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4 (Analytical Spectrum) 1 Biosensors 2 Electro Analysis 3 Environmental 4 Drug Discovery 5 Food Quality and Safety 6 Gas and Liquid-phase Chemical Sensors 7 Life Sciences Research

5 10) 11)

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7 14) 15)

⑴ Automation-robotics, cloning, DNA and RNA purification, electrophoresis, food and GMO testing, genotype analysis, in-vitro Genomics transcription, microarrays, PCR, plant biotechnology, reverse

RNA interference, and transfection Genetic identity Genetic identity analysis Apoptosis, automation-robotics, cell viability, drug discovery, gene Cellular expression and reporter assays,

8 ⑴ Automation-robotics, cloning, DNA and RNA purification, electrophoresis, food and GMO testing, genotype analysis, in-vitro Genomics transcription, microarrays, PCR, plant biotechnology, reverse transcription and DNA synthesis, RNA interference, and sequencing Electrophoresis, gene expression and reporter assays, mutagenesis, Proteomics protein interactions, protein expression and analysis, RNA interference, and transfection Genetic identity Genetic identity analysis Apoptosis, automation-robotics, cell viability, drug discovery, gene Cellular expression and reporter assays, Immunological detection, In vitro analysis toxicology, signal transduction (including neuroscience), transfection CAGR Res Lab ,006 1, % POC 1,803 2,005 2,230 2,439 2,679 2,945 3,218 4,259 6, % HM Diag ,069 1,174 1,290 1,790 2, % Process % Env ,209 2, % Security % 3,905 4,270 4,682 5,106 5,595 6,143 6,723 9,128 14, %

9 BioAgent Detector Bioreporter Multi-analyte Sensing Flow Immunosensor Optical Fiber and Fluoroimmunoassay Medical Telesensors Anthropometry LifeSensors 25.0% 16.0% Biocore 19.0% 10.0% GE 3.9 Affinity Sensors 10.0% Thermo Scientific LifeScan, Inc 16.0% 10.0% Oxford Biosensors 6.0% NASA 5.0% Sensortec Limited(universal Sensors Ltd) 4.0% Ibis BioSciences 4.0% Axela Biosensors 4.0% Honda Trading Co; (Tokyo, Japan) 5.0% 3.0% Biosensor Research Institute of America 3.0% Chiron 2.0% 2.0% % 77.0% ⑵ Glucose Cardiac biomarkers Infectious diseases Coagulation PT Pregnancy Coagulation ACT Cholesterol Hematology AIC Drugs of abuse

10 Roche Diagnostic 16.0% 15.0% Abbott 14.0% 13.0% LifeScan, Inc 13.0% 12.0% Bayer 12.0% 11.0% MediSense 10.0% 9.0% Axela Biosensors, Inc 5.0% Advanced Biosensor Inc 5.0% M-Biotech, Inc; 3.0% Ibis BioSciences, Inc. 2.0% 65.0% 75.0% ⑶ Glucose Meters Coagulation Meters Cholesterol Meters Other Testing Meters LifeScan, Inc 20.0% 18.0% Roche Diagnostic 18.0% 16.0% Abbott 10.0% 10.0% - Bayer 8.0% 8.0% - MediSense 5.0% 5.0% - Oxford Biosensors Ltd 3.0% 3.0% - Ibis BioSciences, Inc. 3.0% Axela Biosensors, Inc 3.0% 64.0% 66.0%

11 ⑷ 방법은 전류측정 전위차 으로분류 Alcohol Glucose Lactic Acid Peptide E.coli Salmonella Listeria Universal Sensors 13.0% 13.0% - Affinity Sensors 12.0% 12.0% - Yellow Springs 11.0% 11.0% - Sensortec Limited(Universal Sensor) 10.0% NASA 7.0% 36.0% 53.0% ⑸

12 Toxicity BOD Ecoli/Coliform Crypto Girdia MicroCystins Strategic Diagnostics(AZUR) 16.0% 16.0% - Waste Technologies of Australia Pty.Ltd 13.0% 13.0% - Remedios 12.0% 12.0% - Sensortec Limited(Universal Sensors) 8.0% Bruno Lange & Hach Lange 8.0% 8.0% % 57.0% ⑹ West Nile, SARS(Severe Acute Respiratory Syndrome), Anthrax Biological detection E.Coli 0157:H7, BSE(Bovine Spongiform Encephalopathy) Drug and narcotic Cocaine, Meth-amphetamines, Ecstasy, Opiates detection THC(cannabis)(Tetrahydrocannabinol) TNT explosives(tri-nitrotoluene), Tetryl, Nitroglycerin Chemical and explosive DNT(Di-nitrotoluene or Dinitro) substance detection RDX(Cyclo tri-methylene tri-nitramine-cyclonite, hexogen, and T4) PETN(Pentaerythritol Tetranitrate)

13 West Nile SARS E.coli BSE Anthrax Cocaine Metha-Phetam Ecstasy Opiates THC cannabis TNT explosives Tetryl DNT RDX Nitro-glycerin PETN ) 전게서 Toray Imdustries(America), Inc. 12.0% 11.0% Gen-Probe 11.0% 10.0% InPro 10.0% 9.0% Prionics 10.0% 9.0% NASA 7.0% Innovative Biosensors 6.0% Biosensor Applications Sweden AB. 6.0% BioRad 8.0% 5.0% ExmovereLLC(ExmovereHoldings) 5.0% 51.0% 68.0% Research Drug Discovery 3.0% 3.3% 3.6% Laboratories Rest of Research 8.4% 8.5% 8.0% Cholesterol 1.2% 1.4% 1.5% Home Diagnostics Coagulation() 1.6% 1.7% 1.9% Glucose* 31.2% 31.6% 30.3% 1.1% 1.5% 1.4% Cholesterol 2.5% 2.0% 1.9% Cardiac Biomarkers 6.8% 7.5% 8.6% Infectious Diseases 5.9% 5.8% 7.3% Pregnancy 4.2% 3.6% 1.9% POC Drugs of Abuse 1.9% 1.7% 0.9% Coagulation PT 4.2% 4.6% 5.2% Coagulation ACT 2.9% 2.6% 2.3% Hematology 3.2% 2.8% 1.8% A1C 1.7% 0.9% 1.2% Alcohol 2.3% 2.3% 2.1% Lactic acid 1.3% 1.3% 1.2% Process Industries Peptides 0.7% 0.7% 0.7% E.coli 0157:H7 0.4% 0.4% 0.3% Salmonella 0.3% 0.3% 0.3% Listeria 0.2% 0.2% 0.2% Toxicity 7.8% 8.8% 10.6% Ecoli/Coliform 3.3% 3.3% 2.9% Env. Monitoring Crypto 0.3% 0.3% 0.3% Girdia 0.3% 0.3% 0.3% Micro Cystins 0.5% 0.5% 0.5% West Nile Virus 0.3% 0.3% 0.4% SARS 0.3% 0.3% 0.4% E.coli 0157:H7 0.3% 0.3% 0.4% Biological Detection BSE (Bovine Spongiform Encephalopathy) 0.3% 0.3% 0.3% Anthrax 0.1% 0.2% 0.2% Cocaine 0.1% 0.1% 0.2% Drug and Narcotic Meth-amphetamines 0.1% 0.1% 0.1% Security & Ecstasy 0.1% 0.1% 0.2% Detection Bio defense Opiates 0.1% 0.1% 0.1% THC (cannabis) 0.0% 0.1% 0.1% TNT Explosives 0.1% 0.1% 0.1% Tetryl 0.0% 0.1% 0.1% DNT 0.1% 0.1% 0.1% Explosive Detection RDX 0.1% 0.1% 0.2% Nitroglycerin 0.0% 0.04% 0.06% PETN(Pentaerythritol Tetratrate) 0.03% 0.03% 0.05% ( )

14 : : Vol.5, No 기계기술정책 KIMM Technology Policy 발행처 한국기계연구원정책연구실 발행일 기획 편집 곽기호, 박효주, 박준식 ( 자연모사연구실 ), 석호준 ( 한국생명공학연구원 ) 김재윤, 오승훈, 정준호 주소 대전광역시유성구가정북로 156번지 전화 (042) ( 정책연구실 ) 35) (2002),

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src.hwp 1. 바이오센서란? 정의 바이오센서는생체감지물질 * 이특정물질과선택적으로반응 결합하는성질을이용하여분석물질 ** 의존재여부를신호변환기 *** 로확인할수있는장치및소자를지칭 - 생체감지물질 (Bio Receptor): DNA, RNA, 항체 (Antibody), 효소, 단백질, 세포, 생체막및호르몬수용체등의바이오물질 - 분석물질 (Analyte): 분석하고자하는물질또는화학성분