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異欄 Gliadel Wafer 7.7 mg/pce 異 carmustine 8 零 20 度不療 2008/12/17 Clexane 6000 anti-xa 60 mg/0.6 ml /amp Pregnyl 1500 IU/amp enoxaparin sodium human chorionic gonadotropin 復復流 Fluarix, adult 0.5 ml/syrg 流 Vaxigrip, ped 0.25 ml/syrg 12 1 量療流 Vaxigrip, adult 0.5 ml/syrg 2008/11/26 2008/12/16 2008/12/3 異欄 1 2008 年 12 2 異 4 Polifeprosan 20 with carmustine implant Gliadel Wafer 立 5 Tetrabenazine Nitoman ()... 6 Decitabine Dacogen ()... 7

<> Glyceryl trinitrate Concentrate Inj 50 mg/10 ml /amp nitroglycerin 領益留療 2008/12/2 2008 年 12 1. Innohep (tinzaparin sodium injection) FDA 臨 Innohep in Renal Insufficiency Study (IRIS) 2008 年料 Innohep 率都參 2008 年 7 Innohep Innohep 不 90 老 FDA IRIS 臨數不 90 老率 FDA Innohep heparin() 臨 Innohep 不老年 70 率不 / 料 FDA 2009 年 1 IRIS 臨 FDA 行論 FDA 數 Innohep Celgene 臨不老 Innohep heparin 更易療不老不論塞都 Innohep 參 FDA htm#innohep 2008/12/2 & 2008/12/31 2. 20 meq Potassium Chloride in 5% Dextrose and 0.45% Sodium Chloride Injection, USP Hospira, Inc. 20 meq Potassium Chloride in 5% Dextrose and 0.45% Sodium Chloride Injection ( 65-620-FW2010/5/NDC 0409-7902-091000 ml ) 數 5% Dextrose InjectioUSP (NDC 0409-7922-09) 不療不良不不異精神亂 2008 年 7 2008 年 9 療若立 Hospira 聯聯 1-877-946-7747 參 FDA http://www.fda.gov/medwatch/safety/2008/safety08.htm#20meqpotchlor 2008/12/09

3. Healon D Ophthalmic Viscosurgical Device Advanced Medical Optics (AMO) FDA Healon D Ophthalmic Viscosurgical Device (OVD) UD30654 30 mg/ml 量量 AMO 連聯 1-877-266-4543 參 FDA htm#healon 2008/12/11 4. Oral Sodium Phosphate (OSP) Products for Bowel Cleansing (marketed as Visicol and OsmoPrep, and oral sodium phosphate products available without a prescription) FDA 類 sodium phosphate products (OSP) () 類 VisicolOsmoPrep OSPs (Fleet Phospho-soda) 例 FDA Visicol OsmoPrep OSPs FDA 行略臨 FDA 不 OSP OSPs 參 FDA htm#osp 2008/12/12 Fleet Ready to Use Enema 133 ml/btl (monobasic sodium phosphate, dibasic sodium phosphate ) 利樂利 ( 不 ) Fleet Phospho-Soda Oral Saline Laxative 45 ml/btl (each 5 ml contains monobasic sodium phosphate 2.4 g, dibasic sodium phosphate 0.9 g) 利 5. Weight Loss Pills FDA 25 sibutramine ( ) rimonabant () phenytoin ()phenolphthalein ( ) 不路零行不良 ( )FDA 立 FDA 勵 25 見 FDA 參 FDA htm#weight 2008/12/22 6. Hydromorphone HCl 2 mg Tablets ETHEX FDA hydromorphone HCl 2 mg Hydromorphone 療量 ( 藍 "E""2" ETHEX KV Pharmaceutical FDA KV 理理

列見列參 FDA htm#hydromorphone 2008/12/24 異 () 97 年 12 12 0970042727 9 Antineoplastics drugs 98 年 1 1 9.30. dasatinib ( Sprycel)(98/1 /1) 1. 療 imatinib 400 mg() 療 2. 療淋 imatinib 400 mg() 療 3. 歷 imatinib 不良. () 97 年 12 18 Exelon capsules) (90/10/1)galantamine hydrobromide ( Reminyl) (92/1/ 95/6/1) 度度 MMSE 10~26 CDR 1 2 類不歷理 0970043999 9 Antineoplastics drugs 98 年 2 1 9.10. Oxaliplatin89/7/191/10/1 93/8/1 98/2/1 1. 5-FU folinic acid (1) 療若 irinotecan Campto 不 (91/10/1) (2) (Duke's C) 切療 98/2/1 2. Capecitabine 復 / 療 Eloxatin Oxalip 98/2/1 () 97 年 12 12 0970043924 1 神 Drugs acting on the nervous system 98 年 1 1 1.3.3. 療 donepezil ( Aricept)rivastigmine ( Exelon capsules) (90/10/1)galantamine hydrobromide ( Reminyl) (92/1/1)memantine ( Witgen Ebixa ) (95/6/1) 1. 列神精神 NINDS-ADRDA DSM ICD MMSE CDR (1) donepezil ( Aricept)rivastigmine( (93/4/1) 神精神六 MMSE CDR MMSE 療 2 ( 不 ) CDR 1 類 (98/1/1) (2) memantine WitgenEbixa(95/6/1 度度 (10MMSE14

CDR 2 ) donepezil, rivastigmine, galantamine 若不 MMSE CDR (10MMSE14 CDR 2 ) memantine memantine 不神精神六 MMSE CDR MMSE 療 2 ( 不 ) CDR 1 類 (98/1/1) 2. 臨 heart block 不 3. 料 (93/4/ 95/6/1) (1) CTMRI 金量 Hachinskki lschemic Scale (2) CB, VDRL, BUN, Creatinine, GOT, GPT, T4, TSH (3) 歷 (4) 95/6/1 (5) MMSE CDR Polifeprosan 20 with carmustine implant Gliadel Wafer 立羅狀 Gliadel Wafer1.451 polifeprosan 20 (polyanhydride copolymer) 192.3 carmustine 7.7 Carmustinepolifeprosan 20 prolifeprosan 20carmustine 理 Gliadel Wafercarmustine DNARNA 惡力 Gliadel Waferpolifeprosan 20 70% carboxyphenoxypropane sebacic acid Prolifeprosan 20 不 Gliadel Wafer carmustine 度量 Gliadel Wafer 率異見留復神不良 1. 度惡神復臨兩率 19% 率 54% (12/22Gliadel Wafer)9% (2/22 ) 數 Gliadel Wafer3.561 2. 罹度惡神療臨率 22.5% (Gliadel Wafer)19.2%( )( 復 ) Gliadel Wafer 留 3. 異度惡神復

臨異率 14%(Gliadel Wafer)5%() 4. 度惡神復臨率 4%(Gliadel Wafer ) 1%( ) Gliadel Wafer 塞 Gliadel Wafer Gliadel Wafer D carmustine Gliadel Wafer Gliadel Wafer 療 Gliadel Wafer 療 Gliadel Wafer 見量 Gliadel Wafercarmustine 7.7 mg 量 61.6 mg 量 Gliadel Wafer 若不數 Gliadel Wafer 臨不 Gliadel Wafer 立 Gliadel wafer carmustine 兩若 Gliadel Wafer Gliadel Wafer Gliadel Wafer 都狀不切理留 Gliadel Wafer 裂裂兩 (Surgicel ) Gliadel Wafer 6 零 20C 參料 1. McEvoy GK, ed. AHFS: Drug Information. Bethesda, MD: American Society of Health-System Pharmacists; 2008:972-7. 2. DRUGDEX System:Klasco RK (Ed): DRUGDEX System (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: http://www.thomsonhc.com (cited: 5/18/2008). 3. The circular from the manufacturer of Gliadel Wafer. 4. Brem H, Piantadosi S, Burger PC, et al. Placebocontrolled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas. Lancet 1995; 345:1008-12. 5. Westphal M, Hilt DC, Bortey E, et al. A phase 3 trial of local chemotherapy with biodegradable carmustine (BCNU) wafers (Gliadel wafers) in patients with primary malignant glioma. Neuro-Oncol 2003; 5: 79-88. 6. Westphal M, Ram Z, Riddle V, et al. Gliadel wafer in initial surgery for malignant gliomas: long-term followup of a multicenter controlled trial. Acta Neurochir 2006; 148: 269-75. Tetrabenazine Nitoman () 林

狀 Nitoman CL25 tetrabenazine 25 mg 理 Tetrabenazinebenzoquinolizine 來療 Tetrabenazine 神 (vesicular) 類神 dopamine norepinephrine serotonin 度 acetylcholin glutamatasparate 度類 reserpine 力 Tetrabenazine 率不穏 hydroxytetrabenazine (Huntington's disease) 不良不 (27.4%)(<5%) 不 1. Tetrabenazine 車 2. tetrabenazine 3. 糖 lactose 見糖不 galactose intolerancelapp 糖 Lapp lactase deficiency 糖 - 糖不良 glucose-galactose malabsorption 不料 1. 2. MAOI MAOI 若 2 Tetrabenazine parkinsonian symptomslevodopa 量量 12.5-25 mg2-3 3412.5 mg 量 200 mg( 量 ) <30 參料 1. DRUGDEX System:Klasco RK (Ed): DRUGDEX System (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: http://www.thomsonhc.com (cited:4/3/2008). 2. The information from the manufacturer of Nitoman. Decitabine Dacogen () 羅狀狀 decitabine 100 mg. 理 Decitabine DNADNA methyltransferase DNAdecitabine ( ) 復 decitabine 來 DNA methyltransferase DNA decitabine

力臨 decitabine 20-30 mg/m 2 /day72 廓率 124 L/hr/m 2 0.51±0.31 率 <1% Decitabine 類切 cytidine deaminase 粒 FDA 療療不 (myelodysplastic syndromes) FAB(French-American- British) IPSS (International Prognostic Scoring System) 數 >0.5 不良 ( ) 療量見 MDS 臨 decitabine 率 90% 89% 82%grade 34 率 87%85% 見不良異 ( 數 ) 見兩臨度 CYP450 量 FDA 量 15 mg/m 2 38 連 3 理立臨參療 Dacogen10 ml(2-8)ml decitabine 5 mg 立 0.9% sodium chloride Injection5% dextrose injection lactated ringer s injection 度 0.1-1 mg/ml15 (2-8)2-8 7 (15-30 參料 1. Decitabine. From AHFS Drug Information (electronic version). At: STAT!Ref Online Electronic Medical Library. Bethesda, MD: American Society of Health-System Pharmacists, Inc.; 2008. Accessed: 10/31/2008). 2. Klasco RK (Ed): DRUGDEX System (electronic version). Thomson Micromedex, Greenwood Village, Colorado, USA. Available at: http://www.thomsonhc.com (cited: 10/31/2008). 3. The circular from the manufacturer of Dacogen. FDAD decitabine 料率 (<1%)