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1 B I O S P E C T R U M Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

2 We offer all our expertise for scientific advice Laboratory for Evaluation of Cosmetic product safety and efficacy and consultancy B I O S P E C T R U M

B I O S P E C T R U M Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions,

3 B I O S P E C T R U M Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

4 B I O S P E C T R U M 바이오스펙트럼생명과학연구소 바이오스펙트럼연구소는피부의학전문연구기관으로기능성물질의탐색에서제품개발에이르는모든과정에대한연구력을수년간구축하여왔습니다. 신물질효능검색을위한 in vitro 시험에서임상시험까지 one-step 으로해결할수있는네트워크구축 [ 제휴협력기관 : 더마프로 ( 임상시험 ), 켐온 ( 동물시험 )] 기능성시험및관련인허가대행업무서비스본연구소에서수행한시험결과는한국식품의약품안전청 (KFDA) 에제출용으로사용가능 유효성시험 in vitro 바이오스펙트럼 안전성시험 동물시험 켐온 임상효능시험 더마프로

5 B I O S P E C T R U M Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

6 유효성시험 IN VITRO SAFETY & EFFICACY EVALUATION 피부자극 ( 홍반, 자극 ) 피부증상 미백 ( 기미, 주근깨, 점 ) 주름 피부면역, 염증 ( 아토피, 건선, 지루, 여드름 ) 감염 ( 여드름, 비듬, 무좀, 아토피, 액취증 ) 비만 발모 실험서비스 - 세포독성시험 (MTT assay) - 항산화실험 (DPPH, SOD, Lipid peroxidation assay) - 염증사이토카인분석 (TNF-α, IL-8, COX-2, Eotaxin, NO 생산억제능시험 ) -Mushroom tyrosinase 활성억제시험 - 멜라닌세포에서 tyrosinase 활성억제시험 - 멜라닌세포에서멜라닌합성측정 -Elastase 활성억제능시험 -Human fibroblast 세포증식시험 (Cell counting kit) -Human fibroblast 에서엘라스틴합성측정 -Human fibroblast 에서콜라겐합성측정 -Human fibroblast 에서 MMP 억제능시험 (Assay kit & Zymogram) - 항산화시험 - 면역조절능분석 : IL-2 - 염증사이토카인분석 (TNF-α, IL-4, IL-8, COX-2, Eotaxin, NO 생산억제능시험 ) -NF-κB luciferase activity 측정 -MIC 시험 -Disk diffusion 시험 - 방부력시험 (Challenge Test) - 비만세포분화억제능측정 (oil-red O 염색 ) -GPDH 억제능시험 -Hair follicle dermal papilla cell proliferation

Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate

7 Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

8 안정성시험 ( 원료 / 제품안정성및유효성분분석 ) 시험분석항목 기능성화장품의주성분분석및안정성시험 실험서비스 - 자외선차단제 : 벤조페논계, 트리아진계, 신나메이트계등 - 주름개선화장품 : 레티놀과그의유도체, 토코페롤과그의유도체, 비타민 C 와그의유도체, 아데노신등 - 미백화장품 : 알부틴, 비타민 C 의유도체, 글라브리딘 ( 유용성감초추출물 ) 보존제및방부제의분석항산화제의분석비타민류의분석천연물의분석 - 파라벤류및살리실산, 안식향산, 트리클로산및기타보존제성분 (BHT etc) - 아스코빅산 -BHT, BHA -Coenzyme Q10(Co-Q10) - 레티놀과그의유도체 - 토코페롤 - 수용성비타민의분석 : 아스코빅산, 니코티닉산, 나이아신아미드등 - 지용성비타민의분석 : 레티놀및그의유도체, 토코페롤및그의유도체 - 페놀릭산, 플라보노이드 ( 플라본, 이소플라본, 플라보놀등 ), 폴리페놀 ( 카테친류 ) - 인삼추출물중의진세노사이드 - 우르솔릭산등의트리터펜 ( 원료및제제 ) - 제제내의천연성분의분석및분리정제

9 B I O S P E C T R U M Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

10 보유세포및균주 주름관련 분류 Fibroblast, NIH3T3 보유세포 미백관련상처치유항암관련여성호르몬효과면역, 염증비만 Human normal melanocyte, B16 melanoma cells, Melan-a Fibroblast, HaCaT B16 melanoma cells, MCF-7, HT-1080 MCF-7 THP-1, EL-4, Jurkat T, RAW264.7, HaCaT, Fibroblast, NIH3T3 3T3-L1 adipocyte cells 여드름비듬무좀세균진균 분류 Propionibacterium acnes Pityrosporum ovale Epidermophyton floccosum 보유미생물 Bacillus subtilis, stapylococcus aureus subsp. aureus, E. coli, Pseudomonas aeruginosa, Yeast: Candida albicans, Filobasidiella neoformans, Pityrosporum ovale Mold: Aspergillus niger, Trichophyton mentagrophytes, Epidermophyton floccosum

11 B I O S P E C T R U M Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

12 연구경력 미백 _Effect of Kojic acid, Arbutin and Vitamin C on cell viability and melanin synthesis in B16BL6 cells. Journal of the society of cosmetic scientists of Korea. 2003,29(1) _Glycyrrhizin(GR) induces melanogenesis by elevating a camp level in B16 melanoma cells. The Journal of Investigative Dermatology. Feb 2005, 124(2), _Mechanisms of of depigmentation by bisabolol. Journal of Dermatological Science. 2008, 52(3), _Melanogenesis inhibitory effect of fatty acid alkyl esters isolated from Oxalis triangularis. Biological & Pharmaceutical Bulletin. July 2010, 33(7): _Whitening effect of α-bisabolol in Asian women. International Journal of Cosmetic Science. Aug 2010, Aug. 32(4) _Mechanisms of depigmentation by propafenone. Archives of Dermatological Research. Sept. 2010, 302(7): _Depigmentation by platycodin D is mediated by camp-pka/rho-dependent signaling pathway. Experimental Dermatology. Dec. 2011, 20(12): 주름 _Asiaticoside induces Human Collagen I Synthesis through TGFb receptor I kinase (TbRI kinase) Independent Smad signaling. Planta Medica in press. _Emodin inhibits TNF alpha-induced MMP-1 expression through suppression of activator protein-1 (AP-1). Life Sci Aug 17 in press _Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling. J Ethnopharmacol Jul 3 in press. _Matrine inhibits PMA-induced MMP-1 expression in human dermal fibroblasts. Biofactors. 2008, 33(2): _Effect of Camellia japonica oil on human type I procollagen production and skin barrier function. Journal of Ethnopharmacology. May 2007, 112, _Mechanisms of carvacrol-induced expression of type I collagen gene. Journal of Dermatological Science. 2008, 52(3), _Effect of a preparation containing asiaticoside on periocular wrinkles of human voluntaries. International Journal of Cosmetic Science. 2008, 30(3)

13 연구경력 항염 _Evaluation of the Anti-inflammatory and immunomodulatory effects of BSASM using in vitro experiments. Kor. J. Pharmacogn. 2003, 34(3) _Evaluation of the anti-inflammatory and atopic dermatitis-mitigating effects of BSASM, a multicompound preparation. J. Ethnopharmacol. Jan 2005, 96(1-2), _Anti-inflammatory effects of magnolol and honokiol are mediated through inhibition of downstream pathway of the MEKK-1 in NF-kB activation signaling. Planta medica Apr (4), _Rosmarinic acid as a downstream inhibitor of IKKbeta in TNF-alpha-induced upregulation of CCL11 and CCR3.Br J Pharmacol Jun;148(3): _Involvement of nuclear factor-kappab in the inhibition of pro-inflammatory mediators by pinosylvin. Planta Med Jul;72(9): Epub 2006 Jun 19 비만 _Isorhamnetin-induced antiadipogenesis is mediated by stabilization of β-catenin protein. Life Sciences. March 2010, 86(11-12): _Anti-adipogenesis by 6-thioinosine is mediated by downregulation of PPARγthrough JNKdependent upregulation of inos. Cellular and Molecular Life Sciences. Feb 2010, 67(3): _Isorhamnetin represses adipogenesis in 3T3-L1 cells. Obesity. Feb 2009, 17(2): _Inhibitory effects of serotonin derivatives isolated from safflower seed extract on adipogenesis. Journal of the Society of Cosmetic Scientists of Korea. 2011, 37(2) _The study on anti-obesity activity of the wild plants of Jeju Island. Journal of the Society of Cosmetic Scientists of Korea. 2007, 33(3)

14 연구경력 항균 _In vitro antibacterial and anti-inflammatory activities of Honokiol and Magnolol against Propionibacterium sp.. European Journal of Pharmacology. 2004, 496(1-3), _Antibacterial activities of Butyrolactone from Spiraea thunbergii Sieb. against foodborne pathogenic microorganisms. Journal of Medicinal Plants Research. 2008, 2(3), _Synthesis and microbiological evaluation of honokiol derivatives as new antibacterial agents. Archives of Pharmacal Research. Jan 2010, 33(1): 줄기세포 _Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-β1. The Journal of Nutritional Biochemistry. Jan. 2012, /j.jnutbio _Mechanisms of edible bird s nest extractinduced proliferation of human adipose-derived stem cells. Evidence-Based Complementary and Alternative Medicine. Nov. 2011, 2012: Article ID , DOI: /2012/ _Melanocyte-Precursor Cell Induction from Human Cord Blood-Derived Mesenchymal Stem Cells. African Journal of Biotechnology. Sept. 2010, 9(36): _Promotion of stem cell proliferation by vegetable peptone. Cell proliferation. Oct 2009, 42(5):

15 B I O S P E C T R U M Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

16 연구경력 발모 _A cell-based system for screening hair growthpromoting agents. Archives of Dermatological Research. Jun 2009, 301(5): 기타 _Transdermal delivery of interferon g (IFN g) mediated by penetratin, a cell-permeable peptide. Biotechnology and applied Biochemistry 24 Dec 2004, submitted _Simple stability-indicating validated HPLC method for diosgenin in cosmeceutical formulations. International Journal of Pharmacy and Pharmaceutical Sciences. Dec 2011, 3(suppl 5); _Myricetin protects cells against oxidative tressinduced apoptosis via regulation of PI3K/Akt and MAPK signaling pathways. International Journal of Molecular Sciences. Nov. 2010, 11(11): _Enzymatic transformation of platycosides and one step separation of platycodin D by highspeed counter-current chromatography. Journal of Separation Science. Jun 2010, 33(13): _Myricetin suppresses oxidative stress-induced cell damage via both direct and indirect antioxidant. Environmental Toxicology and Pharmacology. Jan 2010, 29: _Phloridzin-induced melanogenesis is mediated by camp signaling pathway. Food & Chemical Toxicology. Oct 2009, 47(10):

17 Biospectrum is specialized in the laboratory phase of this progression that enjoys the grater control of environmental conditions, substrate uniformity, application parameters, test methods and so on, and therefore provides the greatest amount of sensitivity, accuracy, reproducibility and objectivity.

18 보유장비 EFFICACY TESTS AND MARKETING CLAIM SUBSTANTIATION - 검증된분석방법에의한정확하고신뢰성있는결과 - 정성확인과동시에정량분석실시 - 다양한분석기기활용가능 ( 고성능액체크래마토그래피, 가스크래마토그래피, 자외선분광광도계, 적외선분광광도계 ) Fluoremeter,Luminometer Real-time PCR HPLC FACS Confocal microscope GC-MS Skin Visiometer PMA9 Fluorescence microscope

19 실험관련기타사항 1. 실험보고서 2 부작성 2. 실험보고서작성시, 다음사항을제외한다른부분에대해수정을요할시추가비용청구 : 실험주제 / 실험의뢰기관 / 시료명 3. 영문보고서요청시별도비용청구 4. 실험보고서양식은바이오스펙트럼보고서형식을따름 5. 기타시험협의가능

20 실험관련문의 _ info@biospectrum.com _TEL : 유효성시험 효능연구팀 ~4(403, 405) 안정성및유효성분분석 품질관리팀 ~4(442) _Fax : _ 주소 : 경기도성남시중원구상대원동 아인스프라츠 3 차 11 층 _ 홈페이지 : We offer all our expertise for scientific advice and consultancy

BioSpectrum can supply you with all type of the functional cosmetics,

We are ready to supply utmost service for foreign cosmetics companies with

B I O S P E C T R U M 11F Eines Platz Bldg, 442-13 Sangdaewon-dong,

21 BioSpectrum can supply you with all type of the functional cosmetics, specially optimized to the cosmetic law in Korea. We are ready to supply utmost service for foreign cosmetics companies with the new functional cosmetics. B I O S P E C T R U M 11F Eines Platz Bldg, Sangdaewon-dong, Jungwon-gu, Seongnam-si Gyeonggi-do , Republic of Korea Tel: ~4, Fax: Homepage: info@biospectrum.com

슬라이드 1

슬라이드 1 Anti-aging Peptide Anti-wrinkle peptide Whitening peptide Anti-hair loss & hair growing peptide BF-Dynorphin Elastin essential peptide Cyclitol Anagen BF-Enkephalin Elastin anti-wrinkle peptide ElaX-MV