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1 KISEP Original Article 생물정신의학 Vol. 11, No. 2, November 2004 만성정신분열병환자들의인지기능과정서인식능력의관련성 * 황혜리 ** 황태연 ** 이우경 ** 한은선 ** The Relationship between Neurocognitive Functioning and Emotional Recognition in Chronic Schizophrenic Patients * Hye-Li Hwang, M.A., ** Tae-Yeon Hwang, M.D., PhD., ** Woo-Kyung Lee, M.A., ** Eun-Sun Han, M.D. ** ABSTRACT O bjective- - Methods Results Conclusion - Yongin Psychiatric Rehabilitation Center, Yongin Mental Hospital, Yongin, Korea 교신저자

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3 1. 피험자 연구대상및방법 2. 측정도구 1) 신경인지기능

4 - 2) 정서인식과제 (Emotional Recognition Task: ERT) 3. 연구설계및통계분석 1. 인구통계학적자료 연구결과 2. 정서인식, 정서변별, 맥락인식, 정서능력과신경인지기능간의상관관계

5 3. 정서인식, 정서변별, 맥락인식, 정서능력에대한신경인지기능과관련된변인들의설명. Table1. Demographic data and baseline characteristics of all patients Characteristics Subjectsn48 Male/Female 14/34 Age Duration of education Age at first onset of illness Age at first admission Number of admission Duration of present admission Duration of illness ) 정서인식을종속변인으로한위계적회귀분석결과 2) 정서변별을종속변인으로한위계적회귀분석결과 Table 2. The relationship between neurocognitive functioning and emotional measure Emotional recognition Emotional discrimination Contextual recognition Emotional capacity Digit Span Block Design **.4351** K-HVLTimmediate recall sum K-HVLTrecall K-HVLTrecogniton Word fluencysemantic *.2923* Word fluencyphonetic *.2095 Working memory **.3627*.4334** Spannumber *.3002* Spannumber *.2982* Cpthit rate p.05, p

6 3) 맥락인식을종속변인으로한위계적회귀분석결과 Table 3. Hierarchical regression analysis predicting emotional recognition Predictor B SE B R 2 R 2 F change 1 Early visual processing SPAN SPAN Sustained attention CPT Working memory Letter number sequencing test Immediate memory Digit span Verbal memory K-HVLTimmediate recall K-HVLTrecall K-HVLTrecognition Executive function Block design Semantic Phonetic Table 4. Hierarchical regression analysis predicting emotional discrimination Predictor B SE B R 2 R 2 F change 1 Early visual processing SPAN * SPAN Sustained attention CPT Working memory * Letter number sequencing test ** 4 Immediate memory * Digit span Verbal memory K-HVLTimmediate recall K-HVLTrecall K-HVLTrecognition Executive function Block design Semantic Phonetic p.05, p

7 Table 5. Hierarchical regression analysis predicting contextual recognition Predictor B SE B R 2 R 2 F change 1 Early visual processing * SPAN * SPAN * 2 Sustained attention * CPT * 3 Working memory * Letter number sequencing test * 4 Immediate memory * Digit span * 5 Verbal memory * K-HVLTimmediate recall * K-HVLTrecall * K-HVLTrecognition * 6 Executive function * Block design * Semantic * Phonetic * p.05 Table 6. Hierarchical regression analysis predicting contextual recognition Predictor B SE B R 2 R 2 F change 1 Early visual processing * SPAN * SPAN * 2 Sustained attention * CPT * 3 Working memory * Letter number sequencing test * 4 Immediate memory * Digit span * 5 Verbal memory * K-HVLTimmediate recall * K-HVLTrecall * K-HVLTrecognition * 6 Executive function * Block design * Semantic * Phonetic * p.05, p.01 4) 정서능력을종속변인으로한위계적회귀분석결과

8 Table 7. Comparison of emotional recognition test between upper 25% and lower 25% in working memory Upper 25%n13 Lower 25%n19 Meansd Meansd t p Emotion recognition Emotion discrimination *.013 Contextual recognition *.036 Emotion capacity **.009 p.05, p 작업기억점수를기준으로상위 25%, 하위 25% 나누어두집단간차이비교 논 의

9 중심단어 : 참고문헌 1. Bleuler E. Dementia praecox or the group of schizophrenia(tran. Zinkin, J). International Universities Press;1950, New York. 2. Heimberg C, Gur RE, Erwin RJ, Shtasel DL, Gur RC. Facial emotion discrimination: III. behavioral findings in schizophrenia. Psychiatry Res 1992;42: Morrison RL, Bellack AS, Mueser KT. Deficits in facial-affect recognition and schizophrenia. Schizophr Bull 1998;14: Kerr SL, Neale JM. Emotion perception in schizophrenia: Specific deficit or further evidence of generalized poor performance? J Abnorm Psychol 1993;102: Schneider F, Heimann H, Himer W, Huss D, Mattes R, Adams B. Computer based analysis of facial action in schizophrenic and depressed patients. European Analysis of Psychiatry and Clinical Neuroscience 1990;40: Kerr SL, Neale JM. Emotion perception in schizophrenia: Specific deficit or further evidence of generalized poor performance? J Abnorm Psycho 1993;102: Salem JE, Kring AM. More evidence for Generalized Poor Performance in Facial Emotion Perception in schizophrenia. J Abnorm Psychol 1996;105: Mueser KT, Doonan R, Penn DL, Blanchard JJ, Bellack AS, Nishith P, Deleon J. Emotion recognition and social Competence in chronic Schizophrenia. J Abnorm Psychol 1996;105: Ihnen GH, Penn DL, Corrigan PW, Martin J. Social perception and social skill in schizophrenia. Psychiatry Res 1998;80: Kee KS, Green MF, Mintz J, Brekke JS. Is Emotion Processing a Predictor of Functional Outcome in Schizophrenia? Schizophrenia Bull 2003;29: Kee KS. Kern RS, Green MF. Perception of Emotion and neurocognitive functioning in Schizophrenia: What s the link? Psychiatry Res 1998b;81: Schneider F, Gur RE, Shtasel DL. Emotion Processing in Schizophrenia: Neurobehavioral probes in relation to

10 psychopathology. Schizophr Res 1995;17: Bryson G, Bell M, Lysaker P. Affect recognition in Schizophrenia:A function of global impairment or a specific cognitive deficit? Psychiatry Res 1997;71: Addington J, Addington D. Facial affect recognition and information processing in schizophrenia and bipolar disorder. Schizophr Res 1998;32: Feinberg TE, Rifkin A, Schaffer C, Walker E. Facial discrimination and emotional recognition in schizophrenia and affective disorder. Arch Gen Psychiatry 1986;43: 이수정. 문제해결과제를이용한정서인식력검사의개발. 한국심리학회지, 사회및성격 2001; 15: 전용신, 서봉연, 오창우. 한국판웩슬러지능검사실시요강 ; 서울, 중앙교육연구소. 18. 신경인지기능연구회. 임상신경인지기능검사집 ; 강연욱. 치매의신경심리학적평가 : 서울신경심리학검사 (SNSB); Wechsler B. The Wechsler Adult Intelligence Scale. Third edition: The Psychological corporation. WAIS; Asarnow RF, Nuechterlein KH. The Span of Apprehension(SPAN) Program for IBM-Compatible Microcomputers, Version 5.3;1999, Los Angeles, Authors. 22. Nuechterlein KH, Asarnow RF. Degraded stimulus Continuous Performance Test(DS-CPT) Program for IBM-Compatoble Microcomputer, Version 8.12.;1999, Los Angeles: Authors. 23. Kohler CG, Bilker W, Hagendoorn M, Gur RE, Gur RC. Emotion recognition deficit in schizophrenia: Association with symptomatology and cognition. Biol Psychiatry 2000;48: Baddely AD. Working memory. Science 255;1992. p Green MF, Marshall BD. Jr., Wirshing WC, Ames D, Marder SR, McGurk S, Kern RS, Mintz J. Does risperidone improve verbal working memory in treatment resistant schizophrenia? Am J Psychiatry 1997;154: 황태연, 김형섭, 이우경, 한은선, 강대엽, 황혜리. 리스페리돈이만성정신분열병환자들의인지기능및정신사회재활성과에미치는영향. 정신분열병클리닉 2004;7:

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Microsoft Word doc KISEP Original Article J Korean Neuropsychiatr Assoc Vol 44, No 3 만화과제를이용한정신분열병환자의사회인지능력의측정 오정은 1,2 나명현 1,2 하태현 1,3 신용욱 1 노규식 1 홍순범 3 이경진 3 신민섭 3 이영호 2 권준수 1,3 Social Cognition Deficits of Schizophrenia