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1 98 年 不 療 理 98 年 類 理 1 不 不 1 類 若 刺 刺 不 2 Acetylation polymorphism 列 ydralazine Sulfonamide Isoniazid p-aminosalicylic acid 3 Digoxin 了 療 度 1 µg/l 量 loading dose 量 digoxin Vd 500 L digoxin 率 50% 量 250 µg 500 µg 1 mg 5 mg 4 列 不 Actinomycin D Doxorubicin Etoposide Bleomycin 5 列 療 量 Doxorubicin Paclitaxel Bleomycin Topotecan 6 Thalidomide TF-α IL-10 7 列 nucleoside reverse transcriptase T- Didanosine Acyclovir Indinavir Ribavirin 8 列 carmustinebcu hemorrhage cystitis 9 列 Penicillin bioavailability first-pass effect Procaine penicillin G IV Beta-lactams probenecid cephalosporin 不 blood-brain barrier

2 adenosine deaminaseadascid 列 ADA Adefovir Pegademase Pancrelipase Tenecteplase 11 列 calcineurin Azathioprine Dexamethasone Leflunomide Tacrolimus 12 Argatroban glycoprotein IIb/IIIa thrombin 13 列 plasminogen plasmin plasmin vitamin K epoxide reductase Aminocaproic acid Phenindione Protamine Urokinase 14 列 Glucocorticoids 泌 D D 狀 15 列 30% semilente 70% ultralente Lente insulin P insulin Lispro insulin Regular insulin 16 列 Follitropin beta 不 糖尿 17 列 progesterone afarelin Mifepristone Mitotane Anastrozole 18 列 Digitalis 理 不 ERP AV node 不 19 列 理 Enalapril Angiotensin converting enzymeace Amlodipine 離 Calcium channel 率 AV node 率 Sodium nitroprusside soluble guanylyl cyclasesgc Pindolol β-adrenoceptor 20 列 降 Insulinoma 度 Diazoxide ifedipine Prazosin Carvedilol 21 列 療 量 Q-T interval Procainamide Propafenone Quinidine Amiodarone 22 列 降 α 2 -Adrenergic receptor Carvediol onidine Sotalol Minoxidil 23 列 降 易 類 icardipine Timolol Irbesartan Diazoxide

3 列 bladder spasm Scopolamine Tropicamide Ipratropium xybutynin 25 列 塞 paralytic ileus 力 療 Physostigmine eostigmine Phenylephrine Atropine 26 列 cholinesterase regenerator Pralidoxime eostigmine Atracurium Atropine 27 列 β-blocker class III 律不 Sotalol Propranolol Atenolol Timolol 28 列 療 刺 diarrhea-predominant IBS Alosetron Dicyclomine Granisetron Tegaserod 29 列 Dextromethorphan 臨 30 macrolide antibiotics a /K ATPase 31 列 療 Acetylsalicylic acid Colchicine Acetaminophen Sulfinpyrazone 32 列 malizumab IgE mast cells Flumazenil GABA Procaine a Citalopram monoamine oxidase 33 列 不 Cocaine 量 34 列 療 Status epilepticus Valproic acid Diazepam Ethosuximide Carbamazepine 35 列 不 療兩 異 Bipolar affective disorder 理 Phenytoin Lithium carbonate Valproic acid Carbamazepine 36 列 Extrapyramidal toxicity aloperidol ozapine Chlorpromazine Aripiprazole 37 臨 來 療 金 Sinemet 列 兩 Levodopa Selegiline Levodopa Carbidopa Levodopa Amantadine 38 列 Caffeine 理 泌 率 量 Levodopa Benztropine 利尿 滑

4 Ipecac Apomorphine 列 Ipecac 若 Phenothiazine 類 Apomorphine Ipecac Ipecac Apomorphine 不 40 療 列 來 療 erpes simplex virus Retrovirus Adeno-associated virus Lentivirus 41 列 morphine 量 -Demethylation 3--Glucuronidation 6--Sulfation 6--Glucuronidation C C 2 5 CYP 450 C C C 2 5 oxidation Amidase C 3,-diethylglycine 2-methylaniline,-diethylglycine 2,6-dimethylaniline -ethylglycine 2-methylaniline -ethylglycine 2,6-dimethylaniline 43 列 不 amphetaminear-c 2 -C(C 3 )( 2 )phase I -Ar-C 2 -C(C 3 )( 2 ) Ar-C 2 -C-C 3 Ar-C--C 2 -C Ar-C()-C(C 3 )( 2 ) 44 列 2 2 C 3 C 3 2 C 3 C 3 C 3 45 列 terbutaline MA β 2 - resorcinol 46 療 arylcarbamate Donepezil Carbachol Tacrine Rivastigmine 47 列 atropine 易 Procaine Lidocaine Pramoxine Dibucaine

5 48 列 Lysergic acid diethylamide Ergotamine Methysergide Methylergonovine Arylanthranilic acid 類 (o-c 2 )Ar-X-Ar(R 1 )(R 2 )X 什 C 2 S 50 C-3 C-6 行 acetylation µ 力 51 列 不 列 X µ antagonist C3 X C 52 列 刺 2 2

6 Molindone 列 β-aminoketones aloperidol Chlorpromazine ndansetron Risperidone 54 列 melatonin 類 Acetylcholine Dopamine orepinephrine 5-T 55 diazepam 列 C 3 3 2' -Demethylation C-2' C-3 C 2 C 3 56 列 dopamine agonist C 3 C 3 C 3 7 C 3 57 Met-enkephalin opioid peptide 列 Tyr-Gly-Gly-Phe-Leu Tyr-Gly-Phe-Phe-Met Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile Tyr-Gly-Gly-Phe-Met 58 列 Enalapril pro-drug chiral centers ACE free carboxylic acid

7 利尿 列 2 2 S S pka 7 sulfonamide 6 3,4 3,4-dihydro 3 60 列 降 prazosin terazosin Quinolinol Quinazoline Quinolone Quinidine 61 FosinoprilACEZn 2 C 2 C 2 C P 62 eparin mucopolysaccharide 列 不 heparin 類 α-d-glucuronic acid α-d-glucose Sulfated α-l-iduronic acid Sulfated -acetyl-α-d-glucosamine 63 aglycone C-3 sugar 連 列 glucosidic linkage α-1,4 β-1,4 α-1,6 β-1,6 64 列 corticosteroid 不 Triamcinolone acetonide Budesonide Mometasone furoate Fluticasone propionate 65 列 狀 thyroxine peptide T3 T4 MIT 狀 66 列 C 3 C 3 C 3 + C Estradiol Anastrozole Ethinyl estradiol Raloxifene

8 Bisphosphonates 理念 類 Phosphate Phosphite Phosphamide Pyrophosphate 68 estrogenic activity 兩 離 A 7.3~ ~ ~ ~ 列 Codeinemorphine Meperidinenormeperidine Cyclophosphamidealdophoramide Terfenadinefexofenadine 70 列 類 Ebastine Loratadine Azathioprine Ketotifen 71 Amikacin L-amino-α-hydroxybutyric acidl-aba kanamycin A Deoxystreptamine Streptidine Streptose Glucosamine 72 列 signal transduction Arsenic trioxide Etoposide Imatinib Interferon alpha-2a 73 列 1,2,4-triazolecarboxamide ribose nucleoside 類 ribavirin zidovudine ganciclovir idoxuridine 74 列 不 bioactivation 6-Mercaptopurine 5-FU Doxorubicin Cyclophosphamide 75 列 methyl carbocation Dacarbazine Procarbazine Cyclophosphamide Busulfan 76 thiabendazole 了 benzimidazole 列 Thiazole Piperazine Imidazole Isoxazole 77 列 isoleucyl transfer-ra synthase Mupirocin Linezolid Fosfomycin ovobiocin 78 Zidovudine AZT 3 -Azido-2,3 -dideoxythymidine 3 -Azido-3 -deoxythymidine 2,3 -Dideoxy-3 -azidothymidine 3 -Deoxy-3 -azidothymidine 79 hypoxanthine 料 phosphorus pentasulfide 理 列 Melphalan Methotrexate Thioguanine Mercaptopurine 80 列 zidovudine 類 錄 non-nucleoside reverse transcriptase inhibitors; RTIs 糖 3-C azido phosphorylation 錄 glucuronide