140 A B 120 C 100 D E 80 60 40 20 0 Agent (mg/ml) rif N -γ 0 1 0 0.0 1 0.1 1 - - + + + + - 719 -
Nitrite concentration µm ) ( 140 120 100 80 60 40 20 0 A B C D E C on 0 0.0 01 0.0 1 0.1 1 10 N G MMA (mm) TNFα (ng/m l) 14 12 10 8 6 4 2 A B C D 0 0 1 0.01 0.1 1 rifn -γ + - + + + - 720 -
- 721 -
- 722 -
- 723 -