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1 理葉 CNFH 行 87 年年 6 30 類葉 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Streptococcus sanguis Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa Candida albicans 行葉葉葉葉度 MIC 殺度 MBC 葉 1500ppm 度 2500ppm 殺蘭 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Streptococcus sanguis 不若葉 2500ppm 度 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Escherichia coli Pseudomonas aeruginosa 更 Candida albicans 葉度 MIC 殺度 MBC 來勞年來切 Areca catechu Piper betle L.; arecaidineareoline 類類 [20] 葉更 safrole eugenol 易 [6] 葉數異 ; 葉 [22] 類 DNA [23] 行不力 1993 年量

2 不年來力類了 [21] 葉利料料 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Streptococcus sanguis Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa Candida albicans 來來葉 MerckKGaA Darmany 葉葉 100g 100ml 離冷度濾利冷濾利硫濾 50 葉 100g 狀 100ml 冷度 watman paper 濾 45 量 250mg/ml (Disk diffusion susceptibility test) 度利度 600nm 0.1A 0.1ml Mueller-Hinton Agar (Streptococcus sanguis Candida albicans Blood Agar Yeast Malt extract Agar) 葉 6mg/per disk 度 8mm Candida albicans 4 量 [17] 度 (the minimum inhibitory concentration MIC) 殺度 (the minimum bactericidal concentration MBC) 利 (Broth microdilution MIC test) 利度 600nm 0.1A 0.1ml 0ppm 500ppm 1000ppm 2000ppm 2500ppm 葉 Mueller-Hinton Broth 連 Plate Count Agar (Candida albicans 4 數 [18] 數 0ppm 數度度 (MIC) 數數殺度 (MBC) 論

3 葉葉葉 [14] 異行 MIC MBC Miranda Miranda 見行葉茶葉 sunphenon Streptococcus mutans Streptococcus sobrinus sunphenon 料降罹率 30%[4] 1000 ppm 2000ppm 便殺 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Klebsiella pneumoniae MIC MBC 500ppm 葉良 1500ppm 度 2500ppm 殺不若葉 2500ppm 度 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Escherichia coli Pseudomonas aeruginosa 更 Candida albicans MBC 2500ppm 度殺 Streptococcus 兩 6 [9] 不若論葉葉葉力 [14] 葉 Escherichia coli 離類類 Staphylococcus aureus Staphylococcus epidermidis MIC MBC 500ppm Staphylococcus Staphylococcus 葉 MIC MBC 葉力不力 [17] 論葉蘭 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Streptococcus sanguis Candida albicans

4 葉隆 [2] [4] 茶葉蘭葉數殺蘭更利來參李 9 3 pp 隆 24 2 pp pp pp 若念 34 3 pp pp 茶 125 pp 料 27 9 pp 若 8 2 pp 葉 22 pp 若不 pp pp 臨 43 3 pp 論立北 1991 Batt, C., Solberg, M. and Ceponis, M., Inhibition of Aflatoxin Production by Carrot Root Extract, J. Food Sci. Vol. 45, pp. 1210, 1980 De Miranda, C. M. Van Wyk, C. W., Van der Bijl K. P.and Basson N. J., The Effect of Areca Nut on Salivary and Selected Oral Microorganisms, International Dental J., Vol. 46, pp , Isenberg, H. D., Clinical Microbiology Procedures Handbook, American Society for Microbiology, Washington, D. C., pp ,1992. Isenberg, H. D., Clinical Microbiology Procedures Handbook, American Society for Microbiology, Washington, D. C., pp , Kyung, K. H. and Fleming, H. P., Antibacterial Activity of Cabbage Juice Against Lactic Acid Bacteria, J. Food Sci., Vol. 59, pp. 125, Rao. A. R., Sinha, A. and Selvan, R. S., Inhibitory Action of Piper betle on the

5 Initiation of 7,-12-dimethylbenz[a]anthracene-induced Mammary Carcinogenesis in Rats, Cancer Letter, Vol. 26, pp207, Shelef, L. A., Naglik, O. A. and Bogen, D. W., Sensitivity of Some Common Food-borne Bacteria to the Spices Sage, Rosemary and Allispice, J Sci., Vol. 45, pp. 1042, 1980 Shinohara, K., Kuroki, M.,Kong, Z., L., and Hosoda, H., Antimutagenicity of Dialyzates of Vegetables and Fruits, Agric. Biol. Chem. Vol. 52, pp. 1369, Stich, H. F. and Stich, W., Chromosome-damaging Activity of Saliva of Betel Nut and Tobacco Chewers, Cancer Letters, Vol. 15, pp193, Zaika, L. L. and Kissinger, Inhibitory and Stimulatory effects of oregano on Lactobacillus plantarum and Pediococcus cervisiae, J. Food Sci. Vol. 46, pp. 1215, 1981, 類度類度 Staphylococcus aureus G(+) 37 Tryptic Soy Agar Staphylococcus epidermidis G(+) 37 Nutrient Agar Streptococcus mutans G(+) 37 Brain Heart Infusion Streptococcus sanguis G(+) 37 Blood Agar Escherichia coli G(-) 37 Nutrient Agar Klebsiella pneumoniae G(-) 37 Nutrient Agar Pseudomonas aeruginosa G(-) 37 Nutrient Agar Candida albicans 24 Yeast Malt extract Agar 不 (mm) () (37 (100 Staphylococcus aureus 9 12 Staphylococcus epidermidis Streptococcus mutans 17 Streptococcus sanguis Escherichia coli Klebsiella pneumoniae 11 Pseudomonas aeruginosa Candida albicans b 度 6mg/disk c 8mm

6 不 (mm) () (37 (100 Staphylococcus aureus 31 Staphylococcus epidermidis 37 Streptococcus mutans 37 Streptococcus sanguis Escherichia coli Klebsiella pneumoniae 12 Pseudomonas aeruginosa Candida albicans b 度 6mg/disk c 8mm 葉不 (mm) () (37 (100 Staphylococcus aureus 35 Staphylococcus epidermidis 37 Streptococcus mutans 46 Streptococcus sanguis Escherichia coli Klebsiella pneumoniae 33 Pseudomonas aeruginosa Candida albicans b 度 6mg/disk c 8mm

7 葉 8 度 MIC 殺度 MBC 葉 Staphylococcus aureus Staphylococcus epidermidis Streptococcus mutans Streptococcus sanguis Escherichia coli Klebsiella pneumoniae Pseudomonas aeruginosa Candida albicans 殺

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